磷酸钙与自体颅骨成形术在儿科人群中的应用。

IF 2.1 2区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Cranio-Maxillofacial Surgery Pub Date : 2025-06-27 DOI:10.1016/j.jcms.2025.05.019

L.L. Verhoef , B. Gareb , J.M.C. van Dijk , R.R.M. Bos

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引用次数: 0

摘要

背景与目的：由于创伤、肿瘤或神经外科手术导致的颅骨缺损通常需要颅骨成形术。自体骨瓣是金标准，但在儿童病例中有很高的并发症风险，特别是骨瓣吸收。本研究评估同种异体HA-βTCP （TricOs™）与自体颅骨成形术，旨在确定儿童颅骨成形术的理想材料。材料与方法：回顾性分析1995年至2021年收治的小儿大颅骨缺损颅骨成形术患者。采用Kaplan-Meier曲线和log-rank检验比较自体和同种异体HA-βTCP （TricOs™）颅骨成形术的生存时间。结果：该队列包括22例颅骨成形术（11例自体，11例异体HA-βTCP （TricOs™））。自体颅骨成形术的失败率为63.6%，而同种异体成形术的失败率为9.1%。同种异体移植组的平均生存时间明显延长，为（67.61±7.96个月）(95% CI [52.00；83.21]))与自体颅骨成形术（32.75±13.20个月）相比(95% CI [6.88；58.61])) （p = 0.035）。结论：与自体颅骨成形术相比，同种异体HA-βTCP （TricOs™）的存活时间明显更长。研究结果表明，HA-βTCP （TricOs™）在降低种植体失败风险方面提供了一种优越的替代方案，可能解决儿科人群骨皮瓣吸收的挑战。有必要进行更多的研究来支持这些回顾性发现。

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Calcium phosphate vs. autologous cranioplasty in a pediatric population

Background and objective

Persistent skull defects due to trauma, tumors, or neurosurgical procedures often necessitate cranioplasty. Autologous bone flaps are the gold standard but have a high risk of complications in pediatric cases, especially bone flap resorption. This study evaluated alloplastic HA-βTCP (TricOs™) versus autologous cranioplasties, aiming to identify the ideal material for pediatric cranioplasties.

Materials and methods

A retrospective analysis of cranioplasties in pediatric patients with large cranial defects operated between 1995 and 2021 was conducted. Survival times of autologous and alloplastic HA-βTCP (TricOs™) cranioplasties were compared using Kaplan-Meier curves and log-rank test.

Results

The cohort included 22 cranioplasties (11 autologous, 11 alloplastic HA-βTCP (TricOs™)). Autologous cranioplasties demonstrated 63,6 % failure rate versus 9,1 % in the alloplastic group. Mean survival time was significantly longer for alloplastic - (67.61 ± 7.96 months (95 % CI [52.00; 83.21])) compared to autologous cranioplasties (32.75 ± 13.20 months (95 % CI [6.88; 58.61])) (p = 0.035).

Conclusion

Alloplastic HA-βTCP (TricOs™) demonstrated a significantly longer survival time compared to autologous cranioplasties. The findings suggest that HA-βTCP (TricOs™) offers a superior alternative in reducing risk of implant failure, potentially addressing the challenges of bone flap resorption in a pediatric population. Additional studies are warranted to endorse these retrospective findings.

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来源期刊

Journal of Cranio-Maxillofacial Surgery 医学-外科

CiteScore

5.20

自引率

22.60%

发文量

117

审稿时长

70 days

期刊介绍： The Journal of Cranio-Maxillofacial Surgery publishes articles covering all aspects of surgery of the head, face and jaw. Specific topics covered recently have included: • Distraction osteogenesis • Synthetic bone substitutes • Fibroblast growth factors • Fetal wound healing • Skull base surgery • Computer-assisted surgery • Vascularized bone grafts