Journal of Pediatrics最新文献

{"title":"Sporotrichosis","authors":"Kevin Tran DO, Vini Vijayan MD","doi":"10.1016/j.jpeds.2024.114439","DOIUrl":"10.1016/j.jpeds.2024.114439","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114439"},"PeriodicalIF":3.9,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental Perceptions of Early Childhood In-Home Research with Monitoring: A Qualitative Study","authors":"Gabriella B. Smith BA ,&nbsp;Mickayla D. Jones MPH ,&nbsp;Mary J. Akel MPH ,&nbsp;Leonardo Barrera MPH ,&nbsp;Marie Heffernan PhD ,&nbsp;Patrick Seed MD, PhD ,&nbsp;Michelle L. Macy MD, MS ,&nbsp;Stephanie A. Fisher MD, MPH ,&nbsp;Leena B. Mithal MD, MSCI","doi":"10.1016/j.jpeds.2024.114437","DOIUrl":"10.1016/j.jpeds.2024.114437","url":null,"abstract":"<div><h3>Objective</h3><div>To explore perceptions, concerns, and enthusiasm from a diverse group of parents regarding early childhood research that involves home monitoring technologies for collecting environmental exposure data.</div></div><div><h3>Study design</h3><div>A diverse group of new and expecting parents participated in semi-structured interviews. A single interviewer conducted all sessions and introduced a hypothetical longitudinal early childhood research study, which included the following novel home monitoring approaches: (1) wearable devices, (2) audio monitoring, and (3) environmental sampling. Interviews were audio-recorded, transcribed, and coded. Qualitative description guided the study, and a constant comparative approach was used to identify themes from transcripts.</div></div><div><h3>Results</h3><div>Twenty-four interviews were completed. Emerging themes included the following: (1) Ready and Willing to Participate; (2) Helping Others, Helping Ourselves: Motivation for Participation; (3) Trust and Transparency: Understanding the “What?” and the “Why?;” (4) Data Privacy and Security: “What If It Gets into the Wrong Hands?;” and (5) It's a Lot to Juggle: Logistical Realities. Perceptions were similar across racial, ethnic, and socioeconomic groups. Perceptions were positive, and participants desired additional information about study feasibility and purpose. Many had concerns related to wearable device safety and data privacy; a trusting relationship with the research team was a priority.</div></div><div><h3>Conclusion</h3><div>Participants had positive sentiments regarding longitudinal observational studies involving pregnancy and infancy yet expressed concerns about safety, privacy, feasibility, and transparency. These findings can inform future early childhood research study design to ensure protocols are transparent, inclusive, and appealing to parents.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114437"},"PeriodicalIF":3.9,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucose Testing Methods: A Systematic Review and Meta-Analysis of Diagnostic Accuracy of Point-of-Care Devices for Neonatal Hypoglycemia","authors":"Sophie L. St Clair ,&nbsp;Caitlyn M. Ulyatt ,&nbsp;Maria T. Corkin PhD ,&nbsp;Libby G. Lord ,&nbsp;Caroline A. Crowther MD ,&nbsp;Jane E. Harding DPhil ,&nbsp;Luling Lin PhD","doi":"10.1016/j.jpeds.2024.114438","DOIUrl":"10.1016/j.jpeds.2024.114438","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the accuracy of various point-of-care device methodologies for measuring blood glucose concentrations in babies at risk of neonatal hypoglycemia.</div></div><div><h3>Study design</h3><div>This systematic review and meta-analysis included studies from Ovid MEDLINE, Ovid Embase, and Web of Science up to May 20, 2024. Studies comparing point-of-care testing methods for neonatal blood glucose to a standard laboratory method were included, excluding those on continuous glucose monitoring or conducted before 1990. Two researchers independently assessed inclusion and evaluated risk of bias using QUADAS-2. Sensitivity and specificity were calculated using contingency tables, and diagnostic accuracy was analyzed using hierarchical random-effects modelling. Studies with insufficient data were summarized by estimation direction.</div></div><div><h3>Results</h3><div>Seventy-one studies were included. The quantitative analysis (n = 31) evaluated glucose oxidase (GO) + photometry (n = 8), glucose-1-dehydrogenase (GDH) + photometry (n = 6), GO + electrochemistry (n = 13), GDH + electrochemistry (n = 12), and hexokinase (HK) + electrochemistry (n = 2). All methods showed high specificity (≥93%), with GO + electrochemistry, GDH + electrochemistry, and HK + electrochemistry showing superior sensitivity. The summary receiver operating characteristic curve confirmed HK + electrochemistry as the most accurate.</div></div><div><h3>Conclusion</h3><div>Certain point-of-care device methodologies demonstrate greater accuracy in measuring neonatal blood glucose concentrations. Of the methods evaluated, HK + electrochemistry proved to be the most reliable. However, the limited number of studies using this method suggests the need for further research to confirm these findings across diverse settings and populations.</div></div><div><h3>Systematic review registration</h3><div>PROSPERO on December 29, 2023 (CRD42023488539).</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114438"},"PeriodicalIF":3.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autism Screening Using the Parent's Observation of Social Interactions in a Large Integrated Healthcare System","authors":"Kek Khee Loo MD ,&nbsp;Su-Jau Yang PhD ,&nbsp;Jerry C. Cheng MD","doi":"10.1016/j.jpeds.2024.114434","DOIUrl":"10.1016/j.jpeds.2024.114434","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the accuracy of the Parent's Observation of Social Interactions (POSI) when deployed for universal autism screening within a large healthcare network.</div></div><div><h3>Study design</h3><div>Retrospective analysis of electronic health record data from children screened for autism spectrum disorder (ASD) using POSI at the 18- and 24- month pediatric well-child care (WCC) visits across Southern California Permanente Medical Group facilities throughout the 2022 calendar year. Data on ASD diagnoses placed in the electronic health record problem list were analyzed 1 year later (until the end of 2023) to calculate sensitivity, specificity, and positive/negative likelihood ratio (LR+ and LR−) values.</div></div><div><h3>Results</h3><div>At the 18-month WCC, 8014 of 30 375 children (26.4%) had elevated POSI scores of ≥3 (positive screen), and the sensitivity and specificity were 77.9% and 76.1%, respectively. At the 24-month WCC, 5988 children of 27 975 (21.4%) had positive POSI screens, and the sensitivity and specificity were 76.5% and 81.4%, respectively. The LR+ was 3.3 at 18 months and 4.2 at 24 months. The LR− was 0.29 at both the 18- and 24-month time points.</div></div><div><h3>Conclusions</h3><div>The POSI screen for ASD had adequate sensitivity and specificity (both &gt;76%) when systematically deployed in a primary care setting at 18- and 24-month WCC visits. Children diagnosed with ASD were 3.3 and 4.2 times more likely to have screened positive at 18 and 24 months, compared with children who were not diagnosed with ASD. Conversely, children not diagnosed with ASD were 3.4 times more likely to have screened negative than children with ASD at 18 and 24 months.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114434"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precocious Puberty in Children with Neurofibromatosis Type 1","authors":"Julia Katz MD ,&nbsp;Sarayu Ratnam MSc, PhD ,&nbsp;Robert H. Listernick MD ,&nbsp;Reema L. Habiby MD ,&nbsp;David H. Gutmann MD, PhD","doi":"10.1016/j.jpeds.2024.114440","DOIUrl":"10.1016/j.jpeds.2024.114440","url":null,"abstract":"<div><div>This multi-institutional, descriptive study of 19 children with neurofibromatosis 1 examines the link between optic pathway gliomas (OPGs) and central precocious puberty (CPP). We report that CPP can arise without OPG chiasmal involvement and that prior OPG chemotherapy does not prevent the development of CPP.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114440"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Risk Infant Developmental Outcome Is Associated with Medical Complexity and Neighborhood Opportunity","authors":"Emily N. Yeo MS ,&nbsp;Nathan D. Young BSc ,&nbsp;Joseph C. Cleveland III BS ,&nbsp;Tamara D. Simon MD, MSPH ,&nbsp;Douglas L. Vanderbilt MD, MS, MBA ,&nbsp;Juan Espinoza MD ,&nbsp;Christine B. Mirzaian MD, MPH ,&nbsp;Tanya L. Alderete PhD","doi":"10.1016/j.jpeds.2024.114433","DOIUrl":"10.1016/j.jpeds.2024.114433","url":null,"abstract":"<div><h3>Objective</h3><div>To assess how medical complexity and neighborhood opportunity jointly affect cognitive, motor, and language Bayley Scales of Infant Development. Secondary objectives involved identifying the factors contributing to developmental disparities across diverse racial and ethnic groups.</div></div><div><h3>Study design</h3><div>Electronic health records from a Southern California high-risk infant follow-up clinic were analyzed for 440 infants from 2014 through 2023 who had either had neonatal intensive care unit stays, prematurity, very low birth weight, or developmental delay risk. Medical complexity was categorized using the Pediatric Medical Complexity Algorithm into complex chronic (CC), noncomplex chronic, or nonchronic (NC). Neighborhood opportunity was assessed using the Child Opportunity Index 2.0. Developmental progress was tracked from ages 4 to 35.6 months.</div></div><div><h3>Results</h3><div>Of the cohort, 56% were male, and 67% were born prematurely, with 143 NC, 115 noncomplex chronic, and 182 CC cases. Developmental scores showed a progressive decline with increased medical complexity. Infants who were CC had lower cognitive (β = −15.20, <em>P</em> &lt; .001, 95% CI −18.75, −11.7), motor (β = −20.50, <em>P</em> &lt; .001, 95% CI −24.25, −16.8), and language scores (β = −11.88, <em>P</em> &lt; .001, 95% CI = −15.13 to −8.6) compared with infants who were NC. Lower Child Opportunity Index score was linked with decreased language scores (β = −0.07, <em>P</em> = .005, 95% CI 0.01-0.12) but not cognitive or motor scores.</div></div><div><h3>Conclusions</h3><div>In high-risk infants, the adverse effects of medical complexities on developmental outcomes exceeded those of prematurity and additionally varied according to child neighborhood opportunity.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"279 ","pages":"Article 114433"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity of Clinical Phenotypes in Severe Acute Respiratory Infections Owing to Respiratory Syncytial Virus: A Need to Look Beyond Hospitalization","authors":"Côme Horvat MD ,&nbsp;Lélia Duclaux-Loras MD ,&nbsp;Antoine Ouziel MD ,&nbsp;Marine Butin MD, PhD ,&nbsp;Sandrine Couray-Targe MD ,&nbsp;Anne-Florence Myard-Dury BSc ,&nbsp;Julie Haesebaert MD, PhD ,&nbsp;Mona Massoud MD, PhD ,&nbsp;Mehdi Benchaib MD, PhD ,&nbsp;Anne Ploin BSc ,&nbsp;Yves Gillet MD, PhD ,&nbsp;Bruno Lina MD, PhD ,&nbsp;Jean-Sebastien Casalegno MD, PhD ,&nbsp;Dominique Ploin MD, PhD","doi":"10.1016/j.jpeds.2024.114441","DOIUrl":"10.1016/j.jpeds.2024.114441","url":null,"abstract":"<div><h3>Objective</h3><div>To use a pre-COVID-19 birth cohort database to describe the clinical heterogeneity of severe acute respiratory infection (SARI) cases of the past seasons as a basis to investigate further distribution of clinical phenotypes in the era of immunization for respiratory syncytial virus (RSV).</div></div><div><h3>Study design</h3><div>Infants with RSV-SARI were identified from a 2014 through 2019 birth cohort in a tertiary care center in Lyon, France, and their medical records extensively reviewed. Using the criteria of the World Health Organization severity definitions, we classified SARI as having nutritional (inability to feed), respiratory (SpO₂ &lt;93%), or neurological (failure to respond, apneas) impairments.</div></div><div><h3>Results</h3><div>We described 3 phenotypes: nutritional impairment, respiratory impairment, and neurological (with respiratory and nutritional) impairment. Respiratory impairment could overlap with nutritional impairment, or not. There was a significant difference in age categories distribution regarding nutritional impairment (greater proportion in 1.5- to 3.0-month-olds; <em>P</em> = .01) and neurological impairment (greater proportion in &lt;1.5-month-olds; <em>P</em> = .002).</div></div><div><h3>Conclusions</h3><div>The present study highlights the presence of 3 potentially overlapping phenotypes as a new way to consider and describe RSV disease. To adapt care and healthcare policies in the RSV immunization era, it is necessary to investigate further and monitor the residual SARI burden of each phenotype.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114441"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospitalizations Following Complex Hip Surgery in Children with Intellectual Disability: A Self-Controlled Case Series Analysis","authors":"Keerthi Anpalagan BBiomedSc(Hons) ,&nbsp;Peter Jacoby MSc ,&nbsp;Katherine Stannage MBBS, FRACS ,&nbsp;Helen Leonard MBChB, MPH ,&nbsp;Katherine Langdon MBBS, FRACP, FAFRM ,&nbsp;Noula Gibson BAppSci(Physiotherapy)(Hon), MPhysiotherapy, PhD ,&nbsp;Lakshmi Nagarajan MBBS, MD, FRACP ,&nbsp;Kingsley Wong MBBS, MPH, MMedStat ,&nbsp;Jenny Downs BAppSci, GradCertPubHlth, MSc, PhD","doi":"10.1016/j.jpeds.2024.114435","DOIUrl":"10.1016/j.jpeds.2024.114435","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the associations between complex hip surgery and subsequent hospitalizations in children with intellectual disability, including a subset of children with cerebral palsy.</div></div><div><h3>Study design</h3><div>We conducted a retrospective cohort study using linked administrative, health, and disability data from Western Australia. Children born between 1983 and 2009 who underwent complex hip surgery by end 2014 were included (intellectual disability, n = 154; subset with cerebral palsy, n = 91). A self-controlled case series analysis using Poisson regression was used to estimate the age-adjusted associations of complex hip surgery on all-cause hospitalizations and when the principal diagnosis was lower respiratory tract infection or epilepsy, for periods following the individual's first major hip surgery, compared with the year before surgery.</div></div><div><h3>Results</h3><div>Age adjusted incidence of all-cause hospitalizations decreased after surgery (year 1: incidence rate ratio [IRR] 0.87 [95% CI, 0.74-1.02]; year 6: IRR 0.57 [95% CI, 0.46-0.72]). The incidence of hospitalizations for lower respiratory tract infection increased (year 1: IRR, 1.03 [95% CI, 0.72-1.51]; year 6: IRR 2.08 [95% CI, 1.18-3.68]). The incidence of hospitalizations for epilepsy decreased (year 1: IRR 0.93 [95% CI, 0.57, 1.54]; year&gt;6: IRR 0.72 [95% CI, 0.34-1.55]) after surgery. A similar pattern was observed for the subset of children with or without cerebral palsy.</div></div><div><h3>Conclusion</h3><div>Complex hip surgeries are associated with fewer hospitalizations overall but not respiratory hospitalizations for children with intellectual disability. Fewer hospitalizations suggest benefits for better musculoskeletal alignment.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114435"},"PeriodicalIF":3.9,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut Check: Addressing Gaps in Gut Microbiome Research for Infants with Congenital Heart Disease","authors":"Mary L. Galemmo","doi":"10.1016/j.jpeds.2024.114429","DOIUrl":"10.1016/j.jpeds.2024.114429","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114429"},"PeriodicalIF":3.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of a Count of Inpatient Morbidities with 2-Year Outcomes among Infants Born Extremely Preterm","authors":"Rebecca A. Dorner MD, MHS ,&nbsp;Lei Li PhD ,&nbsp;Sara B. DeMauro MD, MSCE ,&nbsp;Barbara Schmidt MD, MSc ,&nbsp;Sahar Z. Zangeneh PhD ,&nbsp;Yvonne Vaucher MD, MPH ,&nbsp;Myra H. Wyckoff MD ,&nbsp;Susan Hintz MD, MSEpi ,&nbsp;Waldemar A. Carlo MD ,&nbsp;Kathryn E. Gustafson PhD ,&nbsp;Abhik Das PhD ,&nbsp;Anup Katheria MD","doi":"10.1016/j.jpeds.2024.114428","DOIUrl":"10.1016/j.jpeds.2024.114428","url":null,"abstract":"<div><h3>Objective</h3><div>To determine if number of neonatal morbidities is associated with death or severe neurodevelopmental impairment (sNDI) among infants born extremely preterm who survived to 36 weeks’ postmenstrual age (PMA).</div></div><div><h3>Study design</h3><div>This is a retrospective cohort analysis of prospectively collected data from 15 NICHD Neonatal Research Network centers. Neonatal morbidities and 2-year outcomes were examined for 3794 infants born at 22 to 26 weeks' gestation from 2014 through 2019 who survived to 36 weeks’ PMA.</div></div><div><h3>Results</h3><div>Serious brain injury (SBI), bronchopulmonary dysplasia (BPD), and severe retinopathy of prematurity (ROP) had the strongest bivariate associations with death or sNDI (ORs, 95% CI): 3.96 (3.39, 4.64), 3.41 (2.94, 3.95), and 2.66 (2.28, 3.11)], respectively. A morbidity count variable was constructed using these morbidities. The estimated ORs and 95% CI for death or sNDI with any 1, any 2, or all 3 of these morbidities, adjusted for maternal and infant characteristics and hospital of birth, increased from 2.75 (2.25, 3.37) to 6.10 (4.83, 7.70) to 12.90 (9.07, 18.36), respectively. Corresponding rates of late death or sNDI with none, any 1, any 2, and all 3 morbidities were 12.6%, 30.3%, 51.9%, and 69.9%, respectively. The estimated logistic model produced predictions of death or sNDI with moderate discrimination (C-statistic [95% CI]: 0.765 [0.749, 0.782]) and good calibration (Intercept [CITL] = −0.004, slope = 1.026).</div></div><div><h3>Conclusions</h3><div>Among infants born extremely preterm who survived to 36 weeks’ PMA, a count of SBI, BPD, and severe ROP predicts death or sNDI.</div></div><div><h3>Trial registration</h3><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> ID Generic Database: NCT00063063.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114428"},"PeriodicalIF":3.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}