New England Journal of Medicine最新文献

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Case 9-2025: A 59-Year-Old Man with Hepatocellular Carcinoma.
IF 96.2 1区 医学
New England Journal of Medicine Pub Date : 2025-03-27 DOI: 10.1056/NEJMcpc1909622
Kathleen E Corey, David M Dudzinski, Alexander R Guimaraes, Mari Mino-Kenudson
{"title":"Case 9-2025: A 59-Year-Old Man with Hepatocellular Carcinoma.","authors":"Kathleen E Corey, David M Dudzinski, Alexander R Guimaraes, Mari Mino-Kenudson","doi":"10.1056/NEJMcpc1909622","DOIUrl":"https://doi.org/10.1056/NEJMcpc1909622","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 12","pages":"1216-1227"},"PeriodicalIF":96.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Red Urine after Administration of Hydroxocobalamin.
IF 96.2 1区 医学
New England Journal of Medicine Pub Date : 2025-03-27 Epub Date: 2025-03-22 DOI: 10.1056/NEJMicm2413940
Nilesh Anand Devanand, Robin de Meirsman
{"title":"Red Urine after Administration of Hydroxocobalamin.","authors":"Nilesh Anand Devanand, Robin de Meirsman","doi":"10.1056/NEJMicm2413940","DOIUrl":"10.1056/NEJMicm2413940","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":" ","pages":"e32"},"PeriodicalIF":96.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcatheter Valve Replacement in Severe Tricuspid Regurgitation.
IF 96.2 1区 医学
New England Journal of Medicine Pub Date : 2025-03-27 DOI: 10.1056/NEJMc2501560
Alexander Kempny, Colm McCabe
{"title":"Transcatheter Valve Replacement in Severe Tricuspid Regurgitation.","authors":"Alexander Kempny, Colm McCabe","doi":"10.1056/NEJMc2501560","DOIUrl":"https://doi.org/10.1056/NEJMc2501560","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 12","pages":"1243"},"PeriodicalIF":96.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unexplained or Refractory Chronic Cough in Adults.
IF 96.2 1区 医学
New England Journal of Medicine Pub Date : 2025-03-27 DOI: 10.1056/NEJMra2309906
Richard S Irwin, J Mark Madison
{"title":"Unexplained or Refractory Chronic Cough in Adults.","authors":"Richard S Irwin, J Mark Madison","doi":"10.1056/NEJMra2309906","DOIUrl":"https://doi.org/10.1056/NEJMra2309906","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 12","pages":"1203-1214"},"PeriodicalIF":96.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Partnerships between Pharmaceutical and Telehealth Companies - Increasing Access or Driving Inappropriate Prescribing?
IF 96.2 1区 医学
New England Journal of Medicine Pub Date : 2025-03-27 Epub Date: 2025-03-22 DOI: 10.1056/NEJMp2500379
Erin C Fuse Brown, Olivier J Wouters, Ateev Mehrotra
{"title":"Partnerships between Pharmaceutical and Telehealth Companies - Increasing Access or Driving Inappropriate Prescribing?","authors":"Erin C Fuse Brown, Olivier J Wouters, Ateev Mehrotra","doi":"10.1056/NEJMp2500379","DOIUrl":"10.1056/NEJMp2500379","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":" ","pages":"1148-1151"},"PeriodicalIF":96.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inebilizumab for Treatment of IgG4-Related Disease. 伊奈珠单抗用于治疗 IgG4 相关疾病。
IF 96.2 1区 医学
New England Journal of Medicine Pub Date : 2025-03-27 Epub Date: 2024-11-14 DOI: 10.1056/NEJMoa2409712
John H Stone, Arezou Khosroshahi, Wen Zhang, Emanuel Della Torre, Kazuichi Okazaki, Yoshiya Tanaka, J Matthias Löhr, Nicolas Schleinitz, Lingli Dong, Hisanori Umehara, Marco Lanzillotta, Zachary S Wallace, Mikael Ebbo, George J Webster, Fernando Martinez Valle, Manu K Nayar, Cory A Perugino, Vinciane Rebours, Xinxin Dong, Yanping Wu, Qing Li, Nishi Rampal, Daniel Cimbora, Emma L Culver
{"title":"Inebilizumab for Treatment of IgG4-Related Disease.","authors":"John H Stone, Arezou Khosroshahi, Wen Zhang, Emanuel Della Torre, Kazuichi Okazaki, Yoshiya Tanaka, J Matthias Löhr, Nicolas Schleinitz, Lingli Dong, Hisanori Umehara, Marco Lanzillotta, Zachary S Wallace, Mikael Ebbo, George J Webster, Fernando Martinez Valle, Manu K Nayar, Cory A Perugino, Vinciane Rebours, Xinxin Dong, Yanping Wu, Qing Li, Nishi Rampal, Daniel Cimbora, Emma L Culver","doi":"10.1056/NEJMoa2409712","DOIUrl":"10.1056/NEJMoa2409712","url":null,"abstract":"<p><strong>Background: </strong>IgG4-related disease is a multiorgan, relapsing, fibroinflammatory, immune-mediated disorder with no approved therapy. Inebilizumab targets and depletes CD19+ B cells and may be effective for treating patients with IgG4-related disease.</p><p><strong>Methods: </strong>In this phase 3, multicenter, double-blind, randomized, placebo-controlled trial, adults with active IgG4-related disease underwent randomization in a 1:1 ratio to receive inebilizumab (300-mg intravenous infusions on days 1 and 15 and week 26) or placebo for a 52-week treatment period. Participants in both groups received identical glucocorticoid tapers. Glucocorticoids were allowed to treat disease flares, but background immunosuppressants were not permitted. The primary end point was the first treated, adjudicated disease flare during the treatment period, assessed in a time-to-event analysis. Key secondary end points were the annualized flare rate and treatment-free and glucocorticoid-free complete remission.</p><p><strong>Results: </strong>A total of 135 participants with IgG4-related disease underwent randomization: 68 participants were assigned to receive inebilizumab and 67 were assigned to receive placebo. Treatment with inebilizumab reduced flare risk; 7 participants (10%) in the inebilizumab group had at least one flare, as compared with 40 participants (60%) in the placebo group (hazard ratio, 0.13; 95% confidence interval [CI], 0.06 to 0.28; P<0.001). The annualized flare rate was lower with inebilizumab than with placebo (rate ratio, 0.14; 95% CI, 0.06 to 0.31; P<0.001). More participants in the inebilizumab group than in the placebo group had flare-free, treatment-free complete remission (odds ratio, 4.68; 95% CI, 2.21 to 9.91; P<0.001) and flare-free, glucocorticoid-free complete remission (odds ratio, 4.96; 95% CI, 2.34 to 10.52; P<0.001). Serious adverse events occurred during the treatment period in 12 of the participants (18%) who received inebilizumab and 6 of the participants (9%) who received placebo.</p><p><strong>Conclusions: </strong>Inebilizumab reduced the risk of flares of IgG4-related disease and increased the likelihood of flare-free complete remission at 1 year, confirming the role of CD19-targeted B-cell depletion as a potential treatment for IgG4-related disease. (Funded by Amgen; MITIGATE ClinicalTrials.gov number, NCT04540497.).</p>","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":" ","pages":"1168-1177"},"PeriodicalIF":96.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health Care Bridges - Pathways toward Trust in Gaza and Beyond.
IF 96.2 1区 医学
New England Journal of Medicine Pub Date : 2025-03-27 Epub Date: 2025-03-22 DOI: 10.1056/NEJMp2416553
Yasmeen Abu Fraiha, Abdalrahman Ahmed, Noam Alon, Avner Halperin
{"title":"Health Care Bridges - Pathways toward Trust in Gaza and Beyond.","authors":"Yasmeen Abu Fraiha, Abdalrahman Ahmed, Noam Alon, Avner Halperin","doi":"10.1056/NEJMp2416553","DOIUrl":"10.1056/NEJMp2416553","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":" ","pages":"1145-1148"},"PeriodicalIF":96.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nivolumab plus Ipilimumab in Advanced Melanoma.
IF 96.2 1区 医学
New England Journal of Medicine Pub Date : 2025-03-27 DOI: 10.1056/NEJMc2501311
Akhil Santhosh
{"title":"Nivolumab plus Ipilimumab in Advanced Melanoma.","authors":"Akhil Santhosh","doi":"10.1056/NEJMc2501311","DOIUrl":"https://doi.org/10.1056/NEJMc2501311","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"392 12","pages":"1245-1246"},"PeriodicalIF":96.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NEJM Outbreaks Update - H5N1.
IF 96.2 1区 医学
New England Journal of Medicine Pub Date : 2025-03-27 Epub Date: 2025-03-05 DOI: 10.1056/NEJMe2502267
Eric J Rubin, Lindsey R Baden, Yoshihiro Kawaoka, Stephen Morrissey
{"title":"NEJM Outbreaks Update - H5N1.","authors":"Eric J Rubin, Lindsey R Baden, Yoshihiro Kawaoka, Stephen Morrissey","doi":"10.1056/NEJMe2502267","DOIUrl":"10.1056/NEJMe2502267","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":" ","pages":"e34"},"PeriodicalIF":96.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Definition of Failure.
IF 96.2 1区 医学
New England Journal of Medicine Pub Date : 2025-03-27 Epub Date: 2025-03-22 DOI: 10.1056/NEJMp2414167
Jason Gurney
{"title":"The Definition of Failure.","authors":"Jason Gurney","doi":"10.1056/NEJMp2414167","DOIUrl":"10.1056/NEJMp2414167","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":" ","pages":"1151-1153"},"PeriodicalIF":96.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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