Journal of Ect最新文献_第5页

Efficacy of Adjunctive Deep Transcranial Magnetic Stimulation in Obsessive-Compulsive Disorder: A Randomized Sham-Controlled Study. 辅助深经颅磁刺激治疗强迫症的疗效：一项随机假对照研究。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-04-22 DOI: 10.1097/YCT.0000000000001145

Sachin Reddy, Nishant Goyal, Umesh Shreekantiah

{"title":"Efficacy of Adjunctive Deep Transcranial Magnetic Stimulation in Obsessive-Compulsive Disorder: A Randomized Sham-Controlled Study.","authors":"Sachin Reddy, Nishant Goyal, Umesh Shreekantiah","doi":"10.1097/YCT.0000000000001145","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001145","url":null,"abstract":"Objectives: Obsessive-compulsive disorder is one of the most common neuropsychiatric disorders with a higher lifetime prevalence than schizophrenia, often showing inadequate response to pharmacological and psychotherapeutic treatments. This study aimed to examine the efficacy of adjunctive deep transcranial magnetic stimulation (dTMS) in a randomized, sham-controlled set-up, addressing inadequate response to standard treatments.Methods: Forty-nine obsessive-compulsive disorder patients were randomly allocated to receive either high-frequency dTMS (20 Hz) or sham stimulation and received 10 sessions of treatment using the H7 coil to target the dorsal anterior cingulate cortex and the medial prefrontal cortex over a period of 2 weeks. Change in Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) scores was the primary outcome measure. Secondary efficacy measures were changes in Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores and response rates as measured by Y-BOCS.Results: The active dTMS group demonstrated a significant reduction in Y-BOCS scores compared with sham (-10.4 vs -2.6 points; P < 0.001), with an effect size of 1.39. Full response rates were 75% in the active group versus 5% in the sham group (P < 0.001). Anxiety and depressive symptoms also improved significantly in the active group (Hamilton Anxiety Rating Scale: -9.1 vs -2.4 points, P < 0.001; Hamilton Depression Rating Scale: -5.9 vs -1.8 points, P < 0.001).Conclusion: Our study demonstrated that dTMS targeting the dorsal anterior cingulate cortex and medial prefrontal cortex significantly improved obsessive-compulsive, anxiety, and depressive symptoms, with faster response rates and fewer sessions compared with previous trials, suggesting that dTMS may serve as an effective early intervention for a wider range of obsessive-compulsive disorder patients.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of Flumazenil Utilization in Electroconvulsive Therapy. 氟马西尼在电休克治疗中的应用特点。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-04-15 DOI: 10.1097/YCT.0000000000001142

Michelle Yang, Daniel McGraw, Clint Ross

{"title":"Characterization of Flumazenil Utilization in Electroconvulsive Therapy.","authors":"Michelle Yang, Daniel McGraw, Clint Ross","doi":"10.1097/YCT.0000000000001142","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001142","url":null,"abstract":"Objectives: The primary objective was to evaluate the effectiveness of flumazenil administered after benzodiazepine treatment prior to a patient receiving electroconvulsive therapy (ECT). The secondary objective was to analyze the general practice of flumazenil administration in this patient population.Methods: This retrospective chart review included patients who received at least one dose of a benzodiazepine 18 hours prior to ECT while admitted to a behavioral health unit from July 1, 2018, to June 30, 2023. The primary outcome examined seizure duration. Secondary outcomes included change in electrode placement, induction agent, and/or ECT machine, as well as addition of caffeine.Results: A total of 847 patient encounters were included in the final analysis, with 407 encounters with flumazenil and 440 without flumazenil. The median seizure duration was 33 seconds for the flumazenil cohort and 37.5 seconds for the no flumazenil cohort (P = 0.047). Patients who received flumazenil were more likely than not to experience a change in electrode placement (P = 0.005) and change in ECT machine (P = 0.001).Conclusions: There were statistically significant differences between the two cohorts, with flumazenil being associated with a higher stimulus dose and a shorter seizure duration. The results of this study suggest a smaller impact of flumazenil on benzodiazepine-treated ECT patients than expected. Further studies are needed to explore the utility of flumazenil in this population.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remote Ischemic Preconditioning Does Not Alleviate Post-Electroconvulsive Therapy Cognitive Dysfunction. 远端缺血预处理不能缓解电痉挛治疗后的认知功能障碍。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-04-15 DOI: 10.1097/YCT.0000000000001150

Ravitej Bhat, Venkatapura J Ramesh, Jagadisha Thirthalli, Channaveerachari Naveen Kumar, Kadarapura Nanjundaiah Gopalakrishna

{"title":"Remote Ischemic Preconditioning Does Not Alleviate Post-Electroconvulsive Therapy Cognitive Dysfunction.","authors":"Ravitej Bhat, Venkatapura J Ramesh, Jagadisha Thirthalli, Channaveerachari Naveen Kumar, Kadarapura Nanjundaiah Gopalakrishna","doi":"10.1097/YCT.0000000000001150","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001150","url":null,"abstract":"Objective: This study aimed to evaluate the efficacy of remote ischemic preconditioning in decreasing post-electroconvulsive therapy-induced cognitive dysfunction.Methods: This was a randomized controlled clinical trial in patients with schizophrenia. The patients recruited in the study were subjected to RIPC or sham RIPC. RIPC or sham RIPC was given before each ECT, and the patient was followed up with six ECTs. The cognitive and memory assessments before and after ECT within and between the groups were compared via the Hindi Mental State Examination (HMSE), Battery for Electroconvulsive Therapy-Related Cognitive Deficits (B4ECT ReCoDe), Clinical Global Impression-Severity Index (CGI-SI), and PGI Memory Scale (PGI).Results: The sociodemographic and clinical profiles were similar between the groups. The HMSE (P = 0.824), B4ECT ReCoDe (P = 0.225), PGI (P = 0.111), and CGI-S (P = 0.776) scores were not significantly different between the groups.Conclusions: Remote ischemic preconditioning was not successful in decreasing post-cognitive dysfunction in patients with schizophrenia who were receiving electroconvulsive therapy. However, it was safe and feasible in ECT patients and did not have any significant effect on the primary disease.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Electroconvulsive Therapy on Hippocampal Endoplasmic Reticulum Stress in a Rat Model of Depression. 电痉挛治疗对抑郁症大鼠海马内质网应激的影响。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-04-15 DOI: 10.1097/YCT.0000000000001144

Şükrü Kartalci, Nazmi Özgen, Fatma Kartal, Ahmet Kadir Arslan, Ahmet Koç, Halil Düzova

{"title":"The Effect of Electroconvulsive Therapy on Hippocampal Endoplasmic Reticulum Stress in a Rat Model of Depression.","authors":"Şükrü Kartalci, Nazmi Özgen, Fatma Kartal, Ahmet Kadir Arslan, Ahmet Koç, Halil Düzova","doi":"10.1097/YCT.0000000000001144","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001144","url":null,"abstract":"Objective: The mechanisms underlying the effectiveness of electroconvulsive therapy (ECT), one of the most effective treatments for depression, are still unknown. While the increasing endoplasmic reticulum (ER) stress in depression can retrieve with pharmacological agents, ECT's effectiveness has not been examined yet. In this study, we tested how hippocampal ER stress parameters change after repeated ECT in rats in the chronic unpredictable mild stress (CUMS) model.Methods: Rats were divided into 4 groups. Two groups were included in the experimental group, where the CUMS model was applied for 21 days. Then, the experimental ECT model was applied to 2 groups, one experimental and 1 control group, for 21 days. Weight changes results were evaluated at the end of the 21st and 42nd day. In the final step, 3 prominent ER stress-related proteins (Grp-78, Xbp1, and Atf-4) were measured by western blot in the removed hippocampus.Results: We found that rats administered CUMS exhibited depression-like behavioral responses such as weight loss. In CUMS-treated rats (group 3), Grp-78 levels increased, ATF4 levels did not change, and Xbp1 levels decreased. While ECT increased Grp-78 levels in normal rats, it did not change Atf-4 levels and reduced Xbp1 levels (group 2). When ECT was applied to rats undergoing the CUMS model, Grp-78 and Xbp1 levels decreased, while Atf-4 levels did not change (group 4).Conclusions: These findings show that increased ER stress may play a role in the pathophysiology of depression and that this increase can be reversed with ECT treatment. These findings need to be confirmed by clinical studies in humans.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Lysing of Catatonia With Intravenous Ketamine Prior to Definitive Treatment With Electroconvulsive Therapy. 电休克治疗前静脉氯胺酮治疗紧张症。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-04-15 DOI: 10.1097/YCT.0000000000001151

Erich J Conrad, Zachary F Stielper, Isabelle V Mermilliod, Matthew R Eng

引用次数: 0

Sequential Navigated Multilocus Repetitive Transcranial Magnetic Stimulation for Concurrent Somatic and Psychiatric Conditions. 顺序导航多位点重复经颅磁刺激并发躯体和精神疾病。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-04-09 DOI: 10.1097/YCT.0000000000001141

Satu K Jääskeläinen, Mi Tram, Tero Taiminen

{"title":"Sequential Navigated Multilocus Repetitive Transcranial Magnetic Stimulation for Concurrent Somatic and Psychiatric Conditions.","authors":"Satu K Jääskeläinen, Mi Tram, Tero Taiminen","doi":"10.1097/YCT.0000000000001141","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001141","url":null,"abstract":"Objective: Repetitive transcranial magnetic stimulation (rTMS) is efficient in frequently coexisting neurological and psychiatric disorders. This retrospective study investigated potentially additive efficacy and feasibility of multilocus rTMS in patients treated for more than 1 concurrent disorder.Methods: Thirty-three consecutive patients underwent therapeutic rTMS with several cortical targets for more than 1 disorder. Two patients were excluded (insufficient data). The patients (19 women and 12 men, median age 49 years, range 17-75 years) had combinations of chronic pain (n = 15), depression (n = 30), tinnitus (n = 7), anxiety (n = 6), obsessive-compulsive disorder (n = 3), and eating disorder (n = 3). The combination of pain and depression was most frequent. E-field navigated TMS device (Nexstim Ltd, Helsinki, Finland) was used for a 10-day rTMS-trial (9 in 2 cases). Protocol and cortical target combinations varied according to indications. In addition to clinical evaluation, at least 30% decrease in severity on disorder-specific scales was response limit. All assessments were done at baseline and after 10-day treatment.Results: Response rate to multilocus rTMS in at least 1 condition was 84%. A response to treatment was observed for both indications in 19 patients, for a single indication in 7 patients, and for none in 5 patients. As available (n = 20), Global Impression of Change was positive in 85% of patients, and 15% reported no change.Conclusions: Multilocus rTMS is an efficient tool for comorbid neurological and psychiatric disorders, with no serious adverse effects. Responder rate was rather high in patients with comorbidities, suggesting that rTMS efficacy may be associated with inherent patient-related factors.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electroconvulsive Therapy for Catatonia in a Patient With Schizophrenia Comorbid With Becker Muscular Dystrophy: A Case Report. 电痉挛疗法治疗精神分裂症合并贝克肌萎缩症患者的紧张症1例。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-04-08 DOI: 10.1097/YCT.0000000000001149

Shun Igarashi, Hitomi Hashimoto, Tomoyuki Miyazaki, Hotake Takizawa, Daisuke Hayashi, Kentaro Nagao, Koichiro Kumagai, Koichiro Watanabe, Takamasa Noda, Shinsuke Kito

引用次数: 0

Safety and Blinding of Transcranial Direct Current Stimulation in Schizophrenia Patients. 经颅直流电刺激治疗精神分裂症患者的安全性和致盲性。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-04-08 DOI: 10.1097/YCT.0000000000001148

Adam Wysokiński, Michał Pazdrak, Aleksandra Mazerant-Zielińska, Adrianna Szczakowska

{"title":"Safety and Blinding of Transcranial Direct Current Stimulation in Schizophrenia Patients.","authors":"Adam Wysokiński, Michał Pazdrak, Aleksandra Mazerant-Zielińska, Adrianna Szczakowska","doi":"10.1097/YCT.0000000000001148","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001148","url":null,"abstract":"Introduction: Transcranial direct current stimulation (tDCS) is a method of noninvasive brain stimulation. tDCS clinical efficacy is debatable, but it was proved to be effective at the neurophysiological level. tDCS has a very good safety profile in human subjects. Because the method has been more frequently studied in patients with schizophrenia, we wanted to analyze the safety and tolerability of tDCS treatment in this population. We also evaluated blinding quality of tDCS stimulations.Material and methods: All stimulations were performed using the DC-Stimulator PLUS (neuroCare, Germany) with the sham module installed. For all the stimulations, 2.0-mA current and 5 × 7-cm anode and cathode rubber electrodes in saline-soaked sponges were used.Results: We collected and evaluated safety data in a large dataset of 1139 tDCS stimulations in patients with schizophrenia. No serious adverse events were recorded. None of the subjects discontinued tDCS treatment due to side effects. All the reported events resolved spontaneously within 30 minutes after the tDCS session. In approximately 17% of all the stimulations, no side effects were reported by the patients. The 2 most frequent types of side effects were itching/tingling (reported by 68.4% of the subjects) and burning/warmth sensations (57.4%, when combined).Discussion: This study confirms that tDCS is safe and well tolerated by patients with schizophrenia. The most frequent side effects are itching/tingling and burning/warmth sensations, all of low severity. We found that blinding of tDCS stimulations is imperfect. We recommend that blinding assessment become a routine part of sham-controlled tDCS studies.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Video-Assisted Teaching Program on Knowledge, Attitude, and Stigma Toward Modified Electroconvulsive Therapy Among the Primary Caregivers of Patients With Psychotic Disorder: A Randomized Controlled Trial. 一项随机对照试验：视频辅助教学项目对精神病患者主要照护者对改良电休克治疗的知识、态度和耻辱感的有效性

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-04-07 DOI: 10.1097/YCT.0000000000001147

Meenu Meenu, Nanda Kumar Paniyadi, Biswa Ranjan Mishra, Rakesh Vadakkethil Radhakrishnan, Jaison Jacob

{"title":"Effectiveness of Video-Assisted Teaching Program on Knowledge, Attitude, and Stigma Toward Modified Electroconvulsive Therapy Among the Primary Caregivers of Patients With Psychotic Disorder: A Randomized Controlled Trial.","authors":"Meenu Meenu, Nanda Kumar Paniyadi, Biswa Ranjan Mishra, Rakesh Vadakkethil Radhakrishnan, Jaison Jacob","doi":"10.1097/YCT.0000000000001147","DOIUrl":"https://doi.org/10.1097/YCT.0000000000001147","url":null,"abstract":"Objectives: This study aimed to assess the effectiveness of a video-assisted educational program on knowledge, attitude, and stigma toward modified electroconvulsive therapy (ECT) among the primary caregivers of patients with psychotic disorders.Methods: This experimental study was conducted at the Department of Psychiatry of a tertiary care hospital in India among 94 adult primary caregivers of patients with psychotic disorder. Participants in the experimental group (n = 47) received a 15-minute video-assisted educational program on ECT in addition to the standard care, and those in the control group (n = 47) received only the standard care. The online platform was used to collect data on caregivers' sociodemographic details, knowledge, attitudes, and stigma toward ECT. The data from either group were collected at baseline and 2 weeks after intervention.Results: Both groups were comparable with regard to key sociodemographic variables and baseline level of knowledge, attitude, and stigma toward ECT. In the postintervention, there was a significant difference in the median (interquartile range) score of knowledge, attitude, and stigma toward ECT in the experimental group compared with the control group. There was a significant correlation between the pretest level of knowledge and attitude (r = 0.387). The relationship with the patient was found to be associated with the knowledge level of the subjects (P < 0.001), and caregivers' monthly income was associated (P < 0.05) with stigma toward ECT.Conclusion: The study provides evidence that the video-assisted educational program was effective in increasing knowledge, creating a more positive attitude, and reducing stigma toward ECT.","PeriodicalId":54844,"journal":{"name":"Journal of Ect","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Electroconvulsive Therapy for a 57-Year-Old Woman With Major Depressive Disorder and Dissociative Disorder: A Case Report and Literature Review. 电痉挛成功治疗57岁女性重度抑郁症和分离性障碍1例报告并文献复习。

IF 1.8 4区医学

Journal of Ect Pub Date : 2025-04-04 DOI: 10.1097/YCT.0000000000001146

Hajimu Honda, Toshinori Nakamura, Naoaki Kubota, Saeko Yokotsuka-Ishida, Daimei Sasayama, Shinsuke Washizuka

引用次数: 0