New England Journal of Medicine最新文献

{"title":"Progress toward Mitigating Disability Progression in Multiple Sclerosis.","authors":"Peter A Calabresi","doi":"10.1056/nejme2503891","DOIUrl":"https://doi.org/10.1056/nejme2503891","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"44 1","pages":"1966-1968"},"PeriodicalIF":158.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ph-Positive Acute Lymphoblastic Leukemia - 25 Years of Progress.","authors":"Robin Foà","doi":"10.1056/nejmra2405573","DOIUrl":"https://doi.org/10.1056/nejmra2405573","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"40 1","pages":"1941-1952"},"PeriodicalIF":158.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Changes in Airway Mucus Plugs and FEV₁ in COPD.","authors":"Sofia K Mettler, Pietro Nardelli, Monica Iturrioz Campo, Rubén San José Estépar, Padma P Manapragada, Mostafa Abozeed, Muhammad Usman Aziz, Mohd Zahid, Scott Grumley, Hrudaya P Nath, Andrew Yen, Sushilkumar Sonavane, Christian F Clarenbach, Wei Wang, Carrie L Pistenmaa, George R Washko, Raúl San José Estépar, Michael H Cho, Alejandro A Diaz","doi":"10.1056/NEJMc2502456","DOIUrl":"https://doi.org/10.1056/NEJMc2502456","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 19","pages":"1973-1975"},"PeriodicalIF":96.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xenotransplantation - Long Awaited, Much Learned, Much More to Be Learned.","authors":"Sandy Feng","doi":"10.1056/nejme2504399","DOIUrl":"https://doi.org/10.1056/nejme2504399","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"57 1","pages":"1971-1972"},"PeriodicalIF":158.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Torsion of a Mature Cystic Ovarian Teratoma.","authors":"Xiaodong Zhang,Peng Xie","doi":"10.1056/nejmicm2415320","DOIUrl":"https://doi.org/10.1056/nejmicm2415320","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"14 1","pages":"e45"},"PeriodicalIF":158.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Driving Jackson.","authors":"Rajeev Raghavan","doi":"10.1056/NEJMp2414963","DOIUrl":"10.1056/NEJMp2414963","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":" ","pages":"1879-1881"},"PeriodicalIF":96.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of Subsidized Drug Coverage and Mortality among Medicare Beneficiaries.","authors":"Eric T Roberts,Jessica Phelan,Aaron L Schwartz,Ellen Meara,Dominic Ruggiero,Lilly Estenson,Rachel M Werner,José F Figueroa","doi":"10.1056/nejmsa2414435","DOIUrl":"https://doi.org/10.1056/nejmsa2414435","url":null,"abstract":"BACKGROUNDA total of 14 million Medicare beneficiaries receive the Low-Income Subsidy (LIS), which reduces cost sharing in Medicare Part D. Losing the LIS may impede medication access and affect mortality.METHODSUsing 2015-2023 Medicare data, we identified dual-eligible Medicare-Medicaid beneficiaries, who automatically receive the LIS, and calculated annual rates of Medicaid and LIS loss. To examine the relationship between LIS loss and mortality, we leveraged a natural experiment arising from the relationship between the timing of Medicaid disenrollment and subsequent LIS loss. We compared beneficiaries disenrolling from Medicaid in January through June, who kept the LIS through December (6 to 11 additional months), with those disenrolling in July through December, who kept the LIS through the following December (12 to 17 additional months). Among persons disenrolling from Medicaid during 2015-2017, we examined cumulative mortality 7 to 17 months after disenrollment, when those with earlier disenrollment were more likely to lose the LIS.RESULTSThe sample included 969,606 persons with early (January though June) Medicaid disenrollment and 920,158 with late (July though December) Medicaid disenrollment. Those with early Medicaid disenrollment averaged 13.6 cumulative months of the LIS in the 17 months after disenrollment, as compared with 15.3 months for those with late disenrollment. At 17 months after Medicaid disenrollment, cumulative mortality was higher among persons with early disenrollment (78.3 per 1000) than among those with late disenrollment (75.3 per 1000), a difference of 3.0 deaths per 1000 (95% confidence interval [CI], 2.1 to 3.9). Mortality differences between persons with early disenrollment and those with late disenrollment were amplified among those in the highest quintile of baseline Part D spending (5.6 deaths per 1000; 95% CI, 3.3 to 7.9) and users of medications for cardiovascular disease, chronic lung disease, or human immunodeficiency virus infection.CONCLUSIONSLoss of drug subsidies after Medicaid disenrollment was associated with higher mortality among low-income Medicare beneficiaries. (Funded by the National Institute on Aging and others.).","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"32 1","pages":""},"PeriodicalIF":158.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tirzepatide as Compared with Semaglutide for the Treatment of Obesity.","authors":"Louis J Aronne,Deborah Bade Horn,Carel W le Roux,Wayne Ho,Beverly L Falcon,Elisa Gomez Valderas,Sagar Das,Clare J Lee,Leonard C Glass,Cagri Senyucel,Julia P Dunn,","doi":"10.1056/nejmoa2416394","DOIUrl":"https://doi.org/10.1056/nejmoa2416394","url":null,"abstract":"BACKGROUNDTirzepatide and semaglutide are highly effective medications for obesity management. The efficacy and safety of tirzepatide as compared with semaglutide in adults with obesity but without type 2 diabetes is unknown.METHODSIn this phase 3b, open-label, controlled trial, adult participants with obesity but without type 2 diabetes were randomly assigned in a 1:1 ratio to receive the maximum tolerated dose of tirzepatide (10 mg or 15 mg) or the maximum tolerated dose of semaglutide (1.7 mg or 2.4 mg) subcutaneously once weekly for 72 weeks. The primary end point was the percent change in weight from baseline to week 72. Key secondary end points included weight reductions of at least 10%, 15%, 20%, and 25% and a change in waist circumference from baseline to week 72.RESULTSA total of 751 participants underwent randomization. The least-squares mean percent change in weight at week 72 was -20.2% (95% confidence interval [CI], -21.4 to -19.1) with tirzepatide and -13.7% (95% CI, -14.9 to -12.6) with semaglutide (P<0.001). The least-squares mean change in waist circumference was -18.4 cm (95% CI, -19.6 to -17.2) with tirzepatide and -13.0 cm (95% CI, -14.3 to -11.7) with semaglutide (P<0.001). Participants in the tirzepatide group were more likely than those in the semaglutide group to have weight reductions of at least 10%, 15%, 20%, and 25%. The most common adverse events in both treatment groups were gastrointestinal, and most were mild to moderate in severity and occurred primarily during dose escalation.CONCLUSIONSAmong participants with obesity but without diabetes, treatment with tirzepatide was superior to treatment with semaglutide with respect to reduction in body weight and waist circumference at week 72. (Funded by Eli Lilly; SURMOUNT-5 ClinicalTrials.gov number, NCT05822830.).","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"44 1","pages":""},"PeriodicalIF":158.5,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Driven Clinical Documentation - Driving Out the Chitchat?","authors":"Gordon D Schiff","doi":"10.1056/nejmp2416064","DOIUrl":"https://doi.org/10.1056/nejmp2416064","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"35 1","pages":""},"PeriodicalIF":158.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sixty Years of Community Health Centers - An Anniversary at a Crossroads.","authors":"Alexander E Jacobs","doi":"10.1056/nejmp2416468","DOIUrl":"https://doi.org/10.1056/nejmp2416468","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"1 1","pages":""},"PeriodicalIF":158.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}