Journal of Pediatrics最新文献

{"title":"Unequal Beginnings: Determinants of Child Health Across Europe","authors":"Angel Carrasco-Sanz MD , Donjeta Bali MD , Ida Giardino MD , Maria Pastore MD , Mehmet Vural MD , Tudor Lucian Pop MD, PhD , Massimo Pettoello-Mantovani MD, PhD , Luigi Nigri MD , Antonio D'Avino MD","doi":"10.1016/j.jpeds.2025.114727","DOIUrl":"10.1016/j.jpeds.2025.114727","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"285 ","pages":"Article 114727"},"PeriodicalIF":3.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colic as a Clue to Atopic Destiny","authors":"Robert A. Dudas MD","doi":"10.1016/j.jpeds.2025.114683","DOIUrl":"10.1016/j.jpeds.2025.114683","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"283 ","pages":"Article 114683"},"PeriodicalIF":3.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sick and Hungry with Medical Debt","authors":"Denise M. Goodman MD, MS","doi":"10.1016/j.jpeds.2025.114684","DOIUrl":"10.1016/j.jpeds.2025.114684","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"283 ","pages":"Article 114684"},"PeriodicalIF":3.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S0022-3476(25)00238-0","DOIUrl":"10.1016/S0022-3476(25)00238-0","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"283 ","pages":"Article 114697"},"PeriodicalIF":3.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood Socioeconomic Deprivation Associates with Decreased Serologic Normalization Rates in Pediatric Celiac Disease","authors":"Telly Cheung MD ,&nbsp;Mala Setty MD ,&nbsp;Cynthia Fenton MD ,&nbsp;Christine M. McDonald ScD, MS ,&nbsp;Patrika Tsai MD, MPH ,&nbsp;Jennifer C. Lai MD, MBA ,&nbsp;Sharad I. Wadhwani MD, MPH","doi":"10.1016/j.jpeds.2025.114717","DOIUrl":"10.1016/j.jpeds.2025.114717","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize how neighborhood socioeconomic deprivation affects tissue transglutaminase (tTG) IgA normalization, a marker of effective gluten elimination.</div></div><div><h3>Study design</h3><div>We conducted a single-center, retrospective cohort study of 207 children ≤18 years old with serology- or biopsy-based celiac disease diagnosed between 2013 and 2023. The primary exposure was the neighborhood deprivation index, a continuous measure (0-1) derived from the 2018 5-year American Community Survey. We categorized children from lowest to highest deprivation by quartiles (Q): Q1 (&lt;0.15), Q2 (0.15-0.21), Q3 (0.21-0.29), or Q4 (&gt;0.29). The primary outcome was tTG IgA normalization over the 60 months after seropositivity. We used Cox regression models to estimate hazard ratios (HRs) for tTG IgA normalization, adjusting for race, ethnicity, primary-spoken language, and insurance type in multivariable analyses.</div></div><div><h3>Results</h3><div>Of 207 children, the median deprivation index was 0.22 (IQR: 0.14, 0.29). Higher deprivation was associated with participants identifying as Black or Other race, Hispanic, non-English primary-speaking, and having public insurance. In univariate analysis, children in the highest quartile of neighborhood deprivation had a 50% lower normalization rate compared with those in the lowest quartile (HR 0.50; 95% confidence interval 0.27, 0.92; <em>P</em> = .03). In multivariable analysis, children in the highest quartile of neighborhood deprivation sustained a 67% lower normalization rate after adjusting for race, ethnicity, primary-spoken language, and insurance type (HR0.33; 95% confidence interval 0.15, 0.75; <em>P</em> = .008).</div></div><div><h3>Conclusions</h3><div>Children living in socioeconomically deprived neighborhoods may have inadequate dietary adherence. Addressing the barriers to gluten elimination in deprived neighborhoods may improve outcomes.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"286 ","pages":"Article 114717"},"PeriodicalIF":3.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Race Is an Incomplete Surrogate for Skin Pigmentation in Neonates, with Potential Relevance for Pulse Oximetry","authors":"Megha Sharma MD, MS ,&nbsp;Andrew W. Brown PhD ,&nbsp;Simon Chung MS ,&nbsp;Kevin W. Sexton MD ,&nbsp;Mario Schootman PhD ,&nbsp;Peter M. Mourani MD","doi":"10.1016/j.jpeds.2025.114720","DOIUrl":"10.1016/j.jpeds.2025.114720","url":null,"abstract":"<div><h3>Objective</h3><div>To examine the objective differences and overlap in skin pigment among neonates born to mothers of different racial groups.</div></div><div><h3>Study design</h3><div>We conducted a prospective study assessing neonatal skin tone by spectrophotometry using SkinColorCatch (Delfin, Miami, FL) at the pulse oximetry site (dorsum of foot) in neonatal and cardiac intensive care units. Colorimetric indices were compared between non-Hispanic Black (NHB) and non-Hispanic White (NHW) neonates using Welch's <em>t</em> test. Distribution overlap was evaluated using the overlap coefficient and the probability of a higher value. Bivariate regression assessed the relationships between colorimetric indices and neonatal characteristics, including gestational age and birth weight. A <em>P</em> value of &lt;.05 was considered significant.</div></div><div><h3>Results</h3><div>Among 100 neonates (33 NHB, 57 NHW, 7 Hispanic, 3 other), skin darkness measures (melanin index, perceived lightness, and individual typology angle [ITA°]) were significantly different between NHB and NHW infants. However, substantial overlap was observed: overlap coefficient of 0.66 (95% CI, 0.51-0.83) for the melanin index and 0.73 (95% CI, 0.57-0.90) for the ITA°. The probability of higher value was 0.27 (melanin index) and 0.69 (ITA°), further demonstrating overlap. Lower gestational age and birth weight correlated with darker skin tone characteristics and this association did not differ significantly by race.</div></div><div><h3>Conclusions</h3><div>Despite statistical differences, NHB and NHW neonates exhibit substantial overlap in objectively assessed skin color. These findings support the use of direct skin pigmentation measurements in device accuracy studies rather than race-based classifications, helping to decrease bias in medical algorithms and device research.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"286 ","pages":"Article 114720"},"PeriodicalIF":3.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental Readiness for Complementary Feeding: Associations with Initiation Before Age 6 Months","authors":"Diane L. Putnick PhD ,&nbsp;Akhgar Ghassabian MD, PhD ,&nbsp;Priscilla K. Clayton PhD ,&nbsp;Rajeshwari Sundaram PhD ,&nbsp;Edwina H. Yeung PhD, ScM","doi":"10.1016/j.jpeds.2025.114722","DOIUrl":"10.1016/j.jpeds.2025.114722","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate whether parents who assess their infants as more developmentally advanced are more likely to begin feeding their infants complementary foods before 6 months, and whether developmental readiness explains racial and ethnic differences in complementary food introduction.</div></div><div><h3>Study design</h3><div>In a cohort of mothers of 5475 infants from New York state, 9 markers of infant development and timing of initiating complementary feeding were assessed. Mixed effect models assessed associations between developmental markers and initiation of complementary feeding before 6 months term-corrected age. Direct and indirect effects of racial and ethnic differences in complementary feeding through a total development score were computed.</div></div><div><h3>Results</h3><div>In a fully adjusted model, infant sitting (aOR: 1.60, 95% CI: 1.32, 1.93), head control (aOR: 1.51, 95% CI: 1.26, 1.81), reaching (aOR: 1.19, 95% CI: 1.04, 1.37), mouthing (aOR: 1.26, 95% CI: 1.08, 1.46), and having a good appetite (aOR: 1.61, 95% CI: 1.15, 2.24) were uniquely associated with complementary feeding before age 6 months. A 1-point increase in a total development score was also associated with higher odds of complementary feeding (aOR: 1.26, 95% CI: 1.19, 1.33). The development score explained some racial and ethnic differences in the odds of complementary feeding before 6 months.</div></div><div><h3>Conclusions</h3><div>Results suggest that parents are using their children's developmental markers to decide when to begin complementary feeding. Furthermore, observations of racial and ethnic differences in the timing of complementary feeding may be explained by perceptions of developmental readiness, in line with recommendations. Future research on complementary feeding should incorporate assessments of infant developmental readiness.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"286 ","pages":"Article 114722"},"PeriodicalIF":3.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shaping Neonatal Hemodynamics: The Journey and Future of Targeted Neonatal Echocardiography","authors":"Adrianne R. Bischoff MD ,&nbsp;Angelica Vasquez MD ,&nbsp;Patrick J. McNamara MD","doi":"10.1016/j.jpeds.2025.114718","DOIUrl":"10.1016/j.jpeds.2025.114718","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"286 ","pages":"Article 114718"},"PeriodicalIF":3.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Reporting Guidelines and Trial Registration in Pediatric Journals: A Cross-Sectional Analysis","authors":"Taylor Gardner BS ,&nbsp;Todd Fernandez BA ,&nbsp;Katherine Cox BS ,&nbsp;Caleb Smith BS ,&nbsp;Danya Nees BS ,&nbsp;Griffin Hughes BA, BS ,&nbsp;Matt Vassar PhD","doi":"10.1016/j.jpeds.2025.114714","DOIUrl":"10.1016/j.jpeds.2025.114714","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the prevalence of reporting guideline and clinical trial registration requirements in the “instructions for authors” pages of pediatric journals since a previously completed 2010 publication.</div></div><div><h3>Study design</h3><div>This cross-sectional study analyzed 100 peer-reviewed pediatric journals identified through the 2021 Scopus CiteSource tool. Two investigators independently reviewed journals’ “instructions for authors” pages on December 10, 2023, for references to the Enhancing the QUAlity and Transparency Of health Research (EQUATOR) Network, International Committee of Medical Journal Editors, specific reporting guidelines, and clinical trial registration requirements.</div></div><div><h3>Results</h3><div>Among the 100 journals analyzed, 33% (33/100) did not reference any specific reporting guidelines. Of the 98 journals assessed for clinical trial registration, 43% (42/98) failed to mention study registration. EQUATOR Network guidelines were mentioned by 39% (39/100) of journals, and ICMJE was referenced by 68% (68/100). CONSORT and PRISMA were the most cited reporting guidelines, mentioned by 52% (51/98) and 41% (41/100) of journals, respectively. In contrast, 95% (94/99) of journals did not reference meta-analysis of observational studies in epidemiology, and 99% (99/100) omitted quality of reporting of meta-analyses.</div></div><div><h3>Conclusion</h3><div>Pediatric journals inadequately endorse reporting guidelines and clinical trial registration in their author instructions. These tools are critical for improving research quality, transparency, and reproducibility. Pediatric journals should strengthen publication policies to mandate these practices. Further research is needed to explore barriers and incentives for adoption to enhance integration into clinical research.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"286 ","pages":"Article 114714"},"PeriodicalIF":3.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atropine Versus Placebo for Neonatal Nonemergent Intubation: A Randomized Clinical Trial","authors":"Jehier Afifi MBBCh, MSc ,&nbsp;Walid El-Naggar MD ,&nbsp;Tara Hatfield RN ,&nbsp;Navjot Sandila MPH ,&nbsp;John Baier MD ,&nbsp;Micheal Narvey MD","doi":"10.1016/j.jpeds.2025.114719","DOIUrl":"10.1016/j.jpeds.2025.114719","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the rates of severe bradycardia (&lt;80/min for &gt;10 seconds) between neonates who received atropine-fentanyl-succinylcholine (atropine/standard-of-care group) vs placebo-fentanyl-succinylcholine (placebo/intervention group) before orotracheal intubation.</div></div><div><h3>Study design</h3><div>A multicenter, double-blind, randomized clinical trial of neonates receiving nonemergent intubation. Randomization was by computer generated tables with random block size, stratified by postmenstrual age at randomization (&lt;34 weeks and ≥34 weeks). The primary outcome was severe bradycardia during the whole procedure (from administration of the study medication until completion of last successful intubation). Secondary outcomes included any bradycardia (&lt;100/min for &gt;10 seconds), number and duration of intubation attempts and hypoxemia (&lt;80% for &gt;10 seconds). Safety outcomes included profound bradycardia (&lt;60/min for &gt;10 seconds), and receipt of chest compression or epinephrine. Analysis was by intention to treat.</div></div><div><h3>Results</h3><div>Seventy-three intubation events (60 infants) were randomized to administration of atropine (n = 24) or placebo (n = 49). Multiple attempts occurred in 33% of the events. No safety events occurred in either group. Severe bradycardia during the whole procedure was significantly higher in the placebo group compared with the atropine group (RR, 6.3; 95% CI, 1.2-34.1). The placebo group had significantly higher rates and duration of overall bradycardia, but lower rates and duration of hypoxemia compared with the atropine group, probably related to the lower proportion of multiple attempts (27% vs 46%; <em>P</em> = .09) and longer time to successful intubation (394 seconds vs 283 seconds; <em>P</em> = .08).</div></div><div><h3>Conclusions</h3><div>Among neonates receiving premedication for nonemergent intubation, atropine significantly decreased the rates and duration of severe and overall bradycardia compared with placebo.</div></div><div><h3>Trial registration</h3><div>ClinicalTrials.gov: <span><span>NCT01595399</span><svg><path></path></svg></span> (<span><span>https://clinicaltrials.gov/study/NCT01595399</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"286 ","pages":"Article 114719"},"PeriodicalIF":3.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}