Journal of Cranio-Maxillofacial Surgery最新文献

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Cephalometric landmark detection using vision transformers with direct coordinate prediction 使用直接坐标预测的视觉变压器进行头部测量地标检测。
IF 2.1 2区 医学
Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-07-01 DOI: 10.1016/j.jcms.2025.05.021
Filipe Laitenberger , Hannah T. Scheuer , Hanna A. Scheuer , Enno Lilienthal , Shaodi You , Reinhard E. Friedrich
{"title":"Cephalometric landmark detection using vision transformers with direct coordinate prediction","authors":"Filipe Laitenberger ,&nbsp;Hannah T. Scheuer ,&nbsp;Hanna A. Scheuer ,&nbsp;Enno Lilienthal ,&nbsp;Shaodi You ,&nbsp;Reinhard E. Friedrich","doi":"10.1016/j.jcms.2025.05.021","DOIUrl":"10.1016/j.jcms.2025.05.021","url":null,"abstract":"<div><div>Cephalometric Landmark Detection (CLD), i.e. annotating interest points in lateral X-ray images, is the crucial first step of every orthodontic therapy. While CLD has immense potential for automation using Deep Learning methods, carefully crafted contemporary approaches using convolutional neural networks and heatmap prediction do not qualify for large-scale clinical application due to insufficient performance. We propose a novel approach using Vision Transformers (ViTs) with direct coordinate prediction, avoiding the memory-intensive heatmap prediction common in previous work. Through extensive ablation studies comparing our method against contemporary CNN architectures (ConvNext V2) and heatmap-based approaches (Segformer), we demonstrate that ViTs with coordinate prediction achieve superior performance with more than 2 mm improvement in mean radial error compared to state-of-the-art CLD methods. Our results show that while non-adapted CNN architectures perform poorly on the given task, contemporary approaches may be too tailored to specific datasets, failing to generalize to different and especially sparse datasets. We conclude that using general-purpose Vision Transformers with direct coordinate prediction shows great promise for future research on CLD and medical computer vision.</div></div>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":"53 9","pages":"Pages 1518-1529"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the link between impacted third molars and bad split risk in sagittal split ramus osteotomy: A 12-year retrospective study 揭示第三磨牙阻生与矢状分叉支截骨不良风险之间的联系:一项12年的回顾性研究。
IF 2.1 2区 医学
Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-07-01 DOI: 10.1016/j.jcms.2025.06.004
Asım Nuriyev , Emrah Soylu , Mert Şahin , Gökhan Çoban , Ahmet Emin Demirbaş , Alper Alkan
{"title":"Unveiling the link between impacted third molars and bad split risk in sagittal split ramus osteotomy: A 12-year retrospective study","authors":"Asım Nuriyev ,&nbsp;Emrah Soylu ,&nbsp;Mert Şahin ,&nbsp;Gökhan Çoban ,&nbsp;Ahmet Emin Demirbaş ,&nbsp;Alper Alkan","doi":"10.1016/j.jcms.2025.06.004","DOIUrl":"10.1016/j.jcms.2025.06.004","url":null,"abstract":"<div><div>Bad splits are a known complication of Bilateral Sagittal Split Osteotomy<span><span> (BSSO), yet their occurrence remains unpredictable. This retrospective study investigated whether the presence, impaction status, and anatomical position of mandibular third molars affect the incidence and pattern of bad splits. A total of 819 patients who underwent BSSO between 2012 and 2023 were analyzed, encompassing 1638 osteotomy sites. Patients were grouped based on </span>third molar status at the time of surgery. Bad splits were observed in 2.38 % of all osteotomy sites. There was no statistically significant difference between patients with retained third molars (2.65 %) and those whose third molars were removed at least six months earlier (2.33 %, p = 0.77). Similarly, no significant associations were found between bad split occurrence and impaction status (p = 0.74) or anatomical position (p = 0.33). However, patients with retained third molars who experienced bad splits were significantly older (p = 0.004). These findings suggest that the configuration of third molars alone does not increase bad split risk, but age may play a contributory role.</span></div></div>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":"53 9","pages":"Pages 1538-1542"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Family strategy for nasoalveolar molding in infants with unilateral complete cleft lip and palate 单侧完全性唇腭裂婴儿鼻肺泡成形的家庭策略。
IF 2.1 2区 医学
Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-06-30 DOI: 10.1016/j.jcms.2025.06.005
Shiming Zhang , Min Wu , Jiayi Yin , Meijun Du , Jiali Chen , Karim A. Sakran , Renjie Yang , Jian Song , Qian Zheng , Bing Shi , Hanyao Huang
{"title":"Family strategy for nasoalveolar molding in infants with unilateral complete cleft lip and palate","authors":"Shiming Zhang ,&nbsp;Min Wu ,&nbsp;Jiayi Yin ,&nbsp;Meijun Du ,&nbsp;Jiali Chen ,&nbsp;Karim A. Sakran ,&nbsp;Renjie Yang ,&nbsp;Jian Song ,&nbsp;Qian Zheng ,&nbsp;Bing Shi ,&nbsp;Hanyao Huang","doi":"10.1016/j.jcms.2025.06.005","DOIUrl":"10.1016/j.jcms.2025.06.005","url":null,"abstract":"<div><h3>Background</h3><div>The aim of the study was to demonstrate the therapeutic outcomes after a family strategy for nasoalveolar molding (Family-NAM) in infants with unilateral complete cleft lip and palate.</div></div><div><h3>Methods</h3><div><span>Forty patients with unilateral complete cleft lip and palate<span> were categorized into two groups: the group in which the Family-NAM was used and the control group without Family-NAM. The Family-NAM was applied seven days after birth until primary rhinoplasty, while the 3-D alveolar molding plates were applied until primary </span></span>palatoplasty<span>. Six parameters were measured to evaluate nasal symmetry, and palatal measurements were applied to evaluate the cleft palate size and morphology.</span></div></div><div><h3>Results</h3><div>Before the primary surgical correction, the application of Family-NAM can significantly improve the preoperative nasal morphology. Patients with Family-NAM showed better nasal symmetry at 6-12-month post-operative follow-up compared with the control group. Compared to the control group, the Family-NAM group showed a significantly narrower cleft gap before primary cleft rhinoplasty and before primary palatoplasty.</div></div><div><h3>Conclusion</h3><div>The Family-NAM can effectively reduce the severity of preoperative clefts and improve the degree of asymmetry and postoperative nasal morphology. It is convenient for infant caregivers by avoiding frequent visits, minimizing complications, and simplifying the courses of preoperative molding treatment.</div></div>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":"53 9","pages":"Pages 1495-1500"},"PeriodicalIF":2.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic skull base reconstruction for skull base osteoradionecrosis in nasopharyngeal carcinoma 内镜下颅底重建治疗鼻咽癌颅底放射性骨坏死。
IF 2.1 2区 医学
Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-06-30 DOI: 10.1016/j.jcms.2025.06.012
Li Wang , Ce Wu , Li'ou Chen, Wei Wei, Yan Qi, Jialu Wang, Qinzhan Ren, Junqi Liu, Zhenlin Wang
{"title":"Endoscopic skull base reconstruction for skull base osteoradionecrosis in nasopharyngeal carcinoma","authors":"Li Wang ,&nbsp;Ce Wu ,&nbsp;Li'ou Chen,&nbsp;Wei Wei,&nbsp;Yan Qi,&nbsp;Jialu Wang,&nbsp;Qinzhan Ren,&nbsp;Junqi Liu,&nbsp;Zhenlin Wang","doi":"10.1016/j.jcms.2025.06.012","DOIUrl":"10.1016/j.jcms.2025.06.012","url":null,"abstract":"<div><div>Skull base<span><span> osteoradionecrosis (ORN) is a serious late complication of radiotherapy in patients with </span>nasopharyngeal carcinoma<span><span> (NPC) that significantly affects their quality of life<span> (QOL) and may be life-threatening. We aimed to report the clinical efficacy of endoscopic radical resection of the necrotic tissue and simultaneous skull base repair for patients with ORN.We enrolled 39 patients with ORN who underwent endoscopic radical necrotic tissue resection with concomitant skull base repair using muscle or mucosal flaps at our institution. The 5-year overall survival (OS) was determined. Pain, foul odor, </span></span>epistaxis, and QOL at different time points were assessed using a visual analog rating scale (VAS), and factors affecting OS and QOL were analyzed.</span></span></div><div>The OS rates at 1, 3, and 5 years were 88.33 %, 71.46 %, and 53.60 %, respectively. Internal carotid artery<span> (ICA) risk and serum hemoglobin levels significantly affect patient OS. From 1 week preoperatively to 6 months postoperatively, the patients' VAS scores for pain, foul odor, and epistaxis decreased significantly from 3.81, 2.70, and 1.81 to 0.73, 0.49, and 0.08, respectively (P &lt; 0.001), whereas the QOL score increased from 6.09 to 7.86 (P &lt; 0.001). ICA risk significantly affects patient QOL. Endoscopic necrotic tissue resection combined with skull base repair is safe and effective for treating patients with ORN, significantly relieving their symptoms and improving their QOL. Accurately assessing ICA rupture risk and nutritional status and rational intervention are important in patients with ORN.</span></div></div>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":"53 9","pages":"Pages 1511-1517"},"PeriodicalIF":2.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimally invasive in situ bone extraction–implant implantation–bone augmentation by robot: a case report 微创原位骨提取-人工种植-机器人骨增强术1例报告。
IF 2.1 2区 医学
Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-06-30 DOI: 10.1016/j.jcms.2025.05.002
Changjian Li , Chunhao Yang , Yue Zhang , Yanfeng Li
{"title":"Minimally invasive in situ bone extraction–implant implantation–bone augmentation by robot: a case report","authors":"Changjian Li ,&nbsp;Chunhao Yang ,&nbsp;Yue Zhang ,&nbsp;Yanfeng Li","doi":"10.1016/j.jcms.2025.05.002","DOIUrl":"10.1016/j.jcms.2025.05.002","url":null,"abstract":"<div><h3>Objective</h3><div><span>To present a technical process for robot-assisted, minimally invasive bone extraction–implant implantation–bone augmentation in patients with bone defects or </span>bone atrophy.</div></div><div><h3>Method</h3><div>In this technical process, the surgical trajectory was preplanned within the robotic system. After patient registration and completion of robotic arm calibration, precise movement of the robotic arm enabled minimally invasive bone extraction using a trephine, followed by reaming with a single spiral drill. The final placement of implants was conducted manually. Autologous bone, bone marrow blood, and Bio-Oss granular bone were collectively mixed for grafting into the defect area, accompanied with collagen membrane coverage and subsequent suturing.</div></div><div><h3>Result</h3><div>The osteotomy<span> of autologous bone was precisely executed. Meanwhile, the accuracy of implant placement<span><span> was clinically acceptable. The bone graft surgery was successfully completed without any significant </span>postoperative complications<span>. The vertical and lateral forces exerted by the robotic arm during drilling were within an acceptable range. The robotic surgery exhibited consistent stability throughout its operation and demonstrated a relatively short drilling time.</span></span></span></div></div><div><h3>Conclusion</h3><div>The novel protocol enabled precise osteotomy of autologous bone and enhanced bone grafting in patients with bone defects or atrophy. However, further clinical studies are necessary.</div></div><div><h3>Clinical significance</h3><div>The primary finding of this study is a promising alternative for individuals suffering from bone defects or bone atrophy.</div></div>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":"53 9","pages":"Pages 1487-1494"},"PeriodicalIF":2.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unilateral cleft lip repair: Standardized key steps for Cupid's bow reconstruction 单侧唇裂修复:丘比特弓重建的标准化关键步骤。
IF 2.1 2区 医学
Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-06-27 DOI: 10.1016/j.jcms.2025.05.018
Chuanqi Qin , Yuting Wang , Jian Li , Huixi Jin , Quanmei Yan , Yuchuan Fu , Xiazhou Fu
{"title":"Unilateral cleft lip repair: Standardized key steps for Cupid's bow reconstruction","authors":"Chuanqi Qin ,&nbsp;Yuting Wang ,&nbsp;Jian Li ,&nbsp;Huixi Jin ,&nbsp;Quanmei Yan ,&nbsp;Yuchuan Fu ,&nbsp;Xiazhou Fu","doi":"10.1016/j.jcms.2025.05.018","DOIUrl":"10.1016/j.jcms.2025.05.018","url":null,"abstract":"<div><div>Cleft lip<span><span> repair is a complex and technically demanding surgery, performed by skilled surgeons. Improving surgical outcomes in cleft lip repair offers substantial benefits to patients, yet it remains a persistent challenge for surgical teams. To address this challenge, we developed a systematic protocol based on 40 years of refinements in 7400 cases. By deconstructing the procedure into defined steps, this framework aims to reduce procedural variability while preserving flexibility for case-specific adaptations. The stepwise approach was applied to establish a surgical procedure for Cupid's bow reconstruction in </span>unilateral cleft lip<span> repair, providing quantified, predictable, and repeatable steps for both surgeons and surgical teams. Five empirically refined steps were defined: landmarking; descending of Cupid's peak; correction of the Cupid's bow midline; reconstruction of subanatomical structure and the white roll of Cupid's bow; and restore the symmetry and coordination of Cupid's bow. Both immediate and long-term outcomes demonstrated good and stable results in Cupid's bow reconstruction in unilateral cleft lip repair. This protocol synthesizes four decades of surgical expertise into a reproducible framework, emphasizing adaptability to anatomical diversity while reducing reliance on subjective intraoperative decisions.</span></span></div></div>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":"53 9","pages":"Pages 1471-1480"},"PeriodicalIF":2.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calcium phosphate vs. autologous cranioplasty in a pediatric population 磷酸钙与自体颅骨成形术在儿科人群中的应用。
IF 2.1 2区 医学
Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-06-27 DOI: 10.1016/j.jcms.2025.05.019
L.L. Verhoef , B. Gareb , J.M.C. van Dijk , R.R.M. Bos
{"title":"Calcium phosphate vs. autologous cranioplasty in a pediatric population","authors":"L.L. Verhoef ,&nbsp;B. Gareb ,&nbsp;J.M.C. van Dijk ,&nbsp;R.R.M. Bos","doi":"10.1016/j.jcms.2025.05.019","DOIUrl":"10.1016/j.jcms.2025.05.019","url":null,"abstract":"<div><h3>Background and objective</h3><div>Persistent skull defects due to trauma, tumors, or neurosurgical procedures often necessitate cranioplasty. Autologous bone flaps are the gold standard but have a high risk of complications in pediatric cases, especially bone flap resorption. This study evaluated alloplastic HA-βTCP (TricOs™) versus autologous cranioplasties, aiming to identify the ideal material for pediatric cranioplasties.</div></div><div><h3>Materials and methods</h3><div>A retrospective analysis of cranioplasties in pediatric patients with large cranial defects operated between 1995 and 2021 was conducted. Survival times of autologous and alloplastic HA-βTCP (TricOs™) cranioplasties were compared using Kaplan-Meier curves and log-rank test.</div></div><div><h3>Results</h3><div>The cohort included 22 cranioplasties (11 autologous, 11 alloplastic HA-βTCP (TricOs™)). Autologous cranioplasties demonstrated 63,6 % failure rate versus 9,1 % in the alloplastic group. Mean survival time was significantly longer for alloplastic - (67.61 ± 7.96 months (95 % CI [52.00; 83.21])) compared to autologous cranioplasties (32.75 ± 13.20 months (95 % CI [6.88; 58.61])) (p = 0.035).</div></div><div><h3>Conclusion</h3><div>Alloplastic HA-βTCP (TricOs™) demonstrated a significantly longer survival time compared to autologous cranioplasties. The findings suggest that HA-βTCP (TricOs™) offers a superior alternative in reducing risk of implant failure, potentially addressing the challenges of bone flap resorption in a pediatric population. Additional studies are warranted to endorse these retrospective findings.</div></div>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":"53 9","pages":"Pages 1481-1486"},"PeriodicalIF":2.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The cleft palate-associated gene Midline1 plays a role in mouse palatal development by regulating MMP8 and Snail proteins 腭裂相关基因Midline1通过调控MMP8和Snail蛋白在小鼠腭发育中起作用。
IF 2.1 2区 医学
Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-06-23 DOI: 10.1016/j.jcms.2025.06.006
Yifan Li , Chengxian Jiang , Teng Ma , Mingwei Huang , Chengri Jin
{"title":"The cleft palate-associated gene Midline1 plays a role in mouse palatal development by regulating MMP8 and Snail proteins","authors":"Yifan Li ,&nbsp;Chengxian Jiang ,&nbsp;Teng Ma ,&nbsp;Mingwei Huang ,&nbsp;Chengri Jin","doi":"10.1016/j.jcms.2025.06.006","DOIUrl":"10.1016/j.jcms.2025.06.006","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the role of the Midline1 gene in secondary palate development by analyzing its expression and function in palatal shelf fusion and morphology.</div></div><div><h3>Design</h3><div>Initially, twenty mouse embryos were collected for each of the embryonic stages E13.5, E13.75, and E14.5. Whole-mount in situ hybridization was performed approximately ten times to optimize the experimental protocol and to analyze the expression pattern of Midline1 (MID1) in the palatal tissues at these developmental stages. Subsequently, palatal tissues from E13.5 embryos were treated with varying concentrations of Midline1 small interfering RNA (MID1 siRNA), and the knockdown efficiency was evaluated using Reverse Transcription Quantitative Polymerase Chain Reaction (RT-qPCR), with each concentration tested in triplicate. Based on the results, the most effective concentration, 100 nM MID1 siRNA, was selected for further experiments. Subsequently, twelve E13.5 palatal explants were allocated into two groups: six explants were treated with 100 nM MID1 siRNA (experimental group), and six with scrambled small interfering RNA(Scramble siRNA; control group). After 48 h of in vitro culture, hematoxylin and eosin (HE) staining was performed to evaluate the morphology of palatal shelf fusion. To evaluate apoptotic activity, Terminal deoxynucleotidyl transferase dUTP Nick-End Labeling (TUNEL) staining was performed on both experimental and control groups. Finally, immunohistochemistry and Western blot analyses were conducted to examine the expression levels of Matrix Metalloproteinase 8 (MMP8) and Snail Family Transcription Factors (Snail) proteins in three biological replicates from each group.</div></div><div><h3>Results</h3><div>Midline1 deficiency resulted in incomplete palatal shelf fusion and significantly reduced apoptosis. Additionally, the knockdown of Midline1 led to the upregulation of Snail and MMP8 gene expression, indicating that Midline1 plays a critical role in regulating epithelial-to-mesenchymal transition and maintaining cytoskeletal stability during palate development.</div></div><div><h3>Conclusions</h3><div>Midline1 is essential for normal secondary palate development. Its dysregulation disrupts palatal shelf fusion and morphology, potentially contributing to craniofacial abnormalities such as cleft palate. These findings provide new insights into the molecular mechanisms underlying palate development and suggest that Midline1 could be a therapeutic target for addressing cleft palate and related defects.</div></div>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":"53 9","pages":"Pages 1463-1470"},"PeriodicalIF":2.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis and management of central giant cell granulomas of the jaws: a European and multicenter study 颌骨中央巨细胞肉芽肿的诊断和治疗:一项欧洲和多中心研究。
IF 2.1 2区 医学
Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-06-21 DOI: 10.1016/j.jcms.2025.05.017
Paolo Boffano , Francesca Neirotti , Matteo Brucoli , Muhammad Ruslin , Panagiotis Stathopoulos , Konstantina Tsekoura , Jan Laco , Radovan Mottl , Emil Dediol , Boris Kos , Adam Michcik , Adam Polcyn , Petia Pechalova , Nikolai Pavlov , Angel Sapundzhiev , Juan Carlos de Vicente , Tania Rodríguez Santamarta , Thomas Starch-Jensen , Ivana Mijatov , Branislav V. Bajkin , Christophe Meyer
{"title":"Diagnosis and management of central giant cell granulomas of the jaws: a European and multicenter study","authors":"Paolo Boffano ,&nbsp;Francesca Neirotti ,&nbsp;Matteo Brucoli ,&nbsp;Muhammad Ruslin ,&nbsp;Panagiotis Stathopoulos ,&nbsp;Konstantina Tsekoura ,&nbsp;Jan Laco ,&nbsp;Radovan Mottl ,&nbsp;Emil Dediol ,&nbsp;Boris Kos ,&nbsp;Adam Michcik ,&nbsp;Adam Polcyn ,&nbsp;Petia Pechalova ,&nbsp;Nikolai Pavlov ,&nbsp;Angel Sapundzhiev ,&nbsp;Juan Carlos de Vicente ,&nbsp;Tania Rodríguez Santamarta ,&nbsp;Thomas Starch-Jensen ,&nbsp;Ivana Mijatov ,&nbsp;Branislav V. Bajkin ,&nbsp;Christophe Meyer","doi":"10.1016/j.jcms.2025.05.017","DOIUrl":"10.1016/j.jcms.2025.05.017","url":null,"abstract":"<div><h3>Introduction</h3><div>Central giant cell granulomas (CGCGs) are benign but locally aggressive rare neoplasms that affect the bony skeleton, particularly the maxillofacial region. The purpose of this European multicenter study was to describe and assess the characteristics, diagnosis, management, and recurrence of CGCGs at different European oral and maxillofacial surgery centers.</div></div><div><h3>Methods</h3><div>The data from all the treated CGCGs from the involved oral and maxillofacial surgical units across Europe between January 1st<sup>,</sup> 2014 and December 31st<sup>,</sup> 2023 were recorded.</div></div><div><h3>Results</h3><div>A total of 76 patients, including 37 males and 39 females diagnosed with CGCG met the inclusion criteria and were included. The mean age of the study population at diagnosis was 41.8 years.</div><div>Fifty-three lesions were found in the mandible, with the most frequently involved subsite being the mandibular parasymphysis. Overall, 75.0 % of included CGCGs were unilocular. The most frequent treatment option was surgery alone. A total of 12 recurrences (15.8 %) were observed with a mean follow up of 41 months.</div></div><div><h3>Discussion</h3><div>Further genetic and molecular studies regarding the pathways underlying CGCGs are needed, in order to predict their natural history and to direct non-surgical therapies. In the meantime, surgeons should balance the risks of higher recurrence rates associated with lower surgical morbidity, performing an individualized treatment plan, taking into consideration the clinical and radiological features together with the patients’ age and comorbidities. A radiographic follow-up of patients with treated CGCGs could advised for the first 5 years.</div></div>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":"53 9","pages":"Pages 1455-1462"},"PeriodicalIF":2.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic resonance imaging in dental, oral and maxillofacial trauma: A systematic review 磁共振成像在牙科、口腔和颌面外伤中的应用:系统综述。
IF 2.1 2区 医学
Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-06-21 DOI: 10.1016/j.jcms.2025.05.016
Adib Al-Haj Husain , Suen An Nynke Lie , Sameena Sandhu , Maximilian Eberhard Hermann Wagner , Bernd Stadlinger , Egon Burian , Thomas Frauenfelder , Nicolin Hainc , Peter Kessler , Harald Essig
{"title":"Magnetic resonance imaging in dental, oral and maxillofacial trauma: A systematic review","authors":"Adib Al-Haj Husain ,&nbsp;Suen An Nynke Lie ,&nbsp;Sameena Sandhu ,&nbsp;Maximilian Eberhard Hermann Wagner ,&nbsp;Bernd Stadlinger ,&nbsp;Egon Burian ,&nbsp;Thomas Frauenfelder ,&nbsp;Nicolin Hainc ,&nbsp;Peter Kessler ,&nbsp;Harald Essig","doi":"10.1016/j.jcms.2025.05.016","DOIUrl":"10.1016/j.jcms.2025.05.016","url":null,"abstract":"<div><div>This systematic review evaluates the current literature on state-of-the-art radiation-free MRI techniques for managing dental, oral, and maxillofacial trauma, comparing their diagnostic performance to conventional X-ray-based imaging. Two reviewers conducted an investigation using the PICOS search strategy across multiple databases, including MEDLINE, EMBASE, BIOSIS, Web of Science, Cochrane Library, LILACS, and BBO Dentistry. Twenty-nine studies were included: 12 on orbital trauma, 10 on condylar, subcondylar, or TMJ trauma, five on mandibular fractures, and one each on temporal bone and dental trauma. MRI was performed at post-traumatic, postoperative, or both stages. Despite variability in scan parameters, field strengths, and coil configurations, the results highlight MRI's growing potential in trauma assessment. CT-like and Black Bone MRI sequences enable simultaneous visualization of hard and soft tissues at trauma sites, providing diagnostic insights comparable to X-ray-based techniques. However, despite their superior soft-tissue assessment, they remain less effective at depicting intricate bony pathoanatomical conditions. This diagnostic approach can improve the long-term benefit-to-risk ratio, particularly for younger, radio-sensitive patients requiring repeated imaging and long-term follow-up. However, a modality- and protocol-oriented approach is essential to balance clinical conditions, radiation exposure, and diagnostic accuracy and efficiency, to ensure optimal patient outcomes in comprehensive trauma management.</div></div>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":"53 9","pages":"Pages 1438-1454"},"PeriodicalIF":2.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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