Journal of Dermatology最新文献

{"title":"Development of Descending Thoracic Aortic Aneurysm in a Psoriasis Patient Under Guselkumab Treatment","authors":"Chiharu Nomura, Tomomitsu Miyagaki, Shinya Oba, Ken Go, Takafumi Kadono, Hidenori Watabe","doi":"10.1111/1346-8138.70107","DOIUrl":"10.1111/1346-8138.70107","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 2","pages":"e155-e156"},"PeriodicalIF":2.7,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Outcomes of Surgery and ICI Therapy in 52 Patients With Esophageal Melanoma: A Retrospective Single-Center Cohort Study","authors":"Akihiro Ishiguro,&nbsp;Dai Ogata,&nbsp;Koshiro Ishiyama,&nbsp;Junya Oguma,&nbsp;Daisuke Kurita,&nbsp;Eiji Nakano,&nbsp;Kenjiro Namikawa,&nbsp;Akira Takahashi,&nbsp;Hiroyuki Daiko,&nbsp;Yasuyuki Seto,&nbsp;Naoya Yamazaki","doi":"10.1111/1346-8138.70097","DOIUrl":"10.1111/1346-8138.70097","url":null,"abstract":"<div>\u0000 \u0000 <p>Primary malignant melanoma of the esophagus (PMME) accounts for only 0.5% of all melanomas but is associated with the shortest interval to disease progression and the highest metastasis rate. The optimal treatment for PMME remains elusive. The present study aimed to assess the utility of screening as a means of predicting the prognosis of PMME and to determine the efficacy of surgery and immune checkpoint inhibitors (ICIs) against this disease. Fifty-two patients with PMME treated at the National Cancer Center Hospital in Japan between 2010 and 2023 were enrolled. Survival analysis was performed for (i) patients with PMME (<i>n</i> = 52); (ii) resectable cases at the initial presentation (<i>n</i> = 36); and (iii) cases with systemic therapy (<i>n</i> = 37). The 5-year overall survival (OS) rate was 45.0%, and the median OS was 55.8 months. The 5-year OS rate of the patients in whom PMME was detected by screening and those in whom it was diagnosed clinically was 54.7% and 40.1%, respectively (<i>p</i> = 0.255). The presence of a lymph node metastasis was associated with a significantly higher recurrence and poorer prognosis. The 3-year RFS rate of the patients at the local and nodal stage was 57.8% and 6.9%, respectively (<i>p</i> &lt; 0.0001). At surgery, the rate of lymph node metastasis in the recurrence group and the nonrecurrence group was 68% and 10%, respectively (<i>p</i> = 0.0027). In the patients who received ICI therapy, the 3-year OS was 33.3%, the median OS was 15.0 months, and the overall response rate was 23.5%. Our findings suggested that ICI therapy may improve survival in patients with advanced PMME. However, further research is warranted to identify both the clinical and molecular predictors of the treatment response as a means of improving patient selection.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 2","pages":"264-272"},"PeriodicalIF":2.7,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Melanoma Pathology Report: What to Expect and How to Interpret It","authors":"Alexander Nirenberg,&nbsp;Richard Williams,&nbsp;Howard Steinman,&nbsp;Stuart Anderson,&nbsp;Anthony Dixon","doi":"10.1111/1346-8138.70071","DOIUrl":"10.1111/1346-8138.70071","url":null,"abstract":"<div>\u0000 \u0000 <p>Pathological information is critical to patient management in melanoma. A uniform approach based on current evidence is crucial and is summarized in this paper. Essential clinical and pathological parameters to report are the BAUSSS biomarker prognostic criteria, that is, Breslow thickness, patient age, presence of ulceration, melanoma subtype, patient sex, and anatomic site. Other important parameters to include are adnexal and periadnexal extension, tumor infiltrating lymphocytes, intravascular and abluminal lymphovascular invasion, microsatellites, in-transit metastases, perineural invasion, and margins. Additional parameters that have been recommended for inclusion are mitotic activity, regression, association with nevi and atypical melanocytic hyperplasia. The significance of special stains and genetic studies is also discussed.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 1","pages":"3-13"},"PeriodicalIF":2.7,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145672982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solar Urticaria-Like Symptoms Induced by Conjugated Estrogen","authors":"Megumi Mizawa,&nbsp;Teruhiko Makino,&nbsp;Chieko Inami,&nbsp;Fumina Furukawa,&nbsp;Tadamichi Shimizu","doi":"10.1111/1346-8138.70089","DOIUrl":"10.1111/1346-8138.70089","url":null,"abstract":"&lt;p&gt;Conjugated estrogens prescribed for menopausal symptoms and osteoporosis prevention are composed of water-soluble estrogen sulfate salts. Although their common adverse effects are well known, photosensitive reactions are rare. We herein report a patient who developed solar urticaria-like symptoms during long-term treatment with conjugated estrogens, with complete resolution of symptoms following drug withdrawal.&lt;/p&gt;&lt;p&gt;A 63-year-old woman presented with a 3-month history of facial erythema that appeared within minutes of exposure to sunlight. She experienced tingling and burning without itching and was unresponsive to antihistamines. As examination 30 min after sun exposure revealed erythema on the nose, cheeks, and ears (Figure 1a), that resolved within 30 min indoors. No blistering, scarring, skin fragility, or hypertrichosis was noted. The patient had been taking conjugated estrogen (Premarin) for 10 years and did not consume alcohol.&lt;/p&gt;&lt;p&gt;Laboratory tests revealed mild liver dysfunction and slightly elevated urinary uroporphyrin and coproporphyrin levels (50 and 172 μg/g Cre, respectively; normal: 2–25 and 8–168). Her urine exhibited pale pink fluorescence under Wood's lamp (Figure 1b). Phototesting revealed minimal erythema doses (MEDs) for ultraviolet (UV) A (&gt; 10 J/cm&lt;sup&gt;2&lt;/sup&gt;) and UVB (60 mJ/cm&lt;sup&gt;2&lt;/sup&gt;), consistent with Fitzpatrick skin type III. Visible light exposure using an automatic slide projector (Cabin Industrial Co.; CS-30PX) for 10 min at 7.5 cm induced erythema without wheal formation or itching (Figure 1c) that resolved within 60 min. No reaction occurred with exposure to UVA, UVB, or hot water. The patient was diagnosed with solar urticaria-like symptoms. After discontinuing conjugated estrogen, both her symptoms and laboratory abnormalities resolved within 3 months, and repeat phototesting showed no abnormal reactions. No recurrence was observed during the 1-year follow-up period, suggesting a causal relationship between estrogen therapy and photosensitivity.&lt;/p&gt;&lt;p&gt;The patient developed solar urticaria-like symptoms that completely resolved after discontinuation of the conjugated estrogen. Typical classical solar urticaria presents with wheals and flare reactions within minutes of sun exposure. However, our patient only developed transient erythema without wheals or itching, indicating an atypical urticarial response. Solar urticaria has occasionally been associated with photodermatoses such as polymorphous light eruptions and porphyria cutanea tarda (PCT) [&lt;span&gt;1&lt;/span&gt;]. Interestingly, estrogens have been implicated in several photosensitive disorders, including hepatic porphyria and polymorphous light-eruption-like dermatosis [&lt;span&gt;2&lt;/span&gt;]. Furthermore, diethylstilbestrol, a synthetic estrogen, has been shown to increase porphyrin accumulation by activating aminolevulinic acid synthase [&lt;span&gt;3&lt;/span&gt;]. Although the precise mechanism remains unclear, estrogen may induce photosensitivity through hepatocell","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 2","pages":"e131-e132"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-Arterial Infusion Chemotherapy and Radiotherapy for Right Axillary Advanced Basal Cell Carcinoma Treatment","authors":"Harutaka Seshimo,&nbsp;Kenichiro Mae,&nbsp;Akihiro Ishiguro,&nbsp;Ryokichi Irisawa,&nbsp;Tatsuhiko Zama,&nbsp;Dai Ogata,&nbsp;Kazutoshi Harada","doi":"10.1111/1346-8138.70095","DOIUrl":"10.1111/1346-8138.70095","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 2","pages":"e139-e140"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tinea Nigra","authors":"Yang Bei-bei,&nbsp;Xiao Hua","doi":"10.1111/1346-8138.70094","DOIUrl":"10.1111/1346-8138.70094","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 2","pages":"e102-e103"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis of Vitiligo: Integrating Immune and Non-Immune Cell Crosstalk","authors":"Shintaro Inoue","doi":"10.1111/1346-8138.70067","DOIUrl":"10.1111/1346-8138.70067","url":null,"abstract":"<p>Vitiligo is an acquired autoimmune disease characterized by depigmented macules resulting from melanocyte loss. It is a complex multifactorial disorder in which genetic predisposition is combined with environmental factors; however, its detailed etiology remains unclear. Although Janus kinase (JAK) inhibitors have recently emerged as a therapeutic option, the range of available molecularly targeted drugs is limited compared to those for atopic dermatitis or psoriasis, necessitating an urgent elucidation of its pathogenesis. The pathogenesis of vitiligo is centrally mediated by cytotoxic CD8⁺ T cells (CTLs) specific for melanocyte antigens and their production of interferon-gamma (IFN-γ). In recent years, however, the involvement of other immune cells, such as resident memory T cells and regulatory T cells, innate immune cells, and non-immune cells including keratinocytes and fibroblasts has also garnered attention. Furthermore, pathogenic alterations are also present in clinically normal-appearing non-lesional skin, indicating that this tissue is “primed” for disease development. This finding supports a paradigm shift toward viewing vitiligo as a systemic disease rather than a localized skin disorder. Herein, this review summarizes the current knowledge on the factors leading to the onset and progression of non-segmental vitiligo, while also briefly addressing segmental vitiligo.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 2","pages":"188-199"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12877989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annular Elastolytic Giant Cell Granuloma With Elevated Serum ACE and Lysozyme: Photoprotection as a Key Strategy for Disease Control","authors":"Shiomi Iwata,&nbsp;Saori Takamura,&nbsp;Tomoo Fukuda","doi":"10.1111/1346-8138.70088","DOIUrl":"10.1111/1346-8138.70088","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 2","pages":"e128-e130"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Multifocal Venous Malformation With Two Somatic Pathogenic Variants in the TEK Gene","authors":"Sawako Ochiai,&nbsp;Hiroto Ono,&nbsp;Akira Shimizu,&nbsp;Sumihito Togi,&nbsp;Hiroki Ura,&nbsp;Yo Niida","doi":"10.1111/1346-8138.70078","DOIUrl":"10.1111/1346-8138.70078","url":null,"abstract":"<div>\u0000 \u0000 <p>Multifocal venous malformation (VM) is a rare vascular disorder characterized by multiple cutaneous and visceral venous malformations caused by somatic variants in the <i>TEK</i> gene, which encodes the TIE2 receptor. We report a 30-year-old man presenting with multiple subcutaneous nodules and oral lesions. MRI revealed multiple masses around the left scapula. A biopsy from a lumbar lesion showed dilated venous channels, and immunohistochemistry was positive for CD31. There was no evidence of anemia. Genetic analysis using next-generation sequencing of both skin and blood identified two somatic <i>TEK</i> variants, p.(Tyr897Cys) and p.(Arg918His), restricted to the lesion tissue. Bulk phasing analysis revealed that Y897C and R918H existed both as single variants and as double variants in cis. The absence of these variants in blood confirmed their somatic origin. Based on clinical and pathological findings, the patient was diagnosed with multifocal VM. Clinically, this case resembled multifocal sporadic VM; however, the genetic profile was consistent with blue rubber bleb nevus syndrome, suggesting this case may represent an intermediate phenotype between the two entities. The involvement of the PI3K/AKT/mTOR signaling pathway implies potential therapeutic benefit from mTOR inhibitors, such as sirolimus. Close follow-up is ongoing due to progressive oral involvement.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 2","pages":"314-317"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lichen Nitidus in a Patient With Systemic Sarcoidosis","authors":"Mai Endo,&nbsp;Toshiyuki Yamamoto","doi":"10.1111/1346-8138.70087","DOIUrl":"10.1111/1346-8138.70087","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"53 2","pages":"e126-e127"},"PeriodicalIF":2.7,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}