Epidemiology of Peripheral Neuropathies in Sub-Saharan Africa from 2000 to 2020: Systematic Review and Meta-Analysis.

IF 4 3区医学 Q2 CLINICAL NEUROLOGY

Neuroepidemiology Pub Date : 2025-07-07 DOI:10.1159/000542604

Dieu Donné Gnonlonfoun, Arlos Sowanou, Blaise Choki, Pervenche Fotso, Antoine Gbessemehlan, Pupchen Gnigone, Thierry Metotondji, Richmine Covi, Julien Magne, Farid Boumediene, Dismand Houinato, Pierre-Marie Preux

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引用次数: 0

Abstract

Introduction: Epidemiological studies on peripheral neuropathy (PN) in sub-Saharan Africa (SSA) have been conducted out in various target populations. This systematic review and meta-analysis aim to present and update available descriptive data on PN in SSA from 2000 to 2020.

Methods: Research was performed in indexed databases PubMed (MEDLINE), Web of Science, Google Scholar, Scopus, African Journals Online, and grey literature databases. Studies were selected according to the PRISMA methodology and data were extracted using a collection grid. A meta-analysis with a random-effects model was performed to determine the pooled frequency measures of PNs.

Results: Overall, 116 studies were included in this review, comprising 75,227 subjects (59.71% male, mean age range 9-68.8 years). The highest number of studies were conducted in East Africa (n = 47; 40.5%). The pooled hospital frequency of PN was 39.6% ([95% CI: 34.2-45.2], I2 = 99.32%), the pooled prevalence was 4.30% ([95% CI: 2.50-6.50], I2 = 97.52%), and the pooled hospital incidence was 15.60% per year ([95% CI: 5.10-29.70], I2 = 98.78%). Pooled hospital frequency of PN was higher in diabetic patients (50.30% [95% CI: 28.30-66.70], I2 = 99%) and in Southern Africa (44.30% [95% CI: 27.80-61.10], I2 = 99%). For using electroneuromyogram as a diagnostic tool, the pooled hospital frequency of PN was 76.80% ([95% CI: 67.30-85.40], I2 = 67%). The frequency of polyneuropathy subgroup was 34.40% ([95% CI: 29.90-46.90], I2 = 99.20%).

Conclusion: PNs are frequent in SSA and particularly in certain target groups. It is important to improve preventive measures for HIV and diabetes and increase the understanding of risk factors associated with PN.

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2000年至2020年撒哈拉以南非洲周围神经病变的流行病学：系统回顾和荟萃分析

导论：撒哈拉以南非洲（SSA）周围神经病变（PN）的流行病学研究已经在不同的目标人群中进行了。本系统综述和荟萃分析旨在提供和更新2000年至2020年SSA中PN的可用描述性数据。方法：检索PubMed （Medline）、Web of science、谷歌scholar、Scopus、African Journal Online和灰色文献数据库。根据PRISMA方法选择研究，并使用收集网格提取数据。采用随机效应模型进行meta分析，以确定PNs的合并频率。结果：本综述纳入116项研究，包括75,227名受试者（男性59.71%，平均年龄9-68.8岁）。在东非进行的研究数量最多(n=47；40.5%)。合并住院次数为39.6% ([95% CI: 34.2 ~ 45.2], I²=99.32%)，合并患病率为4.30% ([95% CI: 2.50 ~ 6.50], I²=97.52%)，合并住院发病率为15.60% （[95% CI: 5.10 ~ 29.70], I²=98.78%）。糖尿病患者PN合并住院频次较高(50.30%；[95% CI: 28.30- 66.70], I²=99%)和南部非洲(44.30%；[95% ci: 27.80-61.10]), i²=99%)。使用神经肌电图作为诊断工具，PN的总住院频率为76.80% （[95% CI: 67.30 - 85.40, I²=67%）。多神经病变亚组发生率为34.40% （[95% CI: 29.90 ~ 46.90], I²=99.20%）。结论：PNs在SSA中常见，特别是在某些目标人群中。因此，加强对艾滋病和糖尿病的预防措施，增加对PN相关危险因素的认识是非常重要的。关键词：周围神经病变，流行病学，患病率，发病率，撒哈拉以南非洲。

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来源期刊

Neuroepidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

9.90

自引率

1.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Neuroepidemiology'' is the only internationally recognised peer-reviewed periodical devoted to descriptive, analytical and experimental studies in the epidemiology of neurologic disease. The scope of the journal expands the boundaries of traditional clinical neurology by providing new insights regarding the etiology, determinants, distribution, management and prevention of diseases of the nervous system.