Journal of Pediatrics最新文献

{"title":"Recovery from Pediatric Inflammatory Multisystem Syndrome Temporally-Associated with SARS-CoV-2: Follow-Up from a Nationwide German Cohort.","authors":"Florens Lohrmann, Markus Hufnagel, Maren Doenhardt, Natalie Diffloth, Sarah Christina Goretzki, Christian Dohna-Schwake, Stefan Arens, Juergen Brunner, Katja Reineker, Delphina Gomes, Jakob Armann, Reinhard Berner, André Jakob","doi":"10.1016/j.jpeds.2025.114716","DOIUrl":"10.1016/j.jpeds.2025.114716","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the intermediate-term health impacts of pediatric inflammatory multisystem syndrome temporally-associated with SARS-CoV-2 (PIMS-TS).</p><p><strong>Study design: </strong>Using a standardized questionnaire in a multicenter study, follow-up data from acute PIMS-TS patients were collected, including detailed information on patient characteristics, clinical progression, laboratory findings, imaging results, and outcomes. These follow-up data were then linked to data from the patients' acute-phase PIMS disease, as recorded in the German (and Innsbruck, Austria) PIMS-TS registry.</p><p><strong>Results: </strong>Of the 920 cases originally documented in the acute-phase PIMS-TS registry, follow-up data were collected from 6 pediatric centers on 127 patients; 81 patients were male. Mean age during the acute phase was 8 years (SD: 4.4 years). Median follow-up time was 125 days (IQR: 50.5 to 290.5 days). Overall, a majority of patients achieved full recovery, with 81/127 doing so even before their first follow-up visit. However, abnormal echocardiographic findings continued in 18/67 patients. Coronary dilatation persisted in 14/33 (42%) and resolved in all but 3. Residual cardiovascular and general symptoms were more frequent in older children, as well as among those who had required intensive care unit treatment during the acute phase.</p><p><strong>Conclusion: </strong>Our findings confirm the generally favorable intermediate-term outcome in patients with PIMS-TS. However, a subset of patients in our cohort, particularly older children and those requiring intensive care unit care during the acute phase, experienced prolonged symptoms, especially cardiovascular complications. Close follow-up and multidisciplinary care are recommended in order to monitor these patients' recovery.</p>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114716"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Expert Vocabulary Usage Patterns Between Mental Health and Nonmental Health Clinicians When Diagnosing Pediatric Anxiety Disorders.","authors":"Mayanka Chandrashekar, Jordan Tschida, Jeffrey R Strawn, Heidi A Hanson, Daniel Santel, Ian Goethert, Anuj J Kapadia, Tracy Glauser, John Pestian, Greeshma A Agasthya","doi":"10.1016/j.jpeds.2025.114735","DOIUrl":"10.1016/j.jpeds.2025.114735","url":null,"abstract":"<p><strong>Objective: </strong>To compare the utilization patterns of expert vocabulary (EVo) in diagnosing pediatric anxiety between mental health and non-mental health clinical notes from electronic health records to understand the role of Evo in informing classification and decision-making in anxiety diagnoses.</p><p><strong>Study design: </strong>We conducted a retrospective study using a cohort less than age 25 from Cincinnati Children's Hospital including 897 685 patients with 61 586 446 notes. We analyzed EVo, collected from mental health clinicians, in both mental and nonmental health notes. We compared classification accuracy using EVo-based patient-level embedding from all clinical notes, mental-health notes, and nonmental health notes for 2 tasks: 1) pre-vs postdiagnosis anxiety patients, and 2) prediagnosis anxiety vs nonanxiety patients.</p><p><strong>Results: </strong>EVo usage was highest in prediagnosis anxiety, lower in nonanxiety, and lowest in post-diagnosis. Classification models using EVo features from all, mental-health, and non-mental health notes showed similar F1 scores for prediagnosis anxiety (0.70 ± 0.2 for 2 categories). For anxiety vs nonanxiety classification, all clinical and nonmental health notes had better F1 scores than mental-health notes (above 0.90 for 3 categories). There was a notable difference in class-wise performance across both tasks.</p><p><strong>Conclusions: </strong>There are significant differences in anxiety EVo use between mental health and nonmental health clinicians. Despite less anxiety-specific terminology, non-mental health notes still captured key aspects of patient presentations, emphasizing the importance of including all clinicians' notes in analysis. EVo's utility for anxiety classification is most effective in prediagnostic phases, suggesting the need for a dedicated diagnostic lexicon and further study before incorporating EVo into classification models.</p>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114735"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse Effects on Child Health from United States Retrenchment on Global Scientific Collaboration: Examples from Gastroenterology, Hepatology, and Nutrition.","authors":"Christopher P Duggan","doi":"10.1016/j.jpeds.2025.114744","DOIUrl":"10.1016/j.jpeds.2025.114744","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114744"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Chloe Gao, Donald Szlosek, Anthony Zhong, Scott E Hadland, Sarah S Benes","doi":"10.1016/j.jpeds.2025.114846","DOIUrl":"https://doi.org/10.1016/j.jpeds.2025.114846","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114846"},"PeriodicalIF":3.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The European Vaccination Challenge: Stemming the Resurgence of Vaccine-Preventable Diseases.","authors":"Eli Somekh, Joseph Haddad, Donjeta Bali, Ida Giardino, Mehmet Vural, Esra Sevketoglu, Tudor Lucian Pop, Maria Pastore, Massimo Pettoello-Mantovani","doi":"10.1016/j.jpeds.2025.114844","DOIUrl":"https://doi.org/10.1016/j.jpeds.2025.114844","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114844"},"PeriodicalIF":3.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing the Financial Divide: A Net Present Value Analysis of Lifetime Earnings in Academic vs Private Practice Neonatology.","authors":"Ankita Shukla, Amna Qasim, Lubaina Ehsan, Vikas Chowdhary, Joshua Daily","doi":"10.1016/j.jpeds.2025.114843","DOIUrl":"https://doi.org/10.1016/j.jpeds.2025.114843","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114843"},"PeriodicalIF":3.5,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145276628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Maire A Conrad, Melissa Crawford, Sonia Michail, Maribeth Nicholson, Suchitra Hourigan, Judith R Kelsen, Stacy A Kahn","doi":"10.1016/j.jpeds.2025.114841","DOIUrl":"https://doi.org/10.1016/j.jpeds.2025.114841","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114841"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S0022-3476(25)00359-2","DOIUrl":"10.1016/S0022-3476(25)00359-2","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"286 ","pages":"Article 114818"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Fidaxomicin on the Microbiome in Pediatric Clostridioides Difficile Infection: Proposal of a Microbiota-Sparing Metric.","authors":"Xinya Dai, Yun Chen, Songlin Fang","doi":"10.1016/j.jpeds.2025.114842","DOIUrl":"https://doi.org/10.1016/j.jpeds.2025.114842","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114842"},"PeriodicalIF":3.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of the ICD-10 Code Z51.5 for Identifying Subspecialty Pediatric Palliative Care.","authors":"Sarah W Goldberg, Tara Jamieson, Abby R Rosenberg, Chelsea Heneghan, SoYun Kwan, Emily E Johnston, Katie M Moynihan","doi":"10.1016/j.jpeds.2025.114836","DOIUrl":"https://doi.org/10.1016/j.jpeds.2025.114836","url":null,"abstract":"<p><p>We evaluated accuracy of ICD-10 code Z51.5 in identifying subspecialty pediatric palliative care (SPPC) among decedents at a single center. The code showed excellent sensitivity (98.6%) and specificity (87.8%) for SPPC involvement. Z51.5 is a reliable proxy for SPPC in administrative data, supporting utility in pediatric research on end-of-life outcomes.</p>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114836"},"PeriodicalIF":3.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}