Abdoulaye Fomba, Fadima C Haidara, Mamoudou Kodio, Catherine Arama, Emmanuelle Cambau, Aurélie Chauffour, Nicolas Veziris, Bettina E Broeckling, Alaine K Warren, Bertrand Cauchoix, Alexandre Alcaïs, Laurent Marsollier, Henri Assé, Mary Jackson, Samba Ousmane Sow, Ousmane Faye, Vincent Jarlier, Stewart T Cole, Charlotte Avanzi, Alexandra Aubry, Roch C Johnson
{"title":"Bedaquiline Activity against Leprosy.","authors":"Abdoulaye Fomba, Fadima C Haidara, Mamoudou Kodio, Catherine Arama, Emmanuelle Cambau, Aurélie Chauffour, Nicolas Veziris, Bettina E Broeckling, Alaine K Warren, Bertrand Cauchoix, Alexandre Alcaïs, Laurent Marsollier, Henri Assé, Mary Jackson, Samba Ousmane Sow, Ousmane Faye, Vincent Jarlier, Stewart T Cole, Charlotte Avanzi, Alexandra Aubry, Roch C Johnson","doi":"10.1056/NEJMc2412487","DOIUrl":"10.1056/NEJMc2412487","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 21","pages":"2174-2176"},"PeriodicalIF":96.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fixed-Duration Acalabrutinib Combinations in Untreated Chronic Lymphocytic Leukemia.","authors":"Mohamad Mohty, Mohamed A Kharfan-Dabaja","doi":"10.1056/NEJMc2503839","DOIUrl":"https://doi.org/10.1056/NEJMc2503839","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 21","pages":"2180-2181"},"PeriodicalIF":96.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Semaglutide for Metabolic Dysfunction-Associated Steatohepatitis.","authors":"Tracey G Simon","doi":"10.1056/NEJMe2504717","DOIUrl":"https://doi.org/10.1056/NEJMe2504717","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 21","pages":"2160-2161"},"PeriodicalIF":96.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TAVR for Asymptomatic Severe Aortic Stenosis.","authors":"Benjamin U Hoffman, Ori Ben-Yehuda","doi":"10.1056/NEJMc2502177","DOIUrl":"https://doi.org/10.1056/NEJMc2502177","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 21","pages":"2176-2177"},"PeriodicalIF":96.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TAVR for Asymptomatic Severe Aortic Stenosis.","authors":"Francesco Natale, Paolo Golino, Giovanni Cimmino","doi":"10.1056/NEJMc2502177","DOIUrl":"https://doi.org/10.1056/NEJMc2502177","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 21","pages":"2176"},"PeriodicalIF":96.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bernard Chasekwa, Fortunate Munhanzi, Lenin Madhuyu, Gabriel Mbewe, Vincent Mabika, Dzivaidzo Chidhanguro, Tendai Kofi, Jonthan Munengiwa, Hilda Mapfumo, Mercy Musapa, Sipho Shumba, Elizabeth Hungwe, Mary Nhokwara, Nester Bushe, Rudo Kufa, Phatisiwe Mazula, Muchaneta Chikombingo, Alice Tengende, Admire Zanga, Asaph Ziruma, Tsitsi Bere, Success Munyengwa, Charity Mudimbu, Zvikomborero Murwira, Shepherd Mudzingwa, Eddington Mpofu, Batsirai Mutasa, Virginia Sauramba, Elisha Masakadze, Thompson Runodamoto, Courage Chiorera, Alfred Mushininga, Claire D Bourke, Ruairi C Robertson, Jeniffer Perussolo, Nikos Donos, Chandiwana Nyachowe, Mary Muchekeza, Jefrey Chikunya, Melanie Smuk, Kuda Mutasa, Naume V Tavengwa, Lisa L Langhaug, Robert Ntozini, Stephen P Munjanja, Andrew J Prendergast
{"title":"A Trial of Trimethoprim-Sulfamethoxazole in Pregnancy to Improve Birth Outcomes.","authors":"Bernard Chasekwa, Fortunate Munhanzi, Lenin Madhuyu, Gabriel Mbewe, Vincent Mabika, Dzivaidzo Chidhanguro, Tendai Kofi, Jonthan Munengiwa, Hilda Mapfumo, Mercy Musapa, Sipho Shumba, Elizabeth Hungwe, Mary Nhokwara, Nester Bushe, Rudo Kufa, Phatisiwe Mazula, Muchaneta Chikombingo, Alice Tengende, Admire Zanga, Asaph Ziruma, Tsitsi Bere, Success Munyengwa, Charity Mudimbu, Zvikomborero Murwira, Shepherd Mudzingwa, Eddington Mpofu, Batsirai Mutasa, Virginia Sauramba, Elisha Masakadze, Thompson Runodamoto, Courage Chiorera, Alfred Mushininga, Claire D Bourke, Ruairi C Robertson, Jeniffer Perussolo, Nikos Donos, Chandiwana Nyachowe, Mary Muchekeza, Jefrey Chikunya, Melanie Smuk, Kuda Mutasa, Naume V Tavengwa, Lisa L Langhaug, Robert Ntozini, Stephen P Munjanja, Andrew J Prendergast","doi":"10.1056/NEJMoa2408114","DOIUrl":"10.1056/NEJMoa2408114","url":null,"abstract":"<p><strong>Background: </strong>Maternal infections underlie several adverse birth outcomes. Whether trimethoprim-sulfamethoxazole prophylaxis during pregnancy will improve birth outcomes is unknown.</p><p><strong>Methods: </strong>In a double-blind, randomized, placebo-controlled trial in Zimbabwe, we assigned pregnant women to receive trimethoprim-sulfamethoxazole, at a dose of 960 mg daily, or placebo from at least 14 weeks' gestation until delivery. The primary outcome was birth weight.</p><p><strong>Results: </strong>Among 993 participants (131 with human immunodeficiency virus infection), 498 were randomly assigned to receive placebo and 495 to receive trimethoprim-sulfamethoxazole, with the first dose received at a median of 21.7 weeks' gestation (interquartile range, 17.3 to 26.4). In intention-to-treat analyses, the mean (±SD) birth weight was 3040±460 g in the trimethoprim-sulfamethoxazole group and 3019±526 g in the placebo group (mean difference, 20 g, 95% confidence interval, -43 to 83; P = 0.53). The number of adverse events was similar in the two groups.</p><p><strong>Conclusions: </strong>In Zimbabwe, trimethoprim-sulfamethoxazole prophylaxis during pregnancy did not significantly increase infant birth weight. (Funded by Wellcome and others; Pan African Clinical Trials Registry number, PACTR202107707978619.).</p>","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 21","pages":"2125-2134"},"PeriodicalIF":96.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lead Poisoning in a Child.","authors":"Shalini H Shah, Marissa Hauptman","doi":"10.1056/NEJMicm2501209","DOIUrl":"https://doi.org/10.1056/NEJMicm2501209","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 21","pages":"2150"},"PeriodicalIF":96.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ann Cheung, Jose Bernardo Q Quintos, Shivani Agarwal
{"title":"Setting for Initial Education about Type 1 Diabetes.","authors":"Ann Cheung, Jose Bernardo Q Quintos, Shivani Agarwal","doi":"10.1056/NEJMclde2412266","DOIUrl":"https://doi.org/10.1056/NEJMclde2412266","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 21","pages":"2164-2167"},"PeriodicalIF":96.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TAVR for Asymptomatic Severe Aortic Stenosis.","authors":"Johann Auer, Hendrik J Ankersmit, Lisa Auer","doi":"10.1056/NEJMc2502177","DOIUrl":"https://doi.org/10.1056/NEJMc2502177","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 21","pages":"2177-2178"},"PeriodicalIF":96.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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