Journal of Dermatology最新文献_第7页

Pathogenesis of Pseudocheckerboard Pattern in Mechanic's Hands 机械师手中伪棋盘图案的发病机制。

IF 2.7 3区医学

Journal of Dermatology Pub Date : 2025-07-10 DOI: 10.1111/1346-8138.17826

Kyoko Kanno, Mari Kishibe, Masaru Honma, Akemi Ishida-Yamamoto

{"title":"Pathogenesis of Pseudocheckerboard Pattern in Mechanic's Hands","authors":"Kyoko Kanno, Mari Kishibe, Masaru Honma, Akemi Ishida-Yamamoto","doi":"10.1111/1346-8138.17826","DOIUrl":"10.1111/1346-8138.17826","url":null,"abstract":"Among the relatively common manifestations of dermatomyositis (DM), “mechanic's hands” refer to symmetric hyperkeratotic erythematous lesions on the ulnar aspect of the thumbs and the radial aspect of the index and middle fingers. The “pseudocheckerboard pattern” is a distinct histopathological finding associated with mechanic's hands. This pattern consists of vertical keratotic columns in the stratum corneum, some of which display a striped appearance characterized by alternating bands of orthokeratosis and parakeratosis in both vertical and horizontal orientations. Although this phenomenon is well documented, its underlying mechanism remains poorly understood. In this study, we collected tissue samples from 14 patients with DM accompanied by mechanic's hands and reviewed their clinical presentations and histopathological features. We identified several common histopathological findings of DM, including the characteristic pseudocheckerboard pattern associated with these lesions. Parakeratotic foci of the pseudocheckerboard pattern were observed within the stratum corneum, corresponding to the suprapapillary epidermis, where both CD4- and CD8-positive lymphocytes infiltrated the papillary dermis and suprapapillary epidermis. A portion of these lymphocytes expressed interleukin (IL)-17, and the number of IL-17-positive cells was comparable to that in psoriatic skin lesions. The inflammatory response was relatively confined to the papillary dermis and suprapapillary epidermis, suggesting that Th17-mediated epidermal hyperplasia may be involved in the pathogenesis of mechanic's hands.","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 9","pages":"1418-1423"},"PeriodicalIF":2.7,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17826","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Local Relapse of Pemphigus Vegetans Detected IL-17A+ Tissue-Resident Memory T Cells in Lesional Skin 植物性天疱疮局部复发1例病变皮肤IL-17A+组织驻留记忆T细胞检测

IF 2.7 3区医学

Journal of Dermatology Pub Date : 2025-07-08 DOI: 10.1111/1346-8138.17854

Maho Matsuo, Ryota Asahina, Chisato Tawada, Kayoko Tanaka, Hiroaki Iwata

{"title":"A Case of Local Relapse of Pemphigus Vegetans Detected IL-17A+ Tissue-Resident Memory T Cells in Lesional Skin","authors":"Maho Matsuo, Ryota Asahina, Chisato Tawada, Kayoko Tanaka, Hiroaki Iwata","doi":"10.1111/1346-8138.17854","DOIUrl":"https://doi.org/10.1111/1346-8138.17854","url":null,"abstract":"<div>\u0000 \u0000 A 49-year-old man with pemphigus vegetans (PVeg) relapsed several times due to cessation of therapy. At the age of 66, vegetative plaques developed at the left oral commissure following mechanical plucking of approximately 500 beard hairs. Treatment with prednisolone (20 mg/day) was continued but yielded no clinical improvement. Subsequently, rituximab (1000 mg twice, 2 weeks apart) led to a rapid decline of anti-desmoglein 3 (Dsg3) autoantibody and clinical improvement. The lesion resolved after 18 months, and prednisolone was tapered without recurrence. Based on the site-specific recurrence and chronicity, we hypothesized that tissue-resident memory T (TRM) cells and high endothelial venules (HEV)-like vessels contributed to disease persistence. Immunohistochemical analysis revealed a substantial presence of IL-17A-producing CD69 ++ CD103 ++ TRM cells in the dermis. In addition, PNAd++ HEV-like vessels were increased, accompanied by infiltrates of B cells and plasma cells. Notably, Dsg3-specific B cells were also detected, indicating that rituximab-mediated B cell depletion likely contributed to lesion resolution in this case.\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 9","pages":"1452-1455"},"PeriodicalIF":2.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NEVIGRAV Study: A Case–Control Analysis on Changes in Melanocytic Nevi During Pregnancy NEVIGRAV研究：妊娠期间黑色素细胞痣变化的病例对照分析。

IF 2.7 3区医学

Journal of Dermatology Pub Date : 2025-07-07 DOI: 10.1111/1346-8138.17848

Vincenzo Maione, Anna Venturuzzo, Stefano Bighetti, Carola Romanó, Zeno Fratton, Enzo Errichetti, Marina Venturini, Luca Bettolini

{"title":"NEVIGRAV Study: A Case–Control Analysis on Changes in Melanocytic Nevi During Pregnancy","authors":"Vincenzo Maione, Anna Venturuzzo, Stefano Bighetti, Carola Romanó, Zeno Fratton, Enzo Errichetti, Marina Venturini, Luca Bettolini","doi":"10.1111/1346-8138.17848","DOIUrl":"10.1111/1346-8138.17848","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 Pregnancy can influence modifications and appearance of melanocytic nevi, but studies report inconsistent findings, often lacking standardized methods and comparison groups. This study evaluates dermoscopic changes in nevi and the development of new melanocytic lesions in pregnant women using full-body photography and digital dermoscopy. Nevigrav is an observational case–control study conducted at two university dermatology centers, involving 85 participants (45 pregnant women and 40 controls) with 1614 lesions analyzed. Participants were asked about recent sun exposure or tanning habits. Enrollment was predominantly conducted in autumn and winter months to minimize ultraviolet (UV) exposure as a confounding factor. Total body photography revealed no new lesions in pregnant women when compared to controls. Dimensional growth was observed in the abdomen (p = 0.049) and the back (p < 0.001) between the first and second trimesters, with further abdominal growth in the third trimester (p < 0.001). At the third trimester, pigmentation changes were significant, with phototype III maintaining or increasing pigmentation and phototype II showing a reduction of pigmentation (χ2 = 32.33, p < 0.001). Regional pigmentation differences were noted in the mammary (p = 0.02), abdominal (p = 0.004), and thigh (p = 0.007) areas. No changes in symmetry or dermoscopic nevi patterns, including dots or globules, were observed. Pregnancy does not increase nevi count but may cause size and pigmentation changes, particularly in the abdomen, influenced by phototype and body region. No new dermoscopic patterns or symmetry changes were found.\u0000 </section>\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 10","pages":"1503-1511"},"PeriodicalIF":2.7,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17848","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of Topical 40% Salicylic Acid Ointment Therapy for Recalcitrant Plantar Warts: A Retrospective Case Series of 61 Japanese Patients 外用40%水杨酸软膏治疗顽固性足底疣的疗效和安全性：61例日本患者回顾性研究。

IF 2.7 3区医学

Journal of Dermatology Pub Date : 2025-07-04 DOI: 10.1111/1346-8138.17851

Yuiko Nakanishi, Yui Toyosawa, Ayuka Orimo, Kenta Yoshikawa, Daisuke Yano, Tamae Usami, Yasushi Suga, Tsuyoshi Mitsuishi

引用次数: 0

Exploration of Drugs Associated With the Development of Bullous Pemphigoid: A Nationwide Study 与大疱性类天疱疮发展相关的药物探索：一项全国性研究。

IF 2.7 3区医学

Journal of Dermatology Pub Date : 2025-07-04 DOI: 10.1111/1346-8138.17809

Min Jae Kim, Bo Ri Kim, Kun Hee Lee, Hyun Jeong Ju, Jung Min Bae, Chong Won Choi, Sang Woong Youn

{"title":"Exploration of Drugs Associated With the Development of Bullous Pemphigoid: A Nationwide Study","authors":"Min Jae Kim, Bo Ri Kim, Kun Hee Lee, Hyun Jeong Ju, Jung Min Bae, Chong Won Choi, Sang Woong Youn","doi":"10.1111/1346-8138.17809","DOIUrl":"10.1111/1346-8138.17809","url":null,"abstract":"<div>\u0000 \u0000 Bullous pemphigoid (BP) is an autoimmune blistering skin disorder with an increasing incidence, particularly among older adults. Given the role of medications in developing drug-associated BP (DABP), exploring drugs that cause DABP is crucial for prescribing appropriate drugs to prevent BP development. This study aimed to identify drugs associated with DABP. In this nationwide retrospective cohort study, we compared 5066 patients newly diagnosed with BP with 10 132 matched controls. We first established a comprehensive drug list of all medications used in our country and conducted a case–control study to identify candidate drugs associated with DABP. To validate these associations, we performed a separate cohort study, enrolling patients with a confirmed diagnosis of BP and matched controls. In the screening stage, 88 drugs were associated with an increased risk of DABP, while 27 drugs were linked with a reduced risk. Validation confirmed that 78 drugs increased the risk of DABP, whereas 22 drugs lowered it. Among the candidate drugs, anti-diabetic medications, including dipeptidyl peptidase-4 (DPP4) inhibitors and sulfonylureas, neuropsychiatric drugs such as benserazide and carbidopa (used for Parkinson's disease) and donepezil and memantine (for Alzheimer's disease), increased the risk of DABP. Conversely, several anti-inflammatory medications, including meloxicam and celecoxib and lipid-lowering agents, such as rosuvastatin and atorvastatin, have been found to lower the risk of DABP. Lastly, diazepam, diltiazem, and Ginkgo biloba extracts exhibited protective effects against DABP development. This nationwide study, employing an unbiased analysis of all medications in our country, highlights a substantial number of medications linked to the development of DABP. Our study provides practical insights for drug selection to prevent the development of DABP in elderly patients.\u0000 </div>","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 8","pages":"1304-1313"},"PeriodicalIF":2.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prevalence and Severity of Pain in Patients With Systemic Sclerosis 系统性硬化症患者疼痛的发生率和严重程度。

IF 2.7 3区医学

Journal of Dermatology Pub Date : 2025-07-03 DOI: 10.1111/1346-8138.17843

Sei-ichiro Motegi, Mona Uchida-Yamada, Yoshihito Shima, Taku Shimada, Haruka Ishii, Yoshito Ohya, Yasumasa Kanai

{"title":"The Prevalence and Severity of Pain in Patients With Systemic Sclerosis","authors":"Sei-ichiro Motegi, Mona Uchida-Yamada, Yoshihito Shima, Taku Shimada, Haruka Ishii, Yoshito Ohya, Yasumasa Kanai","doi":"10.1111/1346-8138.17843","DOIUrl":"10.1111/1346-8138.17843","url":null,"abstract":"We investigated pain prevalence and severity in systemic sclerosis (SSc) and patient–physician perceptions. This was an internet-based survey that compared perceptions of pain type, location, severity, associated factors between patients with SSc and physicians, and pain treatment prescription patterns in Japan in March 2023. Data from 301 patients and 129 physicians revealed that 96.0% of patients experienced pain compared with 43.4% estimated by physicians. The median (interquartile range) Short-form McGill Pain Questionnaire (SF-MPQ-2) pain score was 47.0 (14.0–88.0). Continuous pain had the highest score (16.0 [3.0–27.0]), followed by neuropathic pain (14.0 [5.0–25.0]), intermittent pain (11.0 [1.0–25.0]), and affective descriptors (5.0 [1.0–14.0]). Pain at joints, fingertips, Raynaud's phenomenon (RP), and skin tightening were most prevalent across multiple pain types. Pain at fingertips and RP-affected locations were more common in limited cutaneous SSc (lcSSc) than in diffuse cutaneous SSc (dcSSc), and skin tightening was more common in dcSSc. Patients with dcSSc had significantly more severe pain than patients with lcSSc. Patients with nausea, insomnia, or diarrhea showed higher SF-MPQ-2 scores. Of the 129 physicians surveyed, 58.9% prescribed painkillers, 48.8% suggested self-care, 42.6% treated skin symptoms, and 16.3% referred patients to pain clinics for further management. Compared to the percentage of patients having pain in each location, physicians tend to be less aware of pain in the muscles, head, and abdomen. Most patients with SSc experience pain, which physicians tended to underestimate. Physicians' awareness of patients' experiences should be improved to provide adequate treatment for pain in SSc.Trial Registration: UMIN000050368","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 9","pages":"1382-1394"},"PeriodicalIF":2.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17843","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exacerbation of Psoriasis During Treatment With Ofatumumab for Multiple Sclerosis Ofatumumab治疗多发性硬化症期间银屑病加重

IF 2.7 3区医学

Journal of Dermatology Pub Date : 2025-07-02 DOI: 10.1111/1346-8138.17846

Daisuke Watabe, Kanako Tsunoda, Hiroo Amano

引用次数: 0

Use of 5% Topical Minoxidil Application for Telogen Effluvium: An Open-Label Single-Arm Clinical Trial 使用5%局部米诺地尔治疗休止期流涎：一项开放标签单臂临床试验。

IF 2.7 3区医学

Journal of Dermatology Pub Date : 2025-07-02 DOI: 10.1111/1346-8138.17844

Manabu Ohyama, Ryokichi Irisawa, Masaki Uchiyama, Miho Mori, Kazuhiro Aoki, Yuto Ueda, Toru Fujita

{"title":"Use of 5% Topical Minoxidil Application for Telogen Effluvium: An Open-Label Single-Arm Clinical Trial","authors":"Manabu Ohyama, Ryokichi Irisawa, Masaki Uchiyama, Miho Mori, Kazuhiro Aoki, Yuto Ueda, Toru Fujita","doi":"10.1111/1346-8138.17844","DOIUrl":"10.1111/1346-8138.17844","url":null,"abstract":"Telogen effluvium (TE) is an acute and diffuse hair loss due to an abnormal increase in telogen hair follicles in response to external or internal factors. Recently, TE attracts global interest as a major cause of hair loss as a sequela of COVID-19. Typically, hair shedding in TE is expected to cease around 3–6 months from the onset with spontaneous hair regrowth, once the triggering factor is eliminated. However, the substantial shedding causes heavy psychological stress on patients, and there is no evidence-based treatment. To assess the usefulness of topical minoxidil, which has been reported to improve the hair cycle, for TE, an open-label, single-arm clinical trial was conducted enrolling 12 Japanese subjects (3 men and 9 women) who were diagnosed as TE by experts. For each subject, 1 mL of 5% topical minoxidil lotion was applied to the entire scalp twice daily for 24 weeks. Phototrichogram detected that the terminal hair (≥ 60 μm in diameter) count markedly increased respectively by 12.55 ± 4.99 hairs/cm2 at week 4 and 11.20 ± 4.79 hairs/cm2 at week 12 from baseline. In the hair wash test assessment, nearly 70% of the subjects were evaluated as improved at least by 2 grades in the evaluation scale (more than 100 shed hair decrease in the count) from baseline. Of note, all investigators and subjects reported notable improvement at week 24 respectively in their reported outcomes. Adverse event was minimal and within the known safety profile of topical minoxidil. Self-healing nature of TE and small sample size represented major factors affecting the validity of the study. Considering its safety profile and wide-availability, topical minoxidil lotion may be helpful in the management of TE making the patients reassured at earlier stage of clinical course. Still, it should be noted that this application is an off-label use.","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 9","pages":"1351-1359"},"PeriodicalIF":2.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17844","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tirbanibulin 1% Ointment for the Treatment of Hyperkeratotic Actinic Keratosis 1%替巴布林软膏治疗过度角化性光化性角化病。

IF 2.7 3区医学

Journal of Dermatology Pub Date : 2025-07-02 DOI: 10.1111/1346-8138.17845

Federica Li Pomi, Andrea d'Aloja, Michelangelo Rottura, Mario Vaccaro, Francesco Borgia

{"title":"Tirbanibulin 1% Ointment for the Treatment of Hyperkeratotic Actinic Keratosis","authors":"Federica Li Pomi, Andrea d'Aloja, Michelangelo Rottura, Mario Vaccaro, Francesco Borgia","doi":"10.1111/1346-8138.17845","DOIUrl":"10.1111/1346-8138.17845","url":null,"abstract":"Actinic keratosis (AK) is a common cutaneous keratinocyte dysplasia resulting from chronic ultraviolet (UV) exposure, typically presenting as erythematous, scaly patches or plaques on sun-damaged skin. AK is recognized as the main precursor of cutaneous squamous cell carcinoma (cSCC). Given the unpredictable potential for progression, current guidelines recommend treating all AKs, irrespective of their clinical grade. However, many approved treatments are not indicated for hyperkeratotic AKs. Among topical therapies, tirbanibulin 1% ointment is a novel synthetic anti-proliferative agent that has shown good results in treating non-hyperkeratotic AKs on the face and scalp, both in clinical trials and real-life experiences. However, its effectiveness in managing hyperkeratotic AKs remains unexplored. A retrospective, single-center study was conducted at the Dermatology Unit of the University of Messina, Italy, between September 2024 and January 2025. The study included 51 hyperkeratotic AK lesions in 32 consecutive patients, treated with tirbanibulin ointment for five consecutive days. At the 2-month follow-up, total clearance (complete lesion resolution) was observed in 54.9% of hyperkeratotic lesions, whereas partial clearance (> 75% lesion reduction) was recorded in 25.5%. The treatment demonstrated a good safety profile, with high patient tolerability. LSRs were observed in 69.8% of patients (n = 22), of which 54.5% (n = 12/22) were classified as moderate, and 45.5% (n = 10/22) as mild. No patient discontinued the treatment due to the onset of adverse events. Our real-world experience suggests the effectiveness and safety of tirbanibulin ointment for the treatment of hyperkeratotic AKs.","PeriodicalId":54848,"journal":{"name":"Journal of Dermatology","volume":"52 9","pages":"1395-1403"},"PeriodicalIF":2.7,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1346-8138.17845","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifocal Cutaneous Amyloidosis Mimicking Scleroderma Associated With Primary Cutaneous Marginal Zone Lymphoma 与原发性皮肤边缘区淋巴瘤相关的多灶性皮肤淀粉样变模拟硬皮病。

IF 2.7 3区医学

Journal of Dermatology Pub Date : 2025-07-02 DOI: 10.1111/1346-8138.17850

Kazunori Yokoi, Eiji Kiyohara, Manabu Fujimoto

引用次数: 0