Neuroepidemiology最新文献

{"title":"Global, regional, and national epidemiology of Idiopathic Childhood Epilepsy from 1990 to 2021.","authors":"Yifeng Zhang, Shuai Hou, Jian Li, Jianhong Geng, Yulei Xia, Yanqiang Wang","doi":"10.1159/000545830","DOIUrl":"https://doi.org/10.1159/000545830","url":null,"abstract":"<p><strong>Introduction: </strong>Childhood epilepsy is a major global health challenge with severe outcomes such as depression, intellectual disability, and increased suicide risk. It is vital to understand epidemiological trends and risk factors to effectively address the condition's burden.</p><p><strong>Methods: </strong>This cross-sectional study utilized data from the Global Burden of Disease (GBD) study, covering 204 countries from 1990 to 2021, focusing on children aged 0 to 14 years with epilepsy. We analyzed trends in incidence, mortality, and disability-adjusted life years (DALYs), examining variations across different demographics and sociodemographic indices (SDI).</p><p><strong>Results: </strong>In 2021, there were approximately 1.23 million cases of childhood epilepsy worldwide, marking a 26.34% increase from 1990. During the same period, deaths attributed to epilepsy decreased from 25,768 to 18,171. The global incidence rate rose from 55.85 to 61.00 per 100,000 population, while the mortality rate declined from 1.48 to 0.90 per 100,000. The lowest SDI regions recorded the highest mortality rate in 2021 (1.46 per 100,000). Regionally, Southern Latin America saw the largest increase in incidence (EAPC, 0.49), and Eastern Europe observed the most significant mortality decrease (EAPC, -4.65). Ecuador reported the highest incidence rate, Tajikistan the highest mortality, and Zambia the highest DALYs in 2021.</p><p><strong>Conclusions: </strong>The global incidence of childhood epilepsy continues to rise, presenting an ongoing public health challenge. Although there is a global decline in DALYs and mortality rates, the absolute number of affected individuals remains high, especially in lower SDI regions. This study underlines the need for enhanced understanding and targeted interventions to manage and prevent epilepsy effectively.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-23"},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends of Alzheimer's Disease and Other Dementias with Socioeconomic Insights: An Age-period-cohort Analysis and Forecasts for 2046.","authors":"Yi Zeng, Huiqi Yang, Yongqiang Lai, Ying Bi, Chengyang Sun, Huan Jiang, Xinwei Liu, Sai Xu, Ye Li, Jia Meng","doi":"10.1159/000545885","DOIUrl":"https://doi.org/10.1159/000545885","url":null,"abstract":"<p><p>Introduction The disease burden of dementia varies in different economic development regions. This study provides a comprehensive overview of Alzheimer's Disease and Other Dementias(ADOD) trends across regions with varying socio-economic statuses and forecasts global incidence rates from 2022 to 2046. Methods Based on the Global Burden of Disease (GBD) study, we utilized an age-period-cohort (APC) model to analyze annual changes in incidence and the risk factors associated with age, period, and birth cohort across different Socio-Demographic Index (SDI) regions. Additionally, a log-linear APC model was employed to project global trends in ADOD incidence from 2022 to 2046. Results Between 1992 and 2021, We estimated that the net drift of the incidence of ADOD is 0.03(95% CI: 0.01 to 0.04). High-middle SDI regions demonstrated the highest net drift (0.22,95% CI: 0.18 to 0.26). At the country level, the net drift was highest in China, at 0.36 (95% CI: 0.322 to 0.400), and we found a global upward trend in the incidence of the disease in people aged 50-64 years, especially in regions with high SDI. By 2046, there will be 21.24 million cases of ADOD worldwide. The age-standardized incidence rate for all patients with ADOD will increase slowly and is projected to be 120.8 per 100,000 population by 2046. Conclusion We found a steady increase in incidence worldwide, with the greatest increase in High-medium SDI regions. The incidence is declining in areas with high SDI, and higher levels of socioeconomic development have a protective effect against ADOD. Incidence is increasing in younger age groups. Therefore, we believe that improving the level of social and economic development and formulating relevant targeted policies are helpful for the prevention of ADOD. Focusing on the trends in disease incidence across different economic development regions will enable more targeted strategies to address the burden of disease.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-20"},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1159/000544899","DOIUrl":"https://doi.org/10.1159/000544899","url":null,"abstract":"","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1"},"PeriodicalIF":3.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Trends of Pediatric Stroke Burden Attributable to Nonoptimal Temperature in the USA, 1990-2019: An Analysis for the Global Burden of Disease Study.","authors":"Chia-Yi Lin, Hok Leong Chin","doi":"10.1159/000545259","DOIUrl":"10.1159/000545259","url":null,"abstract":"<p><strong>Introduction: </strong>Pediatric stroke, though less common than in the elderly population, imposes a significant societal burden. With the increasing impact of climate change, this study aimed to assess the burden of different pediatric stroke subtypes attributable to nonoptimal temperatures in the USA.</p><p><strong>Methods: </strong>This study analyzed data from the Global Burden of Disease (GBD) Database 2019. The pediatric stroke burden attributable to nonoptimal temperatures was estimated by sex, age, and subtypes. R and Joinpoint were used to conduct the statistical analyses in this study. A p value <0.05 was considered statistically significant.</p><p><strong>Results: </strong>Nationally, there has been a decrease in pediatric stroke death rate and DALY rate attributable to nonoptimal temperature from 1990 to 2019, with an AAPC of -2.36 (95% UI: -3.06 to -1.66, p value <0.05) for death and -2.45 (95% UI: -3.10 to -1.80, p value <0.05) for DALY. Similar trends were observed across sexes, age groups, stroke subtypes, and most states.</p><p><strong>Conclusion: </strong>This study highlighted the pediatric stroke burden attributable to nonoptimal temperature in the USA. More resources should be directed to address the geographic health disparities observed in this study.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-6"},"PeriodicalIF":3.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights on the Association between Antimicrobial Use and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis.","authors":"Moaz Elsayed Abouelmagd, Omar Kassar, Atef Hassan, Maickel AbdelMeseh, Abdelrahman Mady, Hamdy A Makhlouf","doi":"10.1159/000545218","DOIUrl":"10.1159/000545218","url":null,"abstract":"<p><strong>Introduction: </strong>Gut dysbiosis is one of the environmental factors that might contribute to the development of Parkinson's disease (PD). The potential impact of antimicrobial agents on PD risk, particularly through dysbiosis and neuroinflammation, is an area of ongoing investigation, though findings remain inconsistent.</p><p><strong>Methods: </strong>This systematic review and meta-analysis aimed to assess the relationship between antimicrobial use and PD risk. After searching PubMed, Scopus, Web of Science, and Embase, ten studies involving 3,755,583 participants, including 52,974 PD patients, were included.</p><p><strong>Results: </strong>Antibacterial use was not significantly correlated with PD risk (odds ratio [OR] = 1.14; 95% CI: 0.97-1.33; p = 0.11, I2 = 84%). After excluding one study, the odds of PD became significantly higher (OR = 1.22; 95% CI: 1.04-1.44; p = 0.01). Specific antibacterial classes, such as tetracyclines and macrolides, showed no significant associations with PD. However, cephalosporins had a protective effect (OR = 0.86; p = 0.04), while antifungal use increased PD risk (OR = 1.16; p = 0.001). Regarding antiviral use, a significant reduction in PD risk was observed in patients with hepatitis C virus undergoing antiviral treatment (HR = 0.69; p = 0.0008).</p><p><strong>Conclusion: </strong>The findings indicate complex relationships between antimicrobial use and PD risk. While antibacterials, in general, tend to increase PD risk, specific antibacterial may offer a protective effect, while antifungal agents appear to increase PD risk. Antiviral therapy may reduce PD risk in HCV patients. Further research is needed to confirm our results.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-13"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional and national temporal trends in prevalence for migraine in women of childbearing age: an updated age-period-cohort analysis based on Global Burden of Disease Study 2021.","authors":"Ben Hu, Xiaohan Qiu, Yan Wang, Xing Wei, Jun Feng, Linlin Hou","doi":"10.1159/000545221","DOIUrl":"https://doi.org/10.1159/000545221","url":null,"abstract":"<p><strong>Introduction: </strong>To provide a comprehensive assessment of temporal trends in migraine prevalence among women of childbearing age (WCBA) at global, regional and national levels from 1992 to 2021, with particular emphasis on examining the associations between prevalence patterns and age, period and birth cohort effects across different sociodemographic index (SDI) regions.</p><p><strong>Methods: </strong>We conducted a secondary analysis of data from the Global Burden of Disease Study 2021. Migraine prevalence estimates and 95% uncertainty intervals (UI) for WCBA were extracted. An age-period-cohort model was employed to estimate the net drift (primary outcomes), local drift, age/period/cohort relative risks (secondary outcomes).</p><p><strong>Results: </strong>The global number of WCBA with migraine reached 493,937,856.01 (95% UI: 420,683,360.54 to 577,874,600.76) in 2021. The highest burden was found in India (95.7 million) and China (68.1 million), together accounting for substantial proportion of global prevalence. The global net drift showed minimal change 0.01% (95% CI: 0.00-0.02, p<0.01) per year, with variations across sociodemographic index (SDI) regions ranging from -0.03% per year, (95% CI: -0.04 to -0.02, p<0.01) in low-middle SDI regions to 0.16% (95% CI: 0.15-0.17, p<0.01) in middle-SDI regions. Local drift analysis reveals that migraine prevalence increases across young age groups (15-19 years) in high-SDI regions, while lower-SDI regions generally display stable rates. Globally, increases in migraine prevalence among young adults within WCBA are notably persistent. Across SDI regions, age effects follow similar patterns, with risk rising with age and peaking in the mid-reproductive years (ages 30-39). Over time, period risks and unfavorable trends across successive birth cohorts have intensified, particularly in high, high-middle, and middle-SDI regions.</p><p><strong>Conclusion: </strong>Although global migraine prevalence among WCBA remains stable, an unfavorable upward trend in younger age groups (15-19 years) in high, high-middle, and middle SDI regions, alongside worsening period/cohort risks, highlights current gaps in prevention and management. Improved strategies are expected to reduce risks for younger birth cohorts and all age groups over time.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-19"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid Disorders as a Risk Factor for Neurodegenerative Proteinopathies: A Large-Scale Propensity Score-Matched Analysis.","authors":"Eman A Toraih, Sidra Siddiqui, Sarah Siddiqui, Kasra Shirini, Nadra Elfezzani, Ahmed Abdelmaksoud, Rami M Elshazli, Mohaamad H Hussein, Ekramy M Elmorsy, Manal S Fawzy","doi":"10.1159/000545369","DOIUrl":"https://doi.org/10.1159/000545369","url":null,"abstract":"<p><strong>Introduction: </strong>The relationship between thyroid disorders and neurodegenerative diseases remains poorly understood. This large-scale retrospective cohort study aimed to investigate the association between thyroid disorders and various neurodegenerative diseases, as well as the potential impact of thyroidectomy.</p><p><strong>Methods: </strong>We analyzed data from 3,719,666 patients with thyroid disorders and 2,945,438 controls from 120 healthcare organizations. After propensity score matching, each group included 2,033,096 patients. We compared the risk of neurodegenerative diseases between these groups and examined the effect of thyroidectomy in a subgroup analysis of 31,753 matched pairs.</p><p><strong>Results: </strong>Patients with thyroid disorders showed significantly higher risks of Alzheimer's disease (RR=1.15, 95%CI: 1.110-1.195), Parkinson's disease (RR=1.25, 95%CI: 1.187-1.318), amyotrophic lateral sclerosis (RR=1.35, 95%CI: 1.131-1.622), frontotemporal dementia (RR=1.44, 95%CI: 1.219-1.702), Lewy body dementia (RR=1.15, 95%CI: 1.107-1.186), progressive supranuclear palsy (RR=1.41, 95%CI: 1.095-1.819), vascular dementia (RR=1.32, 95%CI: 1.266-1.369), Niemann-Pick disease type C (RR=1.34, 95%CI: 1.092-1.638), and Wilson's disease (RR=1.26, 95%CI: 1.056-1.507). Interestingly, the risk of multiple sclerosis was lower (RR=0.80, 95%CI: 0.738-0.862). Thyroidectomy was associated with a 44.2% lower risk of Lewy body dementia (RR=0.558, 95%CI: 0.339-0.919, p=0.020).</p><p><strong>Conclusion: </strong>Thyroid disorders are significantly associated with an increased risk of several neurodegenerative diseases. Thyroidectomy may have a protective effect against Lewy body dementia. These findings suggest a complex relationship between thyroid function and neurodegeneration, emphasizing the need for neurological monitoring in patients with thyroid disorders and further research into thyroid-brain interactions.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-19"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Possible Rem Sleep without Atonia in the General Population: Insights from the São Paulo Epidemiologic Sleep Study (EPISONO).","authors":"Gabriel Natan Pires, Matteo Cesari, Ambra Stefani, Monica Levy Andersen, Dalva Poyares, Birgit Högl, Sergio Tufik","doi":"10.1159/000545499","DOIUrl":"10.1159/000545499","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to estimate the prevalence of possible rapid eye movement (REM) sleep without atonia (RWA) in the general population.</p><p><strong>Methods: </strong>The study was based on data from the São Paulo Epidemiologic Sleep Study (EPISONO) 4th edition, a non-clinical population-based sleep study performed in the city of São Paulo, Brazil, between 2018 and 2019. All individuals underwent type-I polysomnography with the addition of bilateral electromyography of the flexor digitorum superficialis (FDS) muscles. The FDS activity index was calculated as the percentage of 30-s REM sleep epochs containing at least five 3-s mini-epochs with phasic muscle activity, with a threshold of 7.7% being applied to identify possible RWA cases. The adjusted prevalence of possible RWA was calculated as the proportion of cases above the diagnostic threshold, corrected by the estimated specificity values according to the REM-specific apnea-hypopnea index (AHI; 85% for REM AHI <15 and 60% for REM AHI ≥15).</p><p><strong>Results: </strong>The final sample comprised 632 participants (376 females, 59.49%), and 68 possible RWA cases were identified. The adjusted prevalence of RWA in the whole sample was 8.24% (95% CI: 6.09%-10.38%). The adjusted prevalence stratified by sex was 10.63% among men (95% CI: 6.85%-14.40%) and 6.61% among women (95% CI: 4.10%-9.12%) (p = 0.013), resulting in a male/female prevalence ratio of 1.61. Possible RWA prevalence was similar between men and women in the 20-39 and 40-59 age ranges, but significantly higher among men aged 60-80 (16.57%, 95% CI: 6.66%-26.49%) than women in the same age range (7.35%, 95% CI: 2.62%-12.81%) (p = 0.022).</p><p><strong>Conclusions: </strong>The prevalence of possible RWA in the sample was 8.24% and was similar between the sexes in most age ranges but became more frequent among men from the age of 60 years old.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-14"},"PeriodicalIF":3.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of neutrophil-to-lymphocyte ratio with incidence and disease progression in Parkinson's disease.","authors":"Yi Xiao, Yuanzheng Ma, Huifang Shang","doi":"10.1159/000545314","DOIUrl":"https://doi.org/10.1159/000545314","url":null,"abstract":"<p><strong>Background: </strong>The neutrophil-to-lymphocyte ratio (NLR) is widely regarded as a proxy for system inflammation. The previous study indicated that the NLR might be higher in Parkinson's disease (PD) compared to healthy controls (HC). The study aimed to assess the role of system inflammation indicated by NLR in the incidence and progression of PD.</p><p><strong>Methods: </strong>We included participants from the longitudinal population-based cohort, UK Biobank, to analyze the association of NLR and the risk of PD. We conducted the Cox proportional hazards analyses as the primary analysis to determine the association between baseline NLR value and the risk of PD in UK Biobank. Then we further used data from a disease-specific longitudinal cohort, Parkinson's Progression Markers Initiative (PPMI), to evaluate the differences between individuals with higher PD risk, and early-stage PD patients in the values of NLR. Patients with PD were divided into two groups according to the median value of NLR (2.35). Linear mixed models (random intercept and random slope) were used to evaluate the relationship between the high/low NLR groups and the disease progression.</p><p><strong>Results: </strong>A number of 288837 participants from UK Biobank were included and 1429 were diagnosed with incident PD. Among them, higher NLR was associated with an increased risk of incident PD in HC (per SD increment hazard ratio [HR], 1.041; P < 0.001). A total of 349 early-stage PD patients, 438 individuals with higher PD risk, and 207 HC were included from PPMI. PD patients and individuals with higher PD risk had a significantly higher NLR compared to healthy controls. Higher NLR group was associated with a faster deterioration of the Montreal Cognitive Assessment score in PD patients in two years (β [SE] = -0.225 [0.080], P = 0.005).</p><p><strong>Conclusion: </strong>In conclusion, increased NLR in HC was linked with a higher risk of incident PD, and higher NLR was associated with a faster cognitive decline in PD patients, which indicated that inflammation was involved in the incidence of PD and the cognitive decline in early-stage PD.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-19"},"PeriodicalIF":3.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Annual Incidence of Vascular Dementia and Other Dementias: A Population-Based Study in Eastern Finland.","authors":"Ada Tuominen, Virve Kärkkäinen, Viivi Jetsonen, Tuomas Selander, Olli Lappalainen, Pekka Jäkälä, Anne Koivisto","doi":"10.1159/000545219","DOIUrl":"10.1159/000545219","url":null,"abstract":"<p><strong>Introduction: </strong>Considering the globally growing population and the rising incidence of dementia, it is important to understand the proportion of dementia cases affected by vascular brain disease. We aimed to study the incidence of vascular dementia (VD) and other dementias in a defined population in Finland to better understand VD's contribution to the total incidence of dementias and to assess the sensitivity of their diagnostics.</p><p><strong>Methods: </strong>We aimed to collect all dementia diagnoses made in Northern Savo, Finland, in 2020. The memory disorder diagnoses were identified using the International Classification Codes 10th Revision (ICD-10) diagnosis codes. Finally, we studied the diagnoses in relation to demographic data, focusing on VD.</p><p><strong>Results: </strong>The total number of new diagnoses of dementia with a vascular component or vascular alone was 202, with 20 cases attributable to pure VD. The annual incidence of dementias with a vascular component in Northern Savo was 81.4 per 100,000 across the population and 310.8 per 100,000 in the age group of ≥65. In our study population, 23.8% of all incident dementia cases were associated with vascular disease.</p><p><strong>Conclusion: </strong>According to our findings, dementia associated with vascular pathology has the second highest incidence after Alzheimer's disease, while pure VD is rarely diagnosed. Our findings align with previous international studies and a recent national registry study. Future studies with a prospective study setting, potentially incorporating extensive neuroimaging, would be critical in further understanding the epidemiology of VD.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-7"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}