Journal of Dermatology最新文献

{"title":"Oral administration of ruxolitinib in psoriasis vulgaris: A case report of plaque psoriasis accompanied by myelofibrosis secondary to polisitemia vera successfully treated with oral ruxolitinib","authors":"Tubanur Çetinarslan,&nbsp;İsmet Aydoğdu,&nbsp;Aylin Türel Ermertcan","doi":"10.1111/1346-8138.17510","DOIUrl":"10.1111/1346-8138.17510","url":null,"abstract":"<p>Psoriasis is a chronic inflammatory skin disease characterized by keratinocyte hyperproliferation and immune cell infiltration. Various therapies have been discovered for psoriasis, including topical treatments, phototherapy, conventional systemic agents such as methotrexate, retinoids and ciclosporine, as well as biologics. Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway inhibitors targeting Tumor Necrosis Factor alpha (TNF-α), interleukin (IL)-23 and IL-17 can be effective in psoriasis. Ruxolitinib is a US Food and Drug Administration-approved first-generation Janus kinase inhibitor for polycythemia vera, myelofibrosis, and acute graft-versus-host disease. Ruxolitinib cream has been investigated in various dermatologic diseases, including atopic dermatitis, vitiligo, psoriasis, and alopecia areata. However, there is limited data on the efficacy of oral ruxolitinib in patients with psoriasis vulgaris. Here, we report a patient diagnosed with myelofibrosis coexisting with psoriasis vulgaris, successfully treated with oral ruxolitinib.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 1","pages":"179-182"},"PeriodicalIF":2.9,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum interleukin-10 level is increased and correlated positively with disease severity in patients with dipeptidyl peptidase-4 inhibitor-related bullous pemphigoid","authors":"Shoya Suzuki,&nbsp;Masahiro Kamata,&nbsp;Hideaki Uchida,&nbsp;Teruo Shimizu,&nbsp;Yoshiki Okada,&nbsp;Makoto Ito,&nbsp;Ayu Watanabe,&nbsp;Itsumi Mizukawa,&nbsp;Shota Egawa,&nbsp;Chika Chijiwa,&nbsp;Azusa Hiura,&nbsp;Saki Fukaya,&nbsp;Kotaro Hayashi,&nbsp;Atsuko Fukuyasu,&nbsp;Takamitsu Tanaka,&nbsp;Takeko Ishikawa,&nbsp;Yayoi Tada","doi":"10.1111/1346-8138.17512","DOIUrl":"10.1111/1346-8138.17512","url":null,"abstract":"<p>Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease with a linear deposit of autoantibodies at the epidermal basement membrane zone. It was reported that diabetes patients who took a dipeptidyl peptidase-4 inhibitor (DPP4i), an oral antidiabetic drug, had an increased incidence of BP. However, data on DPP4i-related BP are limited. In our study, we measured serum levels of various cytokines using LEGENDplex and assessed correlations of these serum levels with clinical severity and laboratory data. Serum samples obtained from BP patients who visited our hospital from June 2016 to February 2023 were collected in this study. Patients' background, characteristics, and clinical data were retrospectively collected from their charts. Serum samples from 27 patients with DPP4i-unrelated BP, 17 patients with DPP4i-related BP, and 13 healthy controls were analyzed. Patients with DPP4i-related BP had lower score of Bullous Pemphigoid Disease Area Index (BPDAI)-erythema/urticaria, lower number of circulating eosinophils, and lower titer of anti-BP180 antibody than patients with DPP4i-unrelated BP. The serum interleukin (IL)-6 level was significantly higher in patients with DPP4i-related BP than in healthy controls (<i>P</i> = 0.0037). The serum IL-10 level was significantly higher in patients with DPP4i-related BP than in patients with DPP4i-unrelated BP and in healthy controls (<i>P</i> = 0.0006, <i>P</i> = 0.0448), and was positively correlated with the BPDAI-blister/erosions score (<i>r</i> = 0.757, <i>P</i> = 0.001), BPDAI-erythema/urticaria score (<i>r</i> = 0.616, <i>P</i> = 0.013), and BPDAI-total score (<i>r</i> = 0.833, <i>P</i> &lt; 0.001) in patients with DPP4i-related BP. In conclusion, patients with DPP4i-related BP had increased serum levels of IL-6 and IL-10 compared with healthy controls and positive correlations between the serum IL-10 level and BPDAI scores reflecting clinical severity, indicating that the serum IL-10 level is a potential objective biomarker of disease severity in patients with DPP4i-related BP.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 1","pages":"122-131"},"PeriodicalIF":2.9,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative continuous compression bandaging was a useful technique for improving pseudosyndactyly in recessive dystrophic epidermolysis bullosa patients","authors":"Kosuke Mochida,&nbsp;Yukiyo Narita,&nbsp;Masahiro Amano","doi":"10.1111/1346-8138.17509","DOIUrl":"10.1111/1346-8138.17509","url":null,"abstract":"&lt;p&gt;Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic skin disorder characterized by variants in the &lt;i&gt;COL7A1&lt;/i&gt; gene, which encodes type VII collagen, essential for the basement membrane zone and the formation of anchoring fibrils. Because of the reduced or absent type VII collagen, blistering and subsequent scarring of the hands and feet lead to fusion of the digits accompanied by contractures and pseudosyndactyly. Repeated surgical intervention is often necessary to temporarily improve hand function and delay the recurrence of deformity.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;A 36-year-old woman with RDEB was referred to our department for pseudosyndactyly of the left hand, having undergone four surgeries previously, the latest 3 years earlier (Figure 1a,b). Owing to insufficient donor sites for skin grafts, artificial dermis was used for wound coverage. The operation began with removing the inelastic epidermis, which released the web and flexion contractures. The fingers were separated by blunt dissection to the web base, and flexion contractures were addressed with transverse volar incisions extending to the finger sides (Figure 1c,d). After exposing the dermis, artificial dermis grafts were applied to cover the palm and fingers followed by application of polymyxin B-soaked gauze to maintain a wet-to-dry environment and non-adherent dressing. A boxing-glove type dressing was used to maintain wrist dorsiflexion, metacarpophalangeal (MCP) and interphalangeal (IP) joint extension, and thumb abduction without Kirschner wires.&lt;/p&gt;&lt;p&gt;The first dressing change was on day 5 post-surgery, with the removal of the silicon film from the artificial dermis grafts. Non-adherent vaseline gauze (ADAPTIC&lt;sup&gt;®&lt;/sup&gt;; 3M) was used to cover the hands, and an alginate coating dressing (KALTOSTAT&lt;sup&gt;®&lt;/sup&gt;; Convatec) placed over it. Alginate dressing was also placed between the fingers to prevent web space obliteration and flexion contracture, with each finger fixed using a self-adhesive bandage for traction (Figure 1e–h). Continued dressing changes maintained a good condition, and although complete epithelialization took over 9 weeks (Figure 1i–l), the patient was satisfied with the outcome and improved hand use in daily activities. Three years and 8 months postoperatively, there is no adhesion of the fingers, and the patient has had a favorable clinical course (Figure 1m,n).&lt;/p&gt;&lt;p&gt;Most RDEB patients opt for hand surgeries to regain function. Treatments such as allogeneic fibroblast injections and skin substitutes show benefits but are not curative, and recurrence is unavoidable.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; Box et al. reported that 71.4% of the survey respondents used pins during surgery and recommended wearing post-operative hand orthoses to preserve surgical results. However, recurrence occurred in approximately 50% of cases after 1 year, requiring additional procedure.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; By utilizing postoperative compressive bandaging, the use of ","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 12","pages":"e414-e415"},"PeriodicalIF":2.9,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring racial and ethnic disparities in the hidradenitis suppurativa patient disease journey: Results from a real-world study in Europe and the USA","authors":"Tarannum Jaleel,&nbsp;Beth Mitchell,&nbsp;Russel Burge,&nbsp;Andrea Cohee,&nbsp;Hayley Wallinger,&nbsp;Isabel Truman,&nbsp;Aaron Keal,&nbsp;Chloe Middleton-Dalby,&nbsp;Sophie Barlow,&nbsp;Dipak Patel","doi":"10.1111/1346-8138.17386","DOIUrl":"10.1111/1346-8138.17386","url":null,"abstract":"<p>Hidradenitis suppurativa (HS) is an inflammatory skin disease associated with high morbidity and disability that has limited treatment options. People from racial and ethnic minority groups may experience greater disease severity and delay to diagnosis. This study assessed the impact of race/ethnicity on HS diagnosis and management in real-world clinical settings. Data were derived from the Adelphi Real World Hidradenitis Suppurativa Disease Specific Programme, a survey of dermatologists and their consulting HS patients in five European countries and the USA in 2020/2021. Dermatologists returned demographic and clinical data, and treatment goals and satisfaction for their next five to seven consulting patients. Patients completed a questionnaire on disease history and diagnosis, disease burden, and treatment satisfaction. Groups were compared with bivariate tests. In total, 312 physicians returned data on 1787 patients; 57.6% were female and 77.7% White. People from racial and ethnic minority groups were younger than White patients (32.9 ± 11.6 vs. 34.9 ± 12.4, mean ± standard deviation) and reported symptoms at a younger age (23.3 ± 10.8 vs. 26.2 ± 11.1), but their time to first consultation was longer than for White patients (2.6 ± 5.7 vs. 1.2 ± 2.5 years). People from racial and ethnic minority groups took longer to receive a correct diagnosis following first consultation (2.7 ± 5.3 vs. 1.5 ± 4.1 years) and were more likely to be misdiagnosed with boils (73.5% vs. 40.4%). People from racial and ethnic minority groups had a greater disease awareness at diagnosis and reported wanting greater support. People from racial and ethnic minority groups reported a greater impact on life, more severe pain, and a greater level of activity impairment in the Work Productivity and Activity Impairment: General Health (27.0 ± 25.2 vs. 20.0 ± 20.6). All <i>P</i> values were ≤0.05. These data show evidence of delayed diagnosis and higher HS symptom burden amongst people from racial and ethnic minority groups, highlighting health disparities in HS.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 12","pages":"1547-1558"},"PeriodicalIF":2.9,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of intravenous corticosteroid pulse therapy for rapidly progressive alopecia areata: A single-center retrospective analysis of 106 cases and usefulness evaluation of a scoring system originally designed for half-year efficacy prediction for extended periods","authors":"Masahiro Fukuyama,&nbsp;Misaki Kinoshita-Ise,&nbsp;Manabu Ohyama","doi":"10.1111/1346-8138.17506","DOIUrl":"10.1111/1346-8138.17506","url":null,"abstract":"<p>Intravenous corticosteroid pulse therapy (IVPT) has been preferentially conducted for rapidly progressive alopecia areata (RP-AA); however, the evaluation of long-term outcomes has been insufficient. In this study, 106 IVPT-treated RP-AA patients (36 males and 70 females) who were followed up for more than 1 year and up to 6.8 years were retrospectively analyzed. The mean observation period was 1137.8 ± 587.9 days (range 380–2490). The mean severity of alopecia tool (SALT) score before IVPT was 21.3 ± 23.4 but whole-scalp hair loss was observed in all cases after the intervention, suggesting that IVPT was performed soon after the onset. With additional interventions represented by intralesional triamcinolone acetonide injection with or without topical potent corticosteroid for those who insufficiently responded at 6 months after IVPT, 64.2%, 14.2%, and 21.7% of the patients respectively achieved good response (GR; SALT score ≤25), moderate response (MR; 25 &lt; SALT score &lt;75), and poor response (PR; 75 ≤ SALT score) 1 year after IVPT. On the final evaluation, the proportions of patients with GR, MR, and PR were 79 (74.5%), 7 (6.6%), and 20 (18.9%). Sixteen patients achieved and maintained full hair regrowth with IVPT alone until the end of observation. A previously reported scoring system for the short-term outcome prediction was shown to be useful for distinguishing the final-point GR responders from PR responders (<i>P</i> = 0.003). Of note, 21 patients were found to have some symptoms suggestive of the existence of preceding infectious diseases and tended to relapse. The revised scoring system adding the absence of preceding infectious diseases as one factor successfully predicted the occurrence of the relapse in our cohort (<i>P</i> = 0.002). Taken together, previously unreported real-world efficacy of IVPT to RP-AA was elucidated with the invention of a tool putatively enabling optimal long-term management.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 1","pages":"112-121"},"PeriodicalIF":2.9,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Golden palms: Xanthoma striatum palmare: An illustrative image of an uncommon finding in a quotidian setting","authors":"Tatiana Camayo-Vásquez,&nbsp;Marlon Y. Barrera-Montañez","doi":"10.1111/1346-8138.17502","DOIUrl":"10.1111/1346-8138.17502","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 11","pages":"e384-e385"},"PeriodicalIF":2.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “dietary habits in Japanese patients with palmoplantar pustulosis”","authors":"","doi":"10.1111/1346-8138.17504","DOIUrl":"10.1111/1346-8138.17504","url":null,"abstract":"<p>Serizawa N, Okazaki S, Otsuka Y, Koto M, Okabe K, Ito M, et al. Dietary habits in Japanese patients with palmoplantar pustulosis. <i>J Dermatol</i>. 2021;48:366–375.</p><p>There were errors in Table 1 and Table 5. The correct Table 1 and Table 5 are shown below.</p><p>We apologize for these errors.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 11","pages":"1526-1529"},"PeriodicalIF":2.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17504","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prurigo chronica multiformis: Expert consensus of the Japanese Dermatological Association","authors":"Takahiro Satoh,&nbsp;Hiroyuki Murota,&nbsp;Yumi Aoyama,&nbsp;Takashi Hashimoto,&nbsp;Yozo Ishiuji,&nbsp;Yutaka Hatano,&nbsp;Takeshi Nakahara,&nbsp;Kenji Kabashima,&nbsp;Kenji Takamori,&nbsp;Ichiro Katayama","doi":"10.1111/1346-8138.17487","DOIUrl":"10.1111/1346-8138.17487","url":null,"abstract":"<p>Prurigo chronica multiformis is a commonly used diagnostic designation for a peculiar subtype of prurigo in Japan, although the disease entity might not be well-recognized in other countries. Experts approved by the Japanese Dermatological Association attempted to build a common consensus on prurigo chronica multiformis, agreeing that it is a unique and important disease entity in elderly patients. Skin lesions are characterized by intensely pruritic, edematous, urticarial papules, or small macules, which gradually become solid papules/small nodules. The papules tend to aggregate and occasionally coalesce into polygonal lichenified plaques. The most commonly affected sites are the lower abdomen and lower back, although the chest, thighs, and upper back might also be involved. Common histopathological features of prurigo chronica multiformis include infiltration of lymphocytes and eosinophils in the upper dermis, with minimal epidermal changes. Basophil infiltration is also observed. The epidemiological incidence, differences in clinical manifestations by geographical location, and disease placement among other forms of prurigo and/or related skin diseases need to be further elucidated. Dermatologists should be aware of the clinical characteristics of prurigo chronica multiformis.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 11","pages":"e376-e383"},"PeriodicalIF":2.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17487","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical inertia in onychomycosis treatment: results from the Illuminating Dialogues and Insights in Onychomycosis Management (IDIOM) survey","authors":"Yuichiro Tsunemi,&nbsp;Atsushi Otsuka,&nbsp;Yusuke Nonaka","doi":"10.1111/1346-8138.17495","DOIUrl":"10.1111/1346-8138.17495","url":null,"abstract":"<p>Onychomycosis is a fungal infection of the nail that can serve as a reservoir for tinea infections in other parts of the body and can be transmitted to other individuals. As the disease progresses, it can lead to functional impairment, such as difficulties in walking, and negatively impact the psychosocial aspects of quality of life. Onychomycosis treatment, especially topical, is long-term, and adequate follow-up is essential for cure. However, the realities and issues of patient-physician communication after treatment initiation, including patients' perception of efficacy, treatment satisfaction, and reconsideration of the treatment approach, remain unclear. Therefore, this study aimed to examine the realities and issues associated with onychomycosis treatment, focusing on topical therapies, through a web-based survey of patients with onychomycosis and dermatologists. The duration of topical treatment was prolonged, with 30.5% of patients undergoing topical therapy for more than 2 years. Of these, 54.5% had not perceived clear efficacy. In addition, 93.7% of all patients with onychomycosis expressed a desire to change their treatment if it was ineffective. However, only 29.9% of patients receiving topical treatment discussed changing their treatment with their physicians, and only 7.3% ultimately changed their treatment. These findings indicate that the review of treatment strategies was insufficient. Furthermore, the satisfaction rate among patients treated with oral medications was higher than that of patients treated with topical medication. Despite dermatologists' awareness of low patient satisfaction with topical treatments, approximately 40% recommended alternative topical therapies when the initial topical treatment was ineffective. These results suggest clinical inertia in the treatment of onychomycosis stemming from a lack of appropriate intensification of treatment. In managing onychomycosis, the patient and dermatologist must share a common understanding of the importance of regular evaluation and the optimization of treatment regimens during treatment and must work side by side toward a cure.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 1","pages":"97-111"},"PeriodicalIF":2.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Ozenoxacin suppresses sebum production by inhibiting mTORC1 activation in differentiated hamster sebocytes”","authors":"","doi":"10.1111/1346-8138.17491","DOIUrl":"10.1111/1346-8138.17491","url":null,"abstract":"<p>Kitano T, Koiwai T, Fujikawa K, Mori S,Matsumoto T, Sato T. Ozenoxacin suppresses sebum production by inhibiting mTORC1 activation in differentiated hamster sebocytes. <i>J Dermatol</i>. 2024;51:1187–98. https://doi.org/10.1111/1346-8138.17409</p><p>In the legend of Figure 2, the text “^$<i>P</i> &lt; 0.05 compared with insulin (Tukey's multiple comparison test).” was incorrect. This should have read: “^$<i>P</i> &lt; 0.05 compared with 5α-DHT (Tukey's multiple comparison test).”</p><p>In the legend of Figure 4, the text “^#<i>P</i> &lt; 0.05 compared with insulin +10⁻³ N NaOH (Dunnett's multiple comparison test).” was incorrect. This should have read: “^#<i>P</i> &lt; 0.05 compared with 5α-DHT +10⁻³ N NaOH (Tukey's multiple comparison test).”</p><p>In the legend of Figure 4, the text “^$<i>P</i> &lt; 0.05 compared with insulin (Dunnett's multiple comparison test).” was incorrect. This should have read: “^$<i>P</i> &lt; 0.05 compared with 5α-DHT (Tukey's multiple comparison test).”</p><p>In the legend of Figure 5, the text “^‡<i>P</i> &lt; 0.05 compared with insulin + ozenoxacin 100 μmol/L, or 5α- DHT+ ozenoxacin 10 μmol/L (Tukey's multiple comparison test).” was incorrect. This should have read: “^‡<i>P</i> &lt; 0.05 compared with insulin + ozenoxacin 30 μmol/L, or 5α- DHT+ ozenoxacin 10 μmol/L (Tukey's multiple comparison test).”</p><p>In the legend of Figure S1, the text “^#<i>P</i> &lt; 0.05 compared with insulin + 10–3 N NaOH (Tukey's multiple comparison test).” was incorrect. This should have read: “^#<i>P</i> &lt; 0.05 compared with 5α-DHT + 10⁻³ N NaOH (Tukey's multiple comparison test).”</p><p>We apologize for these errors.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 11","pages":"1525"},"PeriodicalIF":2.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17491","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}