Journal of Dermatology最新文献_第6页

Clinicopathological features of epithelioid hemangioma of 43 patients with long-term follow-up: A two-center retrospective study 长期随访的 43 例上皮样血管瘤患者的临床病理特征：一项双中心回顾性研究。

IF 2.9 3区医学

Journal of Dermatology Pub Date : 2024-11-11 DOI: 10.1111/1346-8138.17546

Si-Yu Luo, Kai-Yi Zhou, Qin-Xiao Wang, Lin Feng, Sheng Fang

{"title":"Clinicopathological features of epithelioid hemangioma of 43 patients with long-term follow-up: A two-center retrospective study","authors":"Si-Yu Luo, Kai-Yi Zhou, Qin-Xiao Wang, Lin Feng, Sheng Fang","doi":"10.1111/1346-8138.17546","DOIUrl":"10.1111/1346-8138.17546","url":null,"abstract":"Epithelioid hemangioma (EH) is a rare angioproliferative disorder for which histopathology is the main approach to diagnosis. The tendency to recur is of concern to clinicians and patients. The factors associated with recurrence have been sporadically reported and a large-scale cohort study has been lacking. This study aims to investigate the clinicopathological characteristics and long-term clinical outcomes of EH patients from two tertiary care hospitals. A two-center retrospective cohort study of 43 patients with a diagnosis of EH between 2013 and 2023 was evaluated at follow-up. A comprehensive and detailed review of clinical and pathological data with long-term follow-up was performed. Information on prognosis was available for 43, and 8 (8/43, 18.6%) experienced local recurrence. Facial (Cramer's V = 0.405, P = 0.029) and multiple (relative risk [RR] 4.306, 95% confidence interval [CI] 1.213, 15.282, Phi = 0.369, P = 0.016) lesions, subcutaneous involvement (RR 5.063, 95% CI 1.157, 22.151, Phi = 0.374, P = 0.014), and the presence of lymphoid follicles (RR 9.750, 95% CI 3.853, 24.671, Phi = 0.670, P < 0.001) were associated with higher recurrence rates. According to the presence or absence of well-differentiated angiogenesis, EH can be pathologically classified into vascular, cellular, and intermediate types, while the depth, degree, and pattern of inflammation, tissue eosinophilia, eosinophilic microabscesses, and hobnail endothelial cells differed significantly between cellular and vascular types. The characteristics of EH are distinguished by different pathological subtypes. This study provides insight into the clinicopathological features and outcome of EH to assist clinicians in the diagnosis and management of this rare condition.","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 2","pages":"329-336"},"PeriodicalIF":2.9,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indirect comparison of deucravacitinib and other systemic treatments for moderate to severe plaque psoriasis in Asian populations: A systematic literature review and network meta-analysis 间接比较亚洲人群中度至重度斑块状银屑病的德拉瓦替尼和其他系统治疗方法：系统性文献综述和网络荟萃分析。

IF 2.9 3区医学

Journal of Dermatology Pub Date : 2024-11-11 DOI: 10.1111/1346-8138.17448

Tsen-Fang Tsai, Yayoi Tada, Camy Kung, Yichen Zhong, Allie Cichewicz, Katarzyna Borkowska, Tracy Westley, Renata M. Kisa, Yu-Huei Huang, Xing-Hua Gao, Seong-Jin Jo, April W. Armstrong

{"title":"Indirect comparison of deucravacitinib and other systemic treatments for moderate to severe plaque psoriasis in Asian populations: A systematic literature review and network meta-analysis","authors":"Tsen-Fang Tsai, Yayoi Tada, Camy Kung, Yichen Zhong, Allie Cichewicz, Katarzyna Borkowska, Tracy Westley, Renata M. Kisa, Yu-Huei Huang, Xing-Hua Gao, Seong-Jin Jo, April W. Armstrong","doi":"10.1111/1346-8138.17448","DOIUrl":"10.1111/1346-8138.17448","url":null,"abstract":"Expanding the systemic treatment options for patients with psoriasis, deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor is approved in the United States, European Union, China, Japan, Taiwan, Korea, and other countries for the treatment of adults with moderate to severe plaque psoriasis who are candidates for systemic therapy. Evidence suggests the comparative efficacy of systemic therapies may be different in Asian versus White patients. This systematic review and network meta-analysis (NMA) evaluated the clinical efficacy associated with deucravacitinib and other biologic or non-biologic systemic treatments for moderate to severe plaque psoriasis in Asian populations. Electronic databases were searched to identify randomized trials of the interventions of interest. Multinomial random effects models adjusting for baseline placebo risk were used to estimate Psoriasis Area and Severity Index (PASI) responses at weeks 10–16. Of 8596 studies identified, 20 were included in the NMA. The estimated PASI 75 and 90 (95% credible interval) response rates for deucravacitinib were estimated to be 66% (49%–80%) and 40% (24%–58%) in Asian populations, notably higher than placebo (6% [4%–9%] and 1% [0.8–2%]) and apremilast (24% [12%–40%] and 9% [4%–20%]). No statistically significant difference was observed in PASI 75 and 90 responses between deucravacitinib and adalimumab, certolizumab pegol, infliximab, ustekinumab, and tildrakizumab. Deucravacitinib demonstrated robust efficacy in the Asian population, with PASI 75 and 90 responses comparable to some biologics. Deucravacitinib provides a convenient oral therapy with efficacy similar to several biologic therapies.","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 12","pages":"1559-1571"},"PeriodicalIF":2.9,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erythroderma in the elderly 老年人的红斑。

IF 2.9 3区医学

Journal of Dermatology Pub Date : 2024-11-11 DOI: 10.1111/1346-8138.17538

Toshiyuki Yamamoto

{"title":"Erythroderma in the elderly","authors":"Toshiyuki Yamamoto","doi":"10.1111/1346-8138.17538","DOIUrl":"10.1111/1346-8138.17538","url":null,"abstract":"Erythroderma is the end-stage condition caused by various inflammatory diseases, presenting with widespread generalized coalesced erythema on the trunk and extremities. Erythroderma is not a disease itself, but rather is a symptom expressing erythrodermic condition, which is frequently associated with inguinal lymphadenopathy, chills, and mild fever. The clinical characteristics include sparing the folds of the trunk and extremities (deck-chair sign), and cobblestone-like disseminated grouping prurigo; however, the deck-chair sign is not specific to papulo-erythroderma (Ofuji disease). Erythroderma is induced by various causes, such as eczema, psoriasis, atopic dermatitis, drug eruption, lymphoma, lichen planus, pityriasis rubra pilaris, autoimmune bullous diseases, graft-versus-host disease, dermatomyositis, internal malignancy, and others. By contrast, it is not uncommon for even thorough investigations to often fail to identify any significant underlying or occult diseases. Such cases are often diagnosed as idiopathic erythroderma. In elderly cases, some regard erythroderma as late-onset atopic dermatitis, even if the patient does not have a history of childhood atopic dermatitis, while others consider it as a distinct condition with immune responses similar to atopic dermatitis. The etiology of erythroderma is suggested to be a Th2-dominant condition with IL-4/IL-13 playing a central role, suggesting that therapies targeting those Th2 molecules may result in sufficient effects. In this review, the characteristics of erythroderma in the elderly and new therapeutic approaches are discussed.","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 2","pages":"221-227"},"PeriodicalIF":2.9,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17538","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of digital papillary adenocarcinoma with human papillomavirus 42 detected 一例检测到人类乳头状瘤病毒 42 的数字乳头状腺癌。

IF 2.9 3区医学

Journal of Dermatology Pub Date : 2024-11-06 DOI: 10.1111/1346-8138.17516

Katsuya Imazaki, Kyosuke Oishi, Motoki Horii, Kyoko Shimizu, Shintaro Maeda, Kazuhiro Komura, Kazushi Anzawa, Akira Shimizu, Takashi Matsushita

引用次数: 0

Effectiveness of long-term bimekizumab treatment and predictive factors for responders in moderate-to-severe psoriasis: A 52-week real-world study 中度至重度银屑病患者长期使用双美珠单抗治疗的疗效及应答者的预测因素：一项为期 52 周的真实世界研究。

IF 2.9 3区医学

Journal of Dermatology Pub Date : 2024-11-05 DOI: 10.1111/1346-8138.17532

Teppei Hagino, Hidehisa Saeki, Eita Fujimoto, Naoko Kanda

{"title":"Effectiveness of long-term bimekizumab treatment and predictive factors for responders in moderate-to-severe psoriasis: A 52-week real-world study","authors":"Teppei Hagino, Hidehisa Saeki, Eita Fujimoto, Naoko Kanda","doi":"10.1111/1346-8138.17532","DOIUrl":"10.1111/1346-8138.17532","url":null,"abstract":"Psoriasis is a chronic, inflammatory skin disease in which the interleukin (IL)-23/IL-17 axis plays a central role. Bimekizumab is a novel antibody that targets both IL-17A and IL-17F. This retrospective study aimed to assess the long-term effectiveness and safety of 52-week treatment with bimekizumab, and to identify predictive factors for short- (16 weeks) and long-term (52 weeks) responders (i.e., achievers of a Psoriasis Area and Severity Index (PASI) score of 100) to bimekizumab in Japanese patients with psoriasis. The study was conducted on 56 Japanese patients (aged ≥ 15 years) with moderate-to-severe psoriasis treated with bimekizumab from May 2022 to March 2024. The therapeutic effectiveness was evaluated by the transition of PASI scores during treatment. Baseline characteristics and clinical and laboratory indexes were compared between responders and poor responders. Treatment-emergent adverse events (TEAEs) were recorded to assess the safety of the treatment. At week 52, the achievement of PASI 100, static Physician's Global Assessment 0/1, and the Dermatology Life Quality Index 0/1 were 72.4%, 94.7%, and 93.3%, respectively. Short-term responders showed lower baseline values of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio (MLR), and systemic inflammatory response index compared to poor responders. Long-term responders showed younger age and lower MLR compared to poor responders. TEAEs were mild or moderate, without serious adverse events. Long-term treatment with bimekizumab is effective and safe for psoriasis patients. Lower MLR and younger age might predict long-term response to treatment with bimekizumab, aiding in personalized treatment strategies.","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 2","pages":"317-328"},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of ingrown hairs in persistent kerion of children: A clinical study 嵌毛在儿童顽固性角膜炎中的作用：临床研究。

IF 2.9 3区医学

Journal of Dermatology Pub Date : 2024-11-05 DOI: 10.1111/1346-8138.17523

Qi-Hao Yao, Hui-Lin Zhi, Xiu-Jiao Xia, Ze-Hu Liu

{"title":"The role of ingrown hairs in persistent kerion of children: A clinical study","authors":"Qi-Hao Yao, Hui-Lin Zhi, Xiu-Jiao Xia, Ze-Hu Liu","doi":"10.1111/1346-8138.17523","DOIUrl":"10.1111/1346-8138.17523","url":null,"abstract":"Tinea capitis, a common public health problem in developing countries, has severe forms such as kerion. However, the underlying mechanisms and standard treatments for persistent cases of tinea capitis or kerion remain controversial. In this work, we investigate the ingrown hairs and corresponding treatment in persistent kerion of children. Children with persistent kerion were enrolled among 312 cases of tinea capitis at the Department of Dermatology, Hangzhou Third People's Hospital from January 2020 to June 2024. The presence of fungal infection was ascertained by direct microscopic examination under calcofluor white staining and routine culture. The structure of the ingrown hairs was observed directly by a dermatoscope, which was subsequently extracted using sterile tools. A total of six cases of persistent kerion among 312 cases of tinea capitis were enrolled. Ingrown hairs were ascertained under dermatoscopy and extracted by minor operation. Except for one patient who continued oral terbinafine, the other five cases were cured by removal alone. Ingrown hairs, induced by fungal infection, may be an aggravating factor of persistent course of tinea capitis. Our study demonstrated that the presence of ingrown hairs could be confirmed through direct dermatoscopy, and patients experienced significant improvement following removal treatment under dermatoscopy.","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 1","pages":"35-42"},"PeriodicalIF":2.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17523","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of indeterminate cell histiocytosis with ETV3-NCOA2 translocation 一例伴有 ETV3-NCOA2 易位的不定形细胞组织细胞增生症。

IF 2.9 3区医学

Journal of Dermatology Pub Date : 2024-11-04 DOI: 10.1111/1346-8138.17530

Norihito Suzuki, Takatoshi Shimauchi, Satoshi Baba, Yuka Nagakura, Juri Takahashi, Sayaka Ajima, Mizuho Tajima, Yurie Kitauchi, Reiko Kageyama, Tetsuya Honda

{"title":"A case of indeterminate cell histiocytosis with ETV3-NCOA2 translocation","authors":"Norihito Suzuki, Takatoshi Shimauchi, Satoshi Baba, Yuka Nagakura, Juri Takahashi, Sayaka Ajima, Mizuho Tajima, Yurie Kitauchi, Reiko Kageyama, Tetsuya Honda","doi":"10.1111/1346-8138.17530","DOIUrl":"10.1111/1346-8138.17530","url":null,"abstract":"Indeterminate cell histiocytosis (ICH) is a rare histiocytic disorder characterized by a proliferation of CD1a+ and CD207/langerin− cells. Recent molecular analyses have identified ETV3-NCOA2 translocation as a possible aetiopathogenesis of ICH. Herein, we describe the first Japanese case of ICH with ETV3-NCOA2 translocation. A 79-year-old Japanese man presented with a 1-year history of pruritic erythematous papules and nodules on his trunk and extremities. Histological examination revealed a dense and diffuse sheets–like infiltration of medium-sized histiocyte-like cells from the epidermis to the deep dermis. Immunohistochemically, the atypical cells were positive for CD1a but negative for CD207/langerin. Fluorescence in situ hybridization using NCOA2 break-apart probes confirmed a chromosomal break occurring on NCOA2 monoallele in the tumor cells. Furthermore, ETV3 exon 4-NCOA2 exon 14 translocation was identified in formalin-fixed paraffin-embedded skin samples using reverse transcription polymerase chain reaction and subsequent direct DNA sequencing. He also presented with interspersed eczematous plaques on his trunk and reactive dermatopathic lymphoadenopathy without any infiltration of ICH. He was treated with topical corticosteroids and narrowband UVB phototherapy. Four months later, his ICH skin eruptions, eczematous plaques, and lymphoadenopathy gradually regressed. Our case supports the notion that the detection of ETV3-NCOA2 translocation can be useful for diagnosis of ICH.","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 2","pages":"373-376"},"PeriodicalIF":2.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pasteurella stomatis and Prevotella heparinolytica infection following dog bite. A case report and review of published works 被狗咬伤后的口腔巴斯德氏菌和肝溶性普雷沃特氏菌感染。一份病例报告和对已发表作品的回顾。

IF 2.9 3区医学

Journal of Dermatology Pub Date : 2024-11-04 DOI: 10.1111/1346-8138.17472

Yuta Norimatsu, Taro Akatsuka, Akari Matsuoka-Nagashima, Sohshi Morimura, Toshihisa Hamada, Makoto Sugaya

引用次数: 0

Response to: “Potential sitosterolemia in necrobiotic xanthogranuloma: Comment on Extensive yellowish masses in bilateral orbit and neck” by Chen et al. 回应：对 "坏死性黄疽瘤潜在的坐骨神经胆固醇血症：对 Chen 等人发表的 "对双侧眼眶和颈部广泛淡黄色肿块的评论 "的回应

IF 2.9 3区医学

Journal of Dermatology Pub Date : 2024-11-01 DOI: 10.1111/1346-8138.17522

Qifeng Zang, Yinshan Zang

引用次数: 0

Is alopecia areata one of the atopic diseases? A two-sample Mendelian randomization analysis 斑秃是特应性疾病之一吗？双样本孟德尔随机分析。