Journal of Dermatology最新文献

{"title":"Association of hidradenitis suppurativa (HS) with waist circumference: A bidirectional two-sample Mendelian randomization study of HS with metabolic syndrome","authors":"Huaiyu Wang,&nbsp;Baofeng Wu,&nbsp;Min Luo,&nbsp;Yue Han,&nbsp;Jinhua Chen,&nbsp;Jingjing Liu,&nbsp;Lihang Lin,&nbsp;Xuemin Xiao","doi":"10.1111/1346-8138.17436","DOIUrl":"10.1111/1346-8138.17436","url":null,"abstract":"<p>Observational studies have suggested an associations between hidradenitis suppurativa (HS) and metabolic syndrome (MetS) and its components. However, it remains unclear whether the relationship is causal or not. Our study aimed to investigate the causal association of HS with MetS and its components. We performed a bidirectional, two-sample Mendelian randomization study using summary-level data from the most comprehensive genome-wide association studies of HS (<i>n</i> = 362 071), MetS (<i>n</i> = 291 107), waist circumference (<i>n</i> = 462 166), hypertension (<i>n</i> = 463 010) fasting blood glucose (FBG, <i>n</i> = 200 622), triglycerides (<i>n</i> = 441 016), and high-density lipoprotein cholesterol (HDL-C, <i>n</i> = 403 943). Genetic instrumental variables were constructed by identifying single nucleotide polymorphisms associated with the corresponding factors. The random-effects inverse-variance weighted method was applied as the primary method. The results showed that genetically predicted HS was positively associated with waist circumference risk in both directions. High waist circumference increased the risk of HS (odds ratio [OR] 4.147; 95% confidence interval [CI] 2.610–6.590; <i>p</i> = 1.746 × 10⁻⁹). In addition, HS was also affected by waist circumference (OR 1.009; 95% CI 1.006–1.012; <i>p</i> = 3.08 × 10⁻⁷). No causal relationships were found between HS and MetS or its components other than waist circumference. The findings highlight the importance of early intervention for obesity in HS patients. Further studies are needed to determine the pathophysiology of HS associated with MetS and its components.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 1","pages":"155-158"},"PeriodicalIF":2.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of one-step and two-step full thickness skin grafting and secondary intention healing for skin defects after surgical management of plantar malignant melanoma","authors":"Hiroshi Kato,&nbsp;Shinji Kano,&nbsp;Maki Yoshimitsu,&nbsp;Yua Nakagawa,&nbsp;Yukiko Yasui,&nbsp;Motoki Nakamura,&nbsp;Akimichi Morita","doi":"10.1111/1346-8138.17398","DOIUrl":"10.1111/1346-8138.17398","url":null,"abstract":"<p>Plantar malignant melanoma is largely managed surgically, particularly in its early stages. However, the plantar region has a lower survival rate of skin grafts than other regions. Furthermore, complete wound healing occurs over a long period of time, postoperatively. Thus, in this study, we retrospectively analyzed the use of skin grafts to reconstruct skin defects, as postoperative complications of plantar malignant melanoma. Forty-nine patients, (23 males, 26 females; mean age 70.4-years) underwent excisional surgery for plantar malignant melanoma at our hospital, between March 2018 and December 2022. The time from initial surgery to wound healing was analyzed, using a multivariate Cox proportional hazards model, to identify related factors. We excluded cases with lesions in non-weight-bearing areas and cases with segmental layer grafts, based on multivariate analysis, to eliminate bias when comparing a one-step resection and reconstruction technique to resection followed by waiting for granulation to occur before reconstruction. Patients were categorized into three cohorts. The first and second cohorts had undergone one-step and two-step skin grafting, respectively. Patients in the third cohort underwent secondary intention healing without skin grafting. The results revealed that the factors associated with wound-healing time included a defect size of &gt;1800 mm², in addition to two-step and split-thickness skin grafting. Therefore, Kaplan–Meier curves were constructed across the three cohorts, based on the data of 37 patients. Nine cases of non-weight-bearing areas and three cases of split-thickness skin grafts were excluded from the original total of 49 patients. The median times from the initial surgery to wound healing were 14.6, 12.0, and 21.9 weeks for the one- and two-step skin grafting and secondary intention healing cohorts, respectively. A statistically significant difference in the treatment time between the skin grafting and secondary intention healing cohorts was observed (<i>p</i> &lt; 0.001) Moreover, a statistically significant difference in the treatment time between the one- and two-step skin grafting cohorts was noted (<i>p</i> = 0.046). Thus, two-step skin grafting after surgical treatment for plantar malignant melanoma may shorten the overall treatment duration by allowing granulation to occur.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 12","pages":"1641-1645"},"PeriodicalIF":2.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert consensus on systemic therapy for plaque psoriasis with limited skin involvement in JAPAN: Results from a DELPHI study","authors":"Akimichi Morita,&nbsp;Yukari Okubo,&nbsp;Shinichi Imafuku,&nbsp;Yayoi Tada,&nbsp;Masatoshi Abe,&nbsp;A. E. J. Gibson,&nbsp;Frauke Becker,&nbsp;Nataliya Bogoeva,&nbsp;Mamitaro Ohtsuki","doi":"10.1111/1346-8138.17444","DOIUrl":"10.1111/1346-8138.17444","url":null,"abstract":"<p>Our objective was to establish consensus on (1) which patients with plaque psoriasis and limited skin involvement (body surface area [BSA] &lt;10%) are suitable for systemic treatment, and (2) a definition of ‘topical therapy failure’. A steering committee refined 13 statements drawn from literature related to the study objectives. An independent panel of 45 clinical experts from Japan indicated their agreement to each statement using a 10-point Likert scale (Round 1; strong consensus, ≥70% of responses = 7–10 and median value ≥8). The steering committee reviewed Round 1 results and refined the statements for Round 2, as necessary. In Round 2, the panel indicated their agreement to each statement using a 3-point scale (strong consensus, ≥70% of responses and median value of 3) and were shown Round 1 responses before voting. Forty-five clinicians participated in Round 1 and 41 of those (91%) participated in Round 2. Consensus was achieved on the criteria of eligibility for systemic treatment among patients with limited skin involvement as disease involvement at special or difficult to treat areas, psoriasis-induced psychological distress, uncontrolled symptoms (e.g., scaling, bleeding, pruritus, insomnia) affecting their social life, psoriatic arthritis, or failure of topical therapy. Consensus on criteria for topical failure were persistent symptoms (e.g., itchiness, pain) and plaques, poor patient satisfaction with treatment, a need to increase medication quantity or application time after treatment with two topicals for 4 weeks; or if the Psoriasis Area Severity Index score of &gt;3 or Physician Global Assessment Score of ≥2 after 8 weeks treatment. Our Delphi panel proposes criteria to help physicians identify patients with psoriasis and limited skin involvement who would benefit from systemic therapy and suggests a definition for topical therapy ‘failure’ which could indicate a move to systemic treatment is warranted.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 1","pages":"56-66"},"PeriodicalIF":2.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of eczematous paradoxical reactions on the extremities during tildrakizumab treatment for plaque psoriasis","authors":"Nao Kawano,&nbsp;Chisa Nakashima,&nbsp;Atsushi Otsuka","doi":"10.1111/1346-8138.17441","DOIUrl":"10.1111/1346-8138.17441","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 2","pages":"e157-e158"},"PeriodicalIF":2.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current clinical practice of prurigo nodularis in Japan: A cross-sectional web-survey among dermatologists","authors":"Hiroyuki Murota,&nbsp;Mai Matsumoto,&nbsp;Kazuhiko Arima,&nbsp;Takuo Yoshida,&nbsp;Hiroyuki Fujita","doi":"10.1111/1346-8138.17400","DOIUrl":"10.1111/1346-8138.17400","url":null,"abstract":"<p>Prurigo nodularis (PN) is a chronic inflammatory skin disease associated with intense pruritic nodules. The unclear patho-etiological mechanisms of PN cause difficulty in disease management; and there is a paucity of information on the current diagnosis and treatment options for PN in Japan. To describe the current management from a dermatologists' perspective we conducted a web-based survey (UMIN Clinical Trial Registry UMIN000047643) in 2022 among dermatologists from a Japanese commercially available physician panel, who had seen at least one patient with PN within the last 3 months. The survey included 117 dermatologists. The dermatologists diagnosed PN mainly by confirming clinical signs and patient interviews, while to assess the severity of PN, the number of pruritic nodules and the degree of itching were primarily utilized. Topical corticosteroids and antihistamines were the most used drugs, as recommended in the current guidelines on the diagnosis and treatment of prurigo. Dermatologists' treatment satisfaction decreased with increasing assumed severity of PN; almost 65% dermatologists were not satisfied with the treatment of severe PN. These results suggest the need of more effective medications and diagnostic tools for better management of PN in Japan.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 2","pages":"348-352"},"PeriodicalIF":2.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17400","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between acne vulgaris and attention deficit hyperactivity disorder in adolescent: A cross-sectional study","authors":"Huriye Aybüke Koç,&nbsp;Bedia Sultan Önal","doi":"10.1111/1346-8138.17435","DOIUrl":"10.1111/1346-8138.17435","url":null,"abstract":"<p>High androgen hormone exposure in intrauterine life is held to be responsible for the etiopathogenesis of both acne vulgaris (AV) and attention-deficit hyperactivity disorder (ADHD). In this study, we aimed to investigate the prevalence of ADHD in AV patients. Patients between the ages of 12 and 17, diagnosed with AV and a control group were included in the study. The Conners-Wells Adolescent Self-Report Scale-Long Form (CASS-L) was applied to both groups to determine the severity of the ADHD. Ninety-eight patients diagnosed with AV and 96 healthy controls participated in the study. All parameters of the CASS-L were found to be significantly higher in AV patients compared to the control group. In addition, with the severity of the Global Acne Grading System, a positive low level among conduct problems (<i>r</i> = 0.223), cognitive problems (<i>r</i> = 0.271), ADHD index (<i>r</i> = 0.238), inattention (<i>r</i> = 0.238), and a positive moderate level among hyperactivity (<i>r</i> = 0.349), hyperactivity-impulsivity (<i>r</i> = 0.414), and total score (<i>r</i> = 0.429). According to our results, patients diagnosed with AV were more prone to ADHD than the control group. Our study showed that adolescent patients diagnosed with AV were more prone to ADHD than people of similar age and gender without a diagnosis of AV. It should be noted that AV is not only a dermatological disease but may also be accompanied by psychiatric morbidities.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 1","pages":"50-55"},"PeriodicalIF":2.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author reply to “regarding “retrospective study of the clinical significance of the neutrophil-to-lymphocyte ratio in 79 patients with palmoplantar pustulosis””","authors":"Tomoya Watanabe,&nbsp;Yukie Yamaguchi","doi":"10.1111/1346-8138.17440","DOIUrl":"10.1111/1346-8138.17440","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 2","pages":"e187-e188"},"PeriodicalIF":2.9,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA-C*06:02 in Danish patients with psoriasis and response to biological treatment","authors":"Mie Siewertsen Bergmann,&nbsp;Nikolai Loft,&nbsp;Christopher Willy Schwarz,&nbsp;Diljit Kaur-Knudsen,&nbsp;Claus Zachariae,&nbsp;Lone Skov","doi":"10.1111/1346-8138.17415","DOIUrl":"10.1111/1346-8138.17415","url":null,"abstract":"<p>Whether clinical and genetic markers can be used to differentiate patients with varying responses to different psoriasis therapies needs to be elucidated. Here, we assess whether human leukocyte antigen C (HLA-C)*06:02 is associated with response to biologics. Response to treatment was defined as a Psoriasis Area and Severity Index score of ≤2 (PASI≤ 2) after 3 months. In total, 648 patients with psoriasis initiating treatment with biologics were included; 289 were HLA-C*06:02 positive and 359 were HLA-C*06:02 negative. Patients were treated with tumor necrosis factor (TNF) inhibitors (<i>n</i> = 469), interleukin (IL)-12/23 inhibitors (<i>n</i> = 92), IL-17 inhibitors (<i>n</i> = 78), and IL-23 inhibitors (<i>n</i> = 9). Significantly more patients positive for HLA-C*06:02 achieved PASI≤ 2 compared with patients negative for HLA-C*06:02 when treated with IL-12/23 inhibitors. There was no significant difference between response in HLA-C*06:02 positive and negative patients for TNF inhibitors or IL-17 inhibitors. No analyses were conducted for IL-23 inhibitors because of the limited number of patients. The data confirm that HLA-C*06:02 may be used as a biomarker for response to anti-IL12/23 treatment.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 1","pages":"142-145"},"PeriodicalIF":2.9,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regarding “retrospective study of the clinical significance of the neutrophil-to-lymphocyte ratio in 79 patients with palmoplantar pustulosis”","authors":"Zhuoqun Wei,&nbsp;Lüe Hong,&nbsp;Xingang Wu","doi":"10.1111/1346-8138.17438","DOIUrl":"10.1111/1346-8138.17438","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 2","pages":"e186"},"PeriodicalIF":2.9,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse planar xanthomatosis in the setting of monoclonal gammopathy of undetermined significance","authors":"Marisa Lenga,&nbsp;Jennifer Nam Choi","doi":"10.1111/1346-8138.17432","DOIUrl":"10.1111/1346-8138.17432","url":null,"abstract":"<p>A woman in her 60s presented to the clinic for progressively accumulating, asymptomatic, yellow plaques for 6 years. Her medical history included monoclonal gammopathy of undetermined significance (MGUS) of IgG lambda light chain subtype for 6 years and hypercholesteremia. On physical examination, well-defined, thin, yellow plaques were located on the eyelids, upper chest, anterior upper arms, axillae, and antecubital fossae without mucosal lesions (Figure 1). Histopathological examination revealed scattered collections of foamy histiocytes in the superficial and midreticular dermis with mild perivascular lymphohistiocytic infiltrate. Lipid panel findings demonstrated a mildly elevated low-density lipoprotein cholesterol at 122 mg/dL (reference &lt; 100 mg/dL). The patient was diagnosed with diffuse planar xanthomatosis in the setting of MGUS. Because the patient did not require treatment for MGUS at the time, skin-directed treatment options were reviewed with the patient, and she elected to treat the left anterior arm with cryotherapy. She was lost to follow-up.</p><p>Diffuse planar xanthomatosis is characterized by the dispersed accumulation of cholesterol-rich material in the skin and can develop in patients either with familial hyperlipidemia or with normal and slightly elevated lipids without family history.<span>^{1, 2}</span> In normolipidemic patients, there is a described phenomenon of diffuse xanthomas forming in the setting of hematological or lymphoproliferative disorders.<span>¹</span> Xanthomas form in the setting of MGUS (most commonly the IgG kappa subtype) through the creation of monoclonal IgG and low-density lipoprotein complexes and the subsequent phagocytosis of these complexes by macrophages.<span>³</span> This disease presents as asymptomatic, symmetric, yellow to orange plaques most commonly on the eyelids, neck, upper trunk, and flexural folds.<span>⁴</span> Histopathologic examination demonstrates diffuse foamy cells in the dermis with variable numbers of giant cells, lymphocytes, and foamy histiocytes.<span>⁴</span> Xanthomatosis may resolve spontaneously, with the treatment of MGUS, or with intervention like excision, chemabrasion, ablative laser, and cryotherapy.<span>^{3, 4}</span></p><p>This case serves as representative examination findings to improve clinical recognition of diffuse xanthomatosis in the setting of MGUS.</p><p>The authors declare no conflicts of interest for this article.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 10","pages":"e327-e328"},"PeriodicalIF":2.9,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17432","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}