Hno最新文献

{"title":"[Evidence-based phytotherapy in otorhinolaryngology-the update].","authors":"F Locquet, S Sertel","doi":"10.1007/s00106-025-01636-x","DOIUrl":"10.1007/s00106-025-01636-x","url":null,"abstract":"<p><strong>Background: </strong>For centuries, phytopharmaceuticals were the primary form of medicine used worldwide to treat, alleviate, or prevent disease. Phytotherapy harnesses the therapeutic effects of plants and their components (phytopharmaceuticals). According to the World Health Organization (WHO), phytotherapy remains a crucial pillar of healthcare today and is expected to become even more important in the future. Referring to our initial review article from 2011, we now present an update to cover the period from 2011 to the present.</p><p><strong>Objective: </strong>Which phytopharmaceuticals are relevant in otorhinolaryngology, and is there evidence-based data supporting their use?</p><p><strong>Materials and methods: </strong>A literature search was conducted for the period from 2011 to 2024 using PubMed (MEDLINE). The search results were further refined by focusing on randomized, clinical, and controlled trials written in English and adhering to Good Clinical Practice (GCP) guidelines.</p><p><strong>Results: </strong>The search term \"phytotherapy\" yielded 44,202 results. After limiting to 2011-2024 and applying the aforementioned criteria, 1685 results remained. With respect to otorhinolaryngology, only six studies remained. This procedure was applied to all search terms and otorhinolaryngology-specific search terms. Exclusion criteria included homeopathy, shamanistic medicine, case reports, studies not conducted according to GCP guidelines, and studies not written in English. The search term \"traditional medicine\" returned 275,079 results. After limiting to 2011-2024 and applying the aforementioned criteria, 6448 results remained. With respect to otorhinolaryngology, only two studies remained. The search term \"Chinese medicine\" returned 378,231 results. After limiting to 2011-2024 and applying the criteria, 7815 results remained. With respect to otorhinolaryngology, only one study remained. In total, 14 studies were selected and presented.</p><p><strong>Conclusion: </strong>Since 2011, a substantial number of new studies on phytotherapy have been published. However, few studies utilize standardized measurement methods and materials, thus precluding objective statements. Such standardization is essential for practical therapeutic application. Due to the frequently inadequate adherence to GCP guidelines, there has been no significant gain in knowledge regarding the effects and efficacy of phytopharmaceuticals. Intensive clinical research is still required to adequately utilize phytotherapy.</p>","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":"558-567"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Inner ear schwannomas and hearing rehabilitation with cochlear implants-an update].","authors":"Stefan K Plontke, Torsten Rahne","doi":"10.1007/s00106-025-01639-8","DOIUrl":"10.1007/s00106-025-01639-8","url":null,"abstract":"","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":"547-549"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Medialization thyroplasty with the VOIS implant : Voice outcomes and experiences].","authors":"Fabian Burk, Gerhard Förster, Kathleen Klinge, Andreas H Müller","doi":"10.1007/s00106-025-01640-1","DOIUrl":"10.1007/s00106-025-01640-1","url":null,"abstract":"<p><strong>Background: </strong>Unilateral vocal fold paralysis (UVFP) often leads to considerable limitations in voice quality and voice-related quality of life. Medialization thyroplasty (MT) is an established procedure for voice rehabilitation in cases of glottic insufficiency. Since December 2019, the APrevent® Vocal Implant System (VOIS, APrevent Biotech, Vienna, Austria) has been available in Germany as the first secondarily adjustable implant.</p><p><strong>Methods: </strong>A retrospective evaluation included 12 patients who received MT with the VOIS implant. Voice quality was analyzed multidimensionally at timepoints T0 (preoperative), T1 (2-3 months postoperatively), and T2 (6 months postoperatively).</p><p><strong>Results: </strong>Significant improvements were observed in all examined parameters. The mean maximum phonation time (MPT) increased from 5.79 s (T0) to 10.07 s at T1 (p < 0.001) and to 13.22 s at T2 (p = 0.001). Maximum sound pressure level (SPLmax) increased from 77.08 to 86.09 dB at T1 (p = 0.004) and to 86.17 dB at T2 (p = 0.005). Perceptual voice quality, particularly breathiness, improved significantly from 2.29 to 0.73 at T1 (p = 0.004) and to 0.67 at T2 (p = 0.002). Additionally, there was a reduction in the VHI-12 score from 30.73 preoperatively to 11.29 at T1 (p = 0.016) and to 15.22 at T2 (p = 0.008). No significant changes were noted between T1 and T2.</p><p><strong>Conclusion: </strong>Medialization thyroplasty with the VOIS implant resulted in significant improvements in voice quality and voice-related quality of life. The unique feature of the VOIS system, i.e., its secondary adjustability without a second surgery, offers potential for further optimization. Further studies are needed on the value of volume correction and the differential indications between MT and reinnervation techniques in UVFP.</p>","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":"574-580"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Current aspects of nanoparticle-based therapy in head and neck cancer].","authors":"Stefan Hansen, Benjamin Kansy, Sven Brandau, Matthias Epple, Stephan Lang","doi":"10.1007/s00106-025-01633-0","DOIUrl":"10.1007/s00106-025-01633-0","url":null,"abstract":"<p><p>The rapid expansion and application of nanoparticles in medicine has meanwhile contributed to a large number of experimental and clinical studies, especially in cancer research. Numerous different fields within nanomedicine have now become established more clearly. These are based on the one hand on the properties of different types of nanoparticles (chemical, physical, and biological) and on the other hand on the possible specific applications such as drug carrier, radioenhancer, in vivo monitoring of drug distribution within the tumor, or tumor-specific immune-modulating effects. Nanoparticles can also be functionalized by multiple properties potentiating their intrinsic antitumoral effects, such as coupling of antibodies to address target tissue or coupling to chemotherapeutic agents. In this work, an up-to-date overview of the developments and applications related to nanoparticles in head and neck cancer is given.</p>","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":"568-573"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12289740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Swallowing and swallowing disorders at the focus of otorhinolaryngology : From diagnosis to individualized treatment].","authors":"Cornelia Schwemmle, Niall Watt, Christoph Arens","doi":"10.1007/s00106-025-01630-3","DOIUrl":"10.1007/s00106-025-01630-3","url":null,"abstract":"<p><p>Dysphagia refers to painless impairment of the transport of liquid or solid food from the oral cavity to the stomach. If pain accompanies swallowing, this is termed odynophagia, and discomfort when swallowing saliva suggests a globus pharyngis. Swallowing disorders can occur during any one or all phases of bolus transport. The causes are manifold, due to the involvement of central control areas within the brain as well as the peripheral nervous system. The diagnosis consists of a detailed case history as well as screening forms and questionnaires. In Germany, the gold standard diagnostic procedure is flexible (video-)endoscopic evaluation of swallowing. Videofluoroscopy and electrophysiological examinations complement the diagnosis. Therapeutic options comprise functional strategies and rehabilitative exercises. However, the most important task of otorhinolaryngologists, in addition to the primary surgical treatment of tumors in the area of the upper swallowing tract (taking into account the preservation of swallowing structures), is the assessment of posttreatment dysphagia with the option of individualized surgical measures to improve swallowing.</p>","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":"527-546"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12289832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Provision of hearing technology in children and adolescents with permanent hearing loss in Germany. German version].","authors":"Elena Pützer, Heike van de Sand, Jasmin Filip, Ingrid Schubert, Ursula Marschall, Ingo Meyer, Karolin Schäfer","doi":"10.1007/s00106-025-01616-1","DOIUrl":"10.1007/s00106-025-01616-1","url":null,"abstract":"<p><strong>Background: </strong>To date, data on the prevalence and age at first management of permanent childhood hearing loss in Germany are lacking.</p><p><strong>Objective: </strong>This study aims to depict how often and at what age children and adolescents receive their (first) hearing technology.</p><p><strong>Materials and methods: </strong>In this study, we analyzed claims data from a large German statutory health insurance company (BARMER). A cross-sectional study determined the provision of hearing devices and cochlear implants for children and adolescents aged under 18 years with permanent hearing loss from 2010 to 2020. A longitudinal analysis of a cohort of children born in 2010 was performed to gain insights about age at first management with hearing technology during the first 10 years of life.</p><p><strong>Results: </strong>Between 2010 and 2020, approximately 2800 to 3600 children and adolescents per year were provided with hearing devices and 10 to 30 with cochlear implants. In the 2010 birth cohort, 1.22% of children received their first prescription for hearing devices before the age of 10. The proportionately highest number of first prescriptions was found between 3 and 6 years. In 2020, particularly few children gained access to hearing technology.</p><p><strong>Conclusion: </strong>The analysis of the prescribed hearing systems reveals inaccuracies in documentation but also a possible care gap in hearing loss management. For a large percentage of children and adolescents, management of hearing loss took place after the age of 1. The frequent initial provision of hearing technology at preschool age indicates that the proportion of hearing loss that is acquired, detected late, or treated late remained quite high even after the introduction of newborn hearing screening. There is an obvious need for comprehensive tracking of children who fail newborn hearing screening and for other screening and hearing tests. The data for 2020 suggest that hearing loss was diagnosed and treated later due to the COVID-19 pandemic.</p>","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":"581-588"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Laryngopharyngeal reflux disease-update 2025 : Revision taking into consideration the European CEORL-HNS guideline].","authors":"Arne Böttcher, Lisa Schmitz, Mihnea C Trache, Ulrich Stortz, Jacob F Clausen, Christian S Betz","doi":"10.1007/s00106-025-01645-w","DOIUrl":"10.1007/s00106-025-01645-w","url":null,"abstract":"<p><p>Laryngopharyngeal reflux disease (LPRD), a common condition with a variety of symptoms, often occurs without heartburn. One of the main causes appears to be the pepsin effect. Systematic recording of symptoms and findings confirms the suspected diagnosis. A patient-individualized multimodal therapy plan can quickly provide relief. Lifestyle modifications and treatment with alginate and proton pump inhibitors are often effective. Carcinophobic patients with foreign body sensation should be informed in detail and, in case of doubt, malignancy should be ruled out. This CME training course provides an overview of the current state of knowledge and refers to the recently published European guideline of the Confederation of European Otorhinolaryngology-Head and Neck Surgery Societies (CEORL-HNS).</p>","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":"589-602"},"PeriodicalIF":0.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Recommendations for selection of target parameters and process recommendations for audiological and technical functional testing of cochlear implant : Prepared by the ERA consortium (AG-ERA) of ADANO in cooperation with the Implantable Hearing Systems expert committee of the DGA. Confirmed by the board of ADANO on 31.01.2025. German version].","authors":"Alexander Müller, M Blümer, O C Dziemba, A Elsholz, L Fröhlich, U Hoppe, D Polterauer, T Rahne, T Steffens, M Walger, T Weißgerber, T Wesarg, S Zirn, T Rader","doi":"10.1007/s00106-025-01628-x","DOIUrl":"10.1007/s00106-025-01628-x","url":null,"abstract":"<p><p>Continuous monitoring of the technical and physiological function of cochlear implants (CI) is a central part of the care process. Despite worldwide efforts to standardise procedures, there is still considerable variation between CI centres, particularly in terms of the methods used, their practical implementation and the definition of meaningful target parameters. A standardised structured test procedure is needed for reliable quality assurance and better comparability. Against this background, the ADANO Working Group for Evoked Response Audiometry (AG-ERA), in close cooperation with the Cochlear Implants and Implantable Hearing Systems Committee of the German Society of Audiology (DGA), developed a minimum standard for audiological and technical functional testing of CIs in an open consensus process. This standard defines basic requirements for performance and documentation and serves as a practical recommendation for CI centres. It is intended to improve interdisciplinary cooperation, increase the quality of care and enable structured long-term optimised care for CI patients.</p>","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":"550-557"},"PeriodicalIF":1.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12289825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Objective evaluation of peripheral vestibulopathies for scientifically founded otorhinolaryngologic assessment].","authors":"Leif Erik Walther","doi":"10.1007/s00106-025-01643-y","DOIUrl":"https://doi.org/10.1007/s00106-025-01643-y","url":null,"abstract":"<p><p>Scientific progress in the diagnosis and treatment of dizziness syndromes has led to a paradigm shift in diagnostic approaches, establishment of a unified international vocabulary, and standardized criteria. Objective methods, including vestibular evoked myogenic potentials and the video head impulse test, are now widely used in otorhinolaryngologic assessments. According to these advancements, new evaluation criteria based on objective measures have been developed. These provide greater clarity in the legal context compared to previous evaluations which were based primarily on subjective standards, thus making the assessments more plausible and comprehensible. It is now possible to definitively substantiate a defined health disorder or functional impairment in the field of otorhinolaryngology with full evidence based on objective criteria.</p>","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Bone conduction and active middle ear implants: systematics and audiological indication criteria].","authors":"Stefan K Plontke, Torsten Rahne","doi":"10.1007/s00106-025-01644-x","DOIUrl":"https://doi.org/10.1007/s00106-025-01644-x","url":null,"abstract":"","PeriodicalId":55052,"journal":{"name":"Hno","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}