New England Journal of Medicine最新文献

{"title":"Perioperative Chemotherapy in Esophageal Cancer.","authors":"Jie Qin,Bei Feng,Juanjuan Huang","doi":"10.1056/nejmc2502283","DOIUrl":"https://doi.org/10.1056/nejmc2502283","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"8 1","pages":"1554"},"PeriodicalIF":158.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated Syphilis Caused by Two Recombining Treponema pallidum Strains.","authors":"Nicole A P Lieberman,Shah A K Mohamed Bakhash,B Ethan Nunley,Muyi Li,Brian Mau,John S Pauk,Paul Swanson,Anand Baxi,Joshua A Lieberman,Alexander L Greninger","doi":"10.1056/nejmc2500231","DOIUrl":"https://doi.org/10.1056/nejmc2500231","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"9 1","pages":"1551-1553"},"PeriodicalIF":158.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart Rhythm Interventions - Devil in the Details.","authors":"Jason G Andrade","doi":"10.1056/nejme2503817","DOIUrl":"https://doi.org/10.1056/nejme2503817","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"28 1","pages":"1548-1550"},"PeriodicalIF":158.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tecovirimat for Clade I MPXV Infection in the Democratic Republic of Congo.","authors":",Rosine Ali,Jules Alonga,Jean-Luc Biampata,Michael Kombozi Basika,Irina Maljkovic Berry,Nella Bisento,Emily Blum,Tyler Bonnett,Katherine Cone,Ian Crozier,Richard Davey,Ali Dilu,Lori E Dodd,Iman Gulati,Dennis Hruby,Augustin Ibanda,Francis Isse,Sylva Sivasingana Kasareka,Gaby Kayembe,Richard Kojan,Esaie Kindombe Luzolo,H Clifford Lane,Leader Lawanga,Laurens Liesenborghs,Claude Shosongo Lunghe,Yves Lula,Mariano Lusakibanza,Gaston Tona Lutete,Placide Mbala-Kingebeni,Alejandra Miranda,Daniel Mukadi-Bamuleka,Gael Mukendi,Patrick Mutombo Lupola,Jean-Jacques Muyembe-Tamfum,Robin Ndungunu,Bruce Nganga,Nsengi Ntamabyaliro,Veronique Nussenblatt,Imoite Omulepu,John Omalokoho Onosomba,Michael Proschan,Kevin Rubenstein,Inga Saknite,Adam Schechner,Kathryn Shaw-Saliba,Billy Sivahera,Mary Smolskis,Amy Tillman,Eric Tkaczyk,Celestin Tshimanga,Olivier Tshiani Mbaya,Antoine Tshomba,Freddy Yemba Unda Tshomba,David Vallee,Susan Vogel,Shera Weyers","doi":"10.1056/nejmoa2412439","DOIUrl":"https://doi.org/10.1056/nejmoa2412439","url":null,"abstract":"BACKGROUNDTecovirimat is available for the treatment of mpox (formerly known as monkeypox) in Europe and the United States, on the basis of findings from efficacy studies in animals and safety evaluations in healthy humans. Evidence from randomized, controlled trials of safety and efficacy in patients with mpox is lacking.METHODSWe conducted a double-blind, randomized, placebo-controlled trial of tecovirimat in patients with mpox in the Democratic Republic of Congo (DRC). Patients with at least one mpox skin lesion and positive polymerase-chain-reaction results for clade I MPXV were assigned in a 1:1 ratio to receive tecovirimat or placebo. All patients received supportive care. The primary end point was resolution of mpox lesions, measured in number of days after randomization. Safety was also assessed.RESULTSFrom October 7, 2022, through July 9, 2024, a total of 597 patients underwent randomization - 295 to receive tecovirimat and 302 to receive placebo. The median time from randomization to lesion resolution was 7 days with tecovirimat and 8 days with placebo; the competing-risks hazard ratio for lesion resolution was 1.13 (95% confidence interval [CI], 0.97 to 1.31; P = 0.14). Results were similar whether patients began the trial regimen within 7 days after the reported onset of symptoms (competing-risks hazard ratio, 1.16; 95% CI, 0.98 to 1.37) or more than 7 days after onset (competing-risks hazard ratio, 1.00; 95% CI, 0.71 to 1.40). Overall mortality was 1.7%, which was lower than the case fatality rate of 4.6% reported in the DRC in 2023. At 14 days, the percentages of patients who had blood, lesion, and oropharyngeal samples negative for MPXV by PCR were similar in the two groups. Adverse events occurred in 72.9% of the patients in the tecovirimat group and 70.5% of those in the placebo group, and serious adverse events were reported in 5.1% and 5.0%, respectively.CONCLUSIONSTecovirimat did not reduce the number of days to lesion resolution in patients with mpox caused by clade I MPXV. No safety concerns were identified. (Funded by the National Institute of Allergy and Infectious Diseases and others; PALM007 ClinicalTrials.gov number, NCT05559099.).","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"40 1","pages":"1484-1496"},"PeriodicalIF":158.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Putting America First\" - Undermining Health for Populations at Home and Abroad.","authors":"Christopher P Duggan,Zulfiqar A Bhutta","doi":"10.1056/nejmp2503243","DOIUrl":"https://doi.org/10.1056/nejmp2503243","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"17 1","pages":""},"PeriodicalIF":158.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value Zeitgeist - Considering the Slowdown in Health Care Spending Growth.","authors":"Melinda B Buntin,Ellen Meara,Carrie H Colla","doi":"10.1056/nejmp2413472","DOIUrl":"https://doi.org/10.1056/nejmp2413472","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"25 1","pages":""},"PeriodicalIF":158.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Doctors in Revolution and War, April-June 1775.","authors":"Justin Barr,Scott H Podolsky,David S Jones","doi":"10.1056/nejmp2500480","DOIUrl":"https://doi.org/10.1056/nejmp2500480","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"40 1","pages":""},"PeriodicalIF":158.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targetable Mutations in BRAF V600E-Negative Hairy-Cell Leukemia.","authors":"Alessia Santi,Alessandra Venanzi,Alessandra Pucciarini,Gianluca Schiavoni,Marta Naccari,Elisa Albi,Lorenzo De Paoli,Tamara Intermesoli,Stefano Lazzi,Esmeralda Conte,Alessandro Mancini,Brunangelo Falini,Alessandro Gozzetti,Gianna M D'Elia,Angelo Genua,Enrico Tiacci","doi":"10.1056/nejmc2500911","DOIUrl":"https://doi.org/10.1056/nejmc2500911","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"15 1","pages":"1451-1452"},"PeriodicalIF":158.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case 10-2025: A 32-Year-Old Woman with Flank Pain, Fever, and Hypoxemia.","authors":"Anushya Jeyabalan,Cynthia L Czawlytko,Laurence H Beck,Claire Trivin-Avillach","doi":"10.1056/nejmcpc2412517","DOIUrl":"https://doi.org/10.1056/nejmcpc2412517","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"17 1","pages":"1428-1437"},"PeriodicalIF":158.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges to the Future of a Robust Physician Workforce. Reply.","authors":"Rochelle P Walensky,Nicole C McCann","doi":"10.1056/nejmc2502032","DOIUrl":"https://doi.org/10.1056/nejmc2502032","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"108 1","pages":"1456"},"PeriodicalIF":158.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}