Neuroepidemiology最新文献

筛选
英文 中文
Prevalence, incidence, and mortality of Myasthenia Gravis and myasthenic syndromes: a systematic review. 重症肌无力和肌无力综合征的患病率、发病率和死亡率:系统综述。
IF 3.2 3区 医学
Neuroepidemiology Pub Date : 2024-10-09 DOI: 10.1159/000539577
Francesco Sciancalepore, Niccolò Lombardi, Giulia Valdiserra, Marco Bonaso, Emiliano Cappello, Giulia Hyeraci, Giada Crescioli, Maria Grazia Celani, Teresa Anna Cantisani, Paola Brunori, Simona Vecchi, Ilaria Bacigalupo, Nicoletta Locuratolo, Eleonora Lacorte, Nicola Vanacore, Ursula Kirchmayer
{"title":"Prevalence, incidence, and mortality of Myasthenia Gravis and myasthenic syndromes: a systematic review.","authors":"Francesco Sciancalepore, Niccolò Lombardi, Giulia Valdiserra, Marco Bonaso, Emiliano Cappello, Giulia Hyeraci, Giada Crescioli, Maria Grazia Celani, Teresa Anna Cantisani, Paola Brunori, Simona Vecchi, Ilaria Bacigalupo, Nicoletta Locuratolo, Eleonora Lacorte, Nicola Vanacore, Ursula Kirchmayer","doi":"10.1159/000539577","DOIUrl":"https://doi.org/10.1159/000539577","url":null,"abstract":"<p><strong>Introduction: </strong>No systematic reviews were published in the last years investigating epidemiological data, involving Myasthenia Gravis (MG) and related myasthenic syndromes. The aim of this systematic review was to estimate the prevalence, incidence, and mortality of all MG types and myasthenic syndromes worldwide.</p><p><strong>Methods: </strong>All literature published up to February 2024 was retrieved by searching the databases \"Medline\", \"Embase\", \"ISI Web of Science\" and \"CINAHL\" using the following search terms: (epidemiolog* OR frequency OR prevalence OR incidence OR mortality) AND (myasth* OR \"anti-acetylcholine receptor antibody\" OR \"AChR\" OR \"MuSK\" OR \"anti-muscle specific kinase antibody\" OR \"LRP4\" OR \"seronegative MG\").</p><p><strong>Results: </strong>A total of 94 studies, performed between 1952 and 2022, were included. Prevalence of MG ranged from 20 to 475 cases per million, with a mean prevalence of 173.3 (95% CI: 129.7-215.5) cases per million and a median prevalence of 129.6 cases per million. Incidence rates ranged from 2.3 to 61.3 cases per million person-years, with a mean incidence of 15.7 (95% CI: 11.5-19.9) and a median of 13.3 cases. Mortality rates showed a mean of 1.4 (95% CI: 0.8-2.1) cases per million person-years. AChR-MG was the clinical subtype more frequent in terms of prevalence and incidence.</p><p><strong>Discussion: </strong>The prevalence and incidence of MG have significantly increased over the last years worldwide, probably due to the improvement of epidemiological methodologies and current advances in diagnosis. However, we observed a significant variation in frequencies of MG between and within countries because of methodological biases and complex heterogeneity of the disease characterized by several phenotypes and different clinical responses.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strength of Association between Coronavirus Disease 2019 and Neurological Disorders in Children: A Case-Control Study. 2019 年冠状病毒疾病与儿童神经系统疾病之间的关联强度:病例对照研究
IF 5.7 3区 医学
Neuroepidemiology Pub Date : 2024-09-12 DOI: 10.1159/000541303
Utcharee Intusoma,Wisarut Srisintorn,Titaporn Thamcharoenvipas,Kemmapon Chumchuen
{"title":"Strength of Association between Coronavirus Disease 2019 and Neurological Disorders in Children: A Case-Control Study.","authors":"Utcharee Intusoma,Wisarut Srisintorn,Titaporn Thamcharoenvipas,Kemmapon Chumchuen","doi":"10.1159/000541303","DOIUrl":"https://doi.org/10.1159/000541303","url":null,"abstract":"Evidence suggests potential neurological complications of Coronavirus Disease 2019 (COVID-19), particularly in adults. While case series have hinted at associations between COVID-19 and neurological disorders (NDs) in children, the extent of this link remains unclear. This study investigates temporal trends in NDs during the pandemic and assesses their potential association with COVID-19 infection in children. We analyzed national Thai hospitalization data (2017-2022) for children under 18 with specific NDs (acute transverse myelitis, central nervous system demyelination, neuromyelitis optica, optic neuritis, polyneuropathy, stroke). An interrupted time series analysis was employed to identify changes in the incidence trends of NDs following the declaration of the COVID-19 pandemic. A matched case-control analysis was conducted using data specific to the Thai COVID-19 outbreak period. This analysis aimed to estimate the association between recent/concurrent COVID-19 infection and NDs in children. A propensity score matching on age group, sex, and month of admission was performed before conducting logistic regression. From 2017-2022, 1,721 children admitted with NDs (2,474 admissions), with a male predominance (55%) and average age of 10.6 years. Significant slope change was observed in optical neuritis trends coinciding with the third COVID-19 wave. The case-control analysis included 468 cases and 2,340 controls. Children with NDs had a significantly higher prevalence of recent/concurrent COVID-19 (matched odds ratio: 1.95, 95% confidence interval: 1.21-3.16). Subgroup analysis revealed an association between stroke and recent/concurrent COVID-19 (matched odds ratio: 3.05, 95% confidence interval: 1.3-7.16). Thus, this study suggests an association between recent/concurrent COVID-19 and NDs, especially pediatric stroke.","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low sun exposure is associated with both progressive-onset and relapse-onset multiple sclerosis risk: a case-control study. 少晒太阳与进展期发病和复发期发病的多发性硬化症风险有关:一项病例对照研究。
IF 5.7 3区 医学
Neuroepidemiology Pub Date : 2024-09-11 DOI: 10.1159/000540921
Ying Li,Alice Saul,Bruce Taylor,Anne-Louise Ponsonby,Steve Simpson-Yap,Leigh Blizzard,Simon Broadley,Jeannette Lechner-Scott,,Ingrid van der Mei
{"title":"Low sun exposure is associated with both progressive-onset and relapse-onset multiple sclerosis risk: a case-control study.","authors":"Ying Li,Alice Saul,Bruce Taylor,Anne-Louise Ponsonby,Steve Simpson-Yap,Leigh Blizzard,Simon Broadley,Jeannette Lechner-Scott,,Ingrid van der Mei","doi":"10.1159/000540921","DOIUrl":"https://doi.org/10.1159/000540921","url":null,"abstract":"BACKGROUNDSun exposure has consistently been associated with Multiple Sclerosis (MS) onset, but case samples are predominantly relapse-onset MS (ROMS), and risk estimates have rarely been reported separately for ROMS and progressive-onset MS (POMS). We aimed to determine whether sun exposure prior to disease onset was associated with POMS, and whether the effect differed between POMS and ROMS.METHODSThis nationwide case-control study included 153 POMS cases, 204 incident ROMS cases, and 558 community controls with data from two separate datasets: the PPMS Study (2015-2019) and the Ausimmune Study (2003-2006). Information on time spent in the sun before first MS symptom, skin phenotype, sun protection behavior was collected. Satellite data on ambient ultraviolet radiation (UVR) was used to calculate cumulative UVR dose. Unconditional logistic regression was used with adjustment for covariates.RESULTSThere were consistent dose-response associations, with higher levels of UVR exposure associated with a reduced risk of POMS, both for leisure-time and occupational UVR from age 6 to symptom onset. Associations were overall stronger for POMS than ROMS. For example, cumulative leisure-time UVR dose (per 100 kJ/m2 increment) was associated with POMS (aOR 0.93, 95% CI 0.91-0.95) and the association was slightly weaker for ROMS (aOR 0.96, 95% CI 0.94-0.99) for age 6 to symptom onset (test for interaction p&lt;0.001).CONCLUSIONSLow levels of sun exposure, throughout the whole life span, are associated with increased risk of POMS and ROMS onset. The sun effects are usually stronger for POMS than ROMS.","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights from ARCOS-V's Transition to Remote Data Collection During the COVID-19 Pandemic: A Descriptive Study. COVID-19 大流行期间 ARCOS-V 向远程数据收集过渡的启示:描述性研究。
IF 5.7 3区 医学
Neuroepidemiology Pub Date : 2024-09-09 DOI: 10.1159/000541368
Nathan I N Henry,Balakrishnan Nair,Anna Ranta,Rita Krishnamurthi,Anjali Bhatia,Valery Feigin
{"title":"Insights from ARCOS-V's Transition to Remote Data Collection During the COVID-19 Pandemic: A Descriptive Study.","authors":"Nathan I N Henry,Balakrishnan Nair,Anna Ranta,Rita Krishnamurthi,Anjali Bhatia,Valery Feigin","doi":"10.1159/000541368","DOIUrl":"https://doi.org/10.1159/000541368","url":null,"abstract":"INTRODUCTIONThe ARCOS-V study, an epidemiological study on stroke and transient ischemic attack (TIA), faced the challenge of continuing data collection amidst the COVID-19 pandemic. This study aims to describe the methodological changes and challenges encountered during the transition from paper-based methods to digital data collection for the ARCOS-V study, and to provide insights into the potential of using digital tools to transform epidemiological research.METHODSThe study adapted to remote data collection using REDCap and Zoom, involving daily health record reviews, direct data entry by trained researchers, and remote follow-up assessments. The process was secured with encryption and role-based access controls. The transition period was analyzed to evaluate the effectiveness and challenges of the new approach.RESULTSThe digital transition allowed for uninterrupted monitoring of stroke and TIA cases during lockdowns. Using REDCap and Zoom improved data reach, accuracy, and security. However, it also revealed issues such as the potential for systematic data entry errors and the need for robust security measures to protect sensitive health information.CONCLUSIONThe ARCOS-V study's digital transformation exemplifies the resilience of epidemiological research in the face of a global crisis. The successful adaptation to digital data collection methods highlights the potential benefits of such tools, particularly as we enter a new age of Artificial Intelligence (AI).","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changing Epidemiology of Neurological Diseases in Africa. 非洲不断变化的神经系统疾病流行病学。
IF 5.7 3区 医学
Neuroepidemiology Pub Date : 2024-09-09 DOI: 10.1159/000539654
G Logroscino,R Kalaria,P M Preux
{"title":"Changing Epidemiology of Neurological Diseases in Africa.","authors":"G Logroscino,R Kalaria,P M Preux","doi":"10.1159/000539654","DOIUrl":"https://doi.org/10.1159/000539654","url":null,"abstract":"","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":null,"pages":null},"PeriodicalIF":5.7,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low Intake of Total Antioxidant Nutrients as a Risk Factor for Incident Dementia in Older Adults: The Shanghai Aging Study. 总抗氧化营养素摄入量低是老年人痴呆症发病的风险因素:上海老龄化研究。
IF 3.2 3区 医学
Neuroepidemiology Pub Date : 2024-09-05 DOI: 10.1159/000541231
Su Liu, Jianfeng Luo, Zhenxu Xiao, Wanqing Wu, Xiaoniu Liang, Qianhua Zhao, Xianfeng Zhao, Yi Wang, Wenhuan Fu, Ding Ding
{"title":"Low Intake of Total Antioxidant Nutrients as a Risk Factor for Incident Dementia in Older Adults: The Shanghai Aging Study.","authors":"Su Liu, Jianfeng Luo, Zhenxu Xiao, Wanqing Wu, Xiaoniu Liang, Qianhua Zhao, Xianfeng Zhao, Yi Wang, Wenhuan Fu, Ding Ding","doi":"10.1159/000541231","DOIUrl":"10.1159/000541231","url":null,"abstract":"<p><strong>Introduction: </strong>Previous longitudinal studies reported the impact of antioxidant nutrients (ANs) on cognitive impairment in the older population, but the conclusions were inconsistent. This study aimed to verify the hypothesis that dietary intake of total AN was associated with incident dementia among older individuals.</p><p><strong>Methods: </strong>Community residents without dementia aged ≥60 years were prospectively followed up for an average of 5.2 years in the Shanghai Aging Study. At baseline, daily intakes of total dietary AN (the sum of carotene, vitamin C, vitamin E, lutein, and flavonoids) and energy were calculated based on an interviewer-administered food frequency questionnaire measuring the dietary intake over the past 1 year for each participant. A battery of neuropsychological tests was used to evaluate cognitive function, and a consensus diagnosis of dementia was made according to the DSM-IV criteria at baseline and follow-up.</p><p><strong>Results: </strong>Among 1,550 dementia-free participants, 135 (8.7%) incident dementia cases were identified during the average of 5.2 years of follow-up. Participants with low AN intake (&lt;112 mg/day) had a significantly higher risk of incident dementia than those with high AN intake (≥112 mg/day) (hazard ratio 1.87, 95% confidence interval 1.26-2.77) after adjusting for age, gender, education, obesity, APOE-ε4, hypertension, diabetes, depression, baseline Mini-Mental State Examination score, and total energy intake. The significant association of total AN intake with incident dementia was only found in individuals ≥70 years.</p><p><strong>Conclusion: </strong>Low total AN intake may be a risk factor for incident dementia among older adults. Maintaining sufficient AN intake may be beneficial against age-related cognitive decline.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Traumatic Brain Injury in the General Adult Population of the USA: A Meta-Analysis. 美国普通成年人群中的创伤性脑损伤患病率:荟萃分析。
IF 3.2 3区 医学
Neuroepidemiology Pub Date : 2024-08-22 DOI: 10.1159/000540676
Armin Karamian, Brandon Lucke-Wold, Ali Seifi
{"title":"Prevalence of Traumatic Brain Injury in the General Adult Population of the USA: A Meta-Analysis.","authors":"Armin Karamian, Brandon Lucke-Wold, Ali Seifi","doi":"10.1159/000540676","DOIUrl":"10.1159/000540676","url":null,"abstract":"<p><strong>Background: </strong>Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. It has been estimated that 64-74 million individuals experience TBI from all causes each year. Due to these variations in reporting TBI prevalence in the general population, we decided to perform a meta-analysis of published studies to better understand the prevalence of TBI in the general adult population of the USA which can help health decision-makers in determining general policies to reduce TBI cases and their costs and burden on the healthcare system.</p><p><strong>Methods: </strong>Our meta-analysis was performed using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist. The study protocol was registered with PROSPERO (CRD42024534598). A comprehensive literature search of PubMed from the National Library of Medicine and Google Scholar was performed from database inception to April 2024. Sixteen studies that evaluated the US general population met our inclusion criteria. A meta-analysis using a random-effects model was performed to estimate the prevalence of TBI in the general adult population of the USA.</p><p><strong>Results: </strong>The total sample consisted of 27,491 individuals, of whom 4,453 reported a lifetime history of TBI with loss of consciousness (LOC) (18.2%, 95% CI 14.4-22.7%). Some studies did not report relevant information based on gender, but based on available data, among males, 1,843 individuals out of 8,854 reported a lifetime history of TBI with LOC (20.8%). Among females, 1,363 individuals out of 11,943 reported a lifetime history of TBI with LOC (11.4%). The odds of sustaining TBI in males were higher than in females with moderate heterogeneity between studies (OR = 2.09, 95% CI 1.85-2.36, p &lt; 0.01, I2 = 40%).</p><p><strong>Conclusion: </strong>The prevalence of TBI in the US general population is 18.2%, making it a major public health concern. In addition, males were more than twice as likely as females to sustain TBI with LOC. Considering the irreparable long-term adverse effects of TBI on survivors, their families, and the healthcare system, prevention strategies can facilitate substantial reductions in TBI-related permanent disabilities and medical care costs.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender Disparities in Neurological Symptoms of Long COVID: A Systematic Review and Meta-Analysis. Long-COVID 神经系统症状的性别差异:系统回顾与荟萃分析。
IF 3.2 3区 医学
Neuroepidemiology Pub Date : 2024-08-19 DOI: 10.1159/000540919
Alon Gorenshtein, Liron Leibovitch, Tom Liba, Shai Stern, Yael Stern
{"title":"Gender Disparities in Neurological Symptoms of Long COVID: A Systematic Review and Meta-Analysis.","authors":"Alon Gorenshtein, Liron Leibovitch, Tom Liba, Shai Stern, Yael Stern","doi":"10.1159/000540919","DOIUrl":"10.1159/000540919","url":null,"abstract":"<p><strong>Background: </strong>Female gender is a known risk factor for long COVID. With the increasing number of COVID-19 cases, the corresponding number of survivors is also expected to rise. To the best of our knowledge, no systematic review has specifically addressed the gender differences in neurological symptoms of long COVID.</p><p><strong>Methods: </strong>We included studies on female individuals who presented with specific neurological symptoms at least 12 weeks after confirmed COVID-19 diagnosis from PubMed, Central, Scopus, and Web of Science. The search limit was put for after January 2020 until June 15, 2024. We excluded studies that did not provide sex-specific outcome data, those not in English, case reports, case series, and review articles Results: A total of 5,632 eligible articles were identified. This article provides relevant information from 12 studies involving 6,849 patients, of which 3,414 were female. The sample size ranged from 70 to 2,856, with a maximum follow-up period of 18 months. The earliest publication date was September 16, 2021, while the latest was June 11, 2024. The following neurological symptoms had a significant difference in the risk ratio (RR) for female gender: fatigue RR 1.40 (95% confidence interval [CI]: 1.22-1.60, p &lt; 0.001), headache RR 1.37 (95% CI: 1.12-1.67, p = 0.002), brain-fog RR 1.38 (95% CI 1.08-1.76, p = 0.011) depression RR 1.49 (95% CI: 1.2-1.86, p &lt; 0.001), and anosmia RR 1.61 (95% CI: 1.36-1.90, p &lt; 0.001). High heterogenicity was found for fatigue, brain fog, and anxiety due to the diverse methodologies employed in the studies.</p><p><strong>Conclusion: </strong>Our findings suggest that women are at a higher risk for long-COVID neurological symptoms, including fatigue, headaches, brain fog, depression, and anosmia, compared to men. The prevalence of these symptoms decreases after 1 year, based on limited data from the small number of studies available beyond this period.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Constipation and the Risk of Parkinson's Disease among Participants in the UK Biobank. 英国生物库参与者中便秘与帕金森病风险之间的关系。
IF 3.2 3区 医学
Neuroepidemiology Pub Date : 2024-08-19 DOI: 10.1159/000540955
Jing Zhang, Mengyao Shi, Qilu Zhang, Yi Chen, Xiangyan Yin, Xiaoxiao Wang, Yonghong Zhang
{"title":"Association between Constipation and the Risk of Parkinson's Disease among Participants in the UK Biobank.","authors":"Jing Zhang, Mengyao Shi, Qilu Zhang, Yi Chen, Xiangyan Yin, Xiaoxiao Wang, Yonghong Zhang","doi":"10.1159/000540955","DOIUrl":"10.1159/000540955","url":null,"abstract":"<p><strong>Introduction: </strong>Constipation is common in patients with Parkinson's disease (PD), but its impact on incident PD remains uncertain. We aimed to prospectively investigate constipation symptoms and the risk of PD.</p><p><strong>Methods: </strong>Participants without PD at baseline from the UK Biobank were included in the study. Information on the regular use of laxatives, bowel movement frequency, and the frequency of hard or lumpy stools was collected. Incident PD was defined by the ICD-10 code. Cox proportional hazards models were used to assess the association between constipation symptoms and incident PD.</p><p><strong>Results: </strong>In the analysis of regular laxative use and PD, 490,797 participants were included and 2,735 incident PD were detected. The multivariable adjusted HR of PD in participants who regularly used laxatives was 1.99 (95% confidence interval [CI], 1.70-2.33) compared with those who did not. In the analysis of bowel movement frequency and hard or lumpy stools and PD, 170,017 participants were included and 519 incident PD were detected. The multivariable adjusted HRs were 2.16 (95% CI, 1.74-2.68) and 2.57 (95% CI, 2.00-3.31) for participants with a bowel movement frequency of 3-6 times/week and &lt;3 times/week, respectively, compared with those with a bowel movement frequency of ≥7 times/week; compared with participants who never had hard or lumpy stools, multivariable adjusted HRs were 1.31 (95% CI, 1.07-1.60), 2.32 (95% CI, 1.77-3.05), and 2.94 (95% CI, 2.14-4.05) for those who sometimes had hard or lumpy stools, often had hard or lumpy stools, and most of time/always had hard or lumpy stools, respectively.</p><p><strong>Conclusions: </strong>Constipation measured by the regular use of laxatives, bowel movement frequency, and the frequency of hard or lumpy stools was significantly associated with an increased risk of incident PD.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of Diet and Lifestyle with Mortality and Stroke: The China Cardiometabolic Disease and Cancer Cohort (4C) Study. 饮食和生活方式与死亡率和中风的关系:中国心脏代谢疾病和癌症队列(4C)研究》。
IF 3.2 3区 医学
Neuroepidemiology Pub Date : 2024-08-14 DOI: 10.1159/000540922
Yue-Yang Zhang, Xin Yang, Ying Miu, Bing-Xue Chen, Qin Wan
{"title":"Associations of Diet and Lifestyle with Mortality and Stroke: The China Cardiometabolic Disease and Cancer Cohort (4C) Study.","authors":"Yue-Yang Zhang, Xin Yang, Ying Miu, Bing-Xue Chen, Qin Wan","doi":"10.1159/000540922","DOIUrl":"https://doi.org/10.1159/000540922","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the individual and combined associations between dietary habits and lifestyle factors concerning all-cause mortality and stroke in Chinese adults.</p><p><strong>Method: </strong>We conducted a nationwide, multicenter, prospective cohort study involving 10,008 participants, gathering baseline data on lifestyle, metabolic status, dietary habits, and living behaviors. Subsequently, a 10-year follow-up was performed, resulting in the inclusion of 7,612 participants in this study. We employed Spearman correlation analysis, restricted cubic spline regression, and Cox regression analysis to evaluate the connections between outcome events, dietary habits, and lifestyle.</p><p><strong>Result: </strong>For each additional serving of pulses consumed per week, there was a slight decrease in the risk of all-cause mortality (HR: 0.91, 95% CI: 0.83-0.99). The hazard ratios for stroke were 2.24 (1.48, 3.37) for current smokers, in comparison to individuals who had never smoked. Appropriate intake of specific dietary factors and certain lifestyle habits were associated with reduced stroke: fruit drinks at 0.51 (0.34, 0.87), and animal viscera at 0.58 (0.32, 1.04). Weekly consumption of at least 21 servings of vegetables (0.72, 0.53-0.98), 0-1 serving of fried food (0.58, 0.38-0.90), and at least 1 serving of carbonated beverages (0.51, 0.28-0.92) was associated with a reduced risk of stroke.</p><p><strong>Conclusion: </strong>Smoking was found to be linked to an increased risk of stroke. A higher intake of fruit drinks and animal viscera was associated with a reduced risk of stroke. In contrast, a higher intake of beans was associated with a decreased risk of overall mortality. Consuming an appropriate amount of vegetables, fried foods, and carbonated drinks was found to potentially lower the risk of stroke. Collectively, these findings underscore the importance of developing tailored dietary interventions conducive to the Chinese populace's health.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信