Journal of Dermatology最新文献

{"title":"A Case of Pseudoxanthoma Elasticum Caused by a Novel Structural Variant of the ABCC6 Gene","authors":"Abe Yurika, Yuko Takamiya, Hiroto Ono, Kiminobu Takeda, Akira Shimizu, Sumihito Togi, Hiroki Ura, Yo Niida","doi":"10.1111/1346-8138.17821","DOIUrl":"10.1111/1346-8138.17821","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 9","pages":"e828-e829"},"PeriodicalIF":2.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-Operative Onychoscopy of Subungual Epidermoid Inclusions","authors":"Grigorios Theodosiou,&nbsp;Peter C. Schalock,&nbsp;Åke Svensson","doi":"10.1111/1346-8138.17825","DOIUrl":"10.1111/1346-8138.17825","url":null,"abstract":"<p>Subungual epidermoid inclusions (SEI) are small epithelial inclusions, sometimes solid but mostly with central keratinization of the onycholemmal type without a granular layer. Exceptionally, they become large enough to produce symptoms such as pain or swelling of the nail bed, resulting in subungual keratosis, onycholysis, or a dystrophic nail plate. Herein, we report a further case of SEI in a female patient with onychodystrophy of the great toe nail and highlight the onychoscopic features of SEI. Intra-operative onychoscopy facilitates the detection of SEI during a nail bed biopsy and reduces the risk of obtaining inadequate specimens for histopathologic examination.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 8","pages":"1314-1316"},"PeriodicalIF":2.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17825","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Melanoma 2025","authors":"Satoshi Fukushima,&nbsp;Takamichi Ito,&nbsp;Jun Asai,&nbsp;Hiroshi Igaki,&nbsp;Ryota Tanaka,&nbsp;Kenjiro Namikawa,&nbsp;Ayato Hayashi,&nbsp;Akane Minagawa,&nbsp;Takuya Miyagawa,&nbsp;Azusa Miyashita,&nbsp;Dai Ogata,&nbsp;Mao Okumura,&nbsp;Yukiko Kiniwa,&nbsp;Hiroyuki Goto,&nbsp;Takeshi Namiki,&nbsp;Hiroki Hashimoto,&nbsp;Tokimasa Hida,&nbsp;Takero Hirata,&nbsp;Taku Maeda,&nbsp;Takamitsu Matsuzawa,&nbsp;Teruki Yanagi,&nbsp;Kanae Sugimoto,&nbsp;Emi Kimura,&nbsp;Hiroshi Koga,&nbsp;Hiroshi Uchi,&nbsp;Tomomitsu Miyagaki,&nbsp;Yasuhiro Nakamura,&nbsp;Takashi Inozume","doi":"10.1111/1346-8138.17740","DOIUrl":"10.1111/1346-8138.17740","url":null,"abstract":"<p>Advancements in melanoma management have underscored the need for periodic guideline updates every few years to reflect current clinical practices. Previous versions of melanoma clinical practice guidelines in Japan have primarily aimed to reflect global standards of care. This focus on international benchmarks was largely attributed to the scarcity of high-quality evidence from East Asia, necessitating reliance on Western references. Recent findings indicate differences in melanoma subtypes and drug efficacy between Western and East Asian populations. Therefore, efforts were made to incorporate data from East Asia in this revision, aiming to develop guidelines that better reflect the region's unique characteristics. This revision was commissioned by the Japanese Dermatological Association (JDA) and Japanese Skin Cancer Society (JSCS) and was undertaken by a committee comprising experts across relevant fields who meticulously reviewed and systematized a wide range of literature on melanoma to develop comprehensive, evidence-based guidelines. Literature searches were conducted by the Japan Medical Library Association. The recommendation statements were determined using the GRADE Grid approach. The guideline was developed in accordance with the Minds Clinical Practice Guideline Creation Manual 2020, ver. 3.0. Twelve clinical questions (CQs) were established, and corresponding recommendation statements were provided for each CQ. For several CQs, the inclusion of data from East Asia resulted in recommendations that differed from those in Western guidelines. Considering that the biology of melanoma has been increasingly recognized to vary by subtype and ethnicity, guidelines should be developed independently for each region based on evidence specific to the melanoma characteristics of that region. We firmly believe that this Japanese clinical guideline for melanoma will contribute to improving melanoma management in East Asia.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 8","pages":"e666-e697"},"PeriodicalIF":2.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17740","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial Skin With Conspicuous Enlarged Pores Closely Related to Severity of Facial Acneiform Rash and Therapeutic Effects of EGFR Inhibitors in RAS Wild-Type Metastatic Colorectal Cancer: Ancillary Analysis of FAEISS Study (NCCH1512)","authors":"Shusuke Yoshikawa,&nbsp;Katsuko Kikuchi,&nbsp;Keiko Nozawa,&nbsp;Yasuko Nakai,&nbsp;Haruhiko Fukuda,&nbsp;Taro Shibata,&nbsp;Ryunosuke Machida,&nbsp;Tetsuya Hamaguchi,&nbsp;Atsuo Takashima,&nbsp;Sumiko Takatsuka,&nbsp;Tomohiro Nishina,&nbsp;Akihito Kawazoe,&nbsp;Takahiro Tsushima,&nbsp;Masanobu Takahashi,&nbsp;Akiko Hasegawa,&nbsp;Toshiki Masuishi,&nbsp;Naoya Yamazaki,&nbsp;Yoshio Kiyohara","doi":"10.1111/1346-8138.17813","DOIUrl":"10.1111/1346-8138.17813","url":null,"abstract":"<p>Prophylactic treatment with oral minocycline or doxycycline, moisturizers, and sunscreens has been reported to be beneficial for acneiform rash (AfR) caused by epidermal growth factor receptor (EGFR) inhibitors. It is desirable to predict which patients may develop severe AfR and provide prophylactic treatment. This study aimed to evaluate the association between the worst grade of facial AfR (FAfR) after initiating therapy with EGFR inhibitors and the characteristic skin type in patients with RAS wild-type metastatic colorectal cancer enrolled in the FAEISS study (a phase III, open-label, randomized trial evaluating topical corticosteroids for Facial Acneiform dermatitis by EGFR Inhibitors: Stepwise rank down from potent corticosteroids). Using pretreatment photographs of the face, characteristic skin types, including enlarged pores, oiliness (greasiness), and skin color/redness, were graded on a scale of 1–3. Grade 2 or higher FAfR developed in 9.1%, 27.0%, and 45.8% of patients with enlarged pore scores of 1, 2, and 3, respectively. Patients with enlarged pores tended to have more severe FAfR (<i>p</i> = 0.0216). Moreover, the disease control rate (complete remission/partial remission/stable disease) of the primary disease was seen in 59.1%, 70.6%, and 87.0% of patients with an enlarged pore score of 1, 2, and 3, respectively, showing a statistically significant trend (<i>p</i> = 0.038). This study suggests that a facial skin type with a high number of enlarged pores may be a marker for predicting AfR risk due to anti-EGFR antibody therapy and better therapeutic effects for RAS wild-type metastatic colorectal cancer.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 8","pages":"1227-1231"},"PeriodicalIF":2.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17813","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Mature Plasmacytoid Dendritic Cell Proliferation in Primary Myelofibrosis: A Case Report","authors":"Min Chong Kim,&nbsp;Mi Jin Gu,&nbsp;Young Seob Park,&nbsp;Joon-Goon Kim","doi":"10.1111/1346-8138.17803","DOIUrl":"10.1111/1346-8138.17803","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 8","pages":"e725-e727"},"PeriodicalIF":2.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Facial-Type Acquired Dermal Melanocytosis on the Lips Successfully Treated With Laser Therapy","authors":"Kana Kawase,&nbsp;Yoko Mizutani,&nbsp;Madoka Inoue,&nbsp;Hirotaka Akita,&nbsp;Kazuhiro Kobayashi,&nbsp;Hiroaki Iwata","doi":"10.1111/1346-8138.17800","DOIUrl":"10.1111/1346-8138.17800","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 8","pages":"e718-e719"},"PeriodicalIF":2.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CARD14-Associated Papulosquamous Eruption (CAPE) With Ichthyosis and Malignant Melanoma","authors":"Takao Kadono,&nbsp;Mayuko Yamamoto,&nbsp;Yukiko Aoyama,&nbsp;Kimiko Nakajima,&nbsp;Takuya Takeichi,&nbsp;Masashi Akiyama,&nbsp;Kozo Nakai","doi":"10.1111/1346-8138.17807","DOIUrl":"10.1111/1346-8138.17807","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 8","pages":"e730-e731"},"PeriodicalIF":2.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coconut Anaphylaxis Induced by Occupational Sensitization to Cosmetics via the Skin in a Spa Therapist","authors":"Daisuke Kawakami,&nbsp;Erina Hagihara,&nbsp;Takayuki Hata,&nbsp;Junya Hasegawa,&nbsp;Ayaka Ito,&nbsp;Sachiko Koshikawa,&nbsp;Naoko Inomata","doi":"10.1111/1346-8138.17820","DOIUrl":"10.1111/1346-8138.17820","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 9","pages":"e825-e827"},"PeriodicalIF":2.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Chinese Patient With Alopecia-Intellectual Disability Syndrome 4 Carrying a Known Missense Variant of LSS Gene and an Unreported Gross Deletion Involving LSS Gene","authors":"Huazhen Liu,&nbsp;Jing Cheng,&nbsp;Xiaodan Chen,&nbsp;Cuili Liang,&nbsp;Xi Yin,&nbsp;Xueying Su,&nbsp;Yanna Cai,&nbsp;Wen Zhang,&nbsp;Li Liu,&nbsp;Yunting Lin","doi":"10.1111/1346-8138.17819","DOIUrl":"10.1111/1346-8138.17819","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 9","pages":"e822-e824"},"PeriodicalIF":2.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Papilloma Virus Type 94–Associated Flat Warts Developing Repeatedly During Tofacitinib Treatment: A Case Report and Review","authors":"Nobuhiro Takahashi,&nbsp;Tomomichi Shimizu,&nbsp;Akio Kondoh,&nbsp;Kazushi Anzawa,&nbsp;Akira Shimizu,&nbsp;Tomotaka Mabuchi","doi":"10.1111/1346-8138.17814","DOIUrl":"10.1111/1346-8138.17814","url":null,"abstract":"<div>\u0000 \u0000 <p>Flat warts are typically caused by human papillomavirus (HPV) type 3 or 10, while HPV 94 is rarely detected. The warts on a 76-year-old Japanese male with rheumatoid arthritis (RA) appeared after 8 months of tofacitinib treatment but disappeared upon switching to filgotinib. However, the warts reappeared when tofacitinib was resumed. Histopathological and DNA sequencing confirmed HPV 94. While Janus kinase (JAK) inhibitors are known to increase viral reactivation risks, including herpes zoster, this case highlights a possible link between tofacitinib and HPV 94-related flat warts. Tofacitinib may suppress IL-15 signaling, weakening antiviral immunity and promoting HPV reactivation. Although HPV-specific immunity in RA- and tofacitinib-treated patients remains unclear, this case provides new insights into JAK inhibitor–related viral reactivation, particularly for HPV 94–associated flat warts.</p>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 8","pages":"1317-1320"},"PeriodicalIF":2.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}