Journal of Pediatrics最新文献

A Rising Tide Lifts all Boats: The Role of the Subspecialist in Recruitment into Pediatrics. 水涨船高：儿科专科医生在招聘中的作用。

IF 3.5 2区医学

Journal of Pediatrics Pub Date : 2025-07-28 DOI: 10.1016/j.jpeds.2025.114757

YoungNa Lee-Kim, Lisa DelSignore, Nicholas J Antos, Christie L Morse, Stacey J Kruger, Lisa S Topor, Miriah Gillispie-Taylor, Lindsay C Johnston, Gary L Beck Dallaghan, Scott H James, Mary E Moffatt, Cary G Sauer, Patrick Myers, Angela Myers, Laura Degnon, Pnina Weiss

引用次数: 0

Can RESPiratory Hospital Admissions in Children with Cerebral Palsy Be Reduced? A Feasibility Randomized Controlled Trial (RESP-ACT). 脑瘫患儿呼吸系统住院率能降低吗？可行性随机对照试验（respa - act）。

IF 3.9 2区医学

Journal of Pediatrics Pub Date : 2025-07-24 DOI: 10.1016/j.jpeds.2025.114755

Rachael M Marpole, A Marie Blackmore, Andrew C Wilson, Monica S Cooper, Julie Depiazzi, Katherine Langdon, Lisa Moshovis, Asha C Bowen, Noula Gibson

{"title":"Can RESPiratory Hospital Admissions in Children with Cerebral Palsy Be Reduced? A Feasibility Randomized Controlled Trial (RESP-ACT).","authors":"Rachael M Marpole, A Marie Blackmore, Andrew C Wilson, Monica S Cooper, Julie Depiazzi, Katherine Langdon, Lisa Moshovis, Asha C Bowen, Noula Gibson","doi":"10.1016/j.jpeds.2025.114755","DOIUrl":"https://doi.org/10.1016/j.jpeds.2025.114755","url":null,"abstract":"Objective: To investigate the feasibility of implementing recommendations of the consensus statement for the Prevention and Management of Respiratory Disease in children with severe cerebral palsy (CP) via RESPiratory hospital Admissions in children with cerebral palsy: a feasibility randomized Controlled Trial (RESP-ACT).Study design: Twenty-two children with CP aged 0-12 years at risk of respiratory disease and receiving care through Perth Children's Hospital in Western Australia were randomized into parallel groups. The control group (n=10) continued with their usual teams, while the intervention group (n=12) received a comprehensive assessment followed by individualized investigations and appointments as needed. The primary outcomes include implementation, acceptability, practicality, and measuring efficacy. During the following year, with the help of a blind assessor, caregivers reported their children's health service use on a fortnightly basis. Caregivers and treating clinicians were interviewed at the end of the trial.Results: Complete data were obtained from 73% of participants at 1 year. They completed 89% of the fortnightly surveys. Hospital service data were assessed for all. The 9 intervention participants interviewed at the end of the trial were satisfied or very satisfied with the service, and all caregivers and clinicians agreed or strongly agreed that such a service should be established. Their practical concerns included managing time, preference for home-based interventions and adequate staffing.Conclusions: The service is feasible to implement but requires close monitoring. This trial provides data on which to base a larger randomized control trial.","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114755"},"PeriodicalIF":3.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severity of Bronchopulmonary Dysplasia in Infants Born Extremely Preterm and Randomized to Early Human Milk Fortification with a Donor Milk-Derived Fortifier for Two Weeks. 极度早产婴儿支气管肺发育不良的严重程度，随机选择两周的早期母乳强化和供体乳来源的强化剂。

IF 3.9 2区医学

Journal of Pediatrics Pub Date : 2025-07-24 DOI: 10.1016/j.jpeds.2025.114750

Marley J Tucker, Seabrook H Jeffcoat, Tori Argent, Colm P Travers, Ariel A Salas

引用次数: 0

Early Vitamin D Supplementation in Infants Born Extremely Preterm and Fed Human Milk: A Randomized Controlled Trial. 早产儿早期补充维生素D和母乳喂养：一项随机对照试验。

IF 3.5 2区医学

Journal of Pediatrics Pub Date : 2025-07-24 DOI: 10.1016/j.jpeds.2025.114754

Ariel A Salas, Tori Argent, Seabrook Jeffcoat, Marley Tucker, Ambika P Ashraf, Colm P Travers

{"title":"Early Vitamin D Supplementation in Infants Born Extremely Preterm and Fed Human Milk: A Randomized Controlled Trial.","authors":"Ariel A Salas, Tori Argent, Seabrook Jeffcoat, Marley Tucker, Ambika P Ashraf, Colm P Travers","doi":"10.1016/j.jpeds.2025.114754","DOIUrl":"10.1016/j.jpeds.2025.114754","url":null,"abstract":"Objective: To evaluate the effects of vitamin D supplementation on short-term respiratory outcomes in infants born at 28 weeks of gestation or less and fed human milk.Study design: This masked, randomized controlled trial included infants born extremely preterm and fed human milk in 2023-2024. Infants received either 800 IU/day vitamin D (intervention) or no additional vitamin D (control) for the first 14 days. Masking was maintained by adding 800 IU of vitamin D to daily feedings. The primary outcome was severity of bronchopulmonary dysplasia (BPD) at 36 weeks of postmenstrual age (PMA). Secondary outcomes included reactance (AX) and resistance (R7-19) measurements, obtained using impulse oscillometry at 36 weeks PMA, and metabolic bone disease (alkaline phosphatase >500 IU/L and phosphorus <5.5 mg/dL) at postnatal day 28.Results: A total of 126 infants were randomized (mean birthweight: 759±228 g; 52% female). The intervention increased 25-hydroxy vitamin D3 concentrations (mean difference: +29 ng/mL; P <0.0001). The severity of BPD did not differ between groups (p=0.60). AX measurements were comparable (674±207 vs 694±240; p=0.64) and R7-19 measurements were not significantly lower in the intervention group (23±8 vs 25±9; p=0.18). On postnatal day 28, the lower risk of metabolic bone disease observed in the intervention group did not reach statistical significance (9% vs 20%; RR: 0.43; 95% CI: 0.16, 1.15; p=0.08). No serious adverse events related to the intervention were reported.Conclusion: Administering 800 IU/day of vitamin D during the first 2 weeks did not reduce BPD severity but may contribute to improved bone health.","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114754"},"PeriodicalIF":3.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resilience in Young Adults with Congenital Heart Disease in Relation to Neurodevelopment in the Preschool Period. 青少年先天性心脏病患者的恢复力与学龄前神经发育的关系

IF 3.9 2区医学

Journal of Pediatrics Pub Date : 2025-07-24 DOI: 10.1016/j.jpeds.2025.114752

Tyler Kuni, Alana Cianciulli, Richard F Ittenbach, Gabrielle Combs, Isabel Randazzo, Daniel J Licht, Lyla Hampton, Marsha Gerdes, Judy Bernbaum, J William Gaynor, Nancy Burnham

{"title":"Resilience in Young Adults with Congenital Heart Disease in Relation to Neurodevelopment in the Preschool Period.","authors":"Tyler Kuni, Alana Cianciulli, Richard F Ittenbach, Gabrielle Combs, Isabel Randazzo, Daniel J Licht, Lyla Hampton, Marsha Gerdes, Judy Bernbaum, J William Gaynor, Nancy Burnham","doi":"10.1016/j.jpeds.2025.114752","DOIUrl":"https://doi.org/10.1016/j.jpeds.2025.114752","url":null,"abstract":"Objective: To determine if resilience among young adults with congenital heart disease (CHD) is associated with patient characteristics and neurobehavioral status during the preschool period.Study design: This study is a prospective, cross-sectional analysis of young adults enrolled in a longitudinal study of neurodevelopmental outcomes in CHD. All subjects underwent surgery with CPB (cardiopulmonary bypass) at age ≤6 months of life. Resilience and general health status were evaluated using standardized questionnaires (RS-14 and SF-36, respectively). The relationships between resilience and patient and management factors as well as neurobehavioral status in the preschool period were examined.Results: The RS-14 and SF-36 were completed by 200 subjects (average age 20.1, IQR 19.2, 21.3 years). Median resilience score was 81.0 (CL0.95 78, 82), higher than the population average of 76.0 (p = 0.014). Higher resilience scores were correlated with higher health-related quality of life (HRQOL) scores (r = 0.506, p < 0.001). Better executive function (p = 0.032) and social skills (p = 0.004) at the 4-year evaluation were associated with higher resilience in young adulthood. Inattention (p = 0.015) and pervasive development problems (p = 0.020) were inversely associated with resilience. No demographic, patient-related, or operative management factors were associated with higher or lower resilience (all p > 0.223).Conclusions: Findings reported here show an association between preschool neurobehavioral status, overall HRQOL, and resilience in young adulthood. Identification of an at-risk population may provide an opportunity for intervention early in life, leading to improved psychosocial development with increased resilience.","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114752"},"PeriodicalIF":3.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body Mass Index Trajectory in Children with Kawasaki Disease. 川崎病儿童的身体质量指数轨迹

IF 3.9 2区医学

Journal of Pediatrics Pub Date : 2025-07-24 DOI: 10.1016/j.jpeds.2025.114749

Jessica Laird-Gion, Kimberlee Gauvreau, Annette Baker, Tom Giorgio, Jane W Newburger, Lauren S Crafts, Audrey Dionne, Mary Beth Son, Sarah D de Ferranti

引用次数: 0

Gestational Diabetes Mellitus and School-Age Cognitive and Health Outcomes in New Zealand: a Matched Cohort Study. 新西兰妊娠期糖尿病与学龄认知和健康结局：一项匹配队列研究

IF 3.9 2区医学

Journal of Pediatrics Pub Date : 2025-07-24 DOI: 10.1016/j.jpeds.2025.114756

J A Alsweiler, F Amitrano, J E Harding, C A Crowther, G T L Brown, A Cavadino, C J D McKinlay

{"title":"Gestational Diabetes Mellitus and School-Age Cognitive and Health Outcomes in New Zealand: a Matched Cohort Study.","authors":"J A Alsweiler, F Amitrano, J E Harding, C A Crowther, G T L Brown, A Cavadino, C J D McKinlay","doi":"10.1016/j.jpeds.2025.114756","DOIUrl":"https://doi.org/10.1016/j.jpeds.2025.114756","url":null,"abstract":"Objective: To determine if children exposed in utero to gestational diabetes mellitus (GDM) have poorer school-age neurocognitive and cardiometabolic function than matched children not exposed to GDM.Study design: In a matched, cohort study, we compared 186 children of women diagnosed with GDM from a trial cohort with 186 children born at the same hospital whose mothers did not have GDM, matched for child sex, maternal body mass index (BMI), ethnicity, socio-economic status, and gestational age. Both GDM-exposed and nonGDM-exposed children were assessed at 6-7 years' corrected age for neurocognitive function (NIH Toolbox), numeracy (Checkout Game), body composition, and peripheral/central blood pressure. The primary outcome was the Composite Cognitive Standard Score. Analysis was by generalized linear models, adjusted for matching criteria; exposure effects were estimated as odds ratio (OR) or mean difference (MD), with 95% confidence intervals(CI).Results: Exposure groups were similar for birthweight z-score, corrected age at assessment, matching criteria, and hypertensive disorders of pregnancy. There was no difference between groups in mean[SD] cognitive score (104[15] vs 104[15]; MD=2[-2,5]) or its components. GDM-exposed children were less likely to have motor impairment (6% vs 11%, aRD=-6[-11,-1] but more likely to have low numeracy (10% v 4%, aRD=6[2,11]) and hypertension (14% vs 6%, aRD=8[1,14]), and had higher mean[SD] BMI z-scores (0·95[1·61] vs 0·51[1·50], MD=0·39[0·13,0·65]).Conclusions: Children exposed to GDM are not at increased risk of poorer school-age cognitive function compared with controls matched for potential confounders. However, GDM exposure was associated with increased childhood BMI and hypertension, which may affect subsequent cardiometabolic health.","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114756"},"PeriodicalIF":3.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bothersome and Impactful Health Conditions in Children and Adolescents with Down Syndrome. 患有唐氏综合症的儿童和青少年的烦人和有影响的健康状况。

IF 3.9 2区医学

Journal of Pediatrics Pub Date : 2025-07-23 DOI: 10.1016/j.jpeds.2025.114748

Mary Witt, Michelle Palumbo, Stephanie L Santoro

{"title":"Bothersome and Impactful Health Conditions in Children and Adolescents with Down Syndrome.","authors":"Mary Witt, Michelle Palumbo, Stephanie L Santoro","doi":"10.1016/j.jpeds.2025.114748","DOIUrl":"https://doi.org/10.1016/j.jpeds.2025.114748","url":null,"abstract":"Objective: To summarize our results regarding how physical and mental health affect or bother children and adolescents with Down syndrome (DS) and to explore the relationship between impactful or bothersome items and participants' overall health.Study design: We surveyed caregivers of individuals aged 0-21 with DS about the aspects of physical health (including communication, hearing, vision, muscle tone, mobility, sleep, genitourinary concerns, and pain) and mental health (including behavior, self-talk, and problem solving) that bother and affect individuals with DS and summarized their responses. We compared the differences in sleep impacts between those with and without sleep apnea through chi square analysis. Spearman correlations were conducted to determine the association between our bother and impact items and total health scores on the DS Health Measure.Result: We received 542 complete survey responses from a nationally-represented sample. Physical and mental health impacted children and adolescents with DS at varied rates. Those with sleep apnea experienced negative impacts of sleep more frequently than those without. Thirty-four of our bother and impact items correlated significantly with total health scores.Conclusions: Many factors influenced some children and adolescents with DS, but most were not highly impactful. Although the bothersome and impactful aspects of physical and mental health were variable in our cohort, many correlated with overall health.","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114748"},"PeriodicalIF":3.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal Mental Health and Emergency Department Visits for Infants Born Preterm and Enrolled in a Transition Home Program Before and During the COVID-19 Pandemic. 在COVID-19大流行之前和期间，对早产婴儿和参加过渡家庭计划的婴儿的孕产妇心理健康和急诊就诊。

IF 3.9 2区医学

Journal of Pediatrics Pub Date : 2025-07-23 DOI: 10.1016/j.jpeds.2025.114753

Julia Mayne, Katheleen Hawes, Elisabeth C McGowan, Richard Tucker, Betty R Vohr

{"title":"Maternal Mental Health and Emergency Department Visits for Infants Born Preterm and Enrolled in a Transition Home Program Before and During the COVID-19 Pandemic.","authors":"Julia Mayne, Katheleen Hawes, Elisabeth C McGowan, Richard Tucker, Betty R Vohr","doi":"10.1016/j.jpeds.2025.114753","DOIUrl":"https://doi.org/10.1016/j.jpeds.2025.114753","url":null,"abstract":"Objective: To determine the association between maternal mental health (MMH) disorders before and during COVID-19 and infant emergency department (ED) visits one- and three-months post-NICU discharge among infants in a transition home program (THP).Study design: Retrospective analysis of a publicly insured neonatal intensive care unit (NICU) mother-infant dyad cohort enrolled in a THP. Groups were stratified to pre-COVID-19 pandemic (January 1, 2017-March 10, 2020) and COVID-19 pandemic (March 11, 2020-December 31, 2022). Contacts between THP families, social workers, and medical staff via phone and in-person visits were analyzed relative to ED visits and rehospitalizations. Regression models estimating effects of MMH on ED visit rates were examined.Results: Rates of MMH disorders trended upwards between time periods but did not reach significance. Maternal characteristics were similar between time periods, yet infant birth weight was higher during COVID-19. Overall, ED visits decreased during COVID-19 for the total cohort. THP in-person visits for the total cohort decreased during COVID-19 whereas phone contacts remained unchanged. However, for infants with an ED visit during COVID-19, phone and in-person THP visits increased. In regression models, MMH disorder was associated with higher odds of ED visits ≤ 1 month of discharge (OR 2.34, CI 1.11-4.91).Conclusions: Over the entire study period, infants of mothers with MMH disorders had more ED visits ≤ 1 month of discharge compared with infants from women without a MMH disorder. THP staff responded with increased phone and in-person contacts to support mother-infant dyads for those who had an ED visit during both time periods.","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114753"},"PeriodicalIF":3.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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IF 3.9 2区医学

Journal of Pediatrics Pub Date : 2025-07-23 DOI: 10.1016/j.jpeds.2025.114732

Satyan Lakshminrusimha, Jacqueline Hoffman, Colleen R Moss

引用次数: 0