Hno最新文献

{"title":"[Current aspects of nanoparticle-based therapy in head and neck cancer].","authors":"Stefan Hansen, Benjamin Kansy, Sven Brandau, Matthias Epple, Stephan Lang","doi":"10.1007/s00106-025-01633-0","DOIUrl":"https://doi.org/10.1007/s00106-025-01633-0","url":null,"abstract":"<p><p>The rapid expansion and application of nanoparticles in medicine has meanwhile contributed to a large number of experimental and clinical studies, especially in cancer research. Numerous different fields within nanomedicine have now become established more clearly. These are based on the one hand on the properties of different types of nanoparticles (chemical, physical, and biological) and on the other hand on the possible specific applications such as drug carrier, radioenhancer, in vivo monitoring of drug distribution within the tumor, or tumor-specific immune-modulating effects. Nanoparticles can also be functionalized by multiple properties potentiating their intrinsic antitumoral effects, such as coupling of antibodies to address target tissue or coupling to chemotherapeutic agents. In this work, an up-to-date overview of the developments and applications related to nanoparticles in head and neck cancer is given.</p>","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evidence-based phytotherapy in otorhinolaryngology-the update].","authors":"F Locquet, S Sertel","doi":"10.1007/s00106-025-01636-x","DOIUrl":"https://doi.org/10.1007/s00106-025-01636-x","url":null,"abstract":"<p><strong>Background: </strong>For centuries, phytopharmaceuticals were the primary form of medicine used worldwide to treat, alleviate, or prevent disease. Phytotherapy harnesses the therapeutic effects of plants and their components (phytopharmaceuticals). According to the World Health Organization (WHO), phytotherapy remains a crucial pillar of healthcare today and is expected to become even more important in the future. Referring to our initial review article from 2011, we now present an update to cover the period from 2011 to the present.</p><p><strong>Objective: </strong>Which phytopharmaceuticals are relevant in otorhinolaryngology, and is there evidence-based data supporting their use?</p><p><strong>Materials and methods: </strong>A literature search was conducted for the period from 2011 to 2024 using PubMed (MEDLINE). The search results were further refined by focusing on randomized, clinical, and controlled trials written in English and adhering to Good Clinical Practice (GCP) guidelines.</p><p><strong>Results: </strong>The search term \"phytotherapy\" yielded 44,202 results. After limiting to 2011-2024 and applying the aforementioned criteria, 1685 results remained. With respect to otorhinolaryngology, only six studies remained. This procedure was applied to all search terms and otorhinolaryngology-specific search terms. Exclusion criteria included homeopathy, shamanistic medicine, case reports, studies not conducted according to GCP guidelines, and studies not written in English. The search term \"traditional medicine\" returned 275,079 results. After limiting to 2011-2024 and applying the aforementioned criteria, 6448 results remained. With respect to otorhinolaryngology, only two studies remained. The search term \"Chinese medicine\" returned 378,231 results. After limiting to 2011-2024 and applying the criteria, 7815 results remained. With respect to otorhinolaryngology, only one study remained. In total, 14 studies were selected and presented.</p><p><strong>Conclusion: </strong>Since 2011, a substantial number of new studies on phytotherapy have been published. However, few studies utilize standardized measurement methods and materials, thus precluding objective statements. Such standardization is essential for practical therapeutic application. Due to the frequently inadequate adherence to GCP guidelines, there has been no significant gain in knowledge regarding the effects and efficacy of phytopharmaceuticals. Intensive clinical research is still required to adequately utilize phytotherapy.</p>","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Fitting of cochlear implant systems].","authors":"Uwe Baumann, Tobias Weißgerber, Ulrich Hoppe","doi":"10.1007/s00106-025-01593-5","DOIUrl":"https://doi.org/10.1007/s00106-025-01593-5","url":null,"abstract":"<p><p>The technical fitting of cochlear implant (CI) systems is a central component of the CI care process. On the one hand, this consists of a standardized procedure, while on the other, the individual needs of the patient are taken into account. It starts with the \"initial fitting\" during basic therapy, where the initial focus is on achieving a satisfactory impression of sound and loudness. In the follow-up therapy, fine adjustment is carried out to achieve the best possible speech perception in quiet and in noise. The aim is to individually adjust the CI processor to audiological targets. The fitting is carried out by a specially qualified professional in accordance with the German CI fitting guidelines and takes into account anatomical conditions, electrophysiological measurements, and audiological evaluation data. The CI fitting should maintain hearing and speech perception throughout life, thus ensuring a significant improvement in quality of life. In children, achieving the best possible CI fitting is fundamental to facilitating normal speech development.</p>","PeriodicalId":55052,"journal":{"name":"Hno","volume":"73 5","pages":"335-356"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Uncontrollable nosebleeds on the right : Medical examination: Preparation for ENT specialisation Part 34].","authors":"J Zenk, K Nagel","doi":"10.1007/s00106-025-01608-1","DOIUrl":"10.1007/s00106-025-01608-1","url":null,"abstract":"","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":"13-17"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[6/m and 36/m with slowly in intensity increasing and now permanent hoarseness : Medical examination: Preparation for ENT specialisation Part 56].","authors":"Thomas Eichhorn, Katrin Palisch","doi":"10.1007/s00106-025-01610-7","DOIUrl":"10.1007/s00106-025-01610-7","url":null,"abstract":"","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":"88-91"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[44/m Unconscious after wasp sting : Medical examination: Preparation for ENT specialisation Part 44].","authors":"M Cuevas","doi":"10.1007/s00106-025-01619-y","DOIUrl":"https://doi.org/10.1007/s00106-025-01619-y","url":null,"abstract":"","PeriodicalId":55052,"journal":{"name":"Hno","volume":"73 Suppl 1","pages":"53-56"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Medical examination: preparation for ENT specialisation : Part 74].","authors":"Michael Herzog, Luisa Röse","doi":"10.1007/s00106-025-01589-1","DOIUrl":"10.1007/s00106-025-01589-1","url":null,"abstract":"","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":"126-130"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[70/m, swelling of the nasal bone : Preparation for the medical specialist examination: part 48].","authors":"Michael Herzog","doi":"10.1007/s00106-025-01569-5","DOIUrl":"10.1007/s00106-025-01569-5","url":null,"abstract":"","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":"63-66"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Runny nose for several weeks : Preparation for the specialist examination].","authors":"A Darbinjan, M Neudert","doi":"10.1007/s00106-025-01576-6","DOIUrl":"10.1007/s00106-025-01576-6","url":null,"abstract":"","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":"29-32"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Language development test for 3-5-year-old children (3;0-5;11 years)-diagnostics of language and auditory memory : Retrospective analysis of children with bilateral cochlear implantation in early childhood].","authors":"Barbara Streicher, Kerstin Kreibohm-Strauß, Stefanie Kröger, Dominique Kronesser, Yvonne Seebens, Cynthia Glaubitz, Dennis Metzeld, Ruth Lang-Roth","doi":"10.1007/s00106-025-01631-2","DOIUrl":"10.1007/s00106-025-01631-2","url":null,"abstract":"<p><strong>Background: </strong>Fitting of a cochlear implant (CI) influences the development of auditory memory and thus the development of speech. Speech development is a prerequisite for the acquisition of written language and reading and, thus, the later educational biography.</p><p><strong>Materials and methods: </strong>Language development tests for 3-5-year-old children (SETK 3-5) represent a standardized procedure to assess receptive and expressive speech development as well as auditory memory. In a retrospective cross-sectional study, data of children who were fitted with bilateral CIs from six CI centers of the ACIR (Arbeitsgemeinschaft CI Rehabilitation) were evaluated. The study group was divided into groups that were analyzed on the basis of age (chronological age; LA) and hearing experience with CI (hearing age; HA). In addition, a distinction was made between CI surgery before the age of 1 year (CI ≤ 12 months) and CI surgery from the second to the fourth year of life (CI > 12 ≤ 48 months). The study group was then subdivided according to the SETK 3;0-3;11 years test into G1LA (CI ≤ 12 months), G2LA (CI > 12 ≤ 48 months), G1HA (CI ≤ 12 months), and G2HA (CI > 12 ≤ 48 months). The study group for the SETK 4;0-5;11 years test was subdivided into G3LA (CI ≤ 12 months), G4LA (CI > 12 ≤ 48 months), G3HA (CI ≤ 12 months), and G4HA (CI > 12 ≤ 48 months).</p><p><strong>Results: </strong>The groups G1LA, G1HA, G3LA, and G3HA (CI ≤ 12 months) achieved age-appropriate values in all subtests of the SETK (3-5). Children who receive CI within the second year of life catch up in terms of language acquisition and some also develop language skills, but the T scores are below the age-adapted norm values. Children with a multilingual background show results below the norm of their hearing peers in both test settings (chronological age and hearing age).</p><p><strong>Conclusion: </strong>Early provision of CI in the first year of life is an important prerequisite for children to develop age-appropriate language skills. Nevertheless, there is wide variation within the groups, so that speech diagnostics and therapy are required as part of follow-up treatment during primary language acquisition to detect and avoid major language delay.</p>","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":"321-334"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}