Journal of Pediatrics最新文献

{"title":"Age-Related Differences in Respiratory Outcomes Among Critically Ill Children with Guillain-Barré Syndrome","authors":"Bradley J. De Souza MB, BCh, BAO ,&nbsp;Ola Kassis MD ,&nbsp;Deepti Nagesh MD ,&nbsp;Patrick A. Ross MD ,&nbsp;Anoopindar K. Bhalla MD, MSCI","doi":"10.1016/j.jpeds.2025.114766","DOIUrl":"10.1016/j.jpeds.2025.114766","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate age-related differences in respiratory outcomes among critically ill children with Guillain-Barré syndrome (GBS), focusing on mechanical ventilation (MV) requirements and tracheostomy placement.</div></div><div><h3>Study design</h3><div>This retrospective cohort study analyzed data collected prospectively within the Virtual Pediatric Systems registry (2009-2020) for US children &lt;21 years diagnosed with GBS and admitted to an intensive care unit (ICU). The primary outcome evaluated was use of invasive mechanical ventilation (IMV). Secondary outcomes included MV duration and use of tracheostomy.</div></div><div><h3>Results</h3><div>Among 497 children, 185 (37.2%) required IMV, 14 (2.8%) required only noninvasive ventilation, and 45 (9.1%) received a tracheostomy. Most patients (82.7%) requiring either invasive or non-IMV received it within 24 hours of ICU admission. Compared with children ≥12 years, younger children had higher odds of requiring IMV (age &lt;2 years: adjusted odds ratio (aOR) 3.12 [95% CI 1.37, 7.10]; age ≥2-6 years: aOR 1.87 [95% CI 1.07, 3.28]), but experienced shorter duration of ventilation (age ≥2-6 years: adjusted hazard ratio 2.37 [95% CI 1.55, 3.63]; age ≥6-12 years: adjusted hazard ratio 1.74 [95% CI 1.21, 2.50]) and had lower tracheostomy rates (age ≥2-6 years: aOR 0.21 [95% CI 0.07, 0.61]; age ≥6-12 years: aOR 0.35 [95% CI 0.12, 0.99]) when they received IMV.</div></div><div><h3>Conclusions</h3><div>Most children with GBS admitted to an ICU in the US do not require MV; among those who do, support is typically initiated within 24 hours of ICU admission. There are age-related variations in respiratory outcomes that may help inform clinical management.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"287 ","pages":"Article 114766"},"PeriodicalIF":3.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caregiver Perspectives on Racism and Bias in Navigating the Care of Children with Long-Term Ventilation via Tracheostomy","authors":"Holly Hòa Võ MD, MPH, MSc, MA ,&nbsp;Kareena Patel BA ,&nbsp;Cyndy Snyder PhD ,&nbsp;William N. Sveen MD MA ,&nbsp;Marcia Hancock MPA, MSW, LCSW-C ,&nbsp;Uchenna E. Anani MD ,&nbsp;Renee D. Boss MD, MHS ,&nbsp;Benjamin S. Wilfond MD","doi":"10.1016/j.jpeds.2025.114765","DOIUrl":"10.1016/j.jpeds.2025.114765","url":null,"abstract":"<div><h3>Objective</h3><div>To explore caregiver experiences of racism and bias in navigating the care of children with long-term ventilation via a tracheostomy (LTV).</div></div><div><h3>Study design</h3><div>Qualitative study with semistructured interviews of caregivers for children who initiated LTV in the previous 5 years at 4 geographically distinct academic medical centers. An interview guide was developed and deployed to include domains about the decision-making process, interactions with medical teams, transition to home, and the care the child received.</div></div><div><h3>Results</h3><div>Thirty-one families with children from racially and ethnically minoritized groups who initiated LTV were interviewed. About half of families described experiences in which racism or another form of bias affected how providers from medical teams interacted with them and their children. Four themes emerged regarding the types of biases that caregivers experienced and described: (1) race and ethnicity; (2) language; (3) socioeconomic status; and (4) caregiver's bedside presence. Caregivers also highlighted suggestions regarding how to support families from racial and ethnic groups that have been economically and socially marginalized in health systems, which include (1) resources for knowledge-building and decision-making; (2) increased representation of families from similar racial and ethnic backgrounds; and (3) increased provider empathy and positive messaging.</div></div><div><h3>Conclusions</h3><div>For families from racial and ethnic minoritized groups, we found that racism and other biases may compound the challenges associated with LTV. The potential for racism and other biases highlights the need for targeted resources to support better those families pursuing LTV.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"287 ","pages":"Article 114765"},"PeriodicalIF":3.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rising Tide Lifts All Boats: The Role of the Subspecialist in Recruitment into Pediatrics","authors":"YoungNa Lee-Kim MD, MEd ,&nbsp;Lisa DelSignore MD ,&nbsp;Nicholas J. Antos MD ,&nbsp;Christie L. Morse MD ,&nbsp;Stacey J. Kruger MD ,&nbsp;Lisa S. Topor MD ,&nbsp;Miriah Gillispie-Taylor MD ,&nbsp;Lindsay C. Johnston MD, MEd ,&nbsp;Gary L. Beck Dallaghan PhD ,&nbsp;Scott H. James MD ,&nbsp;Mary E. Moffatt MD ,&nbsp;Cary G. Sauer MD ,&nbsp;Patrick Myers MD ,&nbsp;Angela Myers MD, MPH ,&nbsp;Laura Degnon CAE ,&nbsp;Pnina Weiss MD, MHPE","doi":"10.1016/j.jpeds.2025.114757","DOIUrl":"10.1016/j.jpeds.2025.114757","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"285 ","pages":"Article 114757"},"PeriodicalIF":3.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Respiratory Hospital Admissions in Children with Cerebral Palsy Be Reduced? A Feasibility Randomized Controlled Trial (RESP-ACT)","authors":"Rachael M. Marpole FRACP ,&nbsp;A Marie Blackmore PhD ,&nbsp;Andrew C. Wilson FRACP ,&nbsp;Monica S. Cooper PhD ,&nbsp;Julie Depiazzi Master Phil ,&nbsp;Katherine Langdon FRACP ,&nbsp;Lisa Moshovis BS ,&nbsp;Asha C. Bowen PhD ,&nbsp;Noula Gibson PhD","doi":"10.1016/j.jpeds.2025.114755","DOIUrl":"10.1016/j.jpeds.2025.114755","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the feasibility of implementing recommendations of the consensus statement for the Prevention and Management of Respiratory Disease in children with severe cerebral palsy (CP) via RESPiratory hospital Admissions in children with cerebral palsy: a feasibility randomized Controlled Trial (RESP-ACT).</div></div><div><h3>Study design</h3><div>Twenty-two children with CP aged 0-12 years at risk of respiratory disease and receiving care through Perth Children's Hospital in Western Australia were randomized into parallel groups. The control group (n = 10) continued with their usual teams, while the intervention group (n = 12) received a comprehensive assessment followed by individualized investigations and appointments as needed. The primary outcomes include implementation, acceptability, practicality, and measuring efficacy. During the following year, with the help of a blind assessor, caregivers reported their children's health service use on a fortnightly basis. Caregivers and treating clinicians were interviewed at the end of the trial.</div></div><div><h3>Results</h3><div>Complete data were obtained from 73% of participants at 1 year. They completed 89% of the fortnightly surveys. Hospital service data were assessed for all. The 9 intervention participants interviewed at the end of the trial were satisfied or very satisfied with the service, and all caregivers and clinicians agreed or strongly agreed that such a service should be established. Their practical concerns included managing time, preference for home-based interventions and adequate staffing.</div></div><div><h3>Conclusions</h3><div>The service is feasible to implement but requires close monitoring. This trial provides data on which to base a larger randomized control trial.</div></div><div><h3>Trial registration</h3><div>Australian New Zealand Clinical Trials Registry-Registration number 12620000114943.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"287 ","pages":"Article 114755"},"PeriodicalIF":3.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity of Bronchopulmonary Dysplasia in Infants Born Extremely Preterm and Randomized to Early Human Milk Fortification with a Donor Milk-Derived Fortifier for 2 Weeks","authors":"Marley J. Tucker,&nbsp;Seabrook H. Jeffcoat BS,&nbsp;Tori Argent MS, RD, LD,&nbsp;Colm P. Travers MD,&nbsp;Ariel A. Salas MD, MSPH","doi":"10.1016/j.jpeds.2025.114750","DOIUrl":"10.1016/j.jpeds.2025.114750","url":null,"abstract":"<div><div>In this secondary analysis of a masked clinical trial involving 150 infants born extremely preterm randomized to receive fortified milk starting on either postnatal day 3 (early group) or day 14 (delayed group), we found a significant difference in the distribution of bronchopulmonary dysplasia severity between the 2 groups (<em>P</em> = .039) with milder forms of bronchopulmonary dysplasia in the early group.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"287 ","pages":"Article 114750"},"PeriodicalIF":3.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Vitamin D Supplementation in Infants Born Extremely Preterm and Fed Human Milk: A Randomized Controlled Trial","authors":"Ariel A. Salas MD, MSPH ,&nbsp;Tori Argent MS, RD, LD ,&nbsp;Seabrook Jeffcoat MSPH ,&nbsp;Marley Tucker ,&nbsp;Ambika P. Ashraf MD ,&nbsp;Colm P. Travers MD","doi":"10.1016/j.jpeds.2025.114754","DOIUrl":"10.1016/j.jpeds.2025.114754","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effects of vitamin D supplementation on short-term respiratory outcomes in infants born at 28 weeks of gestation or less and fed human milk.</div></div><div><h3>Study design</h3><div>This masked, randomized controlled trial included infants born extremely preterm and fed human milk in 2023-2024. Infants received either 800 IU/day vitamin D (intervention) or no additional vitamin D (control) for the first 14 days. Masking was maintained by adding 800 IU of vitamin D to daily feedings. The primary outcome was severity of bronchopulmonary dysplasia (BPD) at 36 weeks of postmenstrual age. Secondary outcomes included reactance and resistance (R_7-19) measurements, obtained using impulse oscillometry at 36 weeks postmenstrual age, and metabolic bone disease (alkaline phosphatase &gt;500 IU/L and phosphorus &lt;5.5 mg/dL) at postnatal day 28.</div></div><div><h3>Results</h3><div>A total of 126 infants were randomized (mean birthweight: 759 ± 228 g; 52% female). The intervention increased 25-hydroxy vitamin D3 concentrations (mean difference: +29 ng/mL; <em>P</em> &lt; .0001). The severity of BPD did not differ between groups (<em>P</em> = .60). area under the reactance curve measurements were comparable (674 ± 207 vs 694 ± 240; <em>P</em> = .64) and R_7-19 measurements were not significantly lower in the intervention group (23 ± 8 vs 25 ± 9; <em>P</em> = .18). On postnatal day 28, the lower risk of metabolic bone disease observed in the intervention group did not reach statistical significance (9% vs 20%; relative risk: 0.43; 95% CI: 0.16, 1.15; <em>P</em> = .08). No serious adverse events related to the intervention were reported.</div></div><div><h3>Conclusions</h3><div>Administering 800 IU/day of vitamin D during the first 2 weeks did not reduce BPD severity but may contribute to improved bone health.</div></div><div><h3>Trial registration</h3><div>ClinicalTrials.gov: <span><span>NCT05615311</span><svg><path></path></svg></span>. <span><span>https://clinicaltrials.gov/study/NCT05615311</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"287 ","pages":"Article 114754"},"PeriodicalIF":3.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resilience in Young Adults with Congenital Heart Disease in Relation to Neurodevelopment in the Preschool Period","authors":"Tyler Kuni BS ,&nbsp;Alana Cianciulli BS ,&nbsp;Richard F. Ittenbach PhD ,&nbsp;Gabrielle Combs MPH ,&nbsp;Isabel Randazzo MD ,&nbsp;Daniel J. Licht MD ,&nbsp;Lyla Hampton PhD, ABPP-CN ,&nbsp;Marsha Gerdes PhD ,&nbsp;Judy Bernbaum MD ,&nbsp;J. William Gaynor MD ,&nbsp;Nancy Burnham RN, MSN, CRNP","doi":"10.1016/j.jpeds.2025.114752","DOIUrl":"10.1016/j.jpeds.2025.114752","url":null,"abstract":"<div><h3>Objective</h3><div>To determine if resilience among young adults with congenital heart disease is associated with patient characteristics and neurobehavioral status during the preschool period.</div></div><div><h3>Study design</h3><div>This study is a prospective, cross-sectional analysis of young adults enrolled in a longitudinal study of neurodevelopmental outcomes in congenital heart disease. All subjects underwent surgery with cardiopulmonary bypass at age ≤6 months of life. Resilience and general health status were evaluated using standardized questionnaires (RS-14 and SF-36, respectively). The relationships between resilience and patient and management factors as well as neurobehavioral status in the preschool period were examined.</div></div><div><h3>Results</h3><div>The RS-14 and SF-36 were completed by 200 subjects (average age 20.1, IQR 19.2, 21.3 years). Median resilience score was 81.0 (CL0.95 78, 82), higher than the population average of 76.0 (<em>P</em> = .014). Higher resilience scores were correlated with higher health-related quality of life scores (<em>r</em> = 0.506, <em>P</em> &lt; .001). Better executive function (<em>P</em> = .032) and social skills (<em>P</em> = .004) at the 4-year evaluation were associated with higher resilience in young adulthood. Inattention (<em>P</em> = .015) and pervasive development problems (<em>P</em> = .020) were inversely associated with resilience. No demographic, patient-related, or operative management factors were associated with higher or lower resilience (all <em>P</em> &gt; .223).</div></div><div><h3>Conclusions</h3><div>Findings reported here show an association between preschool neurobehavioral status, overall health-related quality of life, and resilience in young adulthood. Identification of an at-risk population may provide an opportunity for intervention early in life, leading to improved psychosocial development with increased resilience.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"287 ","pages":"Article 114752"},"PeriodicalIF":3.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Mass Index Trajectory in Children With Kawasaki Disease","authors":"Jessica Laird-Gion MD ,&nbsp;Kimberlee Gauvreau ScD ,&nbsp;Annette L. Baker RN, MSN, PNP ,&nbsp;Thomas Giorgio BS ,&nbsp;Jane W. Newburger MD, MPH ,&nbsp;Lauren S. Crafts MD ,&nbsp;Audrey Dionne MD ,&nbsp;Mary Beth F. Son MD ,&nbsp;Sarah D. de Ferranti MD, MPH","doi":"10.1016/j.jpeds.2025.114749","DOIUrl":"10.1016/j.jpeds.2025.114749","url":null,"abstract":"<div><div>Acquired cardiovascular risk is a concern for children with Kawasaki disease, which might influence obesity. Patients with Kawasaki disease in a single-instruction, retrospective cohort exhibited only a minimal increase in BMI <em>z</em> score in the first 6 weeks after diagnosis that resolved at 1 year. Neither corticosteroid treatment nor the presence of coronary artery aneurysms had adverse impacts on the BMI <em>z</em> score trajectory.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"287 ","pages":"Article 114749"},"PeriodicalIF":3.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational Diabetes Mellitus and School-Age Cognitive and Health Outcomes in New Zealand: A Matched Cohort Study","authors":"J.M. Alsweiler PhD ,&nbsp;F. Amitrano PhD ,&nbsp;J.E. Harding DPhil ,&nbsp;C.A. Crowther MD ,&nbsp;G.T.L. Brown PhD ,&nbsp;A. Cavadino PhD ,&nbsp;C.J.D. McKinlay PhD","doi":"10.1016/j.jpeds.2025.114756","DOIUrl":"10.1016/j.jpeds.2025.114756","url":null,"abstract":"<div><h3>Objective</h3><div>To determine if children exposed <em>in utero</em> to gestational diabetes mellitus (GDM) have poorer school-age neurocognitive and cardiometabolic function than matched children not exposed to GDM.</div></div><div><h3>Study design</h3><div>In a matched, cohort study, we compared 186 children of women diagnosed with GDM from a trial cohort with 186 children born at the same hospital whose mothers did not have GDM, matched for child sex, maternal body mass index (BMI), ethnicity, socio-economic status, and gestational age. Both GDM-exposed and nonGDM-exposed children were assessed at 6-7 years’ corrected age for neurocognitive function (NIH Toolbox), numeracy (Checkout Game), body composition, and peripheral/central blood pressure. The primary outcome was the Composite Cognitive Standard Score. Analysis was by generalized linear models, adjusted for matching criteria; exposure effects were estimated as OR or mean difference (MD), with 95% confidence intervals.</div></div><div><h3>Results</h3><div>Exposure groups were similar for birthweight z-score, corrected age at assessment, matching criteria, and hypertensive disorders of pregnancy. There was no difference between groups in mean cognitive score (104[15] vs 104[15]; MD = 2[−2, 5]) or its components. GDM-exposed children were less likely to have motor impairment (6% vs 11%, aRD = −6[−11, −1] but more likely to have low numeracy (10% vs 4%, aRD = 6[2, 11]) and hypertension (14% vs 6%, aRD = 8[1, 14]), and had higher mean BMI z-scores (0.95[1.61] vs 0.51[1.50], MD = 0.39[0.13, 0.65]).</div></div><div><h3>Conclusions</h3><div>Children exposed to GDM are not at increased risk of poorer school-age cognitive function compared with controls matched for potential confounders. However, GDM exposure was associated with increased childhood BMI and hypertension, which may affect subsequent cardiometabolic health.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"287 ","pages":"Article 114756"},"PeriodicalIF":3.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bothersome and Impactful Health Conditions in Children and Adolescents with Down Syndrome","authors":"Mary Witt ,&nbsp;Michelle Palumbo MD ,&nbsp;Stephanie L. Santoro MD","doi":"10.1016/j.jpeds.2025.114748","DOIUrl":"10.1016/j.jpeds.2025.114748","url":null,"abstract":"<div><h3>Objective</h3><div>To summarize our results regarding how physical and mental health affect or bother children and adolescents with Down syndrome (DS) and to explore the relationship between impactful or bothersome items and participants’ overall health.</div></div><div><h3>Study design</h3><div>We surveyed caregivers of individuals aged 0-21 with DS about the aspects of physical health (including communication, hearing, vision, muscle tone, mobility, sleep, genitourinary concerns, and pain) and mental health (including behavior, self-talk, and problem solving) that bother and affect individuals with DS and summarized their responses. We compared the differences in sleep impacts between those with and without sleep apnea through chi square analysis. Spearman correlations were conducted to determine the association between our bother and impact items and total health scores on the DS health measure.</div></div><div><h3>Result</h3><div>We received 542 complete survey responses from a national sample. Physical and mental health impacted children and adolescents with DS at varied rates. Those with sleep apnea experienced negative impacts of sleep more frequently than those without. Thirty-four of our bother and impact items correlated significantly with total health scores.</div></div><div><h3>Conclusions</h3><div>Many factors influenced some children and adolescents with DS, but most were not highly impactful. Although the bothersome and impactful aspects of physical and mental health were variable in our cohort, many correlated with overall health.</div></div><div><h3>Trial Registration</h3><div>ClinicalTrials.gov: <span><span>NCT04631237</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"287 ","pages":"Article 114748"},"PeriodicalIF":3.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}