New England Journal of Medicine最新文献

{"title":"Intensive Blood-Pressure Control in Patients with Type 2 Diabetes.","authors":"Beatriz Fernandez-Fernandez, Pantelis Sarafidis, Alberto Ortiz","doi":"10.1056/NEJMc2506053","DOIUrl":"https://doi.org/10.1056/NEJMc2506053","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"393 1","pages":"96-97"},"PeriodicalIF":96.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further Comments on Risdiplam for Prenatal Therapy of Spinal Muscular Atrophy.","authors":"Crystal J J Yeo, Darryl C De Vivo, Basil T Darras","doi":"10.1056/NEJMc2504911","DOIUrl":"https://doi.org/10.1056/NEJMc2504911","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"393 1","pages":"103-104"},"PeriodicalIF":96.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections. Reply.","authors":"Nick Daneman, Robert A Fowler","doi":"10.1056/NEJMc2506050","DOIUrl":"https://doi.org/10.1056/NEJMc2506050","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"393 1","pages":"100-101"},"PeriodicalIF":96.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further Comments on Risdiplam for Prenatal Therapy of Spinal Muscular Atrophy. Reply.","authors":"Richard S Finkel,Lutz Mueller,Heidemarie Kletzl","doi":"10.1056/nejmc2504911","DOIUrl":"https://doi.org/10.1056/nejmc2504911","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"27 1","pages":"104"},"PeriodicalIF":158.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensive Blood-Pressure Control in Patients with Type 2 Diabetes.","authors":"Beatriz Fernandez-Fernandez,Pantelis Sarafidis,Alberto Ortiz","doi":"10.1056/nejmc2506053","DOIUrl":"https://doi.org/10.1056/nejmc2506053","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"23 1","pages":"96-97"},"PeriodicalIF":158.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections.","authors":"Lemuel R Non","doi":"10.1056/NEJMc2506050","DOIUrl":"https://doi.org/10.1056/NEJMc2506050","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"393 1","pages":"98-99"},"PeriodicalIF":96.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structured Exercise after Adjuvant Chemotherapy for Colon Cancer.","authors":"Kerry S Courneya, Janette L Vardy, Christopher J O'Callaghan, Sharlene Gill, Christine M Friedenreich, Rebecca K S Wong, Haryana M Dhillon, Victoria Coyle, Neil S Chua, Derek J Jonker, Philip J Beale, Kamal Haider, Patricia A Tang, Tony Bonaventura, Ralph Wong, Howard J Lim, Matthew E Burge, Stacey Hubay, Michael Sanatani, Kristin L Campbell, Fernanda Z Arthuso, Jane Turner, Ralph M Meyer, Michael Brundage, Patti O'Brien, Dongsheng Tu, Christopher M Booth","doi":"10.1056/NEJMoa2502760","DOIUrl":"10.1056/NEJMoa2502760","url":null,"abstract":"<p><strong>Background: </strong>Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking.</p><p><strong>Methods: </strong>In this phase 3, randomized trial conducted at 55 centers, we assigned patients with resected colon cancer who had completed adjuvant chemotherapy to participate in a structured exercise program (exercise group) or to receive health-education materials alone (health-education group) over a 3-year period. The primary end point was disease-free survival.</p><p><strong>Results: </strong>From 2009 through 2024, a total of 889 patients underwent randomization to the exercise group (445 patients) or the health-education group (444 patients). At a median follow-up of 7.9 years, disease-free survival was significantly longer in the exercise group than in the health-education group (hazard ratio for disease recurrence, new primary cancer, or death, 0.72; 95% confidence interval [CI], 0.55 to 0.94; P = 0.02). The 5-year disease-free survival was 80.3% in the exercise group and 73.9% in the health-education group (difference, 6.4 percentage points; 95% CI, 0.6 to 12.2). Results support longer overall survival in the exercise group than in the health-education group (hazard ratio for death, 0.63; 95% CI, 0.43 to 0.94). The 8-year overall survival was 90.3% in the exercise group and 83.2% in the health-education group (difference, 7.1 percentage points; 95% CI, 1.8 to 12.3). Musculoskeletal adverse events occurred more often in the exercise group than in the health-education group (in 18.5% vs. 11.5% of patients).</p><p><strong>Conclusions: </strong>A 3-year structured exercise program initiated soon after adjuvant chemotherapy for colon cancer resulted in significantly longer disease-free survival and findings consistent with longer overall survival. (Funded by the Canadian Cancer Society and others; CHALLENGE ClinicalTrials.gov number, NCT00819208.).</p>","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":" ","pages":"13-25"},"PeriodicalIF":96.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensive Blood-Pressure Control in Patients with Type 2 Diabetes.","authors":"Ehud Grossman, Franz H Messerli","doi":"10.1056/NEJMc2506053","DOIUrl":"https://doi.org/10.1056/NEJMc2506053","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"393 1","pages":"97"},"PeriodicalIF":96.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Corporatization of U.S. Health Care - A New Perspective Series.","authors":"Debra Malina,Atheendar S Venkataramani,Lisa Rosenbaum,Genevra Pittman,Stephen Morrissey","doi":"10.1056/nejme2507231","DOIUrl":"https://doi.org/10.1056/nejme2507231","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"638 1","pages":"81-82"},"PeriodicalIF":158.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144547657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensive Blood-Pressure Control in Patients with Type 2 Diabetes. Reply.","authors":"Yufang Bi, Yu Xu, Weiqing Wang","doi":"10.1056/NEJMc2506053","DOIUrl":"https://doi.org/10.1056/NEJMc2506053","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":"393 1","pages":"97-98"},"PeriodicalIF":96.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}