西班牙裔与极度早产婴儿结局的关系。

IF 3.9 2区医学 Q1 PEDIATRICS

Journal of Pediatrics Pub Date : 2025-01-23 DOI:10.1016/j.jpeds.2025.114474

Jane E. Brumbaugh MD , Carla M. Bann PhD , Edward F. Bell MD , Colm P. Travers MD , Betty R. Vohr MD , Elisabeth C. McGowan MD , Heidi M. Harmon MD, MS , Waldemar A. Carlo MD , Susan R. Hintz MD, MS Epi , Andrea F. Duncan MD, MS

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引用次数: 0

摘要

目的：探讨母亲种族与婴儿无重大并发症存活至出院之间的关系。研究设计：这是一项前瞻性婴儿队列的二级分析结果：14029名受试者中，2155名（15%）为西班牙裔，6116名（44%）非西班牙裔黑人，5758名（41%）非西班牙裔白人。西班牙裔母亲的婴儿无重大并发症的生存率最低（西班牙裔523/2099[25%]，非西班牙裔黑人1701/5940[29%]，非西班牙裔白人1494/5597 [27%]，p=0.002）。西班牙裔和非西班牙裔黑人婴儿无重大发病的调整生存率差异（aOR 0.80, 95% CI 0.69-0.93），但西班牙裔和非西班牙裔白人婴儿之间无差异（aOR 1.07, 95% CI 0.92-1.25）。2岁时，非西班牙裔白人母亲的儿童神经发育障碍发生率最低（西班牙裔544/1235[44%]，非西班牙裔黑人1574/3482[45%]，非西班牙裔白人1004/3182[32%]）。结论：在一个多中心队列中，西班牙裔母亲的婴儿存活至出院无重大疾病的几率低于非西班牙裔黑人母亲的婴儿，与非西班牙裔白人母亲的婴儿存活无重大疾病的几率相似。

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The Relationship Between Hispanic Ethnicity and Outcomes for Infants Born Extremely Preterm

Objective

To characterize the association between maternal ethnicity and infant survival to discharge without major morbidity.

Study design

This is secondary analysis of a prospective cohort of infants born <27 weeks of gestation at National Institute of Child Health and Human Development Neonatal Research Network centers from 2006 through 2020. The primary outcome was survival to discharge without major morbidity (sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia grade 3, intracranial hemorrhage grade ≥3, periventricular leukomalacia, and advanced retinopathy of prematurity). Outcomes were compared by ethnicity and adjusted for center, perinatal characteristics, and sociodemographic characteristics.

Results

Of 14 029 subjects, 2155 (15%) were Hispanic, 6116 (44%) non-Hispanic Black, and 5758 (41%) non-Hispanic White. Infants of Hispanic mothers had the lowest survival to discharge without major morbidity (Hispanic 523/2099 [25%], non-Hispanic Black 1701/5940 [29%], non-Hispanic White 1494/5597 [27%], P = .002). Adjusted odds of survival without major morbidity differed between Hispanic and non-Hispanic Black (adjusted odds ratio [aOR] 0.80, 95% CI 0.69-0.93), but not between Hispanic and non-Hispanic White infants (aOR 1.07, 95% CI 0.92-1.25). At 2 years, children of non-Hispanic White mothers had the lowest incidence of neurodevelopmental impairment (Hispanic 544/1235 [44%], non-Hispanic Black 1574/3482 [45%], and non-Hispanic White 1004/3182 [32%], P < .001). Odds of impairment were greater for Hispanic than non-Hispanic White children (aOR 1.25, 95% CI 1.05-1.48) but did not differ between Hispanic and non-Hispanic Black children (aOR 0.88, 95% CI 0.74-1.04).

Conclusions

In a multicenter cohort, infants of Hispanic mothers had lower odds of survival to discharge without major morbidity than infants of non-Hispanic Black mothers and similar odds of survival without major morbidity as infants of non-Hispanic White mothers.

ClinicalTrials.gov ID

Generic Database: NCT00063063.

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来源期刊

Journal of Pediatrics 医学-小儿科

CiteScore

6.00

自引率

2.00%

发文量

696

审稿时长

31 days

期刊介绍： The Journal of Pediatrics is an international peer-reviewed journal that advances pediatric research and serves as a practical guide for pediatricians who manage health and diagnose and treat disorders in infants, children, and adolescents. The Journal publishes original work based on standards of excellence and expert review. The Journal seeks to publish high quality original articles that are immediately applicable to practice (basic science, translational research, evidence-based medicine), brief clinical and laboratory case reports, medical progress, expert commentary, grand rounds, insightful editorials, “classic” physical examinations, and novel insights into clinical and academic pediatric medicine related to every aspect of child health. Published monthly since 1932, The Journal of Pediatrics continues to promote the latest developments in pediatric medicine, child health, policy, and advocacy. Topics covered in The Journal of Pediatrics include, but are not limited to: General Pediatrics Pediatric Subspecialties Adolescent Medicine Allergy and Immunology Cardiology Critical Care Medicine Developmental-Behavioral Medicine Endocrinology Gastroenterology Hematology-Oncology Infectious Diseases Neonatal-Perinatal Medicine Nephrology Neurology Emergency Medicine Pulmonology Rheumatology Genetics Ethics Health Service Research Pediatric Hospitalist Medicine.