New England Journal of Medicine最新文献

{"title":"Trial of the Oral PCSK9 Inhibitor Enlicitide.","authors":"Hongxuan Fan, Boda Zhou","doi":"10.1056/NEJMc2602975","DOIUrl":"https://doi.org/10.1056/NEJMc2602975","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"394 18","pages":"1867"},"PeriodicalIF":78.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Mission to Margin in Academic Medicine - The Impact of Corporate Medicine on Medical Training.","authors":"Jatin M Vyas","doi":"10.1056/NEJMp2415750","DOIUrl":"10.1056/NEJMp2415750","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":" ","pages":"1769-1772"},"PeriodicalIF":78.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Oral Ivermectin and 5% Permethrin Cream to Treat Severe Scabies.","authors":"Charlotte Bernigaud, Giao Do-Pham, Elie Guichard, Marie Beylot-Barry, Elisa Goujon, Camille Isnard, Nathalie Beneton, Mahtab Samimi, Billal Tedbirt, Henri Adamski, Selma Azib, Emmanuel Mahé, Catherine Michel, Jean-Luc Perrot, Marie Acquitter, Anne-Claire Bursztejn, Guillaume Chaby, Frédéric Caux, Thierry Passeron, Clélia Vanhaecke, Antoine Mahé, Marie-Thérèse Leccia, Sébastien Barbarot, Cédric Lenormand, François Aubin, Françoise Foulet, Laëtitia Grégoire, Bruno Giraudeau, Olivier Chosidow","doi":"10.1056/NEJMoa2411721","DOIUrl":"https://doi.org/10.1056/NEJMoa2411721","url":null,"abstract":"<p><strong>Background: </strong>Severe scabies, a rare parasitic skin disease characterized by abundant skin mites, may be life-threatening and poses public health concerns worldwide. A combination of standard-dose oral ivermectin and topical scabicides is recommended for treatment. However, data from randomized clinical trials are lacking, and the probability of cure is uncertain. Ivermectin at higher doses has been effective in the treatment of some parasitic diseases.</p><p><strong>Methods: </strong>We conducted a blinded randomized trial involving adults with severe scabies (i.e., profuse or crusted), as confirmed by parasitologic or dermoscopic assessment. The patients were assigned in a 1:1 ratio to receive oral ivermectin (to be taken with food) at a dose of 400 μg per kilogram of body weight (higher-dose group) or 200 μg per kilogram (standard-dose group) on days 0, 7, and 14, combined with head-to-toe application of 5% permethrin cream on days 0 and 7 and daily application (as recommended) of an emollient cream. The primary end point was cure of severe scabies, which was defined as the absence of mites and mite-related products (i.e., eggs and feces), as confirmed by parasitologic or dermoscopic assessment on days 18 and 21, and the absence of active clinical lesions on physical examination on day 28.</p><p><strong>Results: </strong>A total of 132 patients (66 in each group) were included in the main analysis. Cure was observed in 75% of the patients in the higher-dose group and in 82% of those in the standard-dose group (odds ratio for cure, 0.64; 95% confidence interval, 0.25 to 1.67). No safety issues were identified.</p><p><strong>Conclusions: </strong>Among adults, the 400-μg-per-kilogram dose of ivermectin plus 5% permethrin cream was not superior to the standard 200-μg-per-kilogram dose of ivermectin plus 5% permethrin cream in curing severe scabies. (Funded by the French Ministry of Health and French Society of Dermatology; ClinicalTrials.gov number, NCT02841215.).</p>","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"394 18","pages":"1814-1823"},"PeriodicalIF":78.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antithrombotic Therapy after Ablation for Atrial Fibrillation.","authors":"Jason G Andrade, Matthew T Bennett","doi":"10.1056/NEJMc2602513","DOIUrl":"https://doi.org/10.1056/NEJMc2602513","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"394 18","pages":"1870"},"PeriodicalIF":78.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reforming Payment for Clinician-Administered Drugs - Most-Favored-Nation Pricing in Medicare Part B.","authors":"Thomas J Hwang, Lisa Clemans-Cope, Aaron S Kesselheim","doi":"10.1056/NEJMp2600417","DOIUrl":"10.1056/NEJMp2600417","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":" ","pages":"1774-1777"},"PeriodicalIF":78.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicaid's GENEROUS Most-Favored-Nation Pricing Model - Promise and Limitations.","authors":"Luca Maini, Rachel E Sachs, Michael Anne Kyle, Pragya Kakani","doi":"10.1056/NEJMp2518292","DOIUrl":"10.1056/NEJMp2518292","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":" ","pages":"1772-1774"},"PeriodicalIF":78.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antithrombotic Therapy after Ablation for Atrial Fibrillation. Reply.","authors":"Atul Verma, David H Birnie","doi":"10.1056/NEJMc2602513","DOIUrl":"https://doi.org/10.1056/NEJMc2602513","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"394 18","pages":"1871-1872"},"PeriodicalIF":78.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antithrombotic Therapy after Ablation for Atrial Fibrillation.","authors":"T Blair McClymont","doi":"10.1056/NEJMc2602513","DOIUrl":"https://doi.org/10.1056/NEJMc2602513","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"394 18","pages":"1870-1871"},"PeriodicalIF":78.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in RAS Therapeutics for Pancreatic Cancer.","authors":"Channing J Der, Jen Jen Yeh","doi":"10.1056/NEJMe2600517","DOIUrl":"https://doi.org/10.1056/NEJMe2600517","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"394 18","pages":"1857-1861"},"PeriodicalIF":78.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Interference.","authors":"Masami Matsumura, Naoki Kanda, Shuji Hatakeyama, Gurpreet Dhaliwal","doi":"10.1056/NEJMcps2511351","DOIUrl":"https://doi.org/10.1056/NEJMcps2511351","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"394 18","pages":"1847-1853"},"PeriodicalIF":78.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}