Journal of Dermatology最新文献

{"title":"Effectiveness of calcipotriol/betamethasone dipropionate aerosol foam in patients with small versus large plaque psoriasis in routine practice in South Korea","authors":"Seong Jin Jo,&nbsp;Chul-Jong Park,&nbsp;Chul Hwan Bang,&nbsp;Ki-Heon Jeong,&nbsp;Bong Seok Shin,&nbsp;Dong Hyun Kim,&nbsp;Hae Jun Song,&nbsp;Ju-Hee Lee,&nbsp;YoungEun Kim,&nbsp;Sun Choi,&nbsp;Sang Woong Youn","doi":"10.1111/1346-8138.17253","DOIUrl":"10.1111/1346-8138.17253","url":null,"abstract":"<p>Small plaque psoriasis is the typical form of chronic plaque psoriasis affecting adults in South Korea. The effectiveness of calcipotriol/betamethasone dipropionate (Cal/BD) aerosol foam for large and small psoriasis plaques has not previously been examined. We performed a post hoc analysis of a recent, 4-week observational study of Cal/BD aerosol foam use in routine clinical practice in South Korea. Investigator Global Assessment response ([IGA] 0/1 at week 4), Patient Global Assessment response ([PaGA] 0/1 at week 4), change in Psoriasis Area and Severity Index (PASI), changes in psoriasis symptom scores, change in the Dermatology Life Quality Index (DLQI), and the proportion of patients achieving DLQI ≤5 were analyzed for patients with small (≤5 cm; <i>n</i> = 131) or large (&gt;5 cm; <i>n</i> = 35) baseline plaque size. IGA response rates were similar for patients with small and large plaques (59.5% and 51.4% respectively). Similarly, there was no significant difference between the small and large groups in mean change in PASI (−2.20 vs −3.34), the proportions of patients with DLQI ≤5 (62.3% vs 54.3%) or PaGA 0/1 (29.2% vs 40.0%). Mean improvements in DLQI (−4.04 vs −6.20) and in psoriasis symptoms including itching (−1.50 vs −2.83), sleep loss (−0.67 vs −1.89), dryness (−1.57 vs −2.97), scaling (−1.21 vs −3.57), and redness (−1.17 vs −3.11) were greater in patients with large plaques than those with small plaques. Itching and DLQI differences were not statistically significant after adjustment for baseline characteristics. Stratification by body surface area affected eliminated statistically significant differences between the groups for most outcomes. In conclusion, this analysis suggests that Cal/BD aerosol foam is an effective, well-accepted treatment for adult patients with the small plaques typical of chronic plaque psoriasis in South Korea, as well as for those with large plaques.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 7","pages":"1010-1016"},"PeriodicalIF":2.9,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17253","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140878281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world efficacy and safety of BRAF-targeted therapy for patients with advanced melanoma: A single-center retrospective study in Japan","authors":"Eiji Nakano,&nbsp;Akira Takahashi,&nbsp;Dai Ogata,&nbsp;Kenjiro Namikawa,&nbsp;Naoya Yamazaki","doi":"10.1111/1346-8138.17263","DOIUrl":"10.1111/1346-8138.17263","url":null,"abstract":"<p>Most clinical trials investigating targeted therapies for patients harboring <i>BRAF</i> V600 mutations have included mostly White patients, and data for Asian patients are scarce. Although there are several retrospective studies in Japanese patients, they have investigated only the dabrafenib + trametinib regimen, and have had a short follow-up period. We conducted a single-center retrospective study to update previous studies and compare the outcomes with those in White patients. We analyzed 89 patients who received dabrafenib + trametinib or encorafenib + binimetinib, including 11 who received both treatment regimens. The overall response rate was 79.8%, with complete response in 25 patients (28.1%) and partial response in 45 patients (51.7%). The median progression-free survival was 13.7 months, and the median overall survival was 32.9 months. The 3-year progression-free and overall survival rates were 31.8% and 47.9%, respectively. Although the two regimens showed no significant differences in efficacy, their safety profiles differed, as reported in clinical trials. Therefore, the most frequent adverse event associated with the dabrafenib + trametinib regimen was pyrexia (61.3%) and that of encorafenib + binimetinib was blurred vision (32.0%). Switching directly to another targeted therapy after progressive disease showed no clinical response; however, rechallenge followed by immune checkpoint inhibitor therapy showed a certain response. As a prognostic factor, performance status was associated with progression-free survival, and performance status, serum lactate dehydrogenase level, and dose interruption were associated with overall survival in the multivariate analysis. Real-world data on targeted therapy for patients with melanoma in Japan suggest that both dabrafenib + trametinib and encorafenib + binimetinib show similar efficacy and safety in Asian and White patients.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 9","pages":"1199-1207"},"PeriodicalIF":2.9,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140878282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of treatment strategies by comparing the minimum inhibitory concentrations and minimum fungicidal concentrations of azole drugs in dermatophytes","authors":"Junichiro Hiruma,&nbsp;Honoka Nojyo,&nbsp;Kazutoshi Harada,&nbsp;Rui Kano","doi":"10.1111/1346-8138.17241","DOIUrl":"10.1111/1346-8138.17241","url":null,"abstract":"<p>We compared the minimum inhibitory concentrations (MICs) and minimum fungicidal concentrations (MFCs) of azoles in antifungal drug-susceptible, terbinafine-resistant, and lowly itraconazole (ITCZ)-susceptible strains of dermatophytes. To assess the MICs of ITCZ, ravuconazole (RVCZ), efinaconazole (EFCZ), and luliconazole (LUCZ) in the isolates, broth microdilution assays were performed based on the Clinical and Laboratory Standards Institute M38-A2 guidelines with modifications. After the assays for determining the MICs, the inoculum suspensions in wells were resuspended, then 10 μL of the growth solution in each well was inoculated onto potato dextrose agar with the use of a pipette. After 7 days of incubation at 28°C, the MFCs were determined as the lowest concentration of a drug that allowed the growth of colonies on the potato dextrose agar. The MICs in the dermatophytes were &lt;0.03 to &gt;32 mg/L for ITCZ, &lt;0.03 to 4 mg/L for RVCZ, &lt;0.03 to 2 mg/L for EFCZ, and &lt;0.03 mg/L for LUCZ. The MFCs in the dermatophytes were 1 to &gt;32 mg/L for ITCZ, 0.06 to &gt;32 mg/L for RVCZ, &lt;0.03 to 4 mg/L for EFCZ, and &lt;0.03 to 2 mg/L for LUCZ. If the drug susceptibility test shows that the fungi are resistant to the drug, the treatment can be changed to a susceptible drug in advance, or if the fungi are low-susceptible, the treatment can be done with the recognition that it may require a longer treatment period than usual.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 11","pages":"1515-1518"},"PeriodicalIF":2.9,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of Hailey-Hailey disease with novel ATP2C1 gene variant (c.G925C) showing unusual phenotype","authors":"Satoko Minakawa,&nbsp;Yasushi Matsuzaki,&nbsp;Toshihide Higashino,&nbsp;Nanako Yamada,&nbsp;Tamio Suzuki,&nbsp;Eijiro Akasaka,&nbsp;Daisuke Sawamura","doi":"10.1111/1346-8138.17258","DOIUrl":"10.1111/1346-8138.17258","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 10","pages":"e346-e348"},"PeriodicalIF":2.9,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regarding the risk factors of rituximab-induced thrombocytopenia in patients with autoimmune bullous diseases","authors":"Jiangling Zheng","doi":"10.1111/1346-8138.17262","DOIUrl":"10.1111/1346-8138.17262","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 10","pages":"e349"},"PeriodicalIF":2.9,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythema nodosum in northern Finland between 1996 and 2019: A register-based study","authors":"Lantto Riina,&nbsp;Jokelainen Jari,&nbsp;Huilaja Laura,&nbsp;Sinikumpu Suvi-Päivikki","doi":"10.1111/1346-8138.17264","DOIUrl":"10.1111/1346-8138.17264","url":null,"abstract":"<p>Erythema nodosum (EN) is seen at any age with varying and often unidentified etiology. We studied the etiology and characteristics of EN in Northern Finland. Medical records of all patients with a diagnosis code for EN between 1996 and 2019 from Oulu University Hospital were retrieved and analyzed. There were in total 142 EN cases with a female predominance (<i>n</i> = 112, 72.9%). The mean age of the patients was 35.9 years. There were five cases diagnosed with EN in those younger than 2 years of age. Almost one third had EN nodules in multiple anatomical locations. In addition to skin findings, systemic symptoms were common (81.0%), and seen more often in men (<i>p</i> &lt; 0.05). In children and adolescents, the most common etiological factors were gastroenteritis caused by ‘Yersinia, Salmonella or Campylobacter’, followed by inflammatory bowel diseases and hormonal contraception. Bacterial infections were the most common etiological factor among adults. In 28.2% of the cases there was no identified causative factor. In this study, EN was seen surprisingly often in small children. Etiological factors varied markedly among different age groups and symptoms differed between the sexes in adults. These aspects should be taken into account when diagnosing EN patients.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 7","pages":"1017-1021"},"PeriodicalIF":2.9,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White patches due to complete loss of melanocytes in vulvar lichen sclerosis: Concomitant presence of vitiligo or not?","authors":"Keiko Watanabe,&nbsp;Mai Otsuki,&nbsp;Yushiro Ohara,&nbsp;Tomoko Wakasa,&nbsp;Naoki Oiso","doi":"10.1111/1346-8138.17265","DOIUrl":"10.1111/1346-8138.17265","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 10","pages":"e350-e351"},"PeriodicalIF":2.9,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term control of giant primary acral melanoma without amputation surgery","authors":"Urara Aitake,&nbsp;Shoichiro Ishizuki,&nbsp;Xiaofeng Lei,&nbsp;Teruaki Izumi,&nbsp;Shigeru Koizumi,&nbsp;Sayaka Takai,&nbsp;Tatsuhiko Mori,&nbsp;Toshifumi Nomura,&nbsp;Naoko Shojiguchi,&nbsp;Yasuhiro Nakamura","doi":"10.1111/1346-8138.17267","DOIUrl":"10.1111/1346-8138.17267","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 10","pages":"e354-e355"},"PeriodicalIF":2.9,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary cutaneous nocardiosis caused by Nocardia beijingensis in an immunocompetent host in Japan","authors":"Mai Wada,&nbsp;Shino Ota,&nbsp;Mariko Sugawara-Mikami,&nbsp;Takashi Yaguchi,&nbsp;Yoshie Kawahara","doi":"10.1111/1346-8138.17266","DOIUrl":"10.1111/1346-8138.17266","url":null,"abstract":"","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 10","pages":"e352-e353"},"PeriodicalIF":2.9,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear atrophoderma of Moulin","authors":"Andrea Paradisi,&nbsp;Irina Ciobotariu,&nbsp;Laura Quattrini,&nbsp;Francesco Ricci,&nbsp;Ketty Peris","doi":"10.1111/1346-8138.17268","DOIUrl":"10.1111/1346-8138.17268","url":null,"abstract":"<p>Linear atrophoderma of Moulin (LAM) is a rare, acquired dermatosis that follows Blaschko's lines.<span>¹</span> Although its exact pathogenesis is unclear, its distribution is believed to reflect genetic mosaicism.<span>²</span></p><p>Linear atrophoderma of Moulin onset is typically sudden, most frequently during adolescence or childhood. It is not commonly preceded by inflammation or followed by sclerosis, and is characterized by hyperpigmented, slightly atrophic patches on the trunk or extremities. The lesions show a unilateral distribution, although bilateral involvement has been reported.<span>^{3, 4}</span> In the first months, LAM usually progresses as linear atrophic lesions, then progression ceases and the lesions persist.</p><p>We present the case of a 16-year-old male with a 3-year history of progressive, asymptomatic, depressed linear lesions on the left upper trunk that became more defined over a short period.</p><p>The disease arose on the posterior trunk as pigmented atrophic plaques extending laterally from the paravertebral region toward the left shoulder, at the level of T3 of the thoracic spine. After 2–3 months the plaques became well defined, but were asymptomatic with no sign of inflammation or induration of the skin (Figure 1a–d).</p><p>There was no underlying disease. None in the patient's family had similar lesions.</p><p>On histopathology, the lesion showed epidermal loss of the rete ridges, mild hyperplasia of basal melanocytes, and a reduced dermal thickness with sparse lymphocytic infiltrate, vasodilatation, and slight thickening of the superficial collagen fibers (Figure S1).</p><p>There is no effective treatment for LAM, but a partial response to topical calcipotriol has been reported.<span>⁵</span> It is debated whether LAM belongs to a spectrum including atrophoderma of Pasini and Pierini and linear scleroderma. However, despite some similarities, the different age at onset, distribution, histology, origin, development, and prognosis of LAM suggest that it is a separate disease and highlights the importance of recognizing its distinct clinical features.</p><p>None declared.</p><p>Written patient consent was obtained for use of the images.</p>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"51 6","pages":"e183-e184"},"PeriodicalIF":3.1,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17268","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}