Neuroepidemiology最新文献

{"title":"Maternal Smoking During Pregnancy, Smoking Initiation and the Risk of Epilepsy in the UK Biobank.","authors":"Qingya Zhao, Qianqian Ji, Qi Liu, Yue Xu, Xiaogang Lv, Yunzhang Wang, Ruoqing Chen, Xiaowei Xu, Yiqiang Zhan","doi":"10.1159/000547681","DOIUrl":"https://doi.org/10.1159/000547681","url":null,"abstract":"<p><strong>Objectives: </strong>The impact of early-life tobacco smoke exposure on epilepsy remains underexplored. Our study examines the associations between maternal smoking during pregnancy (MSDP), age of smoking initiation (ASI) and epilepsy risk, while investigating the mediating role of insulin-like growth factor-1 (IGF-1).</p><p><strong>Methods: </strong>We analyzed data from 427,285 participants for MSDP and 428,178 for ASI from the UK Biobank (UKB). Accelerated failure time (AFT) models and Cox proportional hazard models with time-dependent covariates were applied to evaluate the associations between MSDP, ASI and epilepsy onset. Mediation analyses were conducted to assess the role of IGF-1.</p><p><strong>Results: </strong>Our study involved 427,258 participants in survival analyses for MSDP and 428,178 for ASI. Participants exposed to maternal smoking during pregnancy had an 8% shorter epilepsy-free time (Time Ratio [TR]: 0.92, 95% Confidence Interval [CI]: 0.87-0.98, P<0.01) and significantly higher epilepsy risk (Hazard Ratio [HR]: 9.25, 95% CI: 1.91-44.83, P<0.01). Compared with never-smokers, childhood, adolescent and adult smoking initiation shortened epilepsy-free time by 27%, 18% and 13%, respectively, according to AFT models (P<0.001). Cox models indicated a 62%, 33% and 22% higher risk of epilepsy for smoking initiation during childhood, adolescence and adulthood (P<0.001). IGF-1 mediated 9% (95% CI: 5%-39%) of the effect for MSDP and 5% (95% CI: 3%-11%) for ASI.</p><p><strong>Conclusions: </strong>Smoking exposure in the early life stages, encompassing both prenatal and postnatal periods, accelerates the onset and increases the risk of epilepsy, with IGF-1 serving as a potential mediator. Further research is needed to elucidate these mechanisms.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-20"},"PeriodicalIF":4.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary microplastic intake with all-cause and cardiovascular diseases burden: a global analysis based on GBD 2021.","authors":"Junqi Wang, Dan Lin, Yulong Wei, Fangyuan Cui, Yucheng Yang, Shuangqing Zhai, Haifeng Wang","doi":"10.1159/000547465","DOIUrl":"https://doi.org/10.1159/000547465","url":null,"abstract":"<p><p>Introduction Microplastic (MP) has been proposed as a potential risk factor for cardiovascular disease (CVD), but the available epidemiological evidence remains limited and inconclusive. This study aimed to evaluate the association between dietary MP exposure and the global burden of CVD and all-cause outcomes. Methods We conducted a global analysis using data from 109 countries and regions between 2018 and 2021 to assess the association between dietary MP intake and global CVD burden. Outcomes included age-standardized mortality rate (ASMR), age-standardized disability-adjusted life years rate (ASDR), and age-standardized incidence rate (ASR) for both all causes and CVD. Multivariable linear mixed models were used to estimate associations, supported by nonlinear exposure-response analysis and stratified subgroup evaluations by demographic indicators, sociodemographic index (SDI), and geographic location. Results Dietary MP intake varied widely across regions, with the highest levels observed in low and low-middle SDI countries, particularly in coastal areas of Asia and Africa. Between 2018 and 2021, all-cause ASMR and ASDR increased globally, while CVD-related ASMR and ASDR showed a slight decline. After full adjustment, each 1 mg per capita per day increase in dietary MP intake was associated with an increase of 0.347 per 100,000 in CVD ASMR(P < 0.001) and 7.165 per 100,000 in CVD ASDR(P < 0.001). For all-cause outcomes, dietary MP intake was significantly associated with increased ASR. Subgroup analyses indicated stronger associations among older adults, populations in low SDI countries, and European regions. Conclusions Dietary MP exposure is significantly associated with increased global CVD burden, especially in socioeconomically disadvantaged populations. These findings highlight the growing health risks of MP pollution and support the necessity for global efforts to reduce exposure and guide public environmental health strategies.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-18"},"PeriodicalIF":4.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transparency of Systematic Reviews on Interventions for Multiple Sclerosis: Adherence to the GRADE Approach. Meta-research.","authors":"Adriane Carvalho de Meneses, Giullia Carvalho Mangas Lopes, Letícia Barbosa de Lima, Giovanna Marcilio Santos, Elaine Marcílio Santos, Andrea de Carvalho Anacleto Ferrari de Castro, Ana Luiza Cabrera Martimbianco","doi":"10.1159/000547394","DOIUrl":"https://doi.org/10.1159/000547394","url":null,"abstract":"<p><strong>Introduction: </strong>Many systematic reviews summarize research on interventions for multiple sclerosis (MS), yet concerns persist about their methodological quality. Assessing the certainty of evidence is a crucial step to ensure transparency and reliability in decision-making. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach is a widely accepted framework for this purpose; however, its application in MS systematic reviews remains unclear.</p><p><strong>Methods: </strong>A comprehensive search was conducted across the MEDLINE, Cochrane Database of Systematic Reviews, and Epistemonikos databases. The included reviews were assessed for their use of GRADE and the Summary of Findings (SoF) table.</p><p><strong>Results: </strong>We assessed 276 systematic reviews and observed a growing trend in publication over the past decade. Only 15% (42/276) applied the GRADE approach, of which 83% included a SoF table with explanations for evidence downgrades. Half of these were Cochrane reviews, where a SoF table is mandatory.</p><p><strong>Conclusion: </strong>This meta-research study highlights gaps in methodological rigor in systematic reviews of MS. Strengthening adherence to best practices in evidence synthesis, particularly systematic certainty assessments using the GRADE approach, is essential for improving the reliability of recommendations and supporting evidence-based decision-making in MS care.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-12"},"PeriodicalIF":4.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, Regional, and National Epidemiological Burden of Motor Neuron Disease: A Comprehensive Assessment of Prevalence, Incidence, Mortality, and DALYs with Projections to 2036.","authors":"Yujun He, Jiajia Wang, Jie Tang, Lu Li, Jianying Chen, Hui Xu, Xiaojun Li, Miao Zhou, Yi Xu, Xiaoyi Wang","doi":"10.1159/000547389","DOIUrl":"https://doi.org/10.1159/000547389","url":null,"abstract":"<p><strong>Background: </strong>Motor Neuron Disease (MND) is a rare and fatal neurodegenerative disorder. Understanding its global, regional, and national burden is crucial for healthcare planning. However, existing studies have limitations such as data shortages, insufficient exploration of the impact of sociodemographic factors, and a lack of future projections.</p><p><strong>Objective: </strong>To systematically analyze the global, regional, and national burden of MND from 1990 to 2021, project the trends until 2036, and identify the primary drivers of changes in disease burden, providing evidence for healthcare planning and policy - making.</p><p><strong>Method: </strong>The latest data from the Global Burden of Disease (GBD) 2021 database were used to analyze the prevalence, incidence, mortality, and Disability - Adjusted Life Years (DALYs) of MND in 204 countries and territories. Multiple analytical methods were employed, including trend analysis, Joinpoint regression analysis, SDI correlation analysis, age - period - cohort analysis, decomposition analysis, and predictive analysis.</p><p><strong>Results: </strong>From 1990 to 2021, the global number of MND cases, deaths, and DALYs increased significantly, while the age - standardized prevalence and incidence rates decreased. There were gender and age differences in the disease burden, and non - linear associations with the SDI. Decomposition analysis indicated that population growth and aging aggravated the disease burden to varying degrees, while the impact of epidemiological changes differed. Projections showed that after 2021, the prevalence, incidence, and mortality of MND would exhibit different trends in the total population, males, and females, with a possible increase in male DALYs.</p><p><strong>Conclusions: </strong>The burden of MND is on the rise, with differences across genders, ages, and regions. This study provides important references for healthcare planning and policy - making. Future research should further explore the etiology, improve treatment strategies, and implement targeted public health interventions.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-22"},"PeriodicalIF":3.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Epidemiology of Central Nervous System Tumors in Arab Countries.","authors":"Sarah Al Sharie, Mohammad Araydah, Mouness Obeidat, Asem Mansour, Maysa Al-Hussaini","doi":"10.1159/000546703","DOIUrl":"https://doi.org/10.1159/000546703","url":null,"abstract":"<p><strong>Background: </strong>Brain and Central Nervous System (CNS) tumors represent a significant global health burden, with notable regional disparities in incidence, mortality, and survival. The Arab world, comprising 22 countries across the Middle East and North Africa (MENA), faces unique epidemiological challenges influenced by population demographics, healthcare access, and genetic factors. This study aims to analyze the incidence, mortality, and 5-year prevalence of brain and CNS tumors in Arab countries using Global Cancer Observatory (GLOBOCAN) 2020 and 2022 data, with comparisons by country, gender, and age group.</p><p><strong>Methods: </strong>Data were extracted from the GLOBOCAN \"Cancer Today\" portal for the years 2020 and 2022. We included all Arab countries and examined trends in crude rates, age-standardized incidence rates (ASIR), age-standardized mortality rates (ASMR), and incidence-to-mortality ratios (IMR), stratified by sex and age group.</p><p><strong>Results: </strong>Globally, CNS tumor cases rose from 308,102 in 2020 to 321,731 in 2022 (4.4%), while Arab countries saw an increase from 14,177 to 14,823 cases, (4.6%). Egypt reported the highest incidence, mortality, and prevalence in both years. Iraq demonstrated the highest ASIR and ASMR, while Jordan (in 2020) and Syria (in 2022) had unexpectedly high ASIR and ASMR among males. Older adults (≥50 years) bore the highest disease burden across all regions. Despite modest improvements in survival, IMR remained high in Arab countries, especially among children and older adults.</p><p><strong>Conclusion: </strong>The burden of brain and CNS tumors is increasing in the Arab region, with significant inter-country variation. These findings highlight the need for improved cancer registries, early detection programs, and region-specific strategies to enhance diagnosis and treatment outcomes.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-24"},"PeriodicalIF":3.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guillain-Barré Syndrome in Chile, incidence and mortality (2013-2019).","authors":"Juan Francisco Idiáquez, Rodrigo Salinas, Gabriel Cea","doi":"10.1159/000547305","DOIUrl":"https://doi.org/10.1159/000547305","url":null,"abstract":"<p><strong>Introduction: </strong>Guillain-Barré Syndrome (GBS) is a rare autoimmune disorder of the peripheral nervous system with incidence rates varying across regions. Based on hospital discharge data, this study aimed to analyze the incidence and mortality of GBS in Chile between 2013 and 2019.</p><p><strong>Methods: </strong>A retrospective review of GBS cases, identified using the ICD-10 code G61.0, was conducted using national hospital discharge records. The incidence rates were calculated annually and adjusted for the population. Demographic and clinical variables, including sex, age, insurance type, and outcomes, were analyzed.</p><p><strong>Results: </strong>1,696 cases were identified, yielding an annual incidence rate of 1.46 per 100,000 (95% CI 1.28-2.64). Most cases occurred in males (58.8%), with a mean age of 46.62 years. The mortality rate was 1.7%, and the high survival rate was 98.3%.</p><p><strong>Conclusion: </strong>The incidence of GBS in Chile is comparable to the global rates, with a slight male predominance and a high survival rate. Further studies are warranted to explore the potential rurality and climatic factors influencing GBS incidence in Chile.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-15"},"PeriodicalIF":3.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public knowledge of Alzheimer's disease and attitudes toward Alzheimer's disease in Chongqing, China: a cross-sectional analysis.","authors":"Qing-Qing Yang, Ting Chen, Li-Ling Chen, Wu Jiang, Xian-Bin Ding, Xian-Xian Yang","doi":"10.1159/000547358","DOIUrl":"https://doi.org/10.1159/000547358","url":null,"abstract":"<p><strong>Introduction: </strong>Dementia, particularly Alzheimer's disease (AD), represents a significant public health challenge in China, with Chongqing experiencing rapid population aging and a rising prevalence of dementia. Early prevention and public education are critical to mitigating dementia risk; however, public awareness of AD remains low, with significant knowledge gaps and misconceptions. This study aimed to assess the knowledge and attitudes toward AD among the general public in Chongqing to inform effective public health strategies.</p><p><strong>Methods: </strong>A multistage stratified random sampling approach was employed to recruit 5,994 permanent residents aged 18 years and above from 17 districts in Chongqing between November and December 2024. Face-to-face interviews were conducted via the Chinese versions of the Alzheimer's Disease Knowledge Scale (ADKS) and the Dementia Attitudes Scale (DAS). Descriptive statistics and multivariable linear regression models were used to analyze the data and identify factors influencing AD knowledge and attitudes.</p><p><strong>Results: </strong>The mean ADKS score was 16.81 (55.78% accuracy), indicating low AD knowledge among participants. Knowledge was highest regarding the life impact but lowest concerning caregiving, symptoms, and risk factors. The mean DAS score was 78.61 (SD=10.709), reflecting generally positive attitudes toward dementia patients. Multivariable analysis revealed that ethnic minority status (OR=0.718, 95% CI: 0.561-0.918), junior high school education (OR=1.261, 95% CI: 1.055-1.507), high school/vocational education (OR=1.703, 95% CI: 1.277-2.271), associate or bachelor's degrees or higher (OR=2.624, 95% CI: 1.805-3.815), institution/enterprise-related personnel (OR=1.461, 95% CI: 1.003-2.127), and other workers (OR=1.241, 95% CI: 1.024-1.502) were associated with AD knowledge. High school/vocational education (OR=3.484, 95% CI: 1.115-10.884), associate or bachelor's degrees (OR=4.558, 95% CI: 1.035-20.075), CNY 1000-2999 (OR=3.731, 95% CI: 1.905-7.309), CNY 3000-5999 (OR=14.973, 95% CI: 6.091-36.811), above CNY 6000 (OR=10.761, 95% CI: 2.361-49.038) and prior dementia-related training (OR=5.573, 95% CI: 2.185-14.210) were associated with more positive attitudes toward dementia patients. However, production/transport personnel (OR=0.157, 95% CI: 0.054-0.453) and other workers (OR=0.182, 95% CI: 0.085-0.387) presented lower DAS scores.</p><p><strong>Conclusion: </strong>This study highlights significant gaps in AD knowledge and attitudes among the Chongqing public, emphasizing the need for targeted interventions to improve awareness and reduce stigma, particularly among underserved populations.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-19"},"PeriodicalIF":3.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of peripheral neuropathies in sub-Saharan Africa from 2000 to 2020: systematic review and meta-analysis.","authors":"Dieu Donné Gnonlonfoun, Arlos Sowanou, Blaise Choki, Pervenche Fotso, Antoine Gbessemehlan, Pupchen Gnigone, Thierry Metotondji, Richmine Covi, Julien Magne, Farid Boumediene, Dismand Houinato, Pierre-Marie Preux","doi":"10.1159/000542604","DOIUrl":"https://doi.org/10.1159/000542604","url":null,"abstract":"<p><strong>Introduction: </strong>Epidemiological studies on peripheral neuropathy (PN) in sub-Saharan Africa (SSA) have been conducted out in various target populations. This systematic review and meta-analysis aim to present and update available descriptive data on PN in SSA from 2000 to 2020.</p><p><strong>Methods: </strong>Research was performed in indexed databases PubMed (Medline), Web of science, Google scholar, Scopus, African Journal Online, and grey literature databases. Studies were selected according to the PRISMA methodology and data were extracted using a collection grid. A meta-analysis with a random-effects model was performed to determine the pooled frequency measures of PNs.</p><p><strong>Results: </strong>116 studies were included in this review, comprising 75,227 subjects (59.71% male, mean age range 9-68.8 years). The highest number of studies were conducted in East Africa (n=47; 40.5%). The pooled hospital frequency of PN was 39.6% ([95% CI: 34.2 - 45.2], I²=99.32%), the pooled prevalence was 4.30% ([95% CI: 2.50 - 6.50], I²=97.52%) and the pooled hospital incidence was 15.60% per year ([95% CI: 5.10 - 29.70], I²=98.78%). Pooled hospital frequency of PN was higher in diabetic patients (50.30%; [95% CI: 28.30- 66.70], I²=99%) and in Southern Africa (44.30%; [95% CI: 27.80-61.10]), I²=99%). For using electroneuromyogram as a diagnostic tool, the pooled hospital frequency of PN was 76.80% ([95% CI: 67.30 - 85.40, I²=67%). The frequency of polyneuropathy subgroup was 34.40% ([95% CI: 29.90- 46.90], I²=99.20%).</p><p><strong>Conclusion: </strong>PNs are frequent in SSA and particularly in certain target groups. It's important to improve preventive measures for HIV and diabetes and increase the understanding of risk factors associated with PN.</p><p><strong>Key words: </strong>peripheral neuropathies, epidemiology, prevalence, incidence, sub-Saharan Africa.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-36"},"PeriodicalIF":3.2,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, Regional, and National Burden of Stroke and Its Subtypes: Unravelling the Correlations with the Global Aging Trend.","authors":"Haomiao Wang, Jinxin Lin, Shuixian Zhang, Fengchun Zhao, Xuyang Zhang, Long Wang, Chao Zhang, Yi Yin, Ran Luo, Rong Hu","doi":"10.1159/000546317","DOIUrl":"10.1159/000546317","url":null,"abstract":"<p><strong>Introduction: </strong>The global ageing trend is accelerating, leading to an increase in chronic diseases, and posing a significant health challenge. Stroke, characterised by high rates of disability and mortality, is emerging as one of the most critical public health issues. The aim of this study was to examine current trends in global ageing and, under this condition, to assess the burden of stroke, with a focus on the elderly population at high risk of stroke.</p><p><strong>Methods: </strong>The data utilised in this study was obtained from the Global Burden of Diseases Study 2021, which estimated the burden of stroke and its subtypes, including ischaemic stroke, intracerebral haemorrhage, and subarachnoid haemorrhage focusing on incidence, mortality, and disability-adjusted life year (DALY) rates. To investigate the correlation between ageing and stroke burden as well as its temporal trends, Pearson correlation analysis, decomposition analysis, and estimated annual percentage change were conducted.</p><p><strong>Results: </strong>Globally, the proportion of countries entering ageing society has almost doubled, rising from 30.4% in 1990 to 52.5% in 2021. The Pearson correlation coefficient showed a significant positive association between stroke burden and the degree of ageing, particularly for incidence rate (R = 0.64, p < 2.2e-16) and mortality rate (R = 0.44, p = 5.3e-16). In addition, the global increase in stroke DALYs from 1990 to 2021 was largely attributable to population ageing, which accounted for 99.9% of this increase. In more than half of the countries, the burden of stroke was mainly concentrated in the elderly population aged 65 years and above, especially for ischaemic stroke, while the younger population predominantly borne the burden of haemorrhagic stroke.</p><p><strong>Conclusions: </strong>Despite the observed reductions in the incidence, mortality and DALY rates of stroke and its subtypes, the overall absolute numbers were still on an upward trajectory. Significantly, the majority of the burden of stroke was borne by the elderly. Therefore, the promotion of healthy ageing worldwide is critical and requires the rapid and effective development and implementation of appropriate public health policies and preventive management strategies to reduce the expected increase in the burden of stroke in the near future, particularly in the face of the challenges of global ageing wave.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-20"},"PeriodicalIF":3.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Reported Dystonia and Dystonia on Neurological Examination: Prevalence and Concordance across Time in a Prospectively Followed Essential Tremor Cohort.","authors":"Tomer O Guy, Diane S Berry, Vibhash D Sharma, Elan D Louis","doi":"10.1159/000546428","DOIUrl":"10.1159/000546428","url":null,"abstract":"<p><strong>Introduction: </strong>Screening questions are important in identifying subgroups of individuals within a target population. Dystonic movements and postures are not uncommon in patients with essential tremor (ET). There is a gap in knowledge - no studies have assessed the validity of a self-report of dystonia in ET patients. We assessed the concordance between self-reported dystonia and the presence or absence of dystonia on examination (DOE).</p><p><strong>Methods: </strong>We obtained self-report data from 274 ET cases in a serial study with up to five follow-up evaluations. At each assessment, participants could self-report dystonia, and they underwent a detailed neurological examination, from which a movement disorders neurologist assessed for the presence of DOE.</p><p><strong>Results: </strong>Across time, the prevalence of self-reported dystonia and DOE ranged from 0.0% to 4.3% and 8.6% to 17.5%, respectively. There were 74 cases with either self-reported dystonia or DOE; in only 3 (4.1%) was there a positive concordance between the two at each of their evaluations. Values for sensitivity ranged from 0.0% to 40%; specificity from 96.1% to 100%; positive predictive value from 0.0% to 67.0% (median 30.0%); and negative predictive value from 83.1% to 94.4%.</p><p><strong>Conclusion: </strong>Our study provides important insights into the validity of self-report data on dystonia in ET and the prevalence of DOE in ET. Our findings suggest that self-reported dystonia was not a valid means to identify DOE in ET.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-10"},"PeriodicalIF":3.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}