Dermoscopic Features and Their Association With Breslow Thickness of Facial Lentigo Maligna in Koreans: A Multi-Center Retrospective Study

IF 2.7 3区医学 Q2 DERMATOLOGY

Journal of Dermatology Pub Date : 2025-06-17 DOI:10.1111/1346-8138.17822

Jinie Lee, Ji Su Lee, Jun Young Kim, Jung Min Bae, Jin Park, Je-Ho Mun

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引用次数: 0

Abstract

Background

Owing to the rarity of lentigo maligna (LM) and lentigo maligna melanoma (LMM) in East Asians, their dermoscopic features are underreported. The prognosis and management of LM and LMM depend on the Breslow thickness (BT). However, the association between BT and the dermoscopic features of LMM is largely unknown.

Objectives

To report the dermoscopic features of LM/LMM in Koreans and analyze the association between BT and dermoscopic findings of LMM.

Methods

This retrospective study included 46 patients with facial LM/LMM (32 patients had ≤ 1 mm BT and 14 had > 1 mm) collected from three tertiary hospitals in Korea. The frequency of each dermoscopic feature of LM/LMM was assessed according to the BT. Logistic regression analysis was performed to investigate the association between certain dermoscopic patterns and BT in patients with LM/LMM.

Results

Observed dermoscopic patterns in Korean patients with LM/LMM included asymmetrical pigmented follicular openings (100%), asymmetry of the overall shape (97.8%), annular–granular pattern (95.7%), dark rhomboids (95.7%), blotches (78.3%), polychromy (45.7%), blue–white veil (41.3%), thin brown network (36.4%), regression structures (19.6%), and fingerprint pattern (8.7%). Milky-red areas (32.6%), red rhomboids (26.1%), linear vessels (21.7%), arborizing vessels (8.7%), dotted vessels (2.2%), and hairpin vessels (2.2%) were also observed. Multivariable logistic regression revealed that a blue–white veil (odds ratio [OR], 42.895; 95% confidence interval [CI], 1.878–979.565), red rhomboids (OR, 13.666; 95% CI, 1.070–174.552), and linear vessels (OR, 18.823; 95% CI, 1.357–261.107) were significantly associated with LMM with a BT of > 1 mm. The predictive model (range: 0–7) had a reliable diagnostic value (area under the curve = 0.964).

Conclusions

This study provides an in-depth analysis of the dermoscopic features of LM/LMM in East Asian patients. Preoperative dermoscopy, which provides BT information, may help determine the appropriate management of LMM.

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韩国人面部恶性黄斑的皮肤镜特征及其与乳腺厚度的关系：一项多中心回顾性研究。

背景：由于东亚地区恶性小痣（LM）和恶性小痣黑色素瘤（LMM）的罕见性，其皮肤镜特征被低估。LM和LMM的预后和治疗取决于Breslow厚度（BT）。然而，BT与LMM的皮肤镜特征之间的关系在很大程度上是未知的。目的：报道韩国人LM/LMM的皮肤镜特征，分析BT与LMM皮肤镜表现的关系。方法：回顾性研究韩国三所三级医院46例面部LM/LMM患者（32例BT≤1mm， 14例bbb101mm）。根据BT评估LM/LMM患者各皮肤镜特征的出现频率，并进行Logistic回归分析，探讨LM/LMM患者某些皮肤镜模式与BT之间的关系。结果：韩国LM/LMM患者的皮肤镜类型包括色素毛囊开口不对称（100%）、整体形状不对称（97.8%）、环状颗粒型（95.7%）、暗菱形（95.7%）、斑点（78.3%）、多色（45.7%）、蓝白面纱（41.3%）、薄棕色网络（36.4%）、回归结构（19.6%）和指纹型（8.7%）。乳红色区（32.6%）、红色菱形区（26.1%）、线状血管（21.7%）、树状血管（8.7%）、点状血管（2.2%）和发夹血管（2.2%）也被观察到。多变量logistic回归结果显示，蓝白面纱(比值比[OR]， 42.895；95%可信区间[CI]， 1.878-979.565)，红色菱形(OR, 13.666；95% CI, 1.070-174.552)和线性血管(OR, 18.823；95% CI, 1.357-261.107)与BT为bb0.1 mm的LMM显著相关。预测模型（范围0 ~ 7）具有可靠的诊断价值（曲线下面积= 0.964）。结论：本研究对东亚LM/LMM患者的皮肤镜特征进行了深入分析。术前皮肤镜检查可提供BT信息，有助于确定LMM的适当治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Dermatology 医学-皮肤病学

CiteScore

4.60

自引率

9.70%

发文量

368

审稿时长

4-8 weeks

期刊介绍： The Journal of Dermatology is the official peer-reviewed publication of the Japanese Dermatological Association and the Asian Dermatological Association. The journal aims to provide a forum for the exchange of information about new and significant research in dermatology and to promote the discipline of dermatology in Japan and throughout the world. Research articles are supplemented by reviews, theoretical articles, special features, commentaries, book reviews and proceedings of workshops and conferences. Preliminary or short reports and letters to the editor of two printed pages or less will be published as soon as possible. Papers in all fields of dermatology will be considered.