Chloe Ekelem , Margit Juhasz , Junxiao Yu , Anna-Marie Hosking , Ella Csuka , Franchesca Choi , Christine T. Pham , Andrew Emon Heidari , Manuel Valdebran , Jeffrey A. Rapaport , Zhongping Chen , Natasha Atanaskova Mesinkovska
{"title":"Monitoring Response to Platelet-Rich Plasma in Patients with Alopecia Areata with Optical Coherence Tomography: A Case Series","authors":"Chloe Ekelem , Margit Juhasz , Junxiao Yu , Anna-Marie Hosking , Ella Csuka , Franchesca Choi , Christine T. Pham , Andrew Emon Heidari , Manuel Valdebran , Jeffrey A. Rapaport , Zhongping Chen , Natasha Atanaskova Mesinkovska","doi":"10.1016/j.jisp.2020.05.008","DOIUrl":"10.1016/j.jisp.2020.05.008","url":null,"abstract":"<div><p>Alopecia areata (AA) is an autoimmune hair loss condition that is difficult to treat and frequently disruptive to the psychosocial well-being of patients. Platelet-rich plasma (PRP) is an innovative therapy that provides concentrated GFs that impart anti-inflammatory effects. Optical coherence tomography (OCT) is a noninvasive imaging modality with the potential for providing quantitative monitoring of AA response to PRP. Our objective is to share our experience using OCT to monitor the therapeutic progress of patients with AA treated with PRP. Two patients with patchy AA and one with alopecia universalis were treated with PRP three times at 6-week intervals as part of a larger clinical trial. Patients were followed from baseline to week 24 with OCT imaging. OCT demonstrates an increase in hair density associated with improvement in inflammation at week 24. Conversely, the patient with alopecia universalis did not experience any significant change in follicular activity. This case series exemplifies the potential of PRP in inflammatory regulation as well as hair regrowth in patchy AA, whereas there is no notable advantage in alopecia universalis. Our findings add evidence on the possible value of OCT in quantitatively assessing hair growth progress throughout a treatment course.</p></div>","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"20 1","pages":"Pages S50-S54"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2020.05.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38628582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jouni Uitto, Velina S. Atanasova, Qiujie Jiang, Andrew P. South
{"title":"Precision Medicine for Heritable Skin Diseases—The Paradigm of Epidermolysis Bullosa","authors":"Jouni Uitto, Velina S. Atanasova, Qiujie Jiang, Andrew P. South","doi":"10.1016/j.jisp.2018.09.004","DOIUrl":"10.1016/j.jisp.2018.09.004","url":null,"abstract":"","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"19 2","pages":"Pages S74-S76"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2018.09.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36762082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is the Nervous System More Important Than the Immune System in Itch and Atopic Dermatitis?","authors":"Ethan A. Lerner","doi":"10.1016/j.jisp.2018.10.002","DOIUrl":"10.1016/j.jisp.2018.10.002","url":null,"abstract":"","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"19 2","pages":"Page S94"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2018.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36711813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Delphine Javelaud , Aurélien De Reyniès , Alain Mauviel
{"title":"How Bad Is the Hedgehog? GLI-Dependent, Hedgehog-Independent Cancers on the Importance of Biomarkers for Proper Patients Selection","authors":"Delphine Javelaud , Aurélien De Reyniès , Alain Mauviel","doi":"10.1016/j.jisp.2018.09.010","DOIUrl":"10.1016/j.jisp.2018.09.010","url":null,"abstract":"","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"19 2","pages":"Pages S87-S88"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2018.09.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36712347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of Psoriasis Susceptibility Loci in Psoriatic Arthritis and a Generalized Pustular Psoriasis Cohort","authors":"Zheng Zhang, Jin-Hua Xu","doi":"10.1016/j.jisp.2018.09.008","DOIUrl":"10.1016/j.jisp.2018.09.008","url":null,"abstract":"","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"19 2","pages":"Pages S83-S85"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2018.09.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36712343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}