Journal of Cranio-Maxillofacial Surgery最新文献

{"title":"Lymph node ratio (LNR) and lymph node yield (LNY) in head and neck cancer: A systematic review and meta-analysis.","authors":"Oreste Iocca, Chiara Copelli, Flaminia Campo, Gerardo Petruzzi, Raul Pellini, Guglielmo Ramieri, Pasquale Di Maio","doi":"10.1016/j.jcms.2024.11.016","DOIUrl":"https://doi.org/10.1016/j.jcms.2024.11.016","url":null,"abstract":"<p><strong>Introduction: </strong>A growing amount of evidence points at lymph node yield (LNY) and lymph node ratio (LNR) as useful indicators in the prognostic evaluation of patients affected by head and neck squamous cell carcinoma (HNSCC) who require neck dissection. The aim of this study was to assess the importance of LNY and LNR in the prognostic evaluation of head and neck cancer patients.</p><p><strong>Materials and methods: </strong>Included studies were those examining LNY and/or LNR in head and neck cancer patients. We excluded case reports or case series, thyroid cancer or salivary gland cancer studies, a sample size less than 20, and studies with incomplete or missing survival estimate. Of the 2435 studies identified through a database search, 95 were reviewed for full text and 63 were finally included for the final analysis. Electronic databases, including PubMed (MEDLINE), Embase, and Scopus were screened up to January 1, 2024. The systematic review was conducted according to the MOOSE checklist. A set of sub-group meta-analyses were performed for oral cavity, oropharynx, hypopharynx, larynx, and mixed subsites using a random-effects model. Overall survival (OS), Disease Specific Survival (DSS), and Disease-Free Survival (DFS) Hazard Ratios (HR) related to a prespecified LNR and LNY exact value were chosen as summary statistics. Cumulative Hazard Ratios with 95% Confidence Interval (CI) were presented, calculated through the inverse variance method. Heterogeneity was evaluated with I² statistics.</p><p><strong>Results: </strong>Results of the meta-analysis showed increased OS for a higher LNY (HR 1.33 95% CI 1.23-1.45). Regarding the LNR, a lower LNR value has an impact on survival, with an OS HR of 1.96 (95% CI 1.72-2.24). The same was true for DFS (HR 2.43 95% CI 1.82-3.23), and DSS (HR 2.07 95% CI 1.83-2.33).</p><p><strong>Conclusions: </strong>Our analysis confirms the importance of LNY and LNR as prognostic indicators. Future studies are needed to establish the optimal cut-off values for both factors. LNY and LNR have the potential to be routinely evaluated in patients who undergo neck dissection for HNSCC.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mandibular tongue-shaped flap reconstruction for lip defects following lip tumor surgery.","authors":"Lin Qi, Shu Wang, Xingchi Tao, Chunli Yao","doi":"10.1016/j.jcms.2024.12.010","DOIUrl":"https://doi.org/10.1016/j.jcms.2024.12.010","url":null,"abstract":"<p><p>Lip defects due to lip tumor surgery need proper reconstruction to preserve their function. Traditional methods offer various options for lip repair, but each has limitations, and can lead to deformity, asymmetry, or functional impairment. This study aimed to investigate the clinical application of mandibular tongue-shaped flap reconstruction for postoperative defects following lip tumor surgery. A retrospective analysis was conducted on the clinical data of 29 patients with lip tumors treated between February 2018 and August 2024. Patients were divided into two groups based on the surgical method: the tongue-shaped flap group (group T, n = 17) and the Abbe flap group (group A, n = 12). Preoperative indicators (preoperative pathology, tumor location), intraoperative and postoperative indicators (operation time, intraoperative blood loss, hospitalization duration, defect repair range), follow-up indicators (scar hyperplasia at 1, 6, and 12 months postoperatively, flap color difference, lip function, patient satisfaction), and complications (postoperative bleeding, flap necrosis, microstomia, incomplete closure, salivation) were compared and analyzed between the two groups. Group T had a significantly shorter operation time, less intraoperative blood loss, and shorter hospitalization duration compared with group A (all p < 0.05). The tongue-shaped flap was suitable for repairing defects ranging from half to the full length of the lip, while the Abbe flap was suitable for defects ranging from one-third to half the length of the lip. Group T demonstrated a wider repair range compared with group A. At 1 month postoperatively, group A showed a statistically significant difference in eating difficulty compared with group T (p < 0.05), while no statistically significant differences were found at 3, 6, and 12 months postoperatively (p > 0.05). There were no statistically significant differences between the two groups in terms of scar hyperplasia, flap color difference, or overall patient satisfaction (p > 0.05). The incidence of microstomia was significantly lower in group T compared with group A (p < 0.05). There were no statistically significant differences between the two groups in the rates of postoperative bleeding, flap necrosis, incomplete lip closure, or salivation (p > 0.05). Mandibular tongue-shaped flap reconstruction is a novel method for repairing postoperative defects following lip tumor surgery. This technique simplifies the surgical procedure while achieving both functional and aesthetic preservation. It offers advantages such as a wider repair range, minimal trauma, shorter operation time, faster postoperative recovery, shorter hospitalization duration, and a lower incidence of microstomia. Patients demonstrate good tolerance, making it particularly suitable for elderly and high-risk patients. This method may become a new option for repairing defects following lip tumor excision.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole exome sequencing in 18 Brazilian families with vertical transmission of non-syndromic oral clefts.","authors":"Matheus de Mello Copelli, Milena Atique-Tacla, Eleonore Pairet, Gabriela Roldão Correia-Costa, Tiago Henrique de Souza, Isabella Lopes Monlleó, Társis Paiva Vieira, Raphaël Helaers, Miikka Vikkula, Vera Lúcia Gil-da-Silva-Lopes","doi":"10.1016/j.jcms.2024.12.016","DOIUrl":"https://doi.org/10.1016/j.jcms.2024.12.016","url":null,"abstract":"<p><p>This study describes the results of whole exome sequencing in the etiological investigation and genetic counseling of families presenting with non-syndromic oral clefts with vertical transmission recorded in the Brazilian Database on Craniofacial Anomalies. Whole exome sequencing was performed in 18 families presenting with non-syndromic oral clefts with vertical transmission, and variant filtering was used to identify rare, and also possibly pathogenic variants in genes associated with oral clefts. Overall, our study identified seven families (38.88%) presented with segregating variants possibly related to oral clefts in our cohort: SETX, NOTCH1, FRAS1, ARHGAP29, KMT2D, ANKRD11, SIX1, BMP6, LRP2 and TFAP2A. In another family, all affected members (5.55%) presented a rare variant in FAM193A, which has no recognized function yet, but has prediction of deleterious effect. Our study highlights oral clefts clinical and etiological heterogeneity and shows the complexity of using whole exome sequencing for genetic counseling in non-syndromic oral clefts with vertical transmission.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of smile characteristics in dentofacial deformity patients following orthognathic surgery.","authors":"Birong Zhong, Guilong Zhou, Yong Yang, Shiping Chang, Jingfu Wang, Kezhen Zhao, Jinlong Zhao, Lei Tian, Qin Ma","doi":"10.1016/j.jcms.2024.12.007","DOIUrl":"https://doi.org/10.1016/j.jcms.2024.12.007","url":null,"abstract":"<p><p>The purpose of this study was to investigate the effect of bimaxillary surgery on smile characteristics, including smile line, smile arc, smile index (SI), most posterior teeth displayed(MPTD), buccal corridor ratio (BCR), and smile symmetry. The study consisted of 87 patients with dentofacial deformity: Class II (30 patients), Class III (37 patients), and asymmetry (20 patients). Pearson's chi-squared test and ANOVA were used to analyze the differences in smile characteristics across the preoperative groups. Pearson's chi-square test and the paired-sample t-test were utilized to determine the differences in smile characteristics between the preoperative and postoperative periods. The results showed significant differences in lip thickness ratio (p = 0.021∗), smile line (p = 0.003∗∗), smile arc (p = 0.000∗∗), MPTD (p = 0.015∗), and BCR (p = 0.000∗∗) among the preoperative groups. After orthognathic surgery, in the Class II group there was an increase in the proportion of smile line that transformed from high to average and low (p = 0.001∗∗), an increase in the percentage of upper lip curvature that changed from downward to upward and straight (p = 0.011∗), and an increase in both postoperative SI and BCR (p = 0.007∗∗ and p = 0.002∗∗, respectively), while MPTD decreased (p = 0.031∗). For Class III, the postoperative change in upper lip curvature tended to be more upward and straight (p = 0.002∗∗), the smile arc became more parallel and straight (p = 0.000∗∗), postoperative SI and MPTD increased (p = 0.000∗∗), while BCR decreased (p = 0.000∗). Regarding asymmetry, both MPTD and BCS showed symmetry postoperatively (p = 0.038, p = 0.000∗∗). The findings of this study indicate that orthognathic surgery could enhance some smile characteristics.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Condylar osseous changes following conservative therapies: A cone-beam computed tomography longitudinal study on adult patients with degenerative temporomandibular joint disease.","authors":"Zihan Zhang, Jie Xiang, Chuqiao Xiao, Rui Zhu, Yunhao Zheng, Yating Yi, Jun Wang, Xin Xiong","doi":"10.1016/j.jcms.2024.12.013","DOIUrl":"https://doi.org/10.1016/j.jcms.2024.12.013","url":null,"abstract":"<p><p>This retrospective study aimed to comprehensively investigate the impact of non-surgical treatments on condylar osseous changes in adult patients with degenerative joint disease (DJD). Radiographic and clinical data were collected for analysis. Cone-beam computed tomography (CBCT) was used to diagnose DJD, including flattening, erosion, osteophytes, sclerosis and cysts. Condylar osseous changes were divided into three classifications: progression, stability and remission. Kaplan-Meier analyses were performed to evaluate progression-free probability. Hazard ratios (HRs) of overall and specific DJD progression were calculated with multivariate Cox analysis. Hyaluronic acid (HA) injection significantly reduced the progression-free probability (P = 0.0312). HRs of progression after stabilization splint (SS) treatment within one year, glucosamine treatment within six months and HA injection was 3.41 (95% CI: 1.70-6.84; P = 0.0005), 0.35 (95% CI: 0.14-0.86; P = 0.0226), and 1.84 (95% CI: 1.06-3.20; P = 0.0313), respectively. HRs of progression of flattening, erosion, osteophyte, and sclerosis adjusted for gender and age after HA injection were 2.77 (95% CI: 1.32-5.81; P = 0.0071), 2.12 (95% CI: 1.09-4.10; P = 0.0264), 3.38 (95% CI: 1.08-10.54; P = 0.0361) and 2.78 (95% CI: 1.02-7.52; P = 0.0447) respectively. HA injection and SS treatment were possible risk factors for TMJ deterioration, while glucosamine treatment was possible protective factor against TMJ deterioration.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical course of masticatory function recovery following endoscopic-assisted open reduction and internal fixation in patients with unilateral mandibular condyle fracture.","authors":"Shinnosuke Nogami, Yushi Ezoe, Yuri Takeda, Yoshio Otake, Hiromitsu Morishima, Kensuke Yamauchi","doi":"10.1016/j.jcms.2024.12.005","DOIUrl":"https://doi.org/10.1016/j.jcms.2024.12.005","url":null,"abstract":"<p><p>The purpose of this study was to investigate the clinical course of masticatory function recovery following an endoscopic-assisted open reduction and internal fixation (EAORIF) procedure. Patients with a unilateral mandibular condylar fracture who underwent EAORIF for therapeutic purposes were evaluated, with comparisons made between those who underwent the procedure for base or neck fractures. At each time point analyzed after treatment, the occlusal contact area and maximum bite force in patients with a base fracture were greater, although the differences between the groups were not significant. Moreover, at 12 months following EAORIF for a base fracture, occlusal contact area and maximum bite force on the fractured and non-fractured sides were nearly equal, whereas these were significantly reduced in the fractured as compared with the non-fractured side in patients who underwent that treatment for a neck fracture. Additionally, after 12 months in the neck fracture cases, both occlusal contact area and maximum bite force on the fractured side were lower as compared with those on the non-fractured side. These findings indicate that EAORIF is an optimal method for base fracture treatment with regard to masticatory function.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthrocentesis versus conservative treatments for temporomandibular joint disorders: A systematic review with meta-analyses and trial sequential analyses.","authors":"Y H Tang, N B Van Bakelen, B Gareb, F K L Spijkervet","doi":"10.1016/j.jcms.2024.12.006","DOIUrl":"https://doi.org/10.1016/j.jcms.2024.12.006","url":null,"abstract":"<p><p>This systematic review aimed to evaluate the efficacy of arthrocentesis compared to conservative treatments for symptomatic temporomandibular joint disorders. A systematic search for randomized, prospective and retrospective controlled trials was undertaken in five electronic databases. Various patient outcomes and economic evaluations were analysed for short-term (<6 months), intermediate-term (6 months to 5 years) and long-term (≥5 years) follow-up periods. Primary meta-analyses were performed for randomized controlled trials using random-effects models. Arthrocentesis was superior to conservative treatments regarding pain reduction at short-term (MD 14.5 (95% CI 9.7; 19.4), k= 9 RCTs, n= 545 patients, I²= 48%, high quality of evidence) and intermediate-term follow-up (MD 14.2 (95% CI 7.3; 21.1), k=9 RCTs, n= 547 patients, I²= 81%, moderate quality of evidence). Furthermore, arthrocentesis was superior to conservative treatment regarding maximum mouth opening improvement at short-term (MD 2.4 mm (95% CI 0.8; 4.1), k= 8 RCTs, n= 472 patients, I²= 80%, moderate quality of evidence) and intermediate-term follow-up (MD 2.2 mm (95% CI 0.5; 3.9), k= 8 RCTs, n= 468 patients, I²= 75%, moderate quality of evidence). Trial sequential analysis supported the conclusions of all primary meta-analyses. Results were clinically relevant for pain improvement, but not for maximum mouth opening improvement. Results at long-term follow-up and for other study outcomes were either lacking or too heterogenous for meta-analysis, highlighting the need for more standardized, high-quality research.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of cell morphology in patient-paired primary human osteoblasts from the jaw and the fibula.","authors":"M Selig, R Rothweiler, C Gross, C Rendenbach, S Preissner, M Heiland, T Fretwurst, B Rolauffs, K Nelson, S Nahles, J Wuester","doi":"10.1016/j.jcms.2024.11.021","DOIUrl":"https://doi.org/10.1016/j.jcms.2024.11.021","url":null,"abstract":"<p><p>Previous studies hint at possible differences in osteogenic, osteoimmunologic, and angiogenetic potential among primary human osteoblasts (HOBs) from different origins (iliac and alveolar bone) within the same patient. In this study, HOBs from the jaw and the fibula were investigated for the first time to gain further knowledge about the similarities and differences on the cellular morphological level. Patient-paired HOB cultures from the jaw and fibula of 14 patients (60.3 ± 11.1 years; male: 9; female: 5) were isolated and further processed. Cells were stained with Calcein and Hoechst 33342, and single-cell morphometric shape analysis was performed. For each osteoblast, the shape descriptors area, length, width, aspect ratio, circularity, roundness, and solidity were determined. A site-specific and a gender-specific comparison were conducted. None of the shape descriptors showed any significant differences between HOBs derived from the jaw and the fibula. The same applied to the gender-specific comparison between osteoblasts from female and male patients. Significant correlations between shape descriptors were found. HOBs from both bones possess a comparable cell shape, which might positively influence the ossification between the recipient and the donor bone. Since cell morphology often reflects cell function, both bones might exhibit comparable osteoblast behavior, adding to the favorable outcomes observed with free fibula flaps in reconstructive surgery.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"EGFR and HER-2 oncogenes expression in an experimental model of two-stage chemically induced carcinogenesis in mouse skin\" [J. Craniomaxillofac. Surg. 52 (2024) 413-419].","authors":"Stavroula Diamantopoulou, Christos Yapijakis, Veronica Papakosta, Marcel Ebeling, Andreas C Lazaris, Spyridoula Derka, Antonis Vylliotis, Pantelis Diamantopoulos, Georgia Vairaktari, Stavros Vassiliou","doi":"10.1016/j.jcms.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.jcms.2024.12.001","url":null,"abstract":"","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the clinical utility of lateral cephalometry reconstructed from computed tomography extracted by artificial intelligence.","authors":"Kyung-Han Kim, Jin-Hong Min, Jeong-Hyun Yun, Jae-Ho Baek, In-Seok Song, Sang-Min Lee, Ho-Kyung Lim, Jee-Ho Lee","doi":"10.1016/j.jcms.2024.12.004","DOIUrl":"https://doi.org/10.1016/j.jcms.2024.12.004","url":null,"abstract":"<p><p>This study assessed the accuracy and reliability of artificial intelligence (AI)-reconstructed images of two-dimensional (2D) lateral cephalometric analyses of facial computed tomography (CT) images, which is widely used for the diagnosis of craniofacial deformities and in the planning of their treatment. Facial CT datasets from 40 patients were collected. Original 1 mm slices were reformatted to 3 mm, and then an AI algorithm reconstructed the 3 mm slices and converted them back to 1 mm to generate lateral cephalometric images. Three observers traced the craniofacial landmarks manually and with autotracing. Landmark discrepancies were quantified between the original 1 mm CT slice and the AI-reformatted 1 mm CT slice, as well as between the original 1 mm CT slice and the 3 mm CT slice. Landmark discrepancies were then compared and reliability tests conducted. AI-reconstructed 1 mm CT images showed significantly fewer discrepancies than the 3 mm CT images, particularly in critical landmarks such as the sella, basion, nasion, orbitale, and pogonion (p < 0.05). The greatest discrepancies in the 3 mm images were observed in the sella and basion. Interobserver and intraobserver reliability analyses showed high consistency (Cronbach's α > 0.7 in nearly all cases). These results support the use of AI-reconstructed images for more accurate diagnosis and treatment planning in craniofacial surgery, potentially reducing the need for additional imaging.</p>","PeriodicalId":54851,"journal":{"name":"Journal of Cranio-Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}