Journal of Investigative Dermatology Symposium Proceedings最新文献_第2页

An Imperative Need for Further Genetic Studies of Alopecia Areata 斑秃进一步遗传学研究的迫切需要

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2020-11-01 DOI: 10.1016/j.jisp.2020.04.003

Lynn Petukhova

引用次数: 6

JAK Inhibitors for the Treatment of Pediatric Alopecia Areata JAK抑制剂治疗小儿斑秃

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2020-11-01 DOI: 10.1016/j.jisp.2020.04.005

Claire E. Hamilton , Brittany G. Craiglow

引用次数: 12

Eyebrows Are Important in the Treatment of Alopecia Areata 眉毛在治疗斑秃中很重要

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2020-11-01 DOI: 10.1016/j.jisp.2020.04.006

Lucy Y. Liu , Brett A. King , Justin M. Ko

{"title":"Eyebrows Are Important in the Treatment of Alopecia Areata","authors":"Lucy Y. Liu , Brett A. King , Justin M. Ko","doi":"10.1016/j.jisp.2020.04.006","DOIUrl":"10.1016/j.jisp.2020.04.006","url":null,"abstract":"<div><p>Alopecia areata affects not only scalp hair but also other sites of body hair, including eyebrows. Our objective was to investigate the importance of eyebrows in the treatment goals of patients with alopecia areata. Through an online questionnaire, subjects were asked to assess satisfaction with the visually depicted level of response to treatment, using edited photographs depicting a range of eyebrows and scalp hair growth. The questionnaire was completed by 1,741 adults. Absent or partial growth of eyebrows and scalp hair elicited <25% satisfaction. Images depicting either complete eyebrows or complete scalp hair achieved satisfaction in >50% of participants. More participants were satisfied with complete eyebrows and no scalp hair (69%) than complete eyebrows and partial scalp hair (51%). Only when both eyebrows and scalp hair were completely regrown did extreme satisfaction levels reach 90.4%. Limitations include the online nature of the survey, lack of control group, and self-reported severity of alopecia areata in participants. These results suggest that eyebrows may be as important as scalp hair for patients assessing theoretical responses to treatment for alopecia areata. Future clinical studies should consider growth of eyebrows as an outcome measure on par with scalp hair growth.</p></div>","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"20 1","pages":"Pages S37-S40"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jisp.2020.04.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38628579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Report from the International Dermatology Outcome Measures Initiative 来自国际皮肤病结果测量倡议的报告

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2020-11-01 DOI: 10.1016/j.jisp.2020.05.004

Lourdes M. Perez-Chada , Joseph F. Merola , April W. Armstrong , Amit Garg , John Latella , Alice B. Gottlieb

引用次数: 1

Forging the Future: 2018 Alopecia Areata Research Summit Summary Report 打造未来:2018年斑秃研究峰会总结报告

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2020-11-01 DOI: 10.1016/j.jisp.2020.05.005

Abby Ellison , Dory Kranz , Natasha A. Mesinkovska , Angela M. Christiano , Jerry Shapiro , David A. Norris

引用次数: 1

A Potential Role for IL-4 and IL-13 in an Alopecia Areata–Like Phenotype: A Clinical Perspective IL-4和IL-13在斑秃样表型中的潜在作用:临床观点

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2020-11-01 DOI: 10.1016/j.jisp.2020.04.008

Dustin H. Marks , Maryanne M. Senna

引用次数: 3

Current Treatment of Alopecia Areata 目前斑秃的治疗

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2020-11-01 DOI: 10.1016/j.jisp.2020.04.004

Maria K. Hordinsky

引用次数: 0

The Evolving Pathogenesis of Alopecia Areata: Major Open Questions 斑秃发病机制的演变:主要悬而未决的问题

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2020-11-01 DOI: 10.1016/j.jisp.2020.04.002

Ralf Paus

引用次数: 7

Myeloid Adherent Cells Are Involved in Hair Loss in the Alopecia Areata Mouse Model 髓系贴壁细胞参与斑秃小鼠模型的脱发

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2020-11-01 DOI: 10.1016/j.jisp.2020.04.001

Yunyuan Li , Ruhangiz T. Kilani , Gigi Leung , Aziz Ghahary

{"title":"Myeloid Adherent Cells Are Involved in Hair Loss in the Alopecia Areata Mouse Model","authors":"Yunyuan Li , Ruhangiz T. Kilani , Gigi Leung , Aziz Ghahary","doi":"10.1016/j.jisp.2020.04.001","DOIUrl":"10.1016/j.jisp.2020.04.001","url":null,"abstract":"<div><p>Alopecia areata (AA), which is defined as an autoimmune hair loss disease, has a serious impact on the quality of life for patients with AA worldwide. In this study, to our knowledge, a previously unreported method of AA induction in C3H mice has been established and validated. Using this method, we showed that dermal injection of 1–3 million of a mixture of skin cells freshly isolated from AA-affected skin induces AA in more than 80% of healthy mice. Contrary to the previous protocol, the induction of AA by this approach does not need any surgical AA skin grafting, cell manipulation, or high number of activated T cells. We also showed that dermal injection of adherent myeloid cells (mainly CD11b+) in healthy mice is as potent as a mixture of none adherent CD3+ T cells and CD19+ B cells in the induction of AA. Interestingly, most of the mice (7 out of 8) that received non-adherent cells developed AA universalis, whereas most of the mice (5 out of 7) that received adherent cells developed patchy AA. Finally, we found a high number of stage-specific embryonic antigen-expressing cells whose expression in monocytes in an inflammatory disease causes the release of inflammatory cytokines, TNF-α and IL-1β, from these cells in AA-affected skin.</p></div>","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"20 1","pages":"Pages S16-S21"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087002420300010/pdfft?md5=1b83db1813c129118f60f01e02b0dbad&pid=1-s2.0-S1087002420300010-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38628575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Brigham Eyebrow Tool for Alopecia: A Reliable Assessment of Eyebrow Alopecia Areata 布里格姆眉毛工具脱发:一个可靠的评估眉毛斑秃

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2020-11-01 DOI: 10.1016/j.jisp.2020.06.001

Elizabeth Tkachenko , Kathie P. Huang , Justin M. Ko , Kristina J. Liu , Deborah A. Scott , Maryanne M. Senna , Sara J. Li , Cara J. Joyce , Arash Mostaghimi

{"title":"Brigham Eyebrow Tool for Alopecia: A Reliable Assessment of Eyebrow Alopecia Areata","authors":"Elizabeth Tkachenko , Kathie P. Huang , Justin M. Ko , Kristina J. Liu , Deborah A. Scott , Maryanne M. Senna , Sara J. Li , Cara J. Joyce , Arash Mostaghimi","doi":"10.1016/j.jisp.2020.06.001","DOIUrl":"10.1016/j.jisp.2020.06.001","url":null,"abstract":"<div><p>There are no tools to evaluate eyebrow involvement in patients with alopecia areata. We developed and assessed the reliability of the Brigham Eyebrow Tool for Alopecia (BETA) as a quantitative evaluation of eyebrow alopecia areata. BETA uses facial landmarks of eyebrow anatomy and is calculated using surface area and density. A total of 50 eyebrow images with varying levels of hair loss were distributed to six board-certified dermatologists at three academic medical centers with standardized instructions and examples. Interrater and intrarater reliability were calculated using intraclass correlation coefficients (ICCs). BETA demonstrated high interrater (ICC = 0.88, confidence interval = 0.83–0.92 right eyebrow scores and ICC = 0.90, confidence interval = 0.85–0.94 left eyebrow scores) and intrarater (ICC = 0.90, confidence interval = 0.85–0.93 right eyebrow scores and ICC = 0.91, confidence interval = 0.87–0.94 left eyebrow scores) reliability. When measured in the same patient with varying degrees of hair loss over time, BETA demonstrated sensitivity to change. BETA is a simple and reliable objective assessment of eyebrow alopecia areata. BETA is easy-to-use and quick to calculate, making it feasible for a variety of clinical and research settings. Although developed for alopecia areata, we hope that BETA will be investigated in other etiologies of eyebrow alopecia to serve as a universal tool for monitoring disease progression, improvement, and response to treatment.</p></div>","PeriodicalId":54791,"journal":{"name":"Journal of Investigative Dermatology Symposium Proceedings","volume":"20 1","pages":"Pages S41-S44"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1087002420300198/pdfft?md5=75f793153d7eeaf2960f98addafedd1a&pid=1-s2.0-S1087002420300198-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38628580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3