Neuroepidemiology最新文献

{"title":"High Prevalence of Epilepsy Associated with Onchocerciasis in Northern Uganda.","authors":"Robert Colebunders, Luís-Jorge Amaral, Nolbert Gumisiriza, Joseph N Siewe Fodjo, Thomson Lakwo","doi":"10.1159/000544866","DOIUrl":"10.1159/000544866","url":null,"abstract":"","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-3"},"PeriodicalIF":3.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidity Patterns in Patients with First-Ever Acute Ischemic Stroke and Their Associations with Functional Outcomes.","authors":"Xinying Huang, Zuolin Lu, Tianqi Li, Juan Zhang, Xia Meng, Yachen Wang, Weihao Shao, Xiaoxia Wei, Yong Jiang, Ruitai Shao","doi":"10.1159/000544170","DOIUrl":"10.1159/000544170","url":null,"abstract":"<p><strong>Introduction: </strong>Acute ischemic stroke (AIS) is the most prevalent type of stroke, associated with a significant burden of functional impairments. About 94.2% of AIS patients present with multiple comorbidities, but how they affect AIS prognosis remains largely unknown. This study aimed to comprehensively assess the associations of a wide range of AIS-related comorbidities, their patterns, with functional impairments in AIS patients.</p><p><strong>Methods: </strong>This study utilized data from the China National Stroke Registry 3 (CNSR3), a prospective registry encompassing 201 Chinese hospitals from August 2015 to March 2018. A total of 10,508 AIS patients were included, with a median age of 62.0 years (IQR: 54.0-70.0), and 65% were female. Eighteen AIS-related comorbidities were considered in the analysis and frequent pattern mining was employed to identify potential comorbidity patterns among AIS patients. Functional outcomes at 1 year after an AIS event were assessed using the modified Rankin Scale. Logistic regression models were utilized to evaluate associations of comorbidities, their patterns with AIS prognosis. Furthermore, association rule mining was applied to explore the hidden comorbidity combinations and their relationship with functional outcomes based on the identified patterns.</p><p><strong>Results: </strong>Comorbidity was observed in 88.9% of AIS patients. The majority of AIS patients exhibited one to 3 comorbidities. Eight patterns of main comorbidities among AIS patients were identified. The pattern of common metabolic disorders, coronary heart disease, and atrial fibrillation demonstrated the strongest association (OR = 2.49, 1.59-3.89) with the development of poor functional outcomes. The further combination of heart failure and arthritis significantly increases the probability of poor functional outcomes, with lifts of 3.11 and 5.52, respectively.</p><p><strong>Conclusions: </strong>Our study revealed that comorbidity is highly prevalent among AIS patients in China, encompassing diverse patterns. Specific comorbidities and comorbidity patterns are closely associated with poor functional outcomes. Our findings emphasized the importance of prioritizing comprehensive management of AIS and AIS-related comorbidities to reduce the risk of disability among AIS patients.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-13"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Green Tea Consumption and Cognitive Function: A Meta-Analysis of Current Evidence.","authors":"Shiyao Zhou, Yating Zhu, Na Ren, Mishan Wu, Yu Liu","doi":"10.1159/000543784","DOIUrl":"10.1159/000543784","url":null,"abstract":"<p><strong>Background: </strong>Tea is widely consumed around the world, with green tea showing potential protective effects against cognitive decline, as indicated by multiple studies. These effects are thought to stem from its polyphenols and neuroprotective properties. This study aimed to systematically review and meta-analyze recent observational research on the link between green tea consumption and the risk of cognitive impairment.</p><p><strong>Methods: </strong>A systematic search was performed in PubMed, Embase, Web of Science, and the Cochrane Library for observational studies published between September 2004 and September 2024. The relationship between green tea consumption and cognitive impairment was summarized using odds ratios with 95% confidence intervals. Additionally, the study conducted subgroup analyses, assessed heterogeneity, evaluated publication bias, and performed sensitivity analyses.</p><p><strong>Results: </strong>Eighteen studies were included, comprising a total of 58,929 participants. The quality of these studies was evaluated using the Newcastle-Ottawa Scale, and overall, the quality was found to be high. The random-effects meta-analysis indicated that green tea consumption was inversely associated with cognitive impairment OR 0.63 (95% CI: 0.54-0.73), with the greatest benefit observed in individuals aged 50-69 years. Subgroup analysis showed protective effects for dementia OR 0.74 (95% CI: 0.56-0.99) and mild cognitive impairment OR 0.64 (95% CI: 0.43-0.96). Additionally, a significant reduction in the risk of cognitive impairment was observed in Asian populations, whereas no such association was found in European populations. Both women OR 0.51 (95% CI: 0.28-0.95) and men OR 0.47 (95% CI: 0.28-0.80) showed significant associations. High consumption groups had reduced cognitive impairment risk OR 0.64 (95% CI: 0.50-0.82).</p><p><strong>Conclusion: </strong>Green tea consumption is associated with a reduced risk of cognitive impairment, suggesting potential cognitive benefits. However, large-scale longitudinal studies are needed to confirm dose-response relationships and long-term effects. Future studies should also investigate the long-term effects of green tea and its role in personalized nutrition based on genetic predispositions.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-22"},"PeriodicalIF":3.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microsurgical Treatment versus Endovascular Treatment for Ruptured Intracranial Aneurysms in Elderly Patients: A Multicenter Study in Northern China.","authors":"Yikuan Gao, Xiuhu An, Bangyue Wang, Shunde Liu, Wuqiang Jiang, Xiangping Zhong, Lijin He, Xinyu Yang","doi":"10.1159/000544079","DOIUrl":"10.1159/000544079","url":null,"abstract":"<p><strong>Background: </strong>Management of ruptured intracranial aneurysms (RIAs) in elderly patients remains a major challenge in the treatment of cerebrovascular diseases. This study aims to provide a comprehensive analysis of the impact of microsurgical treatment (MST) and endovascular treatment (EVT) on the outcomes of elderly patients with RIAs in northern China.</p><p><strong>Methods: </strong>We consecutively enrolled elderly patients with RIAs who underwent surgery in the Chinese Multicenter Cerebral Aneurysm Database (CMAD) from January 2017 to December 2020. In this study, in-hospital complications, survival, and functional outcomes were compared between MST and EVT after 1:1 propensity score matching (PSM). Kaplan-Meier survival analyses and Cox proportional hazards modeling identified factors associated with mortality in both groups. Logistic regression analyses identified 2-year survival-dependent risk factors, and subgroup analyses were conducted for key strata.</p><p><strong>Results: </strong>744 elderly patients with RIAs were enrolled in the study. 219 patients with MST after PSM were matched with 219 patients with EVT. Compared to EVT, MST had a higher 2-year mortality rate (32.8% vs. 20.5%, p = 0.002), higher incidence of adverse discharge outcomes (48.4% vs. 32.4%, p = 0.001), longer length of stay (LOS) (16 [12-24] vs. 15 [10-23], p = 0.049), pneumonia (MST: 31.1%; EVT: 21.9%, p = 0.030), and intracranial infection (9.6% vs. 2.7%, p = 0.005). However, there was no difference in the 2-year survival-dependent outcome (22.7% vs. 23.2%, p = 0.924). Differences in risk factors for mortality and 2-year survival-dependent outcomes were observed between the MST and EVT groups in the elderly population. The negative association of EVT with risk of mortality was consistent across specific subgroups.</p><p><strong>Conclusion: </strong>Elderly patients with RIAs who underwent EVT were significantly better than the MST group in terms of short-term functional outcomes, in-hospital complications, long-term survival, and LOS. However, there were no differences in the 2-year survival-dependent outcomes.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-12"},"PeriodicalIF":3.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secular Trends in the Incidence of Encephalitis and Outcomes of Postencephalitic Epilepsy in Taiwan: A Nationwide Population-Based Study.","authors":"Yi-Shan Wang, Chi Fan, Ju-Yin Hou, Yi-Ting Cheng, Yi-Hsuan Liu, Cheng-Yen Kuo, Jainn-Jim Lin, Chang-Fu Kuo, Kuang-Lin Lin, I-Jun Chou","doi":"10.1159/000543853","DOIUrl":"10.1159/000543853","url":null,"abstract":"<p><strong>Background: </strong>Encephalitis can lead to significant disability among survivors. Up-to-date estimates of encephalitis incidence and the risk of postencephalitic epilepsy (PE) are crucial for informing health policy.</p><p><strong>Methods: </strong>We used the National Taiwan Insurance Research Database to estimate the standardized incidence of encephalitis for each year from 2003 to 2017. We analyzed PE among these cases.</p><p><strong>Results: </strong>From 2003 to 2017, the age- and sex-standardized incidence of encephalitis increased from 5.95 (95% confidence interval [CI]: 5.61-6.28) to 10.46 (95% CI: 10.04-10.87) per 100,000 person-years, with an annual percentage change of 1.6% (1.1-2.2, p < 0.05). However, yearly variation was observed. The incidence was consistently higher in patients under 18 years than in those aged ≥ 18 years throughout the study period. In 2017, the highest annual incidence was seen in adults aged ≥ 70 years and in children aged 1-4 years. Approximately 20% of the survivors developed PE within 5 years, with the highest risk observed in infants under 1 year of age.</p><p><strong>Conclusion: </strong>The overall incidence of encephalitis in Taiwan increased from 2003 to 2017. Pediatric patients, particularly those under 1 year of age, are more vulnerable to encephalitis and its long-term complications, including PE, compared to adults, except for those aged ≥ 70 years.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-14"},"PeriodicalIF":3.2,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Mortality in a Large Cohort of Elders with Essential Tremor.","authors":"Ericka D Carter, Diane S Berry, Stephanie Cosentino, Elan D Louis","doi":"10.1159/000543879","DOIUrl":"10.1159/000543879","url":null,"abstract":"<p><strong>Background: </strong>Prospective data show an increased risk of mortality in essential tremor (ET). Understanding the contributors to this increased mortality is of value.</p><p><strong>Methods: </strong>A total of 347 cases were enrolled in a prospective study of cognition in elders with ET (M baseline age = 79.6 years, M follow-up length = 2.7 years). At each visit, cases completed clinical assessments, a cognitive test battery, and were assigned a Clinical Dementia Rating (CDR). Cox proportional hazards regression equations identified predictors of cases' relative risk of mortality.</p><p><strong>Results: </strong>41 (11.8%) of 347 cases died during follow-up. Deceased cases were older at baseline, had fewer years of education, used more medication, had more severe tremor, had more gait impairment, and reported more falls, less physical activity, and more depressive symptoms than did living cases. In univariate analyses, a CDR score of 1 or 2 (dementia) was associated with a six-fold increased risk of mortality (hazard ratio [HR] = 6.33). Moderate rather than milder levels of dementia (CDR 2 rather than 1) were driving this effect, with multivariate models demonstrating HRs in excess of 7.5 (p < 0.001). Gait impairment and falls were also associated with significant increased risk of mortality in multivariate models.</p><p><strong>Conclusion: </strong>We identified several factors that may be used to risk-stratify ET patients with respect to mortality. The information from these analyses can be of value in identifying subgroups of ET patients who demonstrate risk for early death; such subgroups can then be targeted for interventions as well as preventive measures.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-10"},"PeriodicalIF":4.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of Intracerebral Hemorrhage in Asia from 1990 to 2030: A Population-Based Study.","authors":"Haomiao Wang, Jinxin Lin, Fengchun Zhao, Xuyang Zhang, Long Wang, Chao Zhang, Ran Luo, Yi Yin, Shuixian Zhang, Rong Hu","doi":"10.1159/000543638","DOIUrl":"10.1159/000543638","url":null,"abstract":"<p><strong>Background: </strong>Intracerebral hemorrhage represents a critical subtype of stroke, imposing substantial social and economic challenges. Considering the considerable impact of intracerebral hemorrhage in Asia and the absence of studies detailing its epidemiological features, the aim of this study was to elucidate the temporal trends and distribution characteristics of intracerebral hemorrhage in Asia from 1990 to 2021, as well as to forecast the future burden.</p><p><strong>Methods: </strong>The data derived from Global Disease Burden Study 2021 were used to investigate the age-standardized rates and absolute numbers of incident intracerebral hemorrhage cases and related deaths in Asia across genders, age groups, and geographical locations. An estimated annual percentage change was estimated to represent temporal trends, and an autoregressive integrated moving average model was used to forecast the future burden.</p><p><strong>Results: </strong>In Asia, the age-standardized incidence and mortality rates of intracerebral hemorrhage per 100,000 population have declined from 1990 to 2021, despite a continuous increase in the absolute numbers, which exhibit significant heterogeneity across different geographical locations. In terms of gender, males experience a greater burden of intracerebral hemorrhage compared to females, and the impact of risk factors on disability-adjusted life years of intracerebral hemorrhage varies. In comparison to the figures observed in 2021, our forecasts indicate a rise in the burden of intracerebral hemorrhage in Asia.</p><p><strong>Conclusions: </strong>The study offers an extensive depiction of the epidemiological features of intracerebral hemorrhage in Asia spanning from 1990 to 2021 while also outlining the diverse trajectories of the impending burden of this condition in the region. Comprehending the expected increase in disease burden can aid in formulating tailored strategies to tackle upcoming challenges.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-14"},"PeriodicalIF":3.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Epilepsy across 25 Sub-Counties in Three Districts of Northern Uganda.","authors":"Joyce Moriku Kaducu, Fiston Ikwa Ndol Mbutiwi, Luise Keller, Gabriele Escheu, Peter Hauke, Bettina Pfausler, Erich Schmutzhard, Veronika Schmidt, Hélène Carabin, Emilio Ovuga, Andrea S Winkler","doi":"10.1159/000543472","DOIUrl":"10.1159/000543472","url":null,"abstract":"<p><strong>Introduction: </strong>Epilepsy is one of the most common neurological conditions worldwide, with large variation in prevalence across sub-Saharan African countries. Northern Uganda is one of the poorest areas of the country and has seen a high density of pigs and a prevalence of Taenia solium, a zoonotic tapeworm transmitted which causes neurocysticercosis in humans. The objective of this study was to estimate the population-level prevalence of active epilepsy in 25 sub-counties of northern Uganda.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in 2010-2011 in 25 sub-counties of Moyo, Adjumani, and Gulu districts, northern Uganda. Participants were sampled using a multistage cluster sampling strategy including sub-counties, parishes, villages, and households as sampling levels. Eligible individuals were interviewed using a previously validated screening questionnaire for epilepsy. Screen positive individuals were further examined by a team of neurologists for confirmation of active epilepsy. Sampling weights and post-stratification to account for sex distribution in each of the 25 sub-counties sampled based on projected 2010 population sizes were applied.</p><p><strong>Results: </strong>A total of 38,303 individuals were sampled across 299 villages from 25 sub-counties. The overall weighted and post-stratified prevalence estimate of active epilepsy was 3.7% (95% confidence interval [CI]: 3.4%-3.9%). However, there was large variation across sex (4.6% (95% CI: 4.2%-5.0%) in men and 2.7% (95% CI: 2.4%-3.0%) in women) and across sub-counties ranging from 1.7% in Pece Division (Gulu District) and Moyo Town Council (Moyo District) to 6.6% in Awach (Gulu District). People aged between 10 and 19 were the most affected.</p><p><strong>Conclusions: </strong>In northern Uganda, active epilepsy was very prevalent but varied largely across sub-counties. Males were a lot more affected than women, making the use of weighted and post-stratified methods to estimate the prevalence of epilepsy essential. Implementing programs and interventions targeting the control of local risk factors of epilepsy such as neurocysticercosis and improving population health care access could help reduce the rather high prevalence of epilepsy in this area of the country.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-12"},"PeriodicalIF":3.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing Loss as a Risk Factor for Dementia: A Nationwide 15-Year Follow-Up Cohort Study in Taiwan.","authors":"Jia-Fu Lee, Chun-Chia Lai, Chi-Hsiang Chung, Tzu-Hsuan Weng, Yao-Ching Huang, Shi-Hao Huang, Bing-Long Wang, Pi-Ching Yu, Wu-Chien Chien","doi":"10.1159/000542602","DOIUrl":"10.1159/000542602","url":null,"abstract":"<p><strong>Introduction: </strong>Although hearing loss is associated with dementia, the exact causal relationship between hearing loss and dementia remains unclear. Early detection and prevention of hearing loss are essential. In this study, data from the National Health Insurance Research Database (NHIRD) of Taiwan were used to monitor patients with hearing loss for 15 years to determine whether hearing loss leads to dementia.</p><p><strong>Methods: </strong>This retrospective matched-cohort study involved 208,570 individuals, divided into 41,714 patients with hearing loss and 166,856 controls matched by sex, age, and chronic diseases. Cox regression analysis was conducted on data obtained from the NHIRD for the period 2000-2015 to determine the hazard ratio (HR) associated with dementia.</p><p><strong>Results: </strong>The percentage of patients with hearing loss who developed dementia was higher than that of the control group (18.67% vs. 14.10%). The onset age of dementia was younger in the hearing loss group (69.95 vs. 70.31 years, p = 0.001). Middle-aged individuals (45-65 years) with hearing loss were more likely to develop dementia compared with those without hearing loss (48.53% vs. 47.94%, p = 0.03). Compared with the controls, the patients with hearing loss were more likely to develop hyperlipidemia and stroke. In the patients with hearing loss, the adjusted HRs for Alzheimer's disease (AD), vascular dementia, and other types of dementia were significant. The patients were followed up for an average of 7.82 years. Compared with the controls, the patients with hearing loss exhibited a shorter mean time to dementia onset (5.21 vs. 5.49 years, p < 0.001).</p><p><strong>Conclusion: </strong>Hearing loss may increase the risks of AD, dementia, hyperlipidemia, and stroke. Therefore, health-care providers should closely monitor cardiovascular complications in patients with hearing loss.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-15"},"PeriodicalIF":3.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Burden of Alzheimer's Disease and Other Dementias during 1990-2021: A Global Burden of Disease and Risk Factors Study 2021-Based Study.","authors":"Renxi Wang","doi":"10.1159/000543578","DOIUrl":"10.1159/000543578","url":null,"abstract":"<p><strong>Introduction: </strong>In most countries and territories, current data on the burden of Alzheimer's disease (AD) and other dementias are lacking. We aimed to assess the trends, burden, and inequalities of AD and other dementias at global, regional, and national level from 1990 to 2021.</p><p><strong>Methods: </strong>The data on disease burden of AD and other dementias during 1990-2021 were extracted from Global Burden of Disease and Risk Factors Study 2021 (GBD 2021). Average annual percentage changes (AAPCs) of age-standardized prevalence, mortality, and disability-adjusted life-years (DALYs) were estimated as an indicator to evaluate the healthcare system.</p><p><strong>Result: </strong>The global age-standardized prevalence of AD and other dementias increased from 672 (95% uncertainty interval: 589 to 764) per 100,000 population in 1990 to 694 (603 to 794) per 100,000 population in 2021, with AAPCs of 0.09% (95% confidence interval: 0.06% to 0.11%). However, age-standardized mortality did not change (AAPCs: 0.00% [-0.01% to 0.02%]) and age-standardized DALYs slightly increased from 446 (206 to 958) to 451 (213 to 950) per 100,000 population (AAPCs: 0.01% [0.00% to 0.03%]). While the highest prevalence remained in population aged 65-69 and the countries with a high-middle sociodemographic index (SDI) such as East Asia (e.g., China), the highest mortality and DALYs were found in population aged 65-69 and the countries with a low-middle SDI such as South Asia (e.g., India). High fasting plasma glucose ranked the highest risk factor for DALYs during 1990-2021.</p><p><strong>Conclusion: </strong>The global increased prevalence of AD and other dementias may partly be attributed to population aged 65-69 in the countries with a high-middle SDI (e.g., China), whereas mortality and DALY ratio of population aged 65-69 from the countries with a low-middle SDI (e.g., India) is most significantly growing. Controlling of high fasting plasma glucose may be needed for the reduction of DALYs from AD and other dementias.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-12"},"PeriodicalIF":3.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}