Journal of Genetics and Genomics最新文献_第8页

Ancient DNA reveals genetic exchange in the Hehuang valley in the context of demic diffusion during the Han dynasty. 古代DNA揭示了汉代学术传播背景下河黄流域的基因交换。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2024-12-03 DOI: 10.1016/j.jgg.2024.11.013

Langyun Wang, Yutong Wang, Bing Sun, Daxuan Zhang, Guanjin Liang, Pengcheng Ma, Hao Zhang, Chunxiang Li, Xiaojun Hu, Quanchao Zhang, Yinqiu Cui

引用次数: 0

FishCODE: a web-based information platform for comprehensive omics data exploration in fish research. FishCODE：一个基于网络的信息平台，用于在鱼类研究中全面探索 omics 数据。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2024-12-01 Epub Date: 2024-10-09 DOI: 10.1016/j.jgg.2024.09.019

Heng Li, Wanting Zhang, Keyi Ren, Hong Yang, Lei Zhang, Waqar Younas, Yingyin Cheng, Yaping Wang, Mijuan Shi, Xiao-Qin Xia

引用次数: 0

A haplotype-resolved genome reveals the genetic basis of spine formation in Atelerix albiventris. 单倍型解析基因组揭示了 Atelerix albiventris 脊柱形成的遗传基础。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2024-12-01 Epub Date: 2024-06-29 DOI: 10.1016/j.jgg.2024.06.012

Libo Jiang, Jianing Xu, Mengyuan Zhu, Zhongfan Lv, Zemin Ning, Fengtang Yang

引用次数: 0

Capn3b-deficient zebrafish model reveals a key role of autoimmune response in LGMDR1. Capn3b缺陷斑马鱼模型揭示了自身免疫反应在LGMDR1中的关键作用。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2024-12-01 Epub Date: 2024-09-28 DOI: 10.1016/j.jgg.2024.09.011

Yayue Chen, Delai Huang, Aixuan Xie, Ying Shan, Shuyi Zhao, Ce Gao, Jun Chen, Hui Shi, Weihuan Fang, Jinrong Peng

{"title":"Capn3b-deficient zebrafish model reveals a key role of autoimmune response in LGMDR1.","authors":"Yayue Chen, Delai Huang, Aixuan Xie, Ying Shan, Shuyi Zhao, Ce Gao, Jun Chen, Hui Shi, Weihuan Fang, Jinrong Peng","doi":"10.1016/j.jgg.2024.09.011","DOIUrl":"10.1016/j.jgg.2024.09.011","url":null,"abstract":"Mutations in calcium-dependent papain-like protease CALPAIN3 (CAPN3) cause Limb-Girdle Muscular Dystrophy Recessive Type 1 (LGMDR1), the most common limb-girdle muscular dystrophy in humans. In addition to progressive muscle weakness, persistent inflammatory infiltration is also a feature of LGMDR1. Despite the underlying mechanism remaining poorly understood, we consider that it may relate to the newly defined role of CAPN3/Capn3b in the nucleolus. Here, we report that the loss of function of zebrafish capn3b, the counterpart of human CAPN3, induces an autoimmune response akin to that in LGMDR1 patients. capn3b mutant larvae are more susceptible to Listeria monocytogenes injection, characterized by recruiting more macrophages. Under germ-free conditions, transcriptome analysis of the capn3b mutant muscle reveals a significant upregulation of the chemokine-production-related genes. Coincidently, more neutrophils are recruited to the injury site imposed by either muscle stabbing or tail fin amputation. Nucleolar proteomic analysis and enzymatic assays reveal NKAP, an activating factor of the NF-κB pathway, to be a target of CAPN3. We conclude that the accumulation of Nkap and other factors in the capn3b mutant may be involved in the over-activation of innate immunity. Our studies indicate that the zebrafish capn3b mutant is a powerful model for studying the immunity-related progression of human LGMDR1.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":"1375-1388"},"PeriodicalIF":6.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variants within KIF5B are associated with weight loss through mitochondrial transport alteration in sheep. KIF5B 变异与绵羊线粒体转运改变导致的体重减轻有关。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI: 10.1016/j.jgg.2024.09.009

Jieran Chen, Haitao Wang, Tingting Li, Yuting Zhang, Yan Chen, Na Zhang, Hengqian Yang, Zhichao Zhang, Ziyuan Duan, Xia Li, Daxiang Wang, Zhixiong He, Fan Hu, Jianfeng Gao, Runlin Z Ma, Xun Huang, Qiuyue Liu

引用次数: 0

The ABF transcription factor TaABF2 interacts with TaSnRK2s to ameliorate drought tolerance in wheat. ABF转录因子TaABF2与TaSnRK2s相互作用，改善小麦的耐旱性。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2024-12-01 Epub Date: 2024-10-11 DOI: 10.1016/j.jgg.2024.09.022

Linying Du, Ming Yu, Qiannan Wang, Zhenbing Ma, Shumin Li, Li Ding, Fangfang Li, Weijun Zheng, Xiaojing Wang, Hude Mao

引用次数: 0

A programmable CRISPR/dCas9-based epigenetic editing system enabling loci-targeted histone citrullination and precise transcription regulation. 基于 CRISPR/dCas9 的可编程表观遗传编辑系统，可实现基因座靶向组蛋白瓜氨酸化和精确转录调控。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2024-12-01 Epub Date: 2024-06-06 DOI: 10.1016/j.jgg.2024.05.010

Xiaoya Zhang, Abhisek Bhattacharya, Chunxiang Pu, Yan Dai, Jia Liu, Lang Rao, Chaoguang Tian

{"title":"A programmable CRISPR/dCas9-based epigenetic editing system enabling loci-targeted histone citrullination and precise transcription regulation.","authors":"Xiaoya Zhang, Abhisek Bhattacharya, Chunxiang Pu, Yan Dai, Jia Liu, Lang Rao, Chaoguang Tian","doi":"10.1016/j.jgg.2024.05.010","DOIUrl":"10.1016/j.jgg.2024.05.010","url":null,"abstract":"Histone citrullination, an important post-translational modification mediated by peptidyl arginine deiminases, is essential for many physiological processes and epigenetic regulation. However, the causal relationship between histone citrullination and specific gene regulation remains unresolved. In this study, we develop a programmable epigenetic editor by fusing the peptidyl arginine deiminase (PAD) PPAD from Porphyromonas gingivalis with dCas9. With the assistance of gRNA, PPAD-dCas9 can recruit PPADs to specific genomic loci, enabling direct manipulation of the epigenetic landscape and regulation of gene expression. Our citrullination editor allows for the site-specific manipulation of histone H3R2,8,17 and H3R26 at target human gene loci, resulting in the activation or suppression of different genes in a locus-specific manner. Moreover, the epigenetic effects of the citrullination editor are specific and sustained. This epigenetic editor offers an accurate and efficient tool for exploring gene regulation of histone citrullination.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":"1485-1493"},"PeriodicalIF":6.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CancerSRT: a spatially resolved transcriptomics database for human cancers. CancerSRT：人类癌症空间解析转录组学数据库。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2024-12-01 Epub Date: 2024-09-12 DOI: 10.1016/j.jgg.2024.08.012

Yuying Huo, Jiakang Wang, Chengcheng Liu, Jinxia Wang, Chen Wang, Wenbo Guo, Zhiyuan Yuan, Tiantian Guo, Jin Gu, Xiangyu Li

引用次数: 0

Localized production of LECT2 by orthotopic histiocytes during inflammation. 在炎症期间，正位组织细胞局部产生 LECT2。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2024-12-01 Epub Date: 2024-10-05 DOI: 10.1016/j.jgg.2024.09.017

Zhenhan Huang, Xiaojun Yang, Xun Qin, Kemin Chen, Wei Liu, Jin Xu, Jianchao Li, Wenqing Zhang, Zhibin Huang

引用次数: 0

Nitrogen inhibition of nitrogenase activity involves the modulation of cytosolic invertase in soybean nodule. 氮对氮酶活性的抑制涉及对大豆结瘤细胞质转化酶的调节。

IF 6.6 2区生物学

Journal of Genetics and Genomics Pub Date : 2024-12-01 Epub Date: 2024-06-29 DOI: 10.1016/j.jgg.2024.06.013

Qinzhen Xu, Xin Wang, Nan Wang, Suning Li, Xiaolei Yao, Huaqin Kuang, Zhimin Qiu, Danxia Ke, Wenqiang Yang, Yuefeng Guan

{"title":"Nitrogen inhibition of nitrogenase activity involves the modulation of cytosolic invertase in soybean nodule.","authors":"Qinzhen Xu, Xin Wang, Nan Wang, Suning Li, Xiaolei Yao, Huaqin Kuang, Zhimin Qiu, Danxia Ke, Wenqiang Yang, Yuefeng Guan","doi":"10.1016/j.jgg.2024.06.013","DOIUrl":"10.1016/j.jgg.2024.06.013","url":null,"abstract":"Legume symbiotic nitrogen fixation (SNF) is suppressed by inorganic nitrogen (N) in the soil. High N inhibition of nitrogenase activity is associated with the deprivation of carbon allocation and metabolism in nodules. However, the underlying molecular mechanisms remain unclear. Here, we identify GmCIN1, which encodes a cytosolic invertase, as a gateway for the N-tuning of sucrose utilization in nodules. GmCIN1 is enriched in mature soybean nodules, and its expression is regulated by nitrogen status. The knockout of GmCIN1 using genome editing partially mimics the inhibitory effects of N on nitrogenase activity and sugar content and the impact of high N on nodule transcriptomes. This indicates that GmCIN1 partially mediates the high N inhibition of nodule activity. Moreover, ChIP-qPCR and EMSA reveal that SNAP1/2 transcription factors directly bind to the GmCIN1 promoter. In addition, SNAP1/2 may be involved in the repression of GmCIN1 expression in mature nodules at high N concentrations. Our findings provide insights into the involvement of the transcriptional tuning of carbon (C) metabolism genes by N-signaling modulators in the N-induced inhibition of nitrogenase activity.","PeriodicalId":54825,"journal":{"name":"Journal of Genetics and Genomics","volume":" ","pages":"1404-1412"},"PeriodicalIF":6.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0