New Microbiologica最新文献_第2页

Immunological recovery with BIC/FTC/TAF: CD4 T-cell count and CD4/CD8 ratio as markers of response. BIC/FTC/TAF免疫恢复：CD4 t细胞计数和CD4/CD8比值作为应答标志。

IF 1.5 4区医学

New Microbiologica Pub Date : 2025-05-01

Valeria Bono, Giulia C Marchetti

引用次数: 0

Clinical use of dalbavancin in the Italian SUSANA cohort (SUrveillance of SAfety and outcome of New Antibiotics). dalbavancin在意大利SUSANA队列中的临床应用（新抗生素的安全性和结局监测）。

IF 1.5 4区医学

New Microbiologica Pub Date : 2025-05-01

Sara Tordi, Elena Ricci, Luca Mezzadri, Stefania Piconi, Stefania Cicalini, Giovanni Cenderello, Goffredo Angioni, Letizia Attala, Paolo Maggi, Giordano Madeddu, Luca Bisi, Alessandro Pandolfo, Daniela Francisci, Francesco Luzzaro, Paolo Bonfanti, Giuseppe V De Socio

{"title":"Clinical use of dalbavancin in the Italian SUSANA cohort (SUrveillance of SAfety and outcome of New Antibiotics).","authors":"Sara Tordi, Elena Ricci, Luca Mezzadri, Stefania Piconi, Stefania Cicalini, Giovanni Cenderello, Goffredo Angioni, Letizia Attala, Paolo Maggi, Giordano Madeddu, Luca Bisi, Alessandro Pandolfo, Daniela Francisci, Francesco Luzzaro, Paolo Bonfanti, Giuseppe V De Socio","doi":"","DOIUrl":"","url":null,"abstract":"The purpose of the study was to evaluate the therapeutic success and adverse events (AEs) of dalbavancin on-label and off-label use in clinical practice. This was a retrospective, observational, multicentre study that enrolled consecutive patients treated with dalbavancin from January 2017 to May 2024 in the Italian SUSANA cohort. Therapeutic success was defined as clinical cure or infection control if chronic suppressive therapy was performed. Risk factors for treatment failure were evaluated using a logistic regression model. A total of 281 patients were enrolled in the study. On-label administration occurred in 162 (57.6%) cases and off-label in 119 (42.6%). The main off-label prescriptions included 29 cases of osteomyelitis and 25 cases of prosthetic joint infections. Dalbavancin was used mainly as empirical therapy (70.4% of cases) in the on-label group, while in the off-label group as targeted therapy for methicillin-resistant Staphylococcus aureus (29.4%). The therapeutic success rate was similar in both groups (82.7% on-label versus 84.0% off-label). Only one adverse event caused discontinuation of treatment in the on-label group. In addition, one grade-3 AE was observed in each cohort, without treatment interruption. Dalbavancin was widely used in clinical practice for on-label and off-label indications with a comparable success rate of 82.8% and 84.0%, respectively, and a good safety profile.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"48 1","pages":"35-45"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report of central nervous system infection by Nocardia nova in a patient with systemic lupus erythematosus treated with steroids. 用类固醇治疗系统性红斑狼疮患者的中枢神经系统感染诺卡菌1例报告。

IF 1.5 4区医学

New Microbiologica Pub Date : 2025-05-01

Wenchen Guo, Xiaoting Yang, Wanxiang Li, Linlin Dong

引用次数: 0

Green synthesis of silver nanoparticles using Mung bean and the probiotic Bacillus clausii and their evaluation as single or synergistic antibacterial agents. 绿豆与克劳梭菌绿色合成纳米银及其作为单一或协同抗菌剂的评价。

IF 1.5 4区医学

New Microbiologica Pub Date : 2025-05-01

Lamia A Aljarbou, Maha A Alshiekheid, Noura S Aldosari, Maha B Aldhfeeri, Nadine M S Moubayed

{"title":"Green synthesis of silver nanoparticles using Mung bean and the probiotic Bacillus clausii and their evaluation as single or synergistic antibacterial agents.","authors":"Lamia A Aljarbou, Maha A Alshiekheid, Noura S Aldosari, Maha B Aldhfeeri, Nadine M S Moubayed","doi":"","DOIUrl":"","url":null,"abstract":"Biological green synthesis of silver nanoparticles (AgNPs) offers potent antimicrobial properties and provides a promising approach against drug-resistant microbes. The present study aims to synthesize AgNPs using Mung bean (Vigna radiate) aqueous extract and the probiotic Bacillus clausii, and to evaluate their antibacterial activity individually and in combination against several bacterial strains. Synthesized AgNPs were characterized by ultraviolet-visible spectroscopy (UV-vis) and scanning electron microscopy (SEM). V. radiata AgNPs were revealed at 450 nm, with spherical to oval shapes ranging in size from 15.9 to 23.0 nm; probiotic AgNPs were observed at 425 nm, also with a spherical shape ranging in size from 16.4 to 23.7 nm. The antibacterial assay was performed using the agar well diffusion method against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli. Results indicated that V. radiata aqueous extract and the probiotic solution did not exhibit any effect, whereas synthesized V. radiata and probiotic AgNPs showed antibacterial activity against all tested bacteria. AgNPs possessed higher antibacterial activity than individual AgNPs when used in combination against almost all bacteria studied. Therefore, it is suggested that using natural antimicrobial agents to synthesize NPs could serve as an eco-friendly alternative to antibiotics.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"48 1","pages":"27-34"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge Mapping of International Microbiota Research: Analyzing Thirty-Year Citation Classics and Exploring Future Expectations. 国际微生物群研究的知识图谱：三十年引文经典分析与未来展望

IF 1.5 4区医学

New Microbiologica Pub Date : 2025-05-01

Xiang Li, Kunkai Su, Yueyue He, Shimiao Shao, Lei Lan, Qiong Zhang, Lanjuan Li

{"title":"Knowledge Mapping of International Microbiota Research: Analyzing Thirty-Year Citation Classics and Exploring Future Expectations.","authors":"Xiang Li, Kunkai Su, Yueyue He, Shimiao Shao, Lei Lan, Qiong Zhang, Lanjuan Li","doi":"","DOIUrl":"","url":null,"abstract":"Microbiota research has rapidly emerged as a pivotal field, with over 250,000 publications and more than ten million citations recorded in the Web of Science Core Collection database by 2024. There were 1682 original microbiota citation classics (each receiving 400 citations or more) identified over the past three decades, totaling 1,559,594 citations and averaging 927 citations per paper. Collaborative efforts in the production of these citation classics involved 87 out of 89 participating countries and 2107 out of 2142 institutions. The USA, various European countries, and China emerged as the leading contributors to this burgeoning research area. Jeffrey I. Gordon, Rob Knight, and Curtis Huttenhower were the prominent figures in microbiota research. Author keywords were analyzed, which revealed a notable shift in research focus from environmental microorganisms to human gut microbiota. Advances such as high-throughput 16S rRNA sequencing and metagenomics expanded the scope of investigations into host-microbiota interactions. Current research interests encompass exploring mechanisms underlying gut-X-axis conditions, including inflammatory bowel disease, obesity, diabetes, colorectal cancer, liver diseases, and neurological disorders. Moreover, environmental exposures have been evidenced to alter gut microbiota and metabolites, contributing a novel research direction. Future research direction is also anticipated to delve further into biosynthetic gene engineering technologies aimed at microbial interventions, including probiotics and fecal microbiota transplantation. This study outlines the evolving landscape of microbiota research and provides valuable insights to inform future investigations within the field.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"48 1","pages":"46-59"},"PeriodicalIF":1.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological determinants of BIC/FTC/TAF to achieve long term success: potency, genetic barrier and forgiveness. BIC/FTC/TAF取得长期成功的药理学决定因素：效力、遗传屏障和宽恕。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-12-01

Stefano Bonora

引用次数: 0

Molecular Epidemiology of Vancomycin-Resistant Enterococci during 2021 in a tertiary care hospital in Greece. 2021年期间希腊一家三级医院耐万古霉素肠球菌的分子流行病学研究

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-12-01

Eleni Panidou-Tsoulou, Georgios Meletis, Charalampos Kotzamanidis, Esmeralda Dushku, Virginia Giantzi, Areti Tychala, Angeliki Kassomenaki, Paraskevi Mantzana, Lemonia Skoura, Efthymia Protonotariou

{"title":"Molecular Epidemiology of Vancomycin-Resistant Enterococci during 2021 in a tertiary care hospital in Greece.","authors":"Eleni Panidou-Tsoulou, Georgios Meletis, Charalampos Kotzamanidis, Esmeralda Dushku, Virginia Giantzi, Areti Tychala, Angeliki Kassomenaki, Paraskevi Mantzana, Lemonia Skoura, Efthymia Protonotariou","doi":"","DOIUrl":"","url":null,"abstract":"The present study aimed to determine the resistance mechanisms and clonal relationships among vancomycin-resistant Enterococci (VRE) isolated in AHEPA University Hospital during the pandemic year 2021. Overall, 140 clinical VRE were isolated during the study period and 44 were randomly selected for molecular analysis. A multiplex PCR was employed to detect vancomycin resistance genes (vanA, vanB, vanC, vanD, vanE, vanG) using specific primers. Additionally, pulsed-field gel electrophoresis (PFGE) was performed to assess the clonal relatedness of the selected isolates. The multiplex PCR showed that 36 of the 44 studied strains (81.9%) harbored the vanA gene whereas, 7 of 44 (15.9%) co-harbored the vanA and vanB resistance genes; one isolate had a negative PCR result. PFGE analysis unveiled 37 distinct electrophoretic patterns among the 44 VRE isolates with a similarity threshold of 75%. These patterns were clustered into 4 distinct branches. Our findings indicate a polyclonal distribution of vanA genes among the studied isolates and the notable concomitant presence of vanA/vanB genotypes. Furthermore, these results highlight the worsening that took place during the COVID-19 pandemic period regarding antibiotic resistance rates, underscoring the imperative need for stringent infection control measures and active surveillance.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 4","pages":"350-354"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Candida glabrata complex strains isolated from clinical specimens at the species level by molecular methods and determination of their susceptibilities to antifungals. 应用分子方法在种水平上鉴定临床标本分离的光滑假丝酵母复合体菌株及其抗真菌药物的敏感性。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-12-01

Yasemin Ayse Ucar, Ozlem Guven, Gonca Erkose Genc

{"title":"Identification of Candida glabrata complex strains isolated from clinical specimens at the species level by molecular methods and determination of their susceptibilities to antifungals.","authors":"Yasemin Ayse Ucar, Ozlem Guven, Gonca Erkose Genc","doi":"","DOIUrl":"","url":null,"abstract":"Candida glabrata can exhibit resistance or reduced susceptibility to fluconazole, and there is an increasing frequency of resistance to echinocandins. Candida nivariensis and Candida bracarensis, newly described in 2005 and 2006, respectively, belong to the C. glabrata complex along with C. glabrata sensu stricto. C. nivariensis and C. bracarensis have been shown to exhibit higher resistance and virulence compared to C. glabrata sensu stricto. These three species cannot be reliably distinguished based on phenotypic characteristics or biochemical-based identification systems. In this study, 40 strains initially identified as C. glabrata using biochemical-based systems were re-identified to the species level through ITS region sequencing. Antifungal susceptibility testing was conducted using the Sensititre YeastOne susceptibility panel. All strains were identified as C. glabrata sensu stricto and showed dose-dependent susceptibility to fluconazole. Of the 40 strains, 39 (97.5%) were susceptible to caspofungin, anidulafungin, and micafungin, while one (2.5%) was resistant. Further research is needed on the epidemiology, virulence factors, and resistance profiles of C. nivariensis and C. bracarensis. Accurate species-level identification and antifungal susceptibility testing of C. glabrata complex isolates are significant.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 4","pages":"344-349"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Candida krusei pericarditis: A case report and review of the literature. 克鲁氏念珠菌心包炎1例报告及文献复习。

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-12-01

Ahmed Qaedi, Umran Elbahr, Gülcan Abalı, Burcu Çakar, Orhan Şencan, Suha Hejres, Oguz Resat Sipahi

{"title":"Candida krusei pericarditis: A case report and review of the literature.","authors":"Ahmed Qaedi, Umran Elbahr, Gülcan Abalı, Burcu Çakar, Orhan Şencan, Suha Hejres, Oguz Resat Sipahi","doi":"","DOIUrl":"","url":null,"abstract":"A 66-year-old female, a known case of endometrial serous carcinoma, presented with a history of poor oral intake. Elevated C-reactive protein was identified, and an echocardiogram showed evidence of large circumferential pericardial fluid with maximum diameter measuring 4.4 cm. Further analysis of the pericardial fluid revealed growth of Candida krusei. Treatment was initiated with caspofungin 150mg intravenously once daily for 28 days, followed by oral maintenance therapy with voriconazole for 10 days. No relapse or re-infection was observed during 10 days of follow-up. A literature search was performed, which demonstrated that Candida albicans is the most encountered Candida spp. associated with acute pericarditis. Additionally, the following risk factors were observed, including history of major surgery, COVID-19 infection, and use of broad-spectrum antibiotics. This article presents a unique case of acute pericarditis caused by C. krusei. It highlights the importance of identifying the etiology in immunocompromised cohorts and emphasizes the role of establishing formative treatment guidelines for the management of Candida spp. pericarditis.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 4","pages":"355-357"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular characterization and survival of extended-spectrum β-lactamase-producing clinical strains of Klebsiella pneumoniae isolated in Mostar, Bosnia and Herzegovina. 波黑莫斯塔尔产β-内酰胺酶肺炎克雷伯菌临床分离株的分子特征及存活

IF 1.5 4区医学

New Microbiologica Pub Date : 2024-12-01

Tanja Petrović, Marija Tonkić, Ana Maravić, Mia Dželalija, Željana Fredotović, Jasna Hrenović, Sanja Jakovac, Doris Martinović Rizikalo, Ivana Goić-Barišić

{"title":"Molecular characterization and survival of extended-spectrum β-lactamase-producing clinical strains of Klebsiella pneumoniae isolated in Mostar, Bosnia and Herzegovina.","authors":"Tanja Petrović, Marija Tonkić, Ana Maravić, Mia Dželalija, Željana Fredotović, Jasna Hrenović, Sanja Jakovac, Doris Martinović Rizikalo, Ivana Goić-Barišić","doi":"","DOIUrl":"","url":null,"abstract":"The aim of this retrospective study was to investigate the molecular characteristics and survival ability of clinical isolates of extended-spectrum β-lactamase (ESBL)-producing strains of Klebsiella pneumoniae (K. pneumoniae) in a hospital setting. ESBL-producing K. pneumoniae clinical isolates were collected from hospitalized patients at the University Clinical Hospital of Mostar, Bosnia and Herzegovina. Identification and antibiotic susceptibility tests were performed according to established laboratory methods and Clinical and Laboratory Standards Institute standards. Phenotypic identification of the isolates was confirmed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Minimum inhibitory concentrations were determined using the Vitek® 2 Compact System. Clonal relationships between the different isolates were studied using pulsed-field gel electrophoresis. Molecular characterization of ESBL-coding genes was performed using multiplex polymerase chain reaction. The survival and pellicle formation abilities of ESBL-producing K. pneumoniae isolates were also investigated. Among 471 isolated K. pneumoniae strains, 149 isolates (31.6%) were ESBL-producing. The bla genes encoding CTX-M-1-group ESBLs were identified in almost all isolates, with the majority carrying blaCTX-M-15. Two isolates contained blaCTX-M-3. All isolates carried blaTEM-1. The blaSHV genes identified were blaSHV-1, blaSHV-5, blaSHV-11, and blaSHV-28. Six isolates harbored blaOXA-1. ESBL-producing K. pneumoniae strains survived on dry cotton for up to 49 days.","PeriodicalId":54723,"journal":{"name":"New Microbiologica","volume":"47 4","pages":"337-343"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0