Journal of Pediatrics最新文献

{"title":"Increasing Incidence of Serious Head and Neck Infections among Children in the United States, 2018-2023","authors":"Serena Yun-Chen Tsai MD, MMSc ,&nbsp;Stephanie Hadley MD ,&nbsp;Amanda S. Growdon MD ,&nbsp;Kevin Sheng-Kai Ma DDS, FRSPH, FRSM ,&nbsp;Jonathan M. Mansbach MD, MPH","doi":"10.1016/j.jpeds.2024.114458","DOIUrl":"10.1016/j.jpeds.2024.114458","url":null,"abstract":"<div><div>There has been a significant, postpandemic increase in the incidence of serious head and neck infections among children aged &lt;18 years since 2021, compared with the stable incidence of nontransmissible osteomyelitis and serious head and neck infections in adults from 2018 to 2023. The etiology of this increase requires further study.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"279 ","pages":"Article 114458"},"PeriodicalIF":3.9,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Patent Ductus Arteriosus Management and Outcomes in Infants Born at 26-28 Weeks’ Gestation","authors":"Dinushan C. Kaluarachchi MBBS ,&nbsp;Matthew A. Rysavy MD, PhD ,&nbsp;Barbara T. Do MSPH ,&nbsp;Valerie Y. Chock MD, Ms Epi ,&nbsp;Matthew M. Laughon MD, MPH ,&nbsp;Carl H. Backes MD ,&nbsp;Tarah T. Colaizy MD, MPH ,&nbsp;Edward F. Bell MD ,&nbsp;Patrick J. McNamara MB BCh, BAO, MSc","doi":"10.1016/j.jpeds.2024.114456","DOIUrl":"10.1016/j.jpeds.2024.114456","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association between the secular decrease in treatment of patent ductus arteriosus (PDA) and trends in neonatal mortality and morbidity in infants born at 26 0/7-28 6/7 weeks’ gestation.</div></div><div><h3>Study design</h3><div>A retrospective cohort study including infants born between 2012 and 2021 in continually participating hospitals in the National Institute of Child Health and Human Development Neonatal Research Network. The primary composite outcome was defined as surgical necrotizing enterocolitis, grade 2-3 bronchopulmonary dysplasia (BPD), severe intraventricular hemorrhage, or death. Relationships of temporal trends in PDA treatment with the primary composite outcome and its components were analyzed using a multilevel model accounting for patient-level factors. A separate analysis assessed these relationships stratified by hospital changes in PDA treatment.</div></div><div><h3>Results</h3><div>The study included 7864 infants. There was a decrease in any PDA treatment from 21% to 16% (<em>P</em> &lt; .01) and an increase in the primary composite outcome from 24% to 36% (<em>P</em> &lt; .01). Change in the primary outcome was driven by increased grade 2-3 BPD (13%-26%, <em>P</em> &lt; .01), with grade 2 BPD accounting for most of this increase (10%-22%, <em>P</em> &lt; .01). Temporal decreases in PDA treatment were associated with increases in the primary outcome and grade 2-3 BPD after adjusting for patient-level factors (<em>P</em> &lt; .01). However, stratified analyses showed that grade 2-3 BPD increased in all hospital groups, regardless of changes in PDA management.</div></div><div><h3>Conclusions</h3><div>From 2012 to 2021, temporal decreases in PDA treatment for infants 26-28 weeks were associated with an increase in grade 2-3 BPD. However, caution is warranted in determining causality. Reasons for increased grade 2-3 BPD during the past decade warrant investigation.</div></div><div><h3>Trial registration</h3><div>Generic Database: NCT00063063.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"279 ","pages":"Article 114456"},"PeriodicalIF":3.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating Resistance and Adaptation in Health Care: How Pediatricians Can Balance Transformation and Children’s Needs","authors":"Massimo Pettoello-Mantovani MD, PhD ,&nbsp;Donjeta Bali MD ,&nbsp;Ida Giardino MD ,&nbsp;Mehmet Vural MD ,&nbsp;Flavia Indrio MD ,&nbsp;Giuseppe Buonocore MD ,&nbsp;Maria Pastore MD","doi":"10.1016/j.jpeds.2024.114446","DOIUrl":"10.1016/j.jpeds.2024.114446","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114446"},"PeriodicalIF":3.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Milking of the Cut Cord During Stabilization of Infants Born Very Premature: A Randomized Controlled Trial","authors":"Walid El-Naggar MD ,&nbsp;Souvik Mitra MD ,&nbsp;Jayani Abeysekera MD ,&nbsp;Tim Disher PhD ,&nbsp;Christy Woolcott PhD ,&nbsp;Tara Hatfield RN ,&nbsp;Douglas McMillan MD ,&nbsp;Jon Dorling MD","doi":"10.1016/j.jpeds.2024.114444","DOIUrl":"10.1016/j.jpeds.2024.114444","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the feasibility of cut-umbilical cord milking (C-UCM) during stabilization of preterm infants after birth.</div></div><div><h3>Study design</h3><div>This was a pilot randomized controlled trial of initial resuscitation. Infants born to eligible, consenting women presenting in preterm labor at &lt;32 weeks’ gestation were randomized to receive either the standard practice of deferred cord clamping (DCC) for 30-60 seconds at birth or C-UCM while supporting breathing and following 30 seconds of DCC. The primary outcome was feasibility in terms of percentage recruitment, intervention compliance, safety, and study completion. Short-term clinical outcomes were collected. Analysis was by intention to treat.</div></div><div><h3>Results</h3><div>Of the 133 pregnant women approached, 93 consented to participate (70%). Fifty infants delivered &lt;32 weeks’ gestation were randomized to either C-UCM (25) or DCC (25). Baseline characteristics of infants were similar. All participants completed the study. One infant in the C-UCM group and 5 infants in the DCC group did not receive the allocated intervention. Median (IQR) time to cord milking was 62 (54, 99) seconds and median (IQR) length of the cut-cord milked was 20 (14, 29) cm. C-UCM was not associated with increased adverse effects compared with DCC.</div></div><div><h3>Conclusion</h3><div>Milking of the long-cut cord after 30 seconds of DCC while supporting breathing was feasible and not associated with significant adverse effects. A larger randomized controlled trial is required to assess the efficacy and safety of this approach on clinical outcomes. C-UCM may be especially useful in situations when DCC is not feasible.</div></div><div><h3>Trial registration</h3><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>: <span><span>NCT03852134</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114444"},"PeriodicalIF":3.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual-, Hospital-, and Community-Level Factors Associated with Sudden Unexpected Infant Death Among Infants Born Preterm in 5 US States","authors":"Sunah S. Hwang MD, MPH, PhD ,&nbsp;Stephanie L. Bourque MD, MSCS ,&nbsp;Kathleen E. Hannan MD, MSCS ,&nbsp;Molly Passarella MS ,&nbsp;Joshua Radack ,&nbsp;Brielle Formanowski ,&nbsp;Scott A. Lorch MD, MSCE","doi":"10.1016/j.jpeds.2024.114445","DOIUrl":"10.1016/j.jpeds.2024.114445","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate individual-, hospital-, and community-level factors associated with sudden unexpected infant death (SUID) among infants born preterm.</div></div><div><h3>Study design</h3><div>The following linked dataset from 5 states (California, Michigan, Oregon, Pennsylvania, and South Carolina) from 2005 through 2020 was used: (1) infant birth and death certificates; (2) maternal and infant birth hospitalization discharge records; (3) birthing hospital data from the American Hospital Association; and (4) community-level data from the Social Vulnerability Index (SVI).) Multivariable models were used to assess the independent association between these multilevel factors and SUID, adjusting for several maternal and infant characteristics.</div></div><div><h3>Results</h3><div>Overall, we found that maternal demographic factors (race and ethnicity, education, insurance) and infant gestational age were significant predictors of SUID. There was no difference in SUID odds by state, urban influence code, and maternal complications of pregnancy. Compared with mothers who lived in areas with the lowest SVI, those who resided in the highest SVI were more likely to experience SUID. There was no difference in SUID odds between infants who did or did not experience one or more complications of prematurity. For hospital-level factors, there was no difference in SUID odds among infants cared for in teaching vs nonteaching hospitals or in low vs high volume preterm birth hospitals.</div></div><div><h3>Conclusion</h3><div>Individual- and community-level factors were associated with SUID among infants born preterm. The neonatal intensive care unit hospitalization may provide a critical window of opportunity to engage families about SUID-risk reducing practices.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114445"},"PeriodicalIF":3.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Access to Pediatric Bed Capacity According to Social Determinants of Health: All Beds Are Not Created Equal","authors":"Thomas A. Hegland PhD ,&nbsp;R. Thomas Day MD ,&nbsp;Katie M. Moynihan MBBS","doi":"10.1016/j.jpeds.2024.114447","DOIUrl":"10.1016/j.jpeds.2024.114447","url":null,"abstract":"<div><h3>Objective</h3><div>To study pediatric inpatient hospital capacity and resources, characterizing differences according to Social Determinants of Health (SDoH) using market share techniques.</div></div><div><h3>Study design</h3><div>This cross-sectional study uses nonelective inpatient discharges (≥1 month to ≤19 years) from Healthcare Cost and Utilization Project and American Hospital Association surveys to derive hospital capacity and resources/capability. We include US hospitals with ≥1 pediatric bed and ≥1 pediatric discharge and calculate per bed capital, expenditure, and staffing, transfer rates, payer-mix, and adjusted central line-associated blood stream infection rate. We utilize actual discharge data to improve upon traditional geospatial access analyses that assume all patients receive care close to home. SDoH are derived from American Community Survey measures (family income, race and ethnicity, and urban vs rural) and Child Opportunity Index (COI).</div></div><div><h3>Results</h3><div>Using 1 118 502 discharges across 1404 hospitals, mean pediatric bed capacity was 3.26 beds per 10 000 pediatric-aged residents (95% CI: 3.24-3.29). Capacity was similar across racial and ethnic groups, although socially disadvantaged (low income or COI) areas had higher capacity. Hospitals serving non-Hispanic/Latino Black and Hispanic/Latino children, children from socially disadvantaged communities, and rural areas had lower capital, expenditure, and staff per bed; higher transfer rates; and served more Medicaid enrollees. Hospitals serving very-high COI areas had $284 000 greater expenditure per bed (vs very low) and a 16% lower proportion of Medicaid patients. Central line-associated blood stream infection rates did not substantively differ by SDoH.</div></div><div><h3>Conclusions</h3><div>Although pediatric bed capacity was evenly distributed according to SDoH, hospitals serving under-represented, disadvantaged, and rural communities had less capability and resource availability. Future work is required to guide equity-oriented resource allocation.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114447"},"PeriodicalIF":3.9,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Risk Factors for Hypertension among Children with Nephrotic Syndrome.","authors":"Cal Robinson, Stéphanie Wagner, Nowrin Aman, Tonny H M Banh, Vaneet Dhillon, Valerie Langlois, Christoph Licht, Ashlene McKay, Damien Noone, Rachel Pearl, Seetha Radhakrishnan, Chia Wei Teoh, Jovanka Vasilevska-Ristovska, Rulan S Parekh","doi":"10.1016/j.jpeds.2024.114443","DOIUrl":"https://doi.org/10.1016/j.jpeds.2024.114443","url":null,"abstract":"<p><strong>Objectives: </strong>To determine incidence and risk factors for hypertension in childhood nephrotic syndrome.</p><p><strong>Study design: </strong>Using data from the Insight into Nephrotic Syndrome (INSIGHT) study, a prospective observational childhood nephrotic syndrome cohort from Toronto, Canada, we evaluated hypertension incidence and time-to-hypertension overall and stratified by 1) steroid-resistance or steroid-sensitivity, and 2) frequently-relapsing, steroid dependent, or infrequently-relapsing. Hypertension was defined as stage 1-2 hypertensive blood pressure on two consecutive visits or anti-hypertensive medication initiation.</p><p><strong>Results: </strong>We included 748 children with nephrotic syndrome from 1996 to 2023. Median (quartile 1-3 [Q1-3]) age at diagnosis was 4 (2.8-6) years, 473 (63%) children were male, and 240 (32%) were of South Asian ethnicity. Forty (5%) children were steroid-resistant, 177 (24%) steroid-dependent, 113 (15%) frequently-relapsing, and 418 (56%) infrequently-relapsing. Median follow-up was 5.2 years (Q1-3 3.0-9.3). During follow-up, 393 (53%) children developed hypertension or were initiated on an anti-hypertensive medication (incidence rate 8.2 per 100 person-years, 95%CI 7.4-9.1). Hypertension was more common among children steroid-resistance than steroid-sensitivity (70% vs. 52%; adjusted HR 1.47, 95%CI 1.00-2.17). Hypertension was also more common in children who were steroid-dependent (67%; adjusted HR 1.81, 95%CI 1.43-2.30) and frequently-relapsing (63%; adjusted HR 1.64, 95%CI 1.23-2.18), than infrequently-relapsing (42%). Among steroid-sensitive patients, higher BMI Z-score and academic center were also significant hypertension risk factors.</p><p><strong>Conclusions: </strong>Half of children with nephrotic syndrome develop hypertension. Children who are steroid-resistant, steroid-dependent, frequently-relapsing or have obesity are at greatest risk. Close blood pressure surveillance is justified to identify and treat hypertension.</p>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":" ","pages":"114443"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sporotrichosis","authors":"Kevin Tran DO,&nbsp;Vini Vijayan MD","doi":"10.1016/j.jpeds.2024.114439","DOIUrl":"10.1016/j.jpeds.2024.114439","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114439"},"PeriodicalIF":3.9,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental Perceptions of Early Childhood In-Home Research with Monitoring: A Qualitative Study","authors":"Gabriella B. Smith BA ,&nbsp;Mickayla D. Jones MPH ,&nbsp;Mary J. Akel MPH ,&nbsp;Leonardo Barrera MPH ,&nbsp;Marie Heffernan PhD ,&nbsp;Patrick Seed MD, PhD ,&nbsp;Michelle L. Macy MD, MS ,&nbsp;Stephanie A. Fisher MD, MPH ,&nbsp;Leena B. Mithal MD, MSCI","doi":"10.1016/j.jpeds.2024.114437","DOIUrl":"10.1016/j.jpeds.2024.114437","url":null,"abstract":"<div><h3>Objective</h3><div>To explore perceptions, concerns, and enthusiasm from a diverse group of parents regarding early childhood research that involves home monitoring technologies for collecting environmental exposure data.</div></div><div><h3>Study design</h3><div>A diverse group of new and expecting parents participated in semi-structured interviews. A single interviewer conducted all sessions and introduced a hypothetical longitudinal early childhood research study, which included the following novel home monitoring approaches: (1) wearable devices, (2) audio monitoring, and (3) environmental sampling. Interviews were audio-recorded, transcribed, and coded. Qualitative description guided the study, and a constant comparative approach was used to identify themes from transcripts.</div></div><div><h3>Results</h3><div>Twenty-four interviews were completed. Emerging themes included the following: (1) Ready and Willing to Participate; (2) Helping Others, Helping Ourselves: Motivation for Participation; (3) Trust and Transparency: Understanding the “What?” and the “Why?;” (4) Data Privacy and Security: “What If It Gets into the Wrong Hands?;” and (5) It's a Lot to Juggle: Logistical Realities. Perceptions were similar across racial, ethnic, and socioeconomic groups. Perceptions were positive, and participants desired additional information about study feasibility and purpose. Many had concerns related to wearable device safety and data privacy; a trusting relationship with the research team was a priority.</div></div><div><h3>Conclusion</h3><div>Participants had positive sentiments regarding longitudinal observational studies involving pregnancy and infancy yet expressed concerns about safety, privacy, feasibility, and transparency. These findings can inform future early childhood research study design to ensure protocols are transparent, inclusive, and appealing to parents.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114437"},"PeriodicalIF":3.9,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucose Testing Methods: A Systematic Review and Meta-Analysis of Diagnostic Accuracy of Point-of-Care Devices for Neonatal Hypoglycemia","authors":"Sophie L. St Clair ,&nbsp;Caitlyn M. Ulyatt ,&nbsp;Maria T. Corkin PhD ,&nbsp;Libby G. Lord ,&nbsp;Caroline A. Crowther MD ,&nbsp;Jane E. Harding DPhil ,&nbsp;Luling Lin PhD","doi":"10.1016/j.jpeds.2024.114438","DOIUrl":"10.1016/j.jpeds.2024.114438","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the accuracy of various point-of-care device methodologies for measuring blood glucose concentrations in babies at risk of neonatal hypoglycemia.</div></div><div><h3>Study design</h3><div>This systematic review and meta-analysis included studies from Ovid MEDLINE, Ovid Embase, and Web of Science up to May 20, 2024. Studies comparing point-of-care testing methods for neonatal blood glucose to a standard laboratory method were included, excluding those on continuous glucose monitoring or conducted before 1990. Two researchers independently assessed inclusion and evaluated risk of bias using QUADAS-2. Sensitivity and specificity were calculated using contingency tables, and diagnostic accuracy was analyzed using hierarchical random-effects modelling. Studies with insufficient data were summarized by estimation direction.</div></div><div><h3>Results</h3><div>Seventy-one studies were included. The quantitative analysis (n = 31) evaluated glucose oxidase (GO) + photometry (n = 8), glucose-1-dehydrogenase (GDH) + photometry (n = 6), GO + electrochemistry (n = 13), GDH + electrochemistry (n = 12), and hexokinase (HK) + electrochemistry (n = 2). All methods showed high specificity (≥93%), with GO + electrochemistry, GDH + electrochemistry, and HK + electrochemistry showing superior sensitivity. The summary receiver operating characteristic curve confirmed HK + electrochemistry as the most accurate.</div></div><div><h3>Conclusion</h3><div>Certain point-of-care device methodologies demonstrate greater accuracy in measuring neonatal blood glucose concentrations. Of the methods evaluated, HK + electrochemistry proved to be the most reliable. However, the limited number of studies using this method suggests the need for further research to confirm these findings across diverse settings and populations.</div></div><div><h3>Systematic review registration</h3><div>PROSPERO on December 29, 2023 (CRD42023488539).</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"278 ","pages":"Article 114438"},"PeriodicalIF":3.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}