Nutrition Clinique et Metabolisme最新文献

{"title":"Prevalence of malnutrition, dietary trends, and oral nutritional supplements use among Algerian cancer outpatients undergoing chemotherapy","authors":"Abderrezak Kennas ,&nbsp;Saliha Makhoukh ,&nbsp;Kahina Derrar ,&nbsp;Katia Hadji","doi":"10.1016/j.nupar.2024.01.002","DOIUrl":"10.1016/j.nupar.2024.01.002","url":null,"abstract":"<div><h3>Objective</h3><p>It is widely acknowledged that patients with cancer commonly experience malnutrition, and some individuals may adopt specific dietary trends. This study investigated the prevalence of malnutrition and dietary trends among Algerian cancer outpatients undergoing chemotherapy.</p></div><div><h3>Material and methods</h3><p>This cross-sectional, descriptive study was conducted from January to October 2023 with 71 cancer outpatients undergoing chemotherapy. Malnutrition risk was evaluated using the Malnutrition Screening Tool (MST). The questionnaire also collected the occurrence of nutrition impact symptoms, the avoidance of specific food groups, and the use of oral nutritional supplements and dietary supplements.</p></div><div><h3>Results</h3><p>Malnutrition risk was identified in 57.7% (41 cases) of participants. Nutrition impact symptoms were reported by 59.2% (42 cases) of patients. A total of 36 of the patients (50.7%) altered their eating habits by avoiding at least one food group. Among malnourished cancer outpatients, only five used oral nutritional supplements. Dietary supplements were used by 23.9% (27/71) of the patients after cancer diagnosis.</p></div><div><h3>Conclusion</h3><p>Our findings underscore the necessity for a systematic malnutrition assessment in cancer patients. Qualified clinicians should provide nutritional awareness to enhance the quality of life for these patients.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"38 2","pages":"Pages 88-94"},"PeriodicalIF":0.6,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140791838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oil-extracted from flaxseeds protects against endothelial dysfunction and oxidative stress by modulating nitric oxide, thiols contents and improving redox status in ouabain-induced hypertensive rats","authors":"Sadia Berzou ,&nbsp;Fatima Zohra Labbaci ,&nbsp;Akila Guenzet ,&nbsp;Nawal Dida-Taleb ,&nbsp;Hakima Mir ,&nbsp;Djamil Krouf","doi":"10.1016/j.nupar.2024.02.003","DOIUrl":"10.1016/j.nupar.2024.02.003","url":null,"abstract":"<div><h3>Objectives</h3><p>The purpose of this study was to evaluate the antihypertensive and antioxidant effects of flaxseed oil in ouabain-induced hypertensive in normal rats Wistar.</p></div><div><h3>Methods</h3><p>Experimental hypertension was induced by a daily subcutaneous (sc) injection of 10<!--> <!-->μg/kg/day/rat of ouabain diluted in 9<!--> <!-->g/L of saline solution (NaCl) for 21 days (<em>n</em> <!-->=<!--> <!-->16). Animals were then divided into two groups fed an experimental diet containing 20% casein supplemented (Ouab-Oil-<em>Lu</em>) or not (Ouab) with 1% flaxseed oil whereas control rats (<em>n</em> <!-->=<!--> <!-->8) received only a daily sc injection of NaCl.</p></div><div><h3>Results</h3><p>The results showed that supplementing hypertensive rats with 1% flaxseed oil decreased significantly (<em>P</em> <!-->&lt;<!--> <!-->0.05) the systolic, diastolic, and mean arterial pressure, ameliorated plasma and liver lipid profile and reduced glucose levels in plasma. Similarly, flaxseed oil decreased TBARS levels in plasma and tissues, as well as carbonyl levels in the heart. Interestingly, this supplementation increased GSH, thiols and nitric oxide levels and improved AchE and antioxidant enzyme activities (SOD and GSH-Px) in the tissues.</p></div><div><h3>Conclusions</h3><p>Our findings suggested that flaxseed oil may provide a rationale for antihypertensive use in traditional medicine.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"38 2","pages":"Pages 120-128"},"PeriodicalIF":0.6,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140776403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the prescriptive appropriateness of vitamin D: The Italian experience","authors":"Francesco Ferrara ,&nbsp;Andrea Zovi ,&nbsp;Eduardo Nava ,&nbsp;Ugo Trama ,&nbsp;Roberto Langella","doi":"10.1016/j.nupar.2024.02.002","DOIUrl":"10.1016/j.nupar.2024.02.002","url":null,"abstract":"<div><p>At the Asl Napoli 3 SUD a local, regional and national level analysis of prescription and spending related to the prescription and dispensing of drugs intended to increase vitamin D levels in the human body was carried out. The Italian Pharmacy Regulatory Agency (AIFA) in late 2019 introduced a prescriptive note of appropriateness (note 96) to regulate the prescribing activity of a drug that is widely used on the Italian national population, significantly affecting spending by the National Health System (NHS). Despite this action there has been an increase in prescription and expenditure of calcifediol at all levels of analysis (national, regional and local) while regarding the remaining Anatomical Therapeutic Chemical (ATC) referring to drugs used as vitamin D supplement in the Campania Region and at the Asl Napoli 3 SUD there is a slower decrease in expenditure and prescription, sometimes even increasing and in countertendency to the Italian national average. For these reasons, the Campania Region instituted two executive decrees (DD 405/2021 and 91/2022) that led to a marked reduction in spending and prescription in 2022 even higher than in other Italian regional realities. This analysis aims to show how vitamin D prescription is widespread and often inappropriate, attested by wide regional variability. In addition, the main recommendations for the use of these drugs are highlighted in order to raise awareness among all healthcare professionals of the informed use of these molecules ensuring sustainability and governance.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"38 2","pages":"Pages 95-100"},"PeriodicalIF":0.6,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140784222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Le fardeau des aidants dans la nutrition artificielle à domicile","authors":"Jean Castinel ,&nbsp;Florian Poullenot","doi":"10.1016/j.nupar.2023.12.001","DOIUrl":"10.1016/j.nupar.2023.12.001","url":null,"abstract":"<div><p>Non-professional caregivers provide assistance to patients losing their autonomy for some or all of the actions of daily life on a regular and frequent basis. Home artificial nutrition is a healthcare situation where the role of non-professional caregivers can be crucial. Non-professional caregiver burden, a concept initially developed for geriatrics, has been described and analyzed both among non-professional caregivers of enteral nutrition patients and, more recently, among those who support parenteral nutrition patients. In this article, we offer a literature review and an ethical perspective on this difficult social subject.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"38 1","pages":"Pages 11-15"},"PeriodicalIF":0.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139393786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress marker changes and cognitive decline prevention in Pb contaminated mice by Crocus sativus L. Supplementation and interval training","authors":"Sepideh Noruzi ,&nbsp;Zohreh Meshkati ,&nbsp;Rozita Nasiri","doi":"10.1016/j.nupar.2023.12.002","DOIUrl":"10.1016/j.nupar.2023.12.002","url":null,"abstract":"<div><p>Heavy metals are contaminants hazardously affecting the animals’ and humans’ health since they are extensively utilized in the industry where proper physical activity and consuming antioxidant ingredients can be an appropriate solution for decreasing the resultant damages. This work deals with assessing the effects of <em>Crocus sativus</em> L. (saffron) petal extract (SPE) along with eight weeks of interval training on the cytotoxicity of lead (Pb) investigated in exposed adult male mice. SPE reduced the toxic effects of Pb that were indicated by the MTT assay. The morphological alterations of Pb-treated cells were found by fluorescent and normal microscopes when it was co-incubated with SPE. Accordingly, the 50% inhibitory concentration and the 50% lethal dose were calculated. The adult male mice were randomly placed into seven groups (six mice/group) of positive and negative controls, interval training group (Exr), Exr &amp; Pb, SPE, SPE &amp; Pb, and Exr &amp; SPE &amp; Pb treated groups. From the results, SPE did not affect catalase (CAT) activity, but it induced a significant increment of antioxidant enzyme SOD and the levels of malondialdehyde (MDA) is reduced remarkably in the brain. In the last part of the research, mice were exposed to the behavioral tasks examined by step-through ORT, MWM, and YM tests. Having interval training and SPE consumption could reverse the most defective behavioral indicators that may be protecting potential agents inspiringly to the Pb toxicity in the areas with higher heavy metals pollution.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"38 1","pages":"Pages 44-55"},"PeriodicalIF":0.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139888338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of coffee consumption with atherosclerotic cardiovascular disease and all-cause mortality in adults with familial hypercholesterolemia: Results from National Health and Nutrition Examination Survey (NHANES)","authors":"Jun Wen ,&nbsp;Lei-Lei Du ,&nbsp;Qi Pan ,&nbsp;Jing-Jing Song ,&nbsp;Yu-Peng Liu ,&nbsp;Xiang-Bin Meng ,&nbsp;Kuo Zhang ,&nbsp;Jun Gao ,&nbsp;Chun-Li Shao ,&nbsp;Wen-Yao Wang ,&nbsp;Hao Zhou ,&nbsp;Yi-Da Tang","doi":"10.1016/j.nupar.2023.10.002","DOIUrl":"https://doi.org/10.1016/j.nupar.2023.10.002","url":null,"abstract":"<div><h3>Objective</h3><p>Familial hypercholesterolemia (FH) is a common inherited metabolic disorder with an elevated risk of atherosclerotic cardiovascular disease (ASCVD). The effects of coffee on FH individuals remain unclear. The aim of this study is to examine the association between coffee consumption and ASCVD and mortality in adults with clinical diagnosed FH.</p></div><div><h3>Material and methods</h3><p>Cross-sectional and prospective (up to December 31st, 2019) analysis of National Health and Nutrition Examination Survey (NHANES) 1999–2018. Coffee consumption was calculated by 24-hour dietary recalls. Multivariable-adjusted logistic regression and Cox analysis were performed to evaluated the relationship between coffee consumption and ASCVD and all-cause mortality.</p></div><div><h3>Results</h3><p>A total of 1008 FH individuals with coffee information were included and were categorized into four groups: 357 (35.42%) did not consume coffee on a regular basis, 390 (38.69%) consumed 0.5–3 cups per day, 141 (13.99%) consumed 3–5 cups per day and 120 (11.90%) ≥5 cups per day. Higher coffee or caffeine consumption was associated with elevated risk of ASCVD and heart attack. Compared to non-coffee drinkers, ≥5 cups coffee drinking was associated with higher risk of all-cause mortality (multivariate HR: 1.67, 95%CI: 1.02–2.73, <em>P</em> <!-->=<!--> <!-->0.04). The risk of all-cause death increased dose-dependently along with the higher coffee or caffeine intake (<em>P</em> <!-->&lt;<!--> <!-->0.05). The results remained similar among those who excluded non-coffee drinkers.</p></div><div><h3>Conclusion</h3><p>Coffee consumption of up to five cups per day was associated with unfavorable ASCVD and all-cause mortality, suggesting that high coffee consumption should be avoided among patients with FH.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"38 1","pages":"Pages 27-35"},"PeriodicalIF":0.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0985056223002820/pdfft?md5=01df0d63c79f2d489f5b740a70e9824e&pid=1-s2.0-S0985056223002820-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139992379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue contents","authors":"","doi":"10.1016/S0985-0562(24)00057-8","DOIUrl":"https://doi.org/10.1016/S0985-0562(24)00057-8","url":null,"abstract":"","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"38 1","pages":"Page e1"},"PeriodicalIF":0.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0985056224000578/pdfft?md5=5032a4b96cf69fa0c042a7ee5910acca&pid=1-s2.0-S0985056224000578-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139992669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute changes in serum inflammatory signatures after consumption of ready-to-drink immuno-nutrition: A case report","authors":"Matteo Briguglio ,&nbsp;Enrico Ragni ,&nbsp;Francesco Langella ,&nbsp;Laura Scaramuzzo ,&nbsp;Tiziano Crespi ,&nbsp;Thomas W. Wainwright ,&nbsp;Giuseppe Banfi ,&nbsp;Pedro Berjano","doi":"10.1016/j.nupar.2024.01.001","DOIUrl":"10.1016/j.nupar.2024.01.001","url":null,"abstract":"<div><h3>Background</h3><p>Immuno-nutrition administers specific nutrients to improve host defences, in particular supporting the immune system. Given the high invasiveness of some spine operations, strengthening the immune response could effectively balance the surgical stress and boost resilience. However, it is not clear what are the early molecular signatures after the consumption of immuno-modulatory nutrients.</p></div><div><h3>Materials and methods</h3><p>In the context of nutritional prehabilitation, we present the case of a lady with scoliosis scheduled for surgery who was administered immuno-nutrition preoperatively and tested for acute changes in 200 biomolecules after two and four hours.</p></div><div><h3>Results</h3><p>After four hours, we mainly observed 30-fold increase in IL-10, 10-fold increase in IL-18 inhibitory protein, 6-fold increase in IL-1 inhibitory receptor, 12-fold decrease in IL-2 receptor, and 51-fold decrease in IL-23. Gene ontology annotations showed the involvement of genes regulating cytokine activity, response to external organisms, humoral and adaptive response, and lymphocyte immunity.</p></div><div><h3>Conclusion</h3><p>Overall, the trends over the first four hours showed a positive shift of the cytokine balance in favour of anti-inflammatory mediators while keeping active the cell-mediated immunity. The use of immuno-nutrition for prehabilitation patients could prove useful to patients but benefits from chronic consumption and surgical outcomes remain to be determined.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"38 1","pages":"Pages 56-66"},"PeriodicalIF":0.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139875017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La malnutrition aiguë sévère : de la physiopathologie à la prise en charge","authors":"Adrien Noel ,&nbsp;Fanny B. Morel ,&nbsp;Rachel Marion-Letellier","doi":"10.1016/j.nupar.2023.11.003","DOIUrl":"10.1016/j.nupar.2023.11.003","url":null,"abstract":"<div><p>Undernutrition is a major global health issue. In 2022, acute malnutrition affected 45 million children under the age of five, including at least 13.6 million in severe acute malnutrition (SAM). Acutely malnourished children have a high risk of mortality, of staturo-ponderal growth retardation and of co-morbidities such as diarrhea. They can also present cognitive and metabolic disorders in adulthood. SAM includes nutritional edema (<em>kwashiorkor</em>) and severe wasting. Management of SAM is based on the guidelines of the World Health Organization (WHO), updated in 2023. Diagnostic is performed through clinical exam and anthropometric criteria, as middle-upper arm circumference or weight-for-age z-score. Ready-to-use therapeutic food (RUTF) are used to treat children aged 6–59 months up to recovery. Nowadays, a particular focus on improving recovery and coverage is performed, notably through integrated/simplified protocols, formulation of alternative RUTFs or anticipation of risks of relapse for SAM children. Finally, the prevention of SAM, which is now included in WHO's guidelines, deserves greater attention by, for example, targeting nutrition of children of 6–59 months and<em>/</em>or nutritional quality of pregnant and lactating women.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"38 1","pages":"Pages 2-10"},"PeriodicalIF":0.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139394699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum zonulin level as a novel approach in diagnosis and follow-up of patients with celiac disease. A systematic review and meta-analysis","authors":"Reyhaneh Rabiee ,&nbsp;Reza Mahdavi ,&nbsp;Zeinab Nikniaz","doi":"10.1016/j.nupar.2023.11.002","DOIUrl":"10.1016/j.nupar.2023.11.002","url":null,"abstract":"<div><h3>Background</h3><p><span>It has been proposed that zonulin, a tight junction protein<span> regulator, is involved in the pathogenesis of celiac disease (CD). In this regard, various studies compared the mean serum zonulin </span></span>in patients with CD and healthy controls. However, this remains a subject of controversy due to contradictory results. Therefore, the goal of the present study was to summarize the findings of studies comparing CD patients’ serum zonulin levels to healthy controls.</p></div><div><h3>Methods</h3><p>We searched PubMed, Scopus, and ISI Web of Science databases up to May 2022. All observational studies measured serum zonulin in adult patients with CD and healthy controls were included without language or date restrictions. The standardized mean differences (SMDs) and standard deviations were pooled using a random-effects model.</p></div><div><h3>Results</h3><p><span>Of 708 studies, six studies with 184 CD and 206 control participants were included in the systematic review and meta-analysis. According to a pooled analysis, CD patients had significantly higher zonulin levels than healthy controls (SMD</span> <!-->=<!--> <!-->1.08<!--> <!-->ng/mL; 95% CI<!--> <!-->=<!--> <!-->0.64, 1.52; <em>P</em> <!-->&lt;<!--> <span>0.001). Subgroup analyses were performed according to adherence to a gluten-free diet (GFD), zonulin assessment method, and CD diagnosis. The significant effect was maintained in all subgroups.</span></p></div><div><h3>Conclusion</h3><p>CD is significantly correlated with a higher level of serum zonulin. Thus, zonulin could be a potential biomarker for the diagnosis of CD, which deserves further investigation.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"38 1","pages":"Pages 36-43"},"PeriodicalIF":0.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}