Neuroepidemiology最新文献

{"title":"Insights on the Association between Antimicrobial Use and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis.","authors":"Moaz Elsayed Abouelmagd, Omar Kassar, Atef Hassan, Maickel AbdelMeseh, Abdelrahman Mady, Hamdy A Makhlouf","doi":"10.1159/000545218","DOIUrl":"10.1159/000545218","url":null,"abstract":"<p><strong>Introduction: </strong>Gut dysbiosis is one of the environmental factors that might contribute to the development of Parkinson's disease (PD). The potential impact of antimicrobial agents on PD risk, particularly through dysbiosis and neuroinflammation, is an area of ongoing investigation, though findings remain inconsistent.</p><p><strong>Methods: </strong>This systematic review and meta-analysis aimed to assess the relationship between antimicrobial use and PD risk. After searching PubMed, Scopus, Web of Science, and Embase, ten studies involving 3,755,583 participants, including 52,974 PD patients, were included.</p><p><strong>Results: </strong>Antibacterial use was not significantly correlated with PD risk (odds ratio [OR] = 1.14; 95% CI: 0.97-1.33; p = 0.11, I2 = 84%). After excluding one study, the odds of PD became significantly higher (OR = 1.22; 95% CI: 1.04-1.44; p = 0.01). Specific antibacterial classes, such as tetracyclines and macrolides, showed no significant associations with PD. However, cephalosporins had a protective effect (OR = 0.86; p = 0.04), while antifungal use increased PD risk (OR = 1.16; p = 0.001). Regarding antiviral use, a significant reduction in PD risk was observed in patients with hepatitis C virus undergoing antiviral treatment (HR = 0.69; p = 0.0008).</p><p><strong>Conclusion: </strong>The findings indicate complex relationships between antimicrobial use and PD risk. While antibacterials, in general, tend to increase PD risk, specific antibacterial may offer a protective effect, while antifungal agents appear to increase PD risk. Antiviral therapy may reduce PD risk in HCV patients. Further research is needed to confirm our results.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-13"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, Regional, and National Temporal Trends in Prevalence for Migraine in Women of Childbearing Age: An Updated Age-Period-Cohort Analysis Based on Global Burden of Disease Study 2021.","authors":"Ben Hu, Xiaohan Qiu, Yan Wang, Xing Wei, Jun Feng, Linlin Hou","doi":"10.1159/000545221","DOIUrl":"10.1159/000545221","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to provide a comprehensive assessment of temporal trends in migraine prevalence among women of childbearing age (WCBA) at global, regional, and national levels from 1992 to 2021, with particular emphasis on examining the associations between prevalence patterns and age, period, and birth cohort effects across different sociodemographic index (SDI) regions.</p><p><strong>Methods: </strong>We conducted a secondary analysis of data from the Global Burden of Disease Study 2021. Migraine prevalence estimates and 95% uncertainty intervals (UIs) for WCBA were extracted. An age-period-cohort model was employed to estimate the net drift (primary outcomes), local drift, and age/period/cohort relative risks (secondary outcomes).</p><p><strong>Results: </strong>The global number of WCBA with migraine reached 493,937,856.01 (95% UI: 420,683,360.54-577,874,600.76) in 2021. The highest burden was found in India (95.7 million) and China (68.1 million), together accounting for substantial proportion of global prevalence. The global net drift showed a minimal change of 0.01% (95% CI: 0.00-0.02) per year, with variations across sociodemographic index (SDI) regions ranging from -0.03% per year (95% CI: -0.04 to -0.02) in low-middle-SDI regions to 0.16% (95% CI: 0.15-0.17) in middle-SDI regions. Local drift analysis reveals that migraine prevalence increases across young age groups (15-19 years) in high-SDI regions, while lower-SDI regions generally display stable rates. Globally, increases in migraine prevalence among young adults within WCBA are notably persistent. Across SDI regions, age effects follow similar patterns, with risk rising with age and peaking in the mid-reproductive years (ages 30-39). Over time, period risks and unfavorable trends across successive birth cohorts have intensified, particularly in high-, high-middle-, and middle-SDI regions.</p><p><strong>Conclusion: </strong>Although global migraine prevalence among WCBA remains stable, an unfavorable upward trend in younger age groups (15-19 years) in high-, high-middle-, and middle-SDI regions, alongside worsening period/cohort risks, highlights current gaps in prevention and management. Improved strategies are expected to reduce risks for younger birth cohorts and all age groups over time.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-20"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid Disorders as a Risk Factor for Neurodegenerative Proteinopathies: A Large-Scale Propensity Score-Matched Analysis.","authors":"Eman A Toraih, Sidra Siddiqui, Sarah Siddiqui, Kasra Shirini, Nadra Elfezzani, Ahmed Abdelmaksoud, Rami M Elshazli, Mohaamad H Hussein, Ekramy M Elmorsy, Manal S Fawzy","doi":"10.1159/000545369","DOIUrl":"10.1159/000545369","url":null,"abstract":"<p><strong>Background: </strong>The relationship between thyroid disorders and neurodegenerative diseases remains poorly understood. This large-scale retrospective cohort study aimed to investigate the association between thyroid disorders and various neurodegenerative diseases, as well as the potential impact of thyroidectomy.</p><p><strong>Methods: </strong>We analyzed data from 3,719,666 patients with thyroid disorders and 2,945,438 controls from 120 healthcare organizations (TriNetX database). After propensity score matching, each group included 2,033,096 patients. We compared the risk of neurodegenerative diseases between these groups and examined the effect of thyroidectomy in a subgroup analysis of 31,753 matched pairs.</p><p><strong>Results: </strong>Patients with thyroid disorders showed significantly higher risks of Alzheimer's disease (RR = 1.15, 95% CI: 1.110-1.195), Parkinson's disease (RR = 1.25, 95% CI: 1.187-1.318), amyotrophic lateral sclerosis (RR = 1.35, 95% CI: 1.131-1.622), frontotemporal dementia (RR = 1.44, 95% CI: 1.219-1.702), Lewy body dementia (RR = 1.15, 95% CI: 1.107-1.186), progressive supranuclear palsy (RR = 1.41, 95% CI: 1.095-1.819), vascular dementia (RR = 1.32, 95% CI: 1.266-1.369), Niemann-Pick disease type C (RR = 1.34, 95% CI: 1.092-1.638), and Wilson's disease (RR = 1.26, 95% CI: 1.056-1.507). Interestingly, the risk of multiple sclerosis was lower (RR = 0.80, 95% CI: 0.738-0.862). Thyroidectomy was associated with a 44.2% lower risk of Lewy body dementia (RR = 0.558, 95% CI: 0.339-0.919, p = 0.020).</p><p><strong>Conclusions: </strong>Thyroid disorders are significantly associated with an increased risk of several neurodegenerative diseases. Thyroidectomy may have a protective effect against Lewy body dementia. These findings suggest a complex relationship between thyroid function and neurodegeneration, emphasizing the need for neurological monitoring in patients with thyroid disorders and further research into thyroid-brain interactions.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-13"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Possible Rem Sleep without Atonia in the General Population: Insights from the São Paulo Epidemiologic Sleep Study (EPISONO).","authors":"Gabriel Natan Pires, Matteo Cesari, Ambra Stefani, Monica Levy Andersen, Dalva Poyares, Birgit Högl, Sergio Tufik","doi":"10.1159/000545499","DOIUrl":"10.1159/000545499","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to estimate the prevalence of possible rapid eye movement (REM) sleep without atonia (RWA) in the general population.</p><p><strong>Methods: </strong>The study was based on data from the São Paulo Epidemiologic Sleep Study (EPISONO) 4th edition, a non-clinical population-based sleep study performed in the city of São Paulo, Brazil, between 2018 and 2019. All individuals underwent type-I polysomnography with the addition of bilateral electromyography of the flexor digitorum superficialis (FDS) muscles. The FDS activity index was calculated as the percentage of 30-s REM sleep epochs containing at least five 3-s mini-epochs with phasic muscle activity, with a threshold of 7.7% being applied to identify possible RWA cases. The adjusted prevalence of possible RWA was calculated as the proportion of cases above the diagnostic threshold, corrected by the estimated specificity values according to the REM-specific apnea-hypopnea index (AHI; 85% for REM AHI <15 and 60% for REM AHI ≥15).</p><p><strong>Results: </strong>The final sample comprised 632 participants (376 females, 59.49%), and 68 possible RWA cases were identified. The adjusted prevalence of RWA in the whole sample was 8.24% (95% CI: 6.09%-10.38%). The adjusted prevalence stratified by sex was 10.63% among men (95% CI: 6.85%-14.40%) and 6.61% among women (95% CI: 4.10%-9.12%) (p = 0.013), resulting in a male/female prevalence ratio of 1.61. Possible RWA prevalence was similar between men and women in the 20-39 and 40-59 age ranges, but significantly higher among men aged 60-80 (16.57%, 95% CI: 6.66%-26.49%) than women in the same age range (7.35%, 95% CI: 2.62%-12.81%) (p = 0.022).</p><p><strong>Conclusions: </strong>The prevalence of possible RWA in the sample was 8.24% and was similar between the sexes in most age ranges but became more frequent among men from the age of 60 years old.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-14"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Neutrophil-to-Lymphocyte Ratio with Incidence and Disease Progression in Parkinson's Disease.","authors":"Yi Xiao, Yuanzheng Ma, Huifang Shang","doi":"10.1159/000545314","DOIUrl":"10.1159/000545314","url":null,"abstract":"<p><strong>Introduction: </strong>The neutrophil-to-lymphocyte ratio (NLR) is widely regarded as a proxy for system inflammation. The previous study indicated that the NLR might be higher in Parkinson's disease (PD) compared to healthy controls (HC). The study aimed to assess the role of system inflammation indicated by NLR in the incidence and progression of PD.</p><p><strong>Methods: </strong>We included participants from the longitudinal population-based cohort, UK Biobank, to analyze the association of NLR and the risk of PD. We conducted the Cox proportional hazards analyses as the primary analysis to determine the association between baseline NLR value and the risk of PD in UK Biobank. Then we further used data from a disease-specific longitudinal cohort, Parkinson's Progression Markers Initiative (PPMI), to evaluate the differences between individuals with higher PD risk, and early-stage PD patients in the values of NLR. Patients with PD were divided into two groups according to the median value of NLR (2.35). Linear mixed models (random intercept and random slope) were used to evaluate the relationship between the high/low NLR groups and the disease progression.</p><p><strong>Results: </strong>A number of 288,837 participants from UK Biobank were included and 1,429 were diagnosed with incident PD. Among them, higher NLR was associated with an increased risk of incident PD in HC (per SD increment hazard ratio [HR], 1.041; p < 0.001). A total of 349 early-stage PD patients, 438 individuals with higher PD risk, and 207 HC were included from PPMI. PD patients and individuals with higher PD risk had a significantly higher NLR compared to HCs. Higher NLR group was associated with a faster deterioration of the Montreal Cognitive Assessment score in PD patients in 2 years (β [SE] = -0.225 [0.080], p = 0.005).</p><p><strong>Conclusion: </strong>Increased NLR in HC was linked with a higher risk of incident PD, and higher NLR was associated with a faster cognitive decline in PD patients, which indicated that inflammation was involved in the incidence of PD and the cognitive decline in early-stage PD.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-11"},"PeriodicalIF":3.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Annual Incidence of Vascular Dementia and Other Dementias: A Population-Based Study in Eastern Finland.","authors":"Ada Tuominen, Virve Kärkkäinen, Viivi Jetsonen, Tuomas Selander, Olli Lappalainen, Pekka Jäkälä, Anne Koivisto","doi":"10.1159/000545219","DOIUrl":"10.1159/000545219","url":null,"abstract":"<p><strong>Introduction: </strong>Considering the globally growing population and the rising incidence of dementia, it is important to understand the proportion of dementia cases affected by vascular brain disease. We aimed to study the incidence of vascular dementia (VD) and other dementias in a defined population in Finland to better understand VD's contribution to the total incidence of dementias and to assess the sensitivity of their diagnostics.</p><p><strong>Methods: </strong>We aimed to collect all dementia diagnoses made in Northern Savo, Finland, in 2020. The memory disorder diagnoses were identified using the International Classification Codes 10th Revision (ICD-10) diagnosis codes. Finally, we studied the diagnoses in relation to demographic data, focusing on VD.</p><p><strong>Results: </strong>The total number of new diagnoses of dementia with a vascular component or vascular alone was 202, with 20 cases attributable to pure VD. The annual incidence of dementias with a vascular component in Northern Savo was 81.4 per 100,000 across the population and 310.8 per 100,000 in the age group of ≥65. In our study population, 23.8% of all incident dementia cases were associated with vascular disease.</p><p><strong>Conclusion: </strong>According to our findings, dementia associated with vascular pathology has the second highest incidence after Alzheimer's disease, while pure VD is rarely diagnosed. Our findings align with previous international studies and a recent national registry study. Future studies with a prospective study setting, potentially incorporating extensive neuroimaging, would be critical in further understanding the epidemiology of VD.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-7"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How the COVID-19 Pandemic Impacted Neurological Hospital Admissions in Germany: A Retrospective Analysis.","authors":"Nils Diogo Nellessen, Mohamad Samehni, Sven Hohenstein, Andreas Bollmann, Julius Dengler, Frederick Palm, Juraj Kukolja","doi":"10.1159/000543880","DOIUrl":"10.1159/000543880","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic has had a major impact on health care. Shifts in inpatient and outpatient case numbers and morbidity have been quantified in other medical specialties (e.g., oncology and psychiatry). Such an analysis is lacking in neurological cases. Thus, we performed an anonymized, retrospective, multicenter analysis of administrative data from a network of 86 hospitals in Germany.</p><p><strong>Methods: </strong>Over 350,000 neurological cases admitted between January 2019 and December 2022 were included. The main outcome measures were (1) deficit in inpatient hospital admissions during the pandemic compared to changes in outpatient cases; (2) morbidity, mortality, and complication rates during the pandemic; and (3) length of stay for inpatients.</p><p><strong>Results: </strong>There was an evident deficit in inpatient admissions between -11% and -20%, which was not compensated for by outpatient cases. Furthermore, hospitalized patients exhibited several significantly increased measures of mortality (3.7% vs. 3.2%, p < 0.001) and morbidity compared to the pre-pandemic period. Interestingly, the proportion of patients with specific chronic comorbidities at risk for severe COVID-19, such as congestive heart failure, was lower during the pandemic (10% vs. 12%, p < 0.001). Finally, the length of hospital stay was shorter during the pandemic (i.e., 6.5 vs. 6.4 days during the wildtype period, p < 0.001).</p><p><strong>Conclusion: </strong>These findings suggest a significant shift in hospital utilization patterns among neurology departments during the COVID-19 pandemic. While overall admissions decreased, average case severity was significantly higher. The latter was due to a selection bias because elective cases, less urgent and less morbid patients avoided hospital admission, or because their admission may have been delayed. A shorter length of stay was indicative of more efficient treatment. The avoidance of hospital care by patients with severe comorbidities could indicate a changed prioritization and utilization pattern but could also point to unmet health care needs. These observations underline the necessity for healthcare systems to adapt resource allocation and patient management strategies to ensure continuous quality of care during a pandemic.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-10"},"PeriodicalIF":3.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Epidemiological Trends and Prediction of Brain and Central Nervous System Cancer Incidence and Mortality, 1992-2021: Age-Period-Cohort Analysis.","authors":"Yu Li, Kai Zhao","doi":"10.1159/000544932","DOIUrl":"10.1159/000544932","url":null,"abstract":"<p><strong>Introduction: </strong>The study uniquely focuses on the global incidence, mortality, and temporal trends of brain and central nervous system (CNS) cancer from 1992 to 2021. It explores the association between the disease burden and factors such as age, period, and birth cohorts, and provides forecasts for future incidence and mortality.</p><p><strong>Methods: </strong>Leveraging the Global Burden of Disease 2021 data from 1992 to 2021, we calculated incidence, and deaths and their age-standardized rates (ASRs) and assessed temporal trends using the average annual percent change derived from joinpoint regression analysis. To explore the impacts of age, period, and birth cohort in greater depth, we applied an age-period-cohort model. Additionally, a Nordpred age-period-cohort analysis was conducted to forecast the global epidemiological trends from 2022 to 2031.</p><p><strong>Results: </strong>The global incidence of brain and CNS cancer has increased from 2,831,075 in 1992 to 3,420,786 in 2021, and the number of mortalities has risen by 80.62%. The incidence ASR was highest in high sociodemographic index (SDI) regions and showed an increasing trend. Conversely, the mortality ASR displayed downward trends in high-middle and high SDI regions. Notably, the age-period-cohort model suggests a recent increase in incidence risk and a decline in mortality. From 2022 to 2031, the global mortality ASR was predicted to decrease whereas the incidence ASR increases slowly.</p><p><strong>Conclusion: </strong>The global trends in brain and CNS cancer incidence and mortality generally showed an increasing trend with considerable heterogeneity. Furtherly, high SDI regions were displayed where healthcare systems could conduct earlier and better medical interventions with better outcome for brain and CNS cancer.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-13"},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excess Mortality in Adults and Adolescents with Epilepsy, View from a 10-Year Nationwide Cohort.","authors":"Chris Serrand, Frederic Balusson, Adeline Degremont, Erika Nogue, Emmanuel Oger, William Szurhaj, Arielle Crespel, Caroline Brière, Thibault Mura, Marie Christine Picot","doi":"10.1159/000544036","DOIUrl":"10.1159/000544036","url":null,"abstract":"<p><strong>Introduction: </strong>People with epilepsy present an excess risk of mortality, but questions remain regarding the underlying causes and risk distribution. Here, we estimated the excess mortality by age and sex among adults and adolescents with epilepsy in France and identified their main causes.</p><p><strong>Methods: </strong>A national cohort study was conducted between 2009 and 2019, with adults and adolescents aged between 12 and 60 years and having at least one hospitalization, assurance record, or delivery of anti-seizure medication linked to epilepsy on the French National Health Data System (SNDS). Mortality rates and standardized mortality ratios (SMR) were estimated according to age and sex. Specific causes of death from death certificates were also explored.</p><p><strong>Results: </strong>Between 2009 and 2019, 619,753 patients were included, of whom 60,033 (9.7%) died during follow-up, corresponding to a mortality rate of 9.55 [9.30; 9.79] per 1,000 person-years. Compared with the general population, people with epilepsy had a 3.33-fold higher risk of death [3.24; 3.41], with a higher risk in women than in men, with SMRs of 4.11 [3.94; 4.29] and 2.99 [2.90; 3.09], respectively. Excess mortality was found for all causes of death, particularly neurological causes. Women with epilepsy presented a higher excess risk of death than men, especially between 20 and 40 years old.</p><p><strong>Conclusion: </strong>Our findings provide further evidence of increased mortality in patients with epilepsy. Remarkably, we found major differences according to sex, which have been largely overlooked so far. The fact that young women with epilepsy are at risk poses additional clinical and societal challenges.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-13"},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Migraine and Other Types of Primary Headache in China: A Systematic Review and Meta-Analysis.","authors":"Yang Zhang, Changling Li, Ning Chen, Jinghuan Fang, Mengmeng Ma, Peiqi He, Li He","doi":"10.1159/000543086","DOIUrl":"10.1159/000543086","url":null,"abstract":"<p><strong>Introduction: </strong>Migraine and other types of primary headache are widely prevalent and are thought to have substantial economic implications on a global scale. Nevertheless, the precise prevalence rates in China exhibited discrepancies across various studies. The present study aimed to ascertain the prevalence of migraine and other primary headache disorders in China.</p><p><strong>Methods: </strong>A systematic search of peer-reviewed literature was conducted in the Chinese Wanfang, CNKI, PubMed, and MEDLINE databases from January 1988 to December 2023 to identify prevalence data on migraine and other primary headache disorders among the Chinese population, published in either English or Chinese language. The study utilized a random-effects model to summarize pooled prevalence estimates, with subgroup analyses conducted based on sex, age, publication year, and geographical region.</p><p><strong>Results: </strong>A total of 18 studies were included for detailed review and meta-analysis. The pooled prevalence of migraine and tension-type headache (TTH) in China was found to be 6.1% (95% CI: 4.1-8.6%) and 13.4% (95% CI: 7.2-21.2%), respectively. The prevalence of migraine in the years 1988-1999 was 1.3% (95% CI: 1.1-1.5%), while the prevalence of TTH was 5.0% (95% CI: 4.5-5.4%). In contrast, the prevalence of migraine in the years 2000-2023 increased to 7.0% (95% CI: 4.9-9.4%), with TTH prevalence at 13.2% (95% CI: 7.1-20.8%). The weighted-pooled prevalence of both migraine and TTH were higher in females than in males. Subgroup analyses suggested that factors such as geographical region, age, sex, and publication year may be associated with the prevalence of these headache disorders. A single study encompassing 3,457,170 participants revealed a prevalence rate of 0.0068% for cluster headache.</p><p><strong>Conclusion: </strong>Our research suggested an increasing trend in the prevalence of migraine and TTH in China over time, with females being more susceptible to primary headaches than males. This underscores the significance of not disregarding these conditions, especially in females. Future epidemiological studies of high quality are warranted to further investigate the prevalence of migraine and other primary headaches in China.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-11"},"PeriodicalIF":3.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}