Journal of Dermatology最新文献

{"title":"Arthralgia and Ultrasound Characteristics of Subclinical Psoriatic Arthritis: A Cross-Sectional Study Based on the SPAWCH Cohort","authors":"Xiya Peng,&nbsp;Yiyi Wang,&nbsp;Yue Xiao,&nbsp;Hongli Wang,&nbsp;Kun Zhan,&nbsp;Baiq Nickte Annizha Khalik,&nbsp;Jingya Gao,&nbsp;Yi Teng,&nbsp;Hongxiang Hu,&nbsp;Dengmei Xia,&nbsp;Min Yang,&nbsp;Wei Yan,&nbsp;Lingyan Zhang,&nbsp;Wei Li","doi":"10.1111/1346-8138.70326","DOIUrl":"10.1111/1346-8138.70326","url":null,"abstract":"<div>\u0000 \u0000 <p>As a critical stage before psoriatic arthritis (PsA) onset, subclinical PsA provides an opportunity window for early diagnosis and intervention. This study aimed to describe the clinical and ultrasound characteristics of patients fulfilling the EULAR definition of subclinical PsA, and to explore the heterogeneity of arthralgia within this population. Patients fulfilling the EULAR definition of subclinical PsA, characterized by arthralgia and/or ultrasound evidence of synovial/entheseal inflammation without clinical synovitis, were enrolled in the Subclinical Psoriatic Arthritis Cohort of West China Hospital (SPAWCH) Cohort from January 2019 to December 2024. We collected clinical information, arthralgia features, and ultrasound findings, conducting a cross-sectional analysis. Overall, 306 patients were included in the analysis. Among them, 84 (27.5%) had both arthralgia and ultrasound abnormalities (Group AU), 203 (66.3%) had isolated ultrasound abnormalities (Group IU), and 19 (6.2%) had isolated arthralgia (Group IA). Compared with the Group IU, patients in the Group AU were older (49.3 ± 13.7 vs. 43.5 ± 13.2 years, <i>p</i> = 0.001) and had a longer duration of psoriasis (17.7 ± 12.3 vs. 14.1 ± 9.8 years, <i>p</i> = 0.020). Additionally, the two main arthralgia types were activity-related (60, 58.3%) and rest-related (25, 24.3%). Rest-related arthralgia was associated with prolonged arthralgia duration (<i>p</i> = 0.041), higher morning stiffness incidence (<i>p</i> = 0.031), and more prominent inflammatory characteristics (<i>p</i> = 0.001) compared to activity-related cases. In this study, ultrasound abnormalities emerged as the dominant feature in patients meeting the EULAR definition of subclinical PsA. Notably, the coexistence of arthralgia and ultrasound abnormalities was associated with a longer duration of psoriasis. While activity-related arthralgia was the most prevalent type, rest-related arthralgia.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 8","pages":"1133-1141"},"PeriodicalIF":2.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148039118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistence and Contemporary Clinical Applications of Mohs Paste: A Scoping Review","authors":"Airin Sato,&nbsp;Yu Matsui,&nbsp;Shohei Kitayama,&nbsp;Tadamichi Shimizu","doi":"10.1111/1346-8138.70321","DOIUrl":"10.1111/1346-8138.70321","url":null,"abstract":"<div>\u0000 \u0000 <p>Mohs paste (MP), a zinc chloride–based tissue fixative developed by Frederic E. Mohs, was historically central to skin cancer treatment but declined worldwide following the adoption of the fresh-tissue technique and Mohs micrographic surgery (MMS). Japan remains a notable exception; MMS is not as widely adopted there, while MP persists as a symptom-directed practice across multiple disciplines. We systematically characterized the indications, applications, and limitations of MP to contextualize its contemporary clinical relevance. Following PRISMA-ScR guidelines, PubMed and Scopus were searched through March 2025 for peer-reviewed reports describing the clinical use of Mohs paste, ointment, or chemosurgery as therapeutic interventions for surface or ulcerative lesions. Reports using MP solely as an adjunct within MMS or those without original cases were excluded, and data were synthesized thematically. Fifty-two studies (1964–2024) described 88 patients (36 case reports; 16 case series), predominantly from Japan (48 reports). Patients were mostly female (80.7%) with a median age of 68 years, and most presented with locally advanced or stage III–IV disease. Indications included breast, gynecologic, head and neck, and skin cancers, alongside metastatic cutaneous tumors, sarcomas, and oral cancers, with isolated reports of chronic ulcers and schwannoma. At least one local outcome was reported in 87 patients (98.9%), based on descriptive and non-standardized reporting. Frequently reported local outcomes included bleeding control (78.4%), reduction of exudate (62.5%), reduction of malodor (47.7%), and reduction of tumor volume (44.3%). The most commonly reported adverse event was pain, which required analgesics in some cases. MP was occasionally used concurrently with systemic drug therapy or radiotherapy to stabilize local symptoms. Overall, MP has evolved into a pragmatic, symptom-directed intervention bridging oncology and palliative care. These findings highlight the need for standardized protocols, registry-based evaluation, and clearer positioning of MP within contemporary clinical practice.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 8","pages":"1083-1089"},"PeriodicalIF":2.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148059279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Questionnaire Evaluation and Testing for Latex Allergy: A Retrospective Study From 2015 to 2021","authors":"Midori Kawasaki-Nagano,&nbsp;Risa Tamagawa-Mineoka,&nbsp;Koji Masuda,&nbsp;Norito Katoh,&nbsp;Takeshi Fukumoto","doi":"10.1111/1346-8138.70333","DOIUrl":"10.1111/1346-8138.70333","url":null,"abstract":"<div>\u0000 \u0000 <p>Latex allergy is an allergic reaction to natural rubber and may occur in the perioperative period. Between 2015 and 2021, patients at Kyoto Prefectural University of Medicine were screened for latex allergy before surgery using a standardized questionnaire. Patients suspected of having latex allergy underwent skin prick tests (SPTs), wearing tests, and measurement of serum-specific IgE antibody titers. The results of the medical questionnaires, skin tests, and IgE tests were subsequently analyzed. Overall, 467 patients were suspected of having latex allergy based on the questionnaire responses. SPTs and wearing tests were positive in 105 and 10 cases, respectively. Ten patients were diagnosed with latex allergies based on the wearing tests. Questionnaire data from patients diagnosed with latex allergy revealed 8 cases of allergic symptoms after fruit and vegetable intake, 7 associated with rubber product use, 2 of anaphylactic shock of unknown cause, and 2 of involving medical staff with atopic dermatitis. Among these patients, latex-specific IgE and Hev b 6.02–specific IgE antibody titers were measured in 10 and 6 cases, respectively. Latex-specific IgE antibody titers were classified as class ≥ 2 in 3 cases, whereas Hev b 6.02–specific IgE antibody titers reached class ≥ 2 in 1. No intraoperative cases of latex allergy were observed during the study period. These findings suggest latex allergy screening using a questionnaire in combination with diagnostic testing is a useful strategy.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 8","pages":"1184-1188"},"PeriodicalIF":2.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148059308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-Rich Plasma Therapy for Refractory Skin Ulcers: A Case Series of 12 Patients and Concise Review of the Literature","authors":"Teruhiko Makino,&nbsp;Keita Takemoto,&nbsp;Megumi Mizawa,&nbsp;Tadamichi Shimizu","doi":"10.1111/1346-8138.70365","DOIUrl":"10.1111/1346-8138.70365","url":null,"abstract":"<div>\u0000 \u0000 <p>Chronic skin ulcers remain a significant therapeutic challenge, particularly in patients with underlying medical conditions, and often prove difficult to treat with conventional methods. Platelet-rich plasma (PRP), an autologous preparation rich in growth factors, has garnered attention as a promising treatment option; however, its clinical efficacy remains inconsistent. In this study, we retrospectively evaluated 12 patients with refractory skin ulcers who received PRP therapy between 2018 and 2023. PRP was prepared from the patients' own blood and administered once weekly for 4 weeks; treatment efficacy was assessed based on the rate of reduction in ulcer area. Clinical outcomes varied depending on the etiology of the ulcer. Marked improvement was observed in patients with livedoid vasculopathy and burn-related ulcers, whereas moderate to marked improvement was seen in diabetic ulcers only when peripheral blood flow was preserved. In contrast, the response was minimal or absent in ulcers associated with pressure ulcers or peripheral arterial disease. Importantly, no adverse events were observed during treatment. These findings suggest that PRP therapy is a safe and potentially effective option for refractory skin ulcers, particularly in non-ischemic conditions. However, its efficacy appears to be limited in wounds involving ischemia or mechanical injury, highlighting the importance of appropriate patient selection and wound condition optimization. Further studies using standardized protocols are necessary to clarify its clinical indications.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 8","pages":"1208-1212"},"PeriodicalIF":2.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148284879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Prurigo Nodules in Adults With Moderate-To-Severe Atopic Dermatitis in Japan: A 2-Year Observational Study","authors":"Yoko Kataoka,&nbsp;Takafumi Etoh,&nbsp;Hidehisa Saeki,&nbsp;Norito Katoh,&nbsp;Satoshi Teramukai,&nbsp;Yuki Tajima,&nbsp;Kwinten Bosman,&nbsp;Marius Ardeleanu,&nbsp;Kazuhiko Arima","doi":"10.1111/1346-8138.70345","DOIUrl":"10.1111/1346-8138.70345","url":null,"abstract":"<p>Clinical phenotypes of atopic dermatitis (AD) can vary, with some individuals displaying difficult-to-treat prurigo nodularis-like lesions. We aimed to assess the real-world disease burden and treatment course of Japanese adults with AD-associated prurigo nodules (AD-Pn) receiving conventional AD treatments. Of the 300 participants with moderate-to-severe AD registered in the observational ADDRESS-J study between July 29, 2016 and July 4, 2017 (before the first biologic for AD was introduced), 285 had baseline and post-baseline prurigo assessments and were included in this exploratory analysis (108 with AD-Pn and 177 without Pn). Participants with AD-Pn versus those without Pn included more males (73.1% vs. 53.1%), and had more mean ± standard deviation (SD) visits for AD treatment in the previous year (11.5 ± 16.1 vs. 8.7 ± 6.6 visits), a higher proportion with an Investigator's Global Assessment (IGA) 4 score (39.9% vs. 18.6%), a higher mean ± SD Eczema Area and Severity Index (EASI) score (28.4 ± 15.1 vs. 23.5 ± 15.5), and a higher mean ± SD Patient-Oriented Eczema Measure (POEM) score (18.8 ± 6.2 vs. 15.6 ± 6.8). At baseline, 14.8% and 7.4% of participants with AD-Pn had been treated with oral immunosuppressants and oral corticosteroids, respectively, compared with 8.5% and 2.3%, respectively, of those without Pn. Individuals with AD-Pn previously received more intensive topical treatments. At 2 years, participants with AD-Pn had more severe AD than those without Pn, as assessed by IGA 4 scores (9.1% vs. 0.9%), and higher mean ± SD EASI total scores (12.5 ± 10.7 vs. 7.0 ± 8.1). In summary, individuals with AD-Pn were mostly males, whose AD was more severe and had improved less than those without Pn while receiving mostly conventional AD treatments over 2 years. AD-Pn might be an indicator for targeted treatment to improve long-term AD outcomes.</p><p><b>Clinical Trial Registration:</b> ADDRESS-J (UMIN Clinical Trial Registration: UMIN000022623)</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 8","pages":"1099-1114"},"PeriodicalIF":2.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.70345","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational Primary Red Meat Allergy With Sensitization to Serum Albumins, Sus s 1, and Bos d 6","authors":"Manaka Aoyama,&nbsp;Erina Hagihara,&nbsp;Yusuke Furuya,&nbsp;Sachiko Koshikawa,&nbsp;Naoko Inomata","doi":"10.1111/1346-8138.70379","DOIUrl":"10.1111/1346-8138.70379","url":null,"abstract":"<div>\u0000 \u0000 <p>To date, occupational primary red meat allergies have not been reported. A 42-year-old man visited our clinic with allergic symptoms after ingesting red meat. For the past 5 years, he has developed a tingling in the throat and itchy erythema over the whole body immediately after ingesting rare pork and beef, and fresh cream. He had been working at a butcher's shop since he was 22, mainly handling pork and beef. At the age of 26, he noticed wheals appearing on the parts of his body which had been in direct contact with raw meat. At the same time, his atopic dermatitis was worsening. Specific IgE measurements using ImmunoCAP showed positive results for pork, beef, and cow's milk. Skin prick tests showed positive reactions to raw pork and raw beef. In IgE-immunoblotting, one of the two IgE-binding bands to pork and beef was located at 67 kDa, which was consistent with the IgE-binding band to porcine serum albumin, Sus s 1. Furthermore, ImmunoCAP showed positive results for Sus s 1 and the bovine serum albumin, Bos d 6. Poorly controlled atopic dermatitis and occupational skin exposure to red meat likely promoted epicutaneous sensitization, leading to adult-onset primary red meat allergy.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 8","pages":"1217-1220"},"PeriodicalIF":2.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nodular Scleroderma in a Patient With Anti–RNA Polymerase III–Antibody Positive Systemic Sclerosis: A Case Report and Literature Review","authors":"Kyoko Kanno,&nbsp;Yuki Kobayashi,&nbsp;Yasuyuki Fujita","doi":"10.1111/1346-8138.70391","DOIUrl":"10.1111/1346-8138.70391","url":null,"abstract":"<p>Nodular scleroderma (NS) is a rare manifestation of systemic sclerosis (SSc) that can clinically resemble keloids, often leading to diagnostic difficulty. Herein we report a case of a 76-year-old woman with anti–RNA polymerase III antibody–positive SSc who developed progressive erythematous, pruritic, keloid-like plaques 3 months after rituximab therapy. Histopathology showed thickened collagen bundles extending from the superficial to mid-dermis, increased fibroblasts, mucin deposition, and reduced elastic fibers without the hyalinized collagen characteristic of keloids, confirming NS. To date, NS associated with anti-RNA polymerase III antibody-positive SSc has not been reported. The patient was treated with topical PUVA, resulting in reduction of pruritus and softening of nodular lesions. Review of Japanese and international cases indicates that NS commonly arises during active SSc, often in areas of mechanical stress, and shows variable therapeutic response. This case expands the serological spectrum of NS and supports PUVA as a therapeutic option for symptomatic lesions.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 8","pages":"1213-1216"},"PeriodicalIF":2.3,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.70391","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Characteristics Associated With Sensitivity to Message Framing: A Within-Subject Comparison Study Using Data From the Illuminating Dialogues and Insights in Onychomycosis Management (IDIOM) Survey","authors":"Atsushi Otsuka,&nbsp;Yuichiro Tsunemi,&nbsp;Yusuke Nonaka","doi":"10.1111/1346-8138.70304","DOIUrl":"10.1111/1346-8138.70304","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Onychomycosis is a common fungal infection, yet the impact of gain- versus loss-framed messages on treatment intention has not been examined. This within-subject study evaluated whether age and sex modified sensitivity to message framing in onychomycosis. Among 300 treatment-experienced patients, we compared gain- and loss-framed messages under mild- and severe-risk scenarios and measured changes in treatment intention. Participants were classified into gain-dominant, loss-dominant, and neutral clusters based on response differences, and associations with age and sex were examined using multinomial logistic regression analysis. The neutral cluster accounted for the majority of patients, suggesting that the risk information itself may have been persuasive regardless of framing. However, effect modification was observed in the severe-risk scenario: women were more likely to be classified into the loss-dominant cluster, whereas older age was associated with the gain-dominant cluster. These findings highlight the importance of communicating the risks of untreated onychomycosis and suggest that patient characteristics may be associated with directional framing preferences, particularly under severe-risk messages. Given the hypothetical intention outcome and limited robustness in sensitivity analyses, clinical implications should therefore be interpreted cautiously.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>UMIN Clinical Trials Registry registration number: UMIN000050195</p>\u0000 </section>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 7","pages":"1067-1071"},"PeriodicalIF":2.3,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147871084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemoglobin A1c is Associated With Advanced Liver Fibrosis in Psoriasis Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease","authors":"Hidenori Watabe,&nbsp;Tomomitsu Miyagaki,&nbsp;Ken Go,&nbsp;Shinya Oba,&nbsp;Chiharu Nomura,&nbsp;Takafumi Kadono","doi":"10.1111/1346-8138.70274","DOIUrl":"10.1111/1346-8138.70274","url":null,"abstract":"<div>\u0000 \u0000 <p>Psoriasis is a systemic inflammatory disease that is frequently accompanied by metabolic dysfunction-associated steatotic liver disease (MASLD) and is associated with an increased risk of liver fibrosis. Identifying psoriasis patients with MASLD at high risk of advanced liver fibrosis is clinically important; however, readily applicable markers in routine dermatological practice remain limited. Serum mac-2-binding protein glycosylation isomer (M2BPGi) level is a noninvasive and specific marker for assessing the degree of liver fibrosis, but its clinical utility in psoriasis patients with concomitant MASLD has not been fully elucidated. This single-center retrospective cross-sectional study aimed to investigate factors associated with advanced liver fibrosis in psoriasis patients with MASLD. Advanced liver fibrosis was defined as an M2BPGi level ≥ 0.78, and patients were classified into two groups: an M2BPGi &lt; 0.78 group and an M2BPGi ≥ 0.78 group. Clinical characteristics and laboratory parameters were compared between groups, and univariate and multivariable logistic regression analyses were performed. In addition, multivariable receiver operating characteristic (ROC) curve analysis was conducted to evaluate the discriminatory performance of relevant factors. Patients with M2BPGi ≥ 0.78 were more likely to be female and had significantly higher hemoglobin A1c (HbA1c) levels. In multivariable logistic regression analysis, HbA1c remained independently associated with advanced liver fibrosis. A multivariable ROC model incorporating HbA1c, age, and body mass index demonstrated good discriminatory performance, with an area under the curve of 0.829. In conclusion, elevated HbA1c was independently associated with advanced liver fibrosis in psoriasis patients with MASLD. HbA1c may serve as a simple and potentially useful screening marker for identifying patients at high risk of advanced liver fibrosis in routine clinical practice.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 7","pages":"1043-1047"},"PeriodicalIF":2.3,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-Induced Blaschkitis Associated With Dipeptidyl Peptidase-4 Inhibitor: A Case Report and Review of the Literature","authors":"Yasunori Suzaki,&nbsp;Yumi Aoyama","doi":"10.1111/1346-8138.70296","DOIUrl":"10.1111/1346-8138.70296","url":null,"abstract":"<div>\u0000 \u0000 <p>Blaschkitis is an acquired Blaschko-linear inflammatory dermatosis similar to classic lichen striatus. Although the pathomechanisms have not yet been fully elucidated, it has been reported that some cases were triggered by viral infections, vaccines, or drugs. We recently encountered a patient who developed multiple broad bands of erythematous papular plaques accompanied by vesicles along Blaschko lines on the left side of the trunk while taking sitagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4i) for type 2 diabetes mellitus. Histopathology showed necrotic keratinocytes in the epidermis accompanied by subepidermal blisters with infiltration of CD8-positive T cells and eosinophils in the upper dermis. Negative direct and indirect immunofluorescence ruled out DPP-4i-associated bullous pemphigoid. Within 1 week after withdrawal of DPP-4i, the skin lesions resolved, with no subsequent relapse. Furthermore, the distribution of the lesions along Blaschko lines is suggestive of cutaneous mosaicism and may be associated with immune-inflammatory responses induced by DPP-4i. Based on the clinical characteristics of this case, we speculate that DPP-4i activated T lymphocytes, which subsequently reacted to mosaic skin areas and induced blaschkitis. Accordingly, the diagnosis was DPP-4i-associated blaschkitis. We report this case together with a review of the relevant literature on drug-induced blaschkitis and lichen striatus.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 7","pages":"1048-1052"},"PeriodicalIF":2.3,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}