Journal of EctPub Date : 2026-01-20DOI: 10.1097/YCT.0000000000001162
Camilla Elefante, Chiara Fustini, Vittoria Lepri, Marta Del Chicca, Andrea Coccoglioniti, Maria Grazia Grosso, Giulia D'Alessandro, Simone Tidona, Pierpaolo Medda, Lorenzo Lattanzi, Filippo Baldacci, Roberto Ceravolo, Giulio Perugi
{"title":"Electroconvulsive Therapy for Behavioral, Mood, and Catatonic Symptoms in Patients With Frontotemporal Dementia: A Literature Review.","authors":"Camilla Elefante, Chiara Fustini, Vittoria Lepri, Marta Del Chicca, Andrea Coccoglioniti, Maria Grazia Grosso, Giulia D'Alessandro, Simone Tidona, Pierpaolo Medda, Lorenzo Lattanzi, Filippo Baldacci, Roberto Ceravolo, Giulio Perugi","doi":"10.1097/YCT.0000000000001162","DOIUrl":"10.1097/YCT.0000000000001162","url":null,"abstract":"<p><strong>Abstract: </strong>Frontotemporal dementia (FTD) encompasses a group of clinically, neuropathologically, and genetically heterogeneous disorders characterized by atrophy in the frontal and anterior temporal lobes. Psychiatric and behavioral symptoms are common throughout the course of FTD, and pharmacological treatments show limited efficacy. In this review, we analyzed literature on the use of electroconvulsive therapy (ECT) in patients with FTD to assess its effectiveness and predictors of response in this population. A systematic review was conducted following PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines, with searches in the MEDLINE, Scopus, and Web of Science databases. Eligibility criteria included original studies and case reports on FTD patients treated with ECT. Of 88 screened abstracts, 25 studies were included, documenting 37 patients with FTD or Pick disease who were treated with ECT. ECT was primarily administered for catatonia (37.84%) and depressive episodes (35.14%). Most patients had not responded to at least 1 prior medication, primarily antipsychotics. Following the initial ECT course, 40.54% of patients experienced symptom remission, 21.62% showed partial or transient improvement, and 32.43% saw little to no benefit. Continuation and maintenance ECT appeared to be valid treatment options following a response to acute ECT. Notably, patients with the C9orf72 mutation showed a poor response to ECT. For many FTD patients with behavioral, mood, and catatonic symptoms, ECT appears to be more effective than pharmacological treatments; however, its impact on cognition and long-term outcomes requires further investigation. Systematic clinical studies on larger samples are necessary to confirm the efficacy and tolerability of ECT for psychiatric disorders in FTD.</p>","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of EctPub Date : 2026-01-20DOI: 10.1097/YCT.0000000000001227
Kieran W Benn, Rebecca Wong, Mark Bevan, Terence W H Chong
{"title":"Electroconvulsive Therapy Ameliorates Neuropsychiatric Symptoms in an Older Adult Patient With Nonshunted Normal Pressure Hydrocephalus.","authors":"Kieran W Benn, Rebecca Wong, Mark Bevan, Terence W H Chong","doi":"10.1097/YCT.0000000000001227","DOIUrl":"10.1097/YCT.0000000000001227","url":null,"abstract":"<p><p>We report an 80-year-old male with nonshunted normal pressure hydrocephalus (NPH) presenting with an episode of recurrent major depressive disorder who underwent electroconvulsive therapy (ECT) with good effect and consequent amelioration of neuropsychiatric symptoms. NPH had been diagnosed several years prior, although a shunt was not pursued. On admission, it proved initially challenging to separate a mood disorder from behavioral and psychological symptoms of dementia (BPSD), as is the case for many patients with NPH. Following the diagnosis of recurrent major depressive disorder, the patient underwent 14 sessions of ECT. This resulted in a marked and sustained improvement in psychiatric symptoms. This case supports the putative safety of ECT for patients with nonshunted NPH and demonstrates the potentially long-term psychiatric benefit of ECT in this patient population.</p>","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of EctPub Date : 2026-01-20DOI: 10.1097/YCT.0000000000001228
Diane C McLaughlin, Jessica McManus, Shannon Terrell, Salvador F Gutierrez-Aguirre, Otavio De Toledo, Savitha Puttaiah, Mohamad Chmayssani
{"title":"The Use of Electroconvulsive Therapy (ECT) in the New Onset Refractory Status Epilepticus (NORSE)-Case Report and Systematic Review.","authors":"Diane C McLaughlin, Jessica McManus, Shannon Terrell, Salvador F Gutierrez-Aguirre, Otavio De Toledo, Savitha Puttaiah, Mohamad Chmayssani","doi":"10.1097/YCT.0000000000001228","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001228","url":null,"abstract":"<p><p>New-onset refractory status epilepticus (NORSE) is a severe and often fatal neurological condition characterized by continuous or recurrent seizures unresponsive to standard antiseizure therapies. Management remains highly challenging due to unclear etiologies and resistance to conventional treatment. Electroconvulsive therapy (ECT) has emerged as a potential intervention. This study systematically reviewed reported NORSE cases treated with ECT to evaluate efficacy, safety, and outcomes. A comprehensive literature search of PUBMED, EMBASE, and SCOPUS was conducted in June 2024. English-language reports describing ECT-managed NORSE cases were included, while studies focusing on psychiatric disorders or lacking specific neuromodulation details were excluded. Extracted data included demographics, clinical presentation, EEG and imaging findings, prior treatments, ECT parameters, complications, and clinical outcomes. Of 1039 records screened, 5 studies encompassing 6 cases met the inclusion criteria; combined with our local case, 7 total cases were analyzed. The mean patient age was 37.1 years, and 57% were female. Neuroimaging abnormalities were present in 71% of cases, and cerebrospinal fluid abnormalities in 40%. All patients received multiple antiseizure medications (mean 7) before ECT. The average number of ECT sessions was 9.7. Seizure remission occurred in 71% of cases, with partial improvement in 29%. Cognitive impairments were observed in 42% of patients, and overall functional outcomes varied. ECT demonstrated notable efficacy as salvage treatment for NORSE, achieving seizure remission or reduction in most patients without severe adverse effects. These findings support ECT as a potential therapeutic option in NORSE when standard interventions fail.</p>","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of EctPub Date : 2026-01-20DOI: 10.1097/YCT.0000000000001212
Clélia Quiles
{"title":"Treating the Pain After the Cure: Therapeutic Approaches for Post-ECT Headache-A Systematic Review.","authors":"Clélia Quiles","doi":"10.1097/YCT.0000000000001212","DOIUrl":"10.1097/YCT.0000000000001212","url":null,"abstract":"<p><p>Headache is among the most frequently reported side effects of electroconvulsive therapy (ECT), yet it remains understudied and inconsistently managed. This systematic review aimed to synthesize and evaluate the effectiveness of pharmacological and nonpharmacological interventions for post-ECT headache. We conducted a comprehensive search of PubMed and Scopus databases up to July 2025 to identify all reports involving therapeutic interventions specifically targeting post-ECT headache. Seventeen articles were included, comprising case reports, case series, observational studies, and one randomized controlled trial. Treatments evaluated included sumatriptan, nonsteroidal anti-inflammatory drugs (NSAIDs), paracetamol, propranolol, topiramate, valproic acid, mirtazapine, dihydroergotamine, topical salicylates, cryotherapy, and percutaneous electrical nerve stimulation. Sumatriptan, supported only by observational studies, showed the most consistent benefit for acute headache relief, particularly in patients presenting with migraine-like symptoms. Prophylactic agents such as topiramate, valproic acid, and propranolol were effective in individual cases, especially for recurrent or severe headache phenotypes. NSAIDs demonstrated limited efficacy for post-ECT headache, although they may provide some benefit for myalgia. In contrast, paracetamol has been supported by evidence from a large randomized controlled trial, which showed a significant reduction in post-ECT headache. Nondrug interventions like cryotherapy showed promise in small cohorts with minimal side effects. Despite growing clinical interest, the quality of available evidence is low and highly heterogeneous. No standardized treatment recommendations currently exist. However, clinical phenotyping and a stepwise therapeutic approach may improve symptom control. This review provides a comprehensive summary of current options and offers guidance for individualized management of post-ECT headache.</p>","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Safety and Efficacy of Modified Electroconvulsive Therapy in Managing Psychotic Symptoms in a Patient With Schizophrenia With Toxic Cardiomyopathy.","authors":"Aditya Kundu, Apurba Narayan Mahato, Arghya Pal, Sukanto Sarkar, Deepanjan Bhattacharya","doi":"10.1097/YCT.0000000000001232","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001232","url":null,"abstract":"","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of EctPub Date : 2026-01-20DOI: 10.1097/YCT.0000000000001220
Conrad M Swartz
{"title":"Dismissal of Catatonia Diagnosis and Treatment by Nonpsychiatric Physicians.","authors":"Conrad M Swartz","doi":"10.1097/YCT.0000000000001220","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001220","url":null,"abstract":"","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of EctPub Date : 2026-01-20DOI: 10.1097/YCT.0000000000001171
Tariq Parker, Emmanuel Mensah, Khalil St Brice, Joshua Chalif, William Butler, Kristopher Kahle
{"title":"Safety of Electroconvulsive Therapy With Implanted Ventricular Shunts: A Systematic Review and Case Series.","authors":"Tariq Parker, Emmanuel Mensah, Khalil St Brice, Joshua Chalif, William Butler, Kristopher Kahle","doi":"10.1097/YCT.0000000000001171","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001171","url":null,"abstract":"<p><strong>Objectives: </strong>We aim to determine the safety and outcomes of electroconvulsive therapy (ECT) in patients with ventricular shunts, with a focus on shunt function after treatment.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of all patients with ventriculoperitoneal shunts who underwent ECT at the Massachusetts General Hospital between November 2021 and November 2024. We also conducted a systematic review of the literature to identify all studies published between November 1, 1964, and November 1, 2024, reporting the use of ECT in patients with implanted cerebrospinal fluid shunts.</p><p><strong>Results: </strong>Our case cohort comprised 4 patients with implanted programmable VP shunts, of which, 2 cases demonstrated evidence of valve setting changes after ECT. Across all the cases, ECT was effective in reducing psychiatric symptoms without evidence of shunt malfunction, albeit with some ECT-related adverse side effects. Our search yielded 115 studies, of which 12 met the inclusion criteria for review. These studies described the successful administration of ECT in patients with implanted cerebrospinal fluid shunts, with no reports of shunt malfunction or requirement for revision.</p><p><strong>Conclusions: </strong>ECT appears to be a safe and effective treatment for psychiatric patients with indwelling ventricular shunts. ECT administered to patients with programmable shunt valves require particular attention with evaluation for shunt setting changes and reprogramming to pre-ECT settings when appropriate. Our findings support the need for a multidisciplinary approach, involving psychiatry, anesthesia, and neurosurgical teams, to mitigate risks and optimize care in this unique patient population.</p>","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Repetitive Transcranial Magnetic Stimulation in the Management of Premenstrual Syndrome: A Prospective Pilot Study.","authors":"Clarence Silva Ramos, Dennison Carreiro Monteiro, Emmanuela Coeli Alves da Silva, Amaury Cantilino","doi":"10.1097/YCT.0000000000001216","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001216","url":null,"abstract":"<p><strong>Objectives: </strong>Treatment options for premenstrual syndrome (PMS) include lifestyle changes, nutritional supplements, selective serotonin reuptake inhibitors (SSRIs), and hormone therapy. However, these approaches are sometimes ineffective or cause adverse effects. Currently, neuromodulation for premenstrual symptoms remains underrecognized. This study aimed to assess the effects of repetitive transcranial magnetic stimulation (rTMS) on PMS symptoms.</p><p><strong>Materials and methods: </strong>A prospective pilot study was conducted in which 10 women with PMS were followed up over 2 menstrual cycles. Symptomatic progression was analyzed by assessment instruments at the beginning, middle, and end of the luteal phase in both cycles. The participants underwent 10 to 12 right dorsolateral prefrontal cortex (DLPFC) rTMS sessions during the luteal phase in the second menstrual cycle, and the symptomatic scores of the second cycle (with rTMS) were compared with those of the first cycle (without rTMS).</p><p><strong>Results: </strong>The intermediate and final assessments indicated a statistically significant decrease in depressive (P = 0.034 and P < 0.001, respectively) and anxiety symptoms (P = 0.019 and P = 0.001, respectively) in the second cycle compared with the first. The rTMS was generally well tolerated without significant adverse effects. The study sample was small, and a control group was not included. Furthermore, the timeframe was short, with only 2 menstrual cycles assessed.</p><p><strong>Conclusions: </strong>rTMS may provide positive treatment effects for women with PMS, especially in the middle and end of the luteal phase. Future controlled studies to verify its effectiveness are warranted.</p>","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of EctPub Date : 2025-12-22DOI: 10.1097/YCT.0000000000001209
Laure T Mansour, Vanesa Tomatis, Alina Abdul Halim, Ema J Knight
{"title":"Electroconvulsive Therapy in the Presence of Intracranial Pathology: A Literature Review.","authors":"Laure T Mansour, Vanesa Tomatis, Alina Abdul Halim, Ema J Knight","doi":"10.1097/YCT.0000000000001209","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001209","url":null,"abstract":"<p><p>Electroconvulsive therapy (ECT) is a well-established method to treat various psychiatric disorders. However, ECT is not without risk; as such, all patients undergo a thorough workup to ensure appropriate patient selection. An important physiological event during ECT is the transient increase in intracranial pressure (ICP), which raises the question of intracranial contraindications to this treatment modality. A literature review was conducted to explore the safety of ECT in the presence of various intracranial pathologies to establish a summary of recommendations. Neuropathologies considered include malignant or benign brain tumours, arachnoid cysts, neurovascular conditions, neurotrauma, hydrocephalus, idiopathic intracranial hypertension, and Chiari 1 malformations. The literature remains very sparse on this topic, mostly including case series or short retrospective studies. However, there have not been any established absolute contraindications to ECT. Available evidence describes lower risks following ECT in clinically asymptomatic tumors, arachnoid cysts, treated hydrocephalus, and asymptomatic Chiari 1 malformation. Several strategies have been proposed to mitigate the risks of transient rise of intracranial pressure in certain conditions, including the administration of steroid medications and intravenous antihypertensives. The decision to proceed with ECT in the presence of intracranial pathology should be made on a case-by-case basis by a multidisciplinary team involving both psychiatric and neurosurgical teams.</p>","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of EctPub Date : 2025-12-17DOI: 10.1097/YCT.0000000000001226
Larissa Junkes, Richard I Shader, Mauro V Mendlowicz, Antonio E Nardi
{"title":"The Convulsive Therapies of László Meduna Revisited: The First Effective Biological Approach in Psychiatry Turns 90 Years Old.","authors":"Larissa Junkes, Richard I Shader, Mauro V Mendlowicz, Antonio E Nardi","doi":"10.1097/YCT.0000000000001226","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001226","url":null,"abstract":"<p><p>Almost a century after the first experiments with camphor in inducing seizures for the treatment of schizophrenic patients, this past remains present in psychiatry as one of its milestones, being one of the first effective biological approaches conducted for mental illness. In Hungary, László Meduna, a psychiatrist with training in neuropathology, hypothesized that convulsions held therapeutic potential based on a theoretical incompatibility with psychosis and, with firm intellectual dedication, planned and executed a research project that resulted, after generations of improvements, in one of the most effective and timeless treatments in psychiatry. László Meduna entered history. Using the early research methods available at the time, he developed an innovative procedure. Meduna, like many other dedicated scientists throughout history, filled gaps with his research skills. This review situates the work of Meduna within its historical context, examining his development of chemically induced seizures as a treatment for severe psychiatric disorders. This seminal therapeutic advance proved remarkably effective, and its fundamental repercussions continue to resonate in contemporary practice.</p>","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}