[A rare cause of hoarseness-a case study and compact overview of laryngeal amyloidosis].

IF 1.3 4区医学 Q4 OTORHINOLARYNGOLOGY

Hno Pub Date : 2025-10-17 DOI:10.1007/s00106-025-01681-6

Hannah Schützenmeister, Rahel Schwotzer, Jakob Becker, Nathalie Nierobisch, Daniel Runggaldier, Jörg E Bohlender

引用次数: 0

Abstract

This case report describes a patient with localized laryngeal immunoglobulin light chain (AL) amyloidosis. The larynx is one of the most common sites of manifestation of localized amyloidosis. Amyloidosis leads to benign, tumor-like lesions caused by the deposition of insoluble protein aggregates, so-called fibrils. The current patient presented with the main symptom of hoarseness. Amyloidosis is most commonly treated by surgical resection of the mass. However, depending on the extent and course of disease, other therapeutic approaches are also feasible, which are discussed in this review.

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[一种罕见的导致声音嘶哑的原因——喉淀粉样变的病例研究和简要概述]。

本病例报告描述了一个局部喉免疫球蛋白轻链（AL）淀粉样变的患者。喉部是局部淀粉样变最常见的表现部位之一。淀粉样变性导致由不溶性蛋白聚集体（所谓原纤维）沉积引起的良性肿瘤样病变。本例患者以声音嘶哑为主要症状。淀粉样变最常用的治疗方法是手术切除肿块。然而，根据疾病的程度和病程，其他治疗方法也是可行的，本文将对此进行讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hno 医学-耳鼻喉科学

CiteScore

1.50

自引率

33.30%

发文量

116

审稿时长

4-8 weeks

期刊介绍： HNO is an internationally recognized journal and addresses all ENT specialists in practices and clinics dealing with all aspects of ENT medicine, e.g. prevention, diagnostic methods, complication management, modern therapy strategies and surgical procedures. Review articles provide an overview on selected topics and offer the reader a summary of current findings from all fields of ENT medicine. Freely submitted original papers allow the presentation of important clinical studies and serve the scientific exchange. Case reports feature interesting cases and aim at optimizing diagnostic and therapeutic strategies. Review articles under the rubric ''Continuing Medical Education'' present verified results of scientific research and their integration into daily practice.