A Potential Role for IL-4 and IL-13 in an Alopecia Areata–Like Phenotype: A Clinical Perspective

Q2 Medicine

Journal of Investigative Dermatology Symposium Proceedings Pub Date : 2020-11-01 DOI:10.1016/j.jisp.2020.04.008

Dustin H. Marks , Maryanne M. Senna

引用次数: 3

Abstract

Although alopecia areata (AA) has been traditionally classified as a strictly T helper type 1–mediated process, the T helper type 2 (Th2) pathway may contribute to an AA-like phenotype in some individuals. Herein, we describe three clinical cases that support the potential role of Th2 activity through the upregulation of IL-4 and IL-13 in an AA-like phenotype.

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IL-4和IL-13在斑秃样表型中的潜在作用:临床观点

虽然斑秃(AA)传统上被严格归类为辅助性T型1介导的过程，但辅助性T型2 (Th2)途径可能在某些个体中导致AA样表型。在此，我们描述了三个临床病例，这些病例支持Th2活性通过上调IL-4和IL-13在aa样表型中的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Investigative Dermatology Symposium Proceedings 医学-皮肤病学

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期刊介绍： Journal of Investigative Dermatology Symposium Proceedings (JIDSP) publishes peer-reviewed, invited papers relevant to all aspects of cutaneous biology and skin disease. Papers in the JIDSP are often initially presented at a scientific meeting. Potential topics include biochemistry, biophysics, carcinogenesis, cellular growth and regulation, clinical research, development, epidemiology and other population-based research, extracellular matrix, genetics, immunology, melanocyte biology, microbiology, molecular and cell biology, pathology, pharmacology and percutaneous absorption, photobiology, physiology, and skin structure.