Journal of Toxicology and Environmental Health-Part A-Current Issues最新文献

{"title":"Toxic effects of tetracycline on non-target lichen <i>Evernia prunastri</i>.","authors":"Gintarė Sujetovienė, Martynas Jasas, Diana Miškelytė, Austra Dikšaitytė, Irena Januškaitienė, Giedrė Kacienė, Renata Dagiliūtė, Jūratė Žaltauskaitė","doi":"10.1080/15287394.2024.2445081","DOIUrl":"10.1080/15287394.2024.2445081","url":null,"abstract":"<p><p>Tetracycline (TC) antibiotics are one of the class of drugs widely used in clinical practice but also constitute a significant environmental concern. However, the adverse effects of TC on non-target organisms have not been well studied. The aim of this study was to examine the influence of exposure to high levels of TC on thalli of lichens to determine the impact on (1) physiological parameters including integrity of cell membranes, photosynthetic efficiency and viability, (2) oxidative stress response such as membrane lipid peroxidation, and (3) enzymatic antioxidant activities as catalase (CAT), superoxide dismutase (SOD), ascorbate peroxidase (APX), and glutathione reductase (GR). Data demonstrated that exposure to tetracycline did not markedly affect the lichen membrane damage as indicated by no change in conductivity. This antibiotic diminished the potential photosystem II efficiency (F_V/F_M) indicating enhanced susceptibility as evidenced by lower chlorophyll fluorescence and chlorophyll content. The viability of lichens exposed to high concentrations of tetracycline was significantly reduced. The concentrations of thiobarbituric acid reactive substances were markedly elevated with increasing concentrations of antibiotics. At higher TC concentrations, 500 mg/L SOD activity was significantly elevated. In the case of CAT, APX and GR, TC at higher concentrations significantly decreased these enzymic activities. The findings of this study contribute to the knowledge that TC antibiotics exert adverse ecotoxicological effects on lichens at high concentrations and provided a better understanding of the mechanisms underlying toxicity. Data also indicates that lichens may serve as an effective biomonitoring species for TC antibiotic exposure.</p>","PeriodicalId":54758,"journal":{"name":"Journal of Toxicology and Environmental Health-Part A-Current Issues","volume":" ","pages":"395-408"},"PeriodicalIF":2.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicological safety, antioxidant effect, and chemoprotection determination of an extract from the babassu mesocarp (<i>Orbignya phalerata</i> Mart.) in preclinical studies.","authors":"Nicole Debia, Ana Beatriz Santana Sousa, Beatriz Arêa Cassiano de Melo, Athanara Alves de Sousa, Taline Alves Nobre, Victor Alves de Oliveira, José Otávio Carvalho Sena de Almeida, João Sammy Nery de Sousa, Daniel Dias Rufino Arcanjo, Michel Muálem de Moraes Alves, Paulo Michel Pinheiro Ferreira, João Marcelo de Castro E Sousa","doi":"10.1080/15287394.2025.2496959","DOIUrl":"https://doi.org/10.1080/15287394.2025.2496959","url":null,"abstract":"<p><p>Reactive nitrogen species (RNS) and reactive oxygen species (ROS) play a key role in chronic diseases and aging by initiating protein oxidation, impaired cellular membrane damage and functions, and induction of DNA mutations. When endogenous antioxidants are insufficient to counteract oxidant stress, bioactive compounds might serve as physiological therapeutic agents attributed to their ability to neutralize ROS. The aim of this study was to examine the antioxidant, chemoprotective and toxicological aspects of the hydroethanolic extract from <i>Orbignya phalerata</i> Mart. mesocarp using <i>in vitro</i> and <i>in vivo</i> bioassays. The extract presented 9.9 mg/g of total flavonoids, primarily catechin and epicatechin. This extract exhibited no apparent toxicity upon <i>Artemia salina</i> (LC₅₀ > 1000 μg/ml) or <i>Zophobas morio</i> larvae (LD₅₀ > 3000 mg/kg), low hemolysis, genotoxicity, or mutagenicity utilizing <i>Allium cepa</i> cells. Cytotoxicity effects were observed on in L-929 murine fibroblast only at concentrations above 130 μg/ml. This extract effectively neutralized free radicals [DPPH^• (EC₅₀ 25.3 μg/ml) and ABTS^•+ (EC₅₀ 52.6 μg/ml)] and reduced H₂O_2-initiated effects on <i>Saccharomyces cerevisiae</i>. The chemoprotective activity of this extract was also noted in <i>A. salina</i>, L-929 cells, and <i>S. cerevisiae</i> as evidenced from oxidative damage and toxicity tests results. This constitutes the first report describing the toxicological safety profile of a babassu mesocarp extract a rich source of flavonoids (catechin and epicatechin) with antioxidant and chemoprotective activities.</p>","PeriodicalId":54758,"journal":{"name":"Journal of Toxicology and Environmental Health-Part A-Current Issues","volume":" ","pages":"1-21"},"PeriodicalIF":2.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Buthionine sulfoximine acts synergistically with doxorubicin as a sensitizer molecule on different tumor cell lines.","authors":"Joedna Cavalcante Pereira, Rayran Walter Ramos de Sousa, Micaely Lorrana Pereira Conceição, Maria Luísa Lima Barreto do Nascimento, Ana Tárcila Alves de Almeida, Antonielly Campinho Dos Reis, Mickael Laudrup de Sousa Cavalcante, Camila Dos Reis Oliveira, Italo Rossi Roseno Martins, Francisco Leonardo Torres-Leal, Dalton Dittz, João Marcelo de Castro E Sousa, Paulo Michel Pinheiro Ferreira, Felipe Cavalcanti Carneiro da Silva","doi":"10.1080/15287394.2024.2448663","DOIUrl":"10.1080/15287394.2024.2448663","url":null,"abstract":"<p><p>The chemotherapeutic drug doxorubicin (DOX) has been widely used for treating solid tumors attributed to its antiproliferative effectiveness; however, its clinical use is limited due to side effects, including cardiotoxicity, myelosuppression, and drug resistance. Combining DOX with buthionine sulfoximine (BSO), a glutathione (GSH) synthesis inhibitor, showed promising results in overcoming these adverse effects, potentially reducing the required DOX dose while maintaining efficacy. The aim of the present study was to examine the effects of different concentrations of BSO and DOX, both individually and in combination, utilizing B16/F10 (murine melanoma), SNB-19 (human glioblastoma), S180 (murine sarcoma), and SVEC4-10 (murine endothelial) cell lines. Cell viability, migration, and clonogenicity were assessed using the following assays MTT, scratch, and colony formation. Antioxidant levels of GSH, as well as activities catalase (CAT), and superoxide dismutase (SOD) were measured. BSO alone exhibited minimal cytotoxic effects, while DOX alone reduced cell viability significantly. The combination of BSO+DOX decreased IC₅₀ values for most cell lines, demonstrating a synergistic effect, especially in B16/F10, S180, and SVEC4-10 cells. BSO+DOX combination significantly inhibited cell migration and clonogenicity compared to DOX alone. While GSH levels were decreased with BSO+DOX treatment activities of CAT and SOD increased following DOX administration but remained unchanged by BSO. These results suggest that BSO may be considered a valuable tool to improve DOX therapeutic efficacy, particularly in cases of chemotherapy-resistant tumors, as BSO enhances DOX activity while potentially reducing systemic chemotherapeutic drug toxicity.</p>","PeriodicalId":54758,"journal":{"name":"Journal of Toxicology and Environmental Health-Part A-Current Issues","volume":" ","pages":"409-431"},"PeriodicalIF":2.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microcystin-LR induces lung injury in mice through the NF-κB/NLRP3 pathway.","authors":"Yin Zhang, Ying Guan, Manni Dai, Yue Yang, Fei Yang","doi":"10.1080/15287394.2024.2443525","DOIUrl":"10.1080/15287394.2024.2443525","url":null,"abstract":"<p><p>Microcystin-LR (MC-LR) a cyclic toxin produced by cyanobacterial species is known to exert detrimental effects on various organs, including lung. Several investigators demonstrated that MC-LR exerts pulmonary toxicity, but the underlying mechanisms remain unclear. This study aimed to investigate whether exposure to MC-LR-induced lung inflammation and examine the underlying mechanisms. Thirty specific pathogen-free (SPF) male mice were allocated into control and MC-LR treatment groups. Mice were intraperitoneally injected with physiological saline or MC-LR (20 μg/kg) daily for a total of 21 days. Our findings indicated that exposure to MC-LR-produced histopathological changes in lung tissue, including thickening of alveolar walls and inflammatory infiltration. MC-LR was found to upregulate mRNA expression levels of pro-inflammatory cytokines TNFα, IL-6, IL-1β, and IL-18. Further, MC-LR significantly elevated the expression levels of proteins associated with the NF-κB/NLRP3 pathway p-NF-κB, NLRP3, Caspase-1, ASC. The activation of NF-κB/NLRP3 pathway further promoted the release of inflammatory cytokine IL-1β and cleavage of pyroptosis-associated GSDMD protein. These findings indicate that MC-LR may induce lung inflammation by promoting cell pyroptosis via the activation of the NF-κB/NLRP3 pathway.</p>","PeriodicalId":54758,"journal":{"name":"Journal of Toxicology and Environmental Health-Part A-Current Issues","volume":" ","pages":"385-394"},"PeriodicalIF":2.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytogenotoxicity attributed to ioxynil octanoate exposure utilizing <i>Allium cepa</i> L as a model.","authors":"Gabriela Ezequiel Costa Martins, Jade Del Nero Oliveira, João Vitor Barbosa Calvelli, Antonio Rodrigues da Cunha Neto, Eric Batista Ferreira, Luciene de Oliveira Ribeiro Trindade, Sandro Barbosa","doi":"10.1080/15287394.2025.2504144","DOIUrl":"https://doi.org/10.1080/15287394.2025.2504144","url":null,"abstract":"<p><p>Ioxynil octanoate, considered to be non-genotoxic, is widely used as a post-emergence herbicide. However, extensive agricultural usage might potentially adversely affect non-target organisms, indicating the need for a comprehensive toxicological reassessment. The aim of this study was to investigate the phytotoxic and cytogenotoxic effects attributed to exposure to this herbicide on <i>Allium cepa</i> L. examining germination, early growth, cell cycle progression, and genomic stability. Herbicide concentrations of 52, 209, 837, or 3350 ppm were tested. Distilled water was used as a negative control, while 10 ppm methyl methanesulfonate (MMS) served as a positive control in the comet assay. Parameters determined included germination, root and shoot growth, biomass accumulation, qualitative lipid peroxidation, mitotic index, chromosomal aberrations, and DNA fragmentation via the comet assay. All tested concentrations significantly reduced seed germination and seedling development, with 3350 ppm completely inhibiting normal growth. Histochemical analysis demonstrated significant oxidative stress. A mitodepressive effect exceeding 72% was observed after 72 hr exposure. DNA fragmentation induced by 837 and 3350 ppm was comparable to that of MMS. The association between comet assay results and the presence of micronuclei reinforces the compromise of genomic stability in <i>A. cepa</i> exposed to the compound. Data demonstrated that ioxynil octanoate, even at field-relevant concentrations, impaired cell division, and genomic integrity, indicative of significant cytogenotoxicity. These findings emphasize the need to reevaluate agricultural use of ioxynil octanoate, considering potential environmental risks to non-target organisms and the importance of complementary genotoxicological studies involving both target and non-target organisms.</p>","PeriodicalId":54758,"journal":{"name":"Journal of Toxicology and Environmental Health-Part A-Current Issues","volume":" ","pages":"1-15"},"PeriodicalIF":2.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotoxicity of pure compounds and commercial formulations of the maize herbicides mesotrione and s-metolachlor in <i>Vicia faba</i> L.","authors":"Larissa Fonseca Andrade-Vieira, Sylvie Cotelle","doi":"10.1080/15287394.2025.2502965","DOIUrl":"https://doi.org/10.1080/15287394.2025.2502965","url":null,"abstract":"<p><p>Herbicides containing the active components mesotrione and S-metolachlor persist in the environment and adversely affect non-target organisms. Therefore, it was of interest to examine the toxicological risk associated with these compounds. This study aimed to investigate the toxic effects of the active pure compounds mesotrione and S-metolachlor and their respective commercial formulations as evidenced by MN bioassays utilizing <i>Vicia faba</i> L. (broad bean) as a model. The experiments followed the 48-hr protocol of ISO 29200. Dilutions of the active components and their commercial formulations, ranging from 1.56 to 50 mg/L, were tested. Hoagland's solution was used as a negative control, and maleic hydrazide as a positive control. A decrease in mitotic index (MI) was observed with the pure compounds, where mesotrione significantly reduced the frequency of cell division at concentrations >12.5 mg/L, and S-metolachlor initiated a significant fall at only the highest concentration (50 mg/L). In addition, the MN frequency was markedly increased at treatments of 3.125 mg/L mesotrione and 6.25 to 25 mg/L S-metolachlor. However, herbicide treatments with the commercial formulation containing the same concentrations of active compounds did not significantly damage plant DNA. Taken together, the findings demonstrated that in commercial formulations, the combined effects of the pure compounds and solvents or other substances included in the product might occur and consequently interfere with the genotoxic potential of the active compounds. Although the cytotoxicity was of the same order of magnitude for both S-metolachlor and mesotrione, mesotrione alone appears to be more genotoxic than S-metolachlor.</p>","PeriodicalId":54758,"journal":{"name":"Journal of Toxicology and Environmental Health-Part A-Current Issues","volume":" ","pages":"1-13"},"PeriodicalIF":2.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum miR-30c serves as potential biomarkers for the diagnosis and prognosis of gastric cancer.","authors":"Xiao-Yan Tian, Yong-Ping Mu","doi":"10.1080/15287394.2025.2495952","DOIUrl":"https://doi.org/10.1080/15287394.2025.2495952","url":null,"abstract":"<p><p>Gastric cancer (GC)，the fourth leading cause of cancer-related deaths globally and thus early detection, is considered critical for diagnosis and treatment of this disease. It is well known that measurement of microRNA (miRNA) may serve as diagnostic and prognostic biomarker for GC. The aim of this study was to determine whether miR-30c was present in patients with gastric cancer and to correlate relative expression with patient survival. A total of 162 GC patients and 150 healthy controls were recruited. miR-30c levels were quantified in serum using quantitative real-time PCR(QRT-PCR). The sensitivity and specificity of circulating miR-30c was compared to carbohydrate antigen (CA) CA72-4, CA19-9, and carcinoembryonic antigen (CEA), 3 known markers associated with GC. QRT-PCR demonstrated downregulation of gene expression of miR-30c in GC patients. Downregulation of miR-30c gene expression was significantly correlated with stage of cancer, lymphatic metastasis, and distal metastasis. The sensitivity to detect GC of miR-30c, CA72-4, CA19-9, and CEA in serum of GC was 80%, 43%, 21%, and 42%, respectively, while specificity was 89%, 57%, 30%, and 78% respectively. Kaplan-Meier survival analysis showed that the presence of low gene expression of miR-30c was effective in predicting poor prognosis in GC patients. Our data suggest that circulating serum miR-30c concentrations may serve as a reliable biomarker for GC occurrence. (212words).</p>","PeriodicalId":54758,"journal":{"name":"Journal of Toxicology and Environmental Health-Part A-Current Issues","volume":" ","pages":"1-9"},"PeriodicalIF":2.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attenuating effects of vitamin C on lead (Pb)-induced toxicological and endocrine responses in male Wistar rats.","authors":"Ukam U Uno, Oju R Ibor, Utip B Ekaluo, Monday M Onakpa, Augustine Arukwe","doi":"10.1080/15287394.2025.2501016","DOIUrl":"https://doi.org/10.1080/15287394.2025.2501016","url":null,"abstract":"<p><p>The aim of this study was to investigate the attenuating effect of vitamin C (VC) on lead (Pb)-induced toxicity in male Wistar rats. Twenty-four mature male rats were divided into 4 groups consisting of 6 animals using a completely randomized design. Rats were treated orally with either 60 mg/kg body weight (BW) Pb acetate or 100 mg/kg BW VC singly or combination. Controls group received water (vehicle control). After 65 days exposure, testes and epididymis of the animals were measured for testicular weight, epididymal weight and sperm estimations, while blood and liver samples were collected for liver function, hormonal assays, and oxidative stress responses including transcript expression using real-time PCR. Lead initiated significant increases in expression and activities of antioxidant enzymes catalase (CAT), superoxide dismutase (SOD,) glutathione peroxidase (Gpx) and levels of malondialdehyde (MDA) and nitric oxide (NO). Liver function enzyme activities for alkaline phosphatase (ALP,) aspartate aminotransferase (AST), and alanine aminotransferase (ALP) were also elevated in Pb exposed rats. In contrast, a significant decrease was noted in reproductive hormones testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), sperm variables including motility, viability and counts, as well as testes and epididymis weights following Pb treatment. However, the oxidative stress responses and liver function enzymes were reduced in the combined Pb and VC exposure group, while reproductive hormones and sperm profile increased significantly compared to Pb alone. Data indicate that VC exerts an attenuating effect. Our findings showed the attenuating potential of VC on Pb-induced toxicity of male rats.</p>","PeriodicalId":54758,"journal":{"name":"Journal of Toxicology and Environmental Health-Part A-Current Issues","volume":" ","pages":"1-15"},"PeriodicalIF":2.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel chemical constituents identified by UPLC-QTOF-MS/MS and biological activities attributed to extracts from three species of <i>Mimosa</i>.","authors":"Rodrigo Ferreira Santiago, Mariana Helena Chaves, João Paulo da Silva Gomes, Gerardo Magela Vieira Júnior, José Delano Barreto Marinho Filho, Ana Jérsia Araujo, Stéphanie Aguiar de Negreiros Matos Silva, Chistiane Mendes Feitosa, Pedro Vitor Oliveira Silva Furtado, Maria Do Carmo Gomes Lustosa, Mahendra Rai","doi":"10.1080/15287394.2025.2496460","DOIUrl":"https://doi.org/10.1080/15287394.2025.2496460","url":null,"abstract":"<p><p>The genus <i>Mimosa</i> (Fabaceae), includes approximately 540 species, some of which are popularly known as \"Jurema\" and are extensively used in traditional medicine. This study aimed to identify the chemical constituents and examine the antioxidant, anticholinesterase, and cytotoxic activities of ethanolic extracts obtained from the stem bark of <i>Mimosa pteridifolia</i>, <i>M. tenuiflora</i>, and <i>M. verrucosa</i>. Plant materials were subjected to ethanol extraction, followed by (ultra performance liquid chromatography with quadrupole time-of-flight (UPLC-QTOF-MS/MS) analysis and qualitative phytochemical screening. Antioxidant activity was assessed using the DPPH radical assay, while total phenol and flavonoid contents were quantified using the Folin-Ciocalteu and aluminum trichloride (AlCl₃) complexation methods, respectively. Anticholinesterase activity was determined using the Ellman method, and cytotoxicity by the MTT method utilizing human colorectal adenocarcinoma (HCT-116), human breast adenocarcinoma (MDA-MB-231), and non-tumor mouse fibroblast (L929) cell lines. After analysis of the extracts, 14 compounds, including indole and a new phytoindole alkaloid (10), tannins, proanthocyanidins, flavonoids, and triterpene saponins were identified. While all extracts demonstrated significant antioxidant and anticholinesterase properties. <i>M. tenuiflora</i> exhibited the highest total phenol content (570.06   ±   5.7 GAE/g) while all extracts contained low flavonoid content. Further, <i>M. tenuiflora</i> exhibited the strongest effects (EC₅₀ = 76.87   ±   1.41 μg/ml for antioxidant and IC₅₀ = 2.35 mg/ml for anticholinesterase activity). Importantly, none of the extracts demonstrated significant cytotoxicity against the tested cell lines, indicating non-toxicity to non-cancer cells. Data demonstrated a greater understanding of the chemical composition of three <i>Mimosa</i> species and indicates potential anticholinesterase and antioxidant activities, particularly extracts of <i>M. tenuiflora</i>.</p>","PeriodicalId":54758,"journal":{"name":"Journal of Toxicology and Environmental Health-Part A-Current Issues","volume":" ","pages":"1-17"},"PeriodicalIF":2.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between long-term exposure to fine particulate air pollution and colorectal cancer mortality in Taiwan.","authors":"ChunYuh Yang","doi":"10.1080/15287394.2025.2497074","DOIUrl":"https://doi.org/10.1080/15287394.2025.2497074","url":null,"abstract":"<p><p>The International Agency for Research on Cancer classified fine particulate matter (PM_2.5) air pollution as carcinogenic to humans (Group I). Although PM_2.5 exposure has been associated with lung cancer occurrence, few studies investigated this association with non-lung cancer. Colorectal cancer (CRC) is the third leading cause of cancer deaths both among men and women. In Taiwan, deaths attributed to CRC vary considerably across townships, suggesting involvement of the environment. The aim of this study was to examine the association between long-term ambient PM_2.5 exposure and deaths attributed to CRC in 66 municipal areas across Taiwan. Annual PM_2.5 levels were compared against age-standardized CRC mortality rates in male and female residents of these municipalities from 2012 to 2021. Annual PM_2.5 levels of different municipalities were sub-divided into tertiles. Adjusted risk ratio (RR) was calculated by multiple regression analyses, controlling for municipal lung cancer deaths, urbanization level, annual average household income, and density of physicians in the municipal areas. For males, adjusted RRs for CRC death were 1.1 (95% CI = 1.05-1.15) for municipalities with PM_2.5 levels ranging from 18.96 to 25.19 µg/m³and 1.15 (95% CI = 1.1-1.21) for levels ranging from 25.2 to 29.48 µg/m³, respectively, compared to those areas belonging to the lowest tertiles. Our analysis of trend suggested that risk of CRC-related death paralleled increases PM_2.5 levels in males. For females, adjusted RRs were 1.18 (95% CI = 1.12-1.25) and 1.12 (95% CI = 1.06-1.19), respectively. Evidence indicated that long-term exposure to PM_2.5 may elevate the risk of CRC-related death in both men and women in Taiwan.</p>","PeriodicalId":54758,"journal":{"name":"Journal of Toxicology and Environmental Health-Part A-Current Issues","volume":" ","pages":"1-10"},"PeriodicalIF":2.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}