Journal of Ect最新文献_第9页

Dire Need and Disproportionate Access: ECT In Youth With Autism Spectrum Disorders and Other Neurodevelopmental Disorders. 迫切需要和不成比例的获取：青少年自闭症谱系障碍和其他神经发育障碍的ECT治疗。

IF 1.8 4区医学

Journal of Ect Pub Date : 2026-06-01 Epub Date: 2025-06-02 DOI: 10.1097/YCT.0000000000001159

Lee Elizabeth Wachtel, Neera Ghaziuddin

引用次数: 0

Cranial Sutures Alter Computational Models of Transcranial Electrical Stimulation. 颅缝改变经颅电刺激的计算模型。

IF 2.4 4区医学

Journal of Ect Pub Date : 2026-06-01 Epub Date: 2025-05-02 DOI: 10.1097/YCT.0000000000001154

Alistair Carroll, Caroline Rae, Donel Martin, Socrates Dokos, Colleen Loo

{"title":"Cranial Sutures Alter Computational Models of Transcranial Electrical Stimulation.","authors":"Alistair Carroll, Caroline Rae, Donel Martin, Socrates Dokos, Colleen Loo","doi":"10.1097/YCT.0000000000001154","DOIUrl":"10.1097/YCT.0000000000001154","url":null,"abstract":"Background: ROAST (Realistic vOlumetric-Approach-based Simulator for Transcranial electric stimulation) has been increasingly utilized to inform studies of transcranial electrical stimulation (tES). The precision of ROAST is dependent on anatomical accuracy.Objectives: The aims of the study were to compare using only T1 magnetic resonance images in ROAST (T1 model), with a combination of T1 and T2 magnetic resonance images (T1 and T2 model) and to model the electrical fields generated by tES with commonly used ECT montages: bitemporal, bifrontal, and right unilateral and varying the skull conductivities (based on the electrode position) and including cranial sutures.Methods: The \"T1 model\" was selected for computational modeling. The skull conductivity was varied from the \"default setting in ROAST\" (0.01S/m) to that of temporal bone (0.0038S/m) and frontal bone (0.0126S/m). \"Disc\" electrodes (5 cm in diameter) were applied with 1 mA of current. \"Pad\" electrodes, 0.1 mm high and 40 mm wide, were positioned over the squamous suture, coronal suture and sagittal suture and the skull conductivity changed to approximate suture conductivity (0.32S/m).Results: The \"T1 model\" differed from the \"T1 and T2 model,\" which resulted in variable electric fields reaching individual tissue layers. Changing skull conductivity and simulating the cranial sutures resulted in changes to the electric current reaching the cortical and subcortical structures with the later having a greater impact.Conclusions: This study demonstrates the importance of anatomically accurate head models in ROAST computational modeling of tES. Varying the skull conductivity based on studies in vivo and including cranial sutures is imperative for more realistic predictions of electric field and reproducibility.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":"112-118"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13196852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Legislation Limiting Access to Electroconvulsive Therapy Is Increasing-A Call for Reasonable and Evidence-Based Legislation. 立法限制获得电痉挛疗法正在增加-呼吁合理和基于证据的立法。

IF 2.4 4区医学

Journal of Ect Pub Date : 2026-06-01 Epub Date: 2025-06-23 DOI: 10.1097/YCT.0000000000001173

Emily M Beydler, Lauren M Katzell, Joseph Dragonetti, Nicholas Ortiz

引用次数: 0

Electroconvulsive Therapy Changes Peripheral Blood Neurotrophic and Inflammatory Markers in Depressed Patients. 电惊厥治疗改变抑郁症患者外周血神经营养和炎症标志物。

IF 2.4 4区医学

Journal of Ect Pub Date : 2026-06-01 Epub Date: 2025-05-12 DOI: 10.1097/YCT.0000000000001139

Nadia Falhani, Lisa-Marie Brunner, Doris Melchner, Jens Volkmar Schwarzbach, Rainer Rupprecht, Caroline Nothdurfter

{"title":"Electroconvulsive Therapy Changes Peripheral Blood Neurotrophic and Inflammatory Markers in Depressed Patients.","authors":"Nadia Falhani, Lisa-Marie Brunner, Doris Melchner, Jens Volkmar Schwarzbach, Rainer Rupprecht, Caroline Nothdurfter","doi":"10.1097/YCT.0000000000001139","DOIUrl":"10.1097/YCT.0000000000001139","url":null,"abstract":"Background: Electroconvulsive therapy (ECT) is one of the most effective treatments for treatment-resistant depression, yet its precise mechanisms of action remain to be further elucidated. Among other effects, ECT induces an acute inflammatory immune response that might reinforce the expression of neurotrophins such as brain-derived neurotrophic factor (BDNF). The aim of this study is to unveil the potentially beneficial role of inflammation observed during ECT.Methods: Within a repeated measures design study of 6 weeks, 9 patients diagnosed with depressive disorder received 3 ECT sessions per week. We tracked the clinical progress using the Hamilton Depression rating scale (HAMD-21) and Beck's depression inventory. By collecting peripheral blood samples before and throughout the entire course of ECT, we investigated week-by-week changes in inflammation markers such as IL-6, IL-1β, TNF-α, and IL-4, serum BDNF, and cortisol levels.Results: Seven out of 9 patients successfully responded to ECT according to HAMD-21 scores. Serum BDNF levels progressively increased during the ECT series, and negatively correlated with HAMD-21 scores. TNF-α levels increased until week 4 and decreased after the end of the therapy. Moreover, we found altered expression of the anti-inflammatory cytokine IL-4, while serum cortisol levels did not change during ECT.Conclusions: The initial activation of the immune-inflammatory response observed during ECT may be beneficial for therapeutic effects, as it is related to a long-term stimulation of BDNF, which enhances neuronal plasticity. The downregulation of proinflammatory markers after the end of the ECT series may be associated with clinical improvement.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":"96-105"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Experience With Dexmedetomidine for Postictal Agitation After Electroconvulsive Therapy: A Case Series of 7 Patients and 137 Sessions. 右美托咪定治疗电惊厥后躁动的临床经验：7例137次。

IF 1.8 4区医学

Journal of Ect Pub Date : 2026-06-01 DOI: 10.1097/YCT.0000000000001288

Hiroshi Katagai, Yasushi Kawamata, Norio Sugawara, Chika Kudo, Hiromi Narita, Hiroichi Tasaki, Norio Yasui-Furukori

{"title":"Clinical Experience With Dexmedetomidine for Postictal Agitation After Electroconvulsive Therapy: A Case Series of 7 Patients and 137 Sessions.","authors":"Hiroshi Katagai, Yasushi Kawamata, Norio Sugawara, Chika Kudo, Hiromi Narita, Hiroichi Tasaki, Norio Yasui-Furukori","doi":"10.1097/YCT.0000000000001288","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001288","url":null,"abstract":"Background: Postictal agitation (PIA) is a clinically significant complication of electroconvulsive therapy (ECT), reported in approximately 7% to 12% of treatments and associated with safety and workflow concerns. Dexmedetomidine (DEX), a selective α2-adrenergic agonist, may help mitigate PIA while minimizing respiratory suppression.Methods: We retrospectively reviewed 137 ECT sessions in 7 high-risk patients with documented prior PIA requiring rescue anesthetics. DEX was administered using an infusion-rate-based loading protocol of 6 µg/kg/h for 10 minutes, followed by individualized maintenance dosing at 0.2 to 0.7 µg/kg/h until 15 minutes after seizure termination. Posttreatment agitation and sedation were quantified using the Richmond Agitation-Sedation Scale (RASS).Results: RASS scores were within the prespecified target range (-1 to +1) at 15 minutes in 88/137 sessions (64%). Rescue anesthetics were administered for agitation in 18/137 sessions (13%), and extended observation beyond the routine 30 minutes was required in 31/137 sessions (23%). No respiratory depression occurred.Conclusions: In this high-risk cohort, DEX prophylaxis was generally safe and clinically useful for improving postictal behavioral stability, although marked interindividual and intraindividual variability in dose requirements highlights the need for individualized titration and careful monitoring.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148145445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral Oxygenation and Systemic Hemodynamic Changes in Adolescents and Adults Undergoing Modified Electroconvulsive Therapy: A Prospective Observational Study. 接受改良电休克治疗的青少年和成人脑氧合和全身血流动力学改变：一项前瞻性观察研究。

IF 1.8 4区医学

Journal of Ect Pub Date : 2026-06-01 DOI: 10.1097/YCT.0000000000001293

Rajeeb K Mishra, Sonia Bansal, Sriganesh Kamath, K N Gopalakrishna, John V S Kommu, K M Rajendra, Jagadisha Thirthalli, Vanteemar S Sreeraj

{"title":"Cerebral Oxygenation and Systemic Hemodynamic Changes in Adolescents and Adults Undergoing Modified Electroconvulsive Therapy: A Prospective Observational Study.","authors":"Rajeeb K Mishra, Sonia Bansal, Sriganesh Kamath, K N Gopalakrishna, John V S Kommu, K M Rajendra, Jagadisha Thirthalli, Vanteemar S Sreeraj","doi":"10.1097/YCT.0000000000001293","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001293","url":null,"abstract":"Objectives: The study aimed to evaluate the effect of modified electroconvulsive therapy (ECT) on cerebral oxygen saturation (rSO2), heart rate (HR), mean blood pressure (MBP), and peripheral oxygen saturation (SpO2) in adolescents both within and across multiple ECT sessions and compare those with adults.Methods: We prospectively recruited adolescents (less than 18 y) and gender-matched adults (18 to 24 y) undergoing ECT and monitored rSO2, SpO2, HR, and MBP up to 15 minutes during each session, from the second to the sixth session (T2 to T6). Linear mixed-effect models were used to analyze.Results: Twenty-five adolescents and 20 adults were included. Within an individual ECT session, adolescents exhibited a significant increase in rSO2 at the first and second minutes following ECT (P<0.001), and the increase was greater in adolescents than adults. Post-ECT, SpO2 and MBP showed an initial rise followed by a gradual decline in both groups, while HR remained elevated till the 15th minute in both groups. Relative to the T2 session, rSO2 values remained stable across the sessions and did not differ between groups. No clinically relevant changes were noted in SpO2 and MBP across the ECT sessions. Compared with the T2, the HR consistently increased in the T4 to T6 sessions in both groups (all P<0.001).Conclusion: Both adolescents and adults demonstrated an acute increase (a significantly greater increase in adolescents), followed by a gradual decline in rSO2, SpO2, and MBP during a single ECT session, except for HR, which remained elevated. Across the ECT sessions, these variables remained stable in both groups.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148145457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of Electroconvulsive Therapy in a Patient With Marfan Syndrome With Associated Cardiac Complications. 电痉挛治疗马凡氏综合征合并心脏并发症患者的安全性

IF 1.8 4区医学

Journal of Ect Pub Date : 2026-06-01 Epub Date: 2025-11-03 DOI: 10.1097/YCT.0000000000001199

Alyssa C Smith, Susan K Conroy

引用次数: 0

The Effect of Electroconvulsive Therapy on Hippocampal Endoplasmic Reticulum Stress in a Rat Model of Depression. 电痉挛治疗对抑郁症大鼠海马内质网应激的影响。

IF 2.4 4区医学

Journal of Ect Pub Date : 2026-06-01 Epub Date: 2025-04-15 DOI: 10.1097/YCT.0000000000001144

Şükrü Kartalci, Nazmi Özgen, Fatma Kartal, Ahmet Kadir Arslan, Ahmet Koç, Halil Düzova

{"title":"The Effect of Electroconvulsive Therapy on Hippocampal Endoplasmic Reticulum Stress in a Rat Model of Depression.","authors":"Şükrü Kartalci, Nazmi Özgen, Fatma Kartal, Ahmet Kadir Arslan, Ahmet Koç, Halil Düzova","doi":"10.1097/YCT.0000000000001144","DOIUrl":"10.1097/YCT.0000000000001144","url":null,"abstract":"Objective: The mechanisms underlying the effectiveness of electroconvulsive therapy (ECT), one of the most effective treatments for depression, are still unknown. While the increasing endoplasmic reticulum (ER) stress in depression can retrieve with pharmacological agents, ECT's effectiveness has not been examined yet. In this study, we tested how hippocampal ER stress parameters change after repeated ECT in rats in the chronic unpredictable mild stress (CUMS) model.Methods: Rats were divided into 4 groups. Two groups were included in the experimental group, where the CUMS model was applied for 21 days. Then, the experimental ECT model was applied to 2 groups, one experimental and 1 control group, for 21 days. Weight changes results were evaluated at the end of the 21st and 42nd day. In the final step, 3 prominent ER stress-related proteins (Grp-78, Xbp1, and Atf-4) were measured by western blot in the removed hippocampus.Results: We found that rats administered CUMS exhibited depression-like behavioral responses such as weight loss. In CUMS-treated rats (group 3), Grp-78 levels increased, ATF4 levels did not change, and Xbp1 levels decreased. While ECT increased Grp-78 levels in normal rats, it did not change Atf-4 levels and reduced Xbp1 levels (group 2). When ECT was applied to rats undergoing the CUMS model, Grp-78 and Xbp1 levels decreased, while Atf-4 levels did not change (group 4).Conclusions: These findings show that increased ER stress may play a role in the pathophysiology of depression and that this increase can be reversed with ECT treatment. These findings need to be confirmed by clinical studies in humans.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":"106-111"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presyncope During Repetitive Transcranial Magnetic Stimulation With Treatment Continuation. 反复经颅磁刺激引起的晕厥前期与持续治疗。

IF 2.4 4区医学

Journal of Ect Pub Date : 2026-06-01 DOI: 10.1097/YCT.0000000000001290

Shotaro Fujiwara, Atsuo Nakagawa

引用次数: 0

A Comparison of Electroconvulsive Therapy and Repetitive Transcranial Magnetic Stimulation for Nonpsychotic Treatment-Resistant Depression: A Real-World Study in Taiwan. 电惊厥治疗与重复经颅磁刺激治疗非精神病性难治性抑郁症之比较：台湾真实世界研究。

IF 2.4 4区医学

Journal of Ect Pub Date : 2026-06-01 Epub Date: 2025-11-25 DOI: 10.1097/YCT.0000000000001205

Ching-Hua Lin, Chih-Jen Wang

{"title":"A Comparison of Electroconvulsive Therapy and Repetitive Transcranial Magnetic Stimulation for Nonpsychotic Treatment-Resistant Depression: A Real-World Study in Taiwan.","authors":"Ching-Hua Lin, Chih-Jen Wang","doi":"10.1097/YCT.0000000000001205","DOIUrl":"10.1097/YCT.0000000000001205","url":null,"abstract":"Objectives: The goal of this study was to compare the response/remission rates, time to response/remission, and common side effects between treatment-resistant depression (TRD) patients receiving the electroconvulsive therapy (ECT) and those receiving standard repetitive transcranial magnetic stimulation (standard rTMS).Methods: TRD patients who received ECT or standard rTMS between March 2014 and August 2023 were included. Only patients receiving 20 standard rTMS treatments or at least 6 ECT treatments entered the analysis. Six-item Hamilton Depression Rating Scale (HAMD-6) and common side effects were routinely assessed during the treatment period. Response and remission were defined as a HAMD-6 ≥50% reduction and a HAMD-6 ≤4, respectively. Survival analysis was used to compare the time to response/remission between the two groups.Results: Compared with the standard rTMS group (N = 96), the ECT group (N = 92) showed a significantly higher treatment completion rate. For completers, the ECT group (N = 74) had significantly higher response rate/remission rate and shorter time to response/remission than the standard rTMS group (N = 63). No patients treated with standard rTMS experienced subjective memory impairment or nausea/vomiting, while 82.4% and 32.4% of patients receiving ECT experienced subjective memory impairment and nausea/vomiting, respectively. The ECT group experienced significantly higher rates of headache and muscle pain than the standard rTMS group.Conclusions: Compared with the standard rTMS group, the ECT group was more likely to have a higher completion rate, have higher response/remission rates, a short time to response/remission, and experience more side effects during the treatment period.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":"136-142"},"PeriodicalIF":2.4,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145716870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0