{"title":"使用特定工具评估坚持无麸质饮食及其他决定因素对患有乳糜泻的儿童、青少年和成人生活质量的影响：系统回顾与荟萃分析","authors":"Morad Guennouni , Nadia Hidar , Aicha Yacouti , Mustapha Mouallif , Raja Hazime , Noureddine Elkhoudri , Mohamed Cherkaoui , Saad El Madani , Aicha Bourrahouat , Abderraouaf Hilali , Brahim Admou","doi":"10.1016/j.nupar.2024.04.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>Celiac disease (CD) is an autoimmune disease that affects many aspects of patients including their quality of life (QoL). The aim of this meta-analysis was to highlight the impact of gluten-free diet (GFD) adherence on QoL using specific instruments.</p></div><div><h3>Materials and methods</h3><p>The included studies should meet to PRISMA guidelines. Thirty-nine studies using developed or adapted specific instruments were included in review, and 25 of them were included in meta-analysis.</p></div><div><h3>Results</h3><p>In overall, the results showed a neutral QoL both in children and adolescents (47.81, 95% CI [40.50; 55.12]), and in adults (45.12, 95% CI [38.24; 52.00]). The QoL was low in subscales related to GFD such as “Diet” in CD-Dux, “Inadequate treatment” in CD-QoL and in “Dietary burden” in CD-AQ instruments. In children, the QoL was higher in patients adhering to GFD, with mean difference (MD) estimated at 8.24 (95% CI [5.11; 11.37]; <em>P</em> <!--><<!--> <!-->0.00001). All studies used CD-Dux as specific instrument and the results showed that the QoL was significantly lower in proxies than their children and adolescents (MD −5.60, 95% CI [−8.06; −3.15]; <em>P</em> <!--><<!--> <!-->0.00001). In adults, no significant difference was observed regarding the impact of GFD adherence on QoL (MD 3.68, 95% CI [−0.53; 7.88]; <em>P</em> <!-->=<!--> <!-->0.09).</p></div><div><h3>Conclusion</h3><p>Using specific instruments, this meta-analysis highlighted a reduced QoL in subscales related to GFD, and has been improved after GFD adherence.</p></div>","PeriodicalId":54702,"journal":{"name":"Nutrition Clinique et Metabolisme","volume":"38 3","pages":"Pages 144-157"},"PeriodicalIF":0.5000,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Assessment of the impact of adherence to gluten-free diet and other determinants on quality of life in children, adolescents and adults with celiac disease using specific instruments: A systematic review with meta-analysis\",\"authors\":\"Morad Guennouni , Nadia Hidar , Aicha Yacouti , Mustapha Mouallif , Raja Hazime , Noureddine Elkhoudri , Mohamed Cherkaoui , Saad El Madani , Aicha Bourrahouat , Abderraouaf Hilali , Brahim Admou\",\"doi\":\"10.1016/j.nupar.2024.04.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><p>Celiac disease (CD) is an autoimmune disease that affects many aspects of patients including their quality of life (QoL). The aim of this meta-analysis was to highlight the impact of gluten-free diet (GFD) adherence on QoL using specific instruments.</p></div><div><h3>Materials and methods</h3><p>The included studies should meet to PRISMA guidelines. Thirty-nine studies using developed or adapted specific instruments were included in review, and 25 of them were included in meta-analysis.</p></div><div><h3>Results</h3><p>In overall, the results showed a neutral QoL both in children and adolescents (47.81, 95% CI [40.50; 55.12]), and in adults (45.12, 95% CI [38.24; 52.00]). The QoL was low in subscales related to GFD such as “Diet” in CD-Dux, “Inadequate treatment” in CD-QoL and in “Dietary burden” in CD-AQ instruments. In children, the QoL was higher in patients adhering to GFD, with mean difference (MD) estimated at 8.24 (95% CI [5.11; 11.37]; <em>P</em> <!--><<!--> <!-->0.00001). All studies used CD-Dux as specific instrument and the results showed that the QoL was significantly lower in proxies than their children and adolescents (MD −5.60, 95% CI [−8.06; −3.15]; <em>P</em> <!--><<!--> <!-->0.00001). In adults, no significant difference was observed regarding the impact of GFD adherence on QoL (MD 3.68, 95% CI [−0.53; 7.88]; <em>P</em> <!-->=<!--> <!-->0.09).</p></div><div><h3>Conclusion</h3><p>Using specific instruments, this meta-analysis highlighted a reduced QoL in subscales related to GFD, and has been improved after GFD adherence.</p></div>\",\"PeriodicalId\":54702,\"journal\":{\"name\":\"Nutrition Clinique et Metabolisme\",\"volume\":\"38 3\",\"pages\":\"Pages 144-157\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2024-08-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition Clinique et Metabolisme\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S098505622400092X\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition Clinique et Metabolisme","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S098505622400092X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
摘要
目的：乳糜泻（CD）是一种自身免疫性疾病，会影响患者的许多方面，包括生活质量（QoL）。本荟萃分析旨在利用特定工具强调坚持无麸质饮食（GFD）对 QoL 的影响。结果总体而言，结果显示儿童和青少年（47.81，95% CI [40.50；55.12]）以及成人（45.12，95% CI [38.24；52.00]）的 QoL 均为中性。在与胃食管反流有关的子量表中，如 CD-Dux 中的 "饮食"、CD-QoL 中的 "治疗不足 "和 CD-AQ 工具中的 "饮食负担"，QoL 都较低。在儿童中，接受胃食管反流治疗的患者的 QoL 更高，平均差异 (MD) 估计为 8.24 (95% CI [5.11; 11.37]; P < 0.00001)。所有研究都使用 CD-Dux 作为特定工具，结果显示，代理人的 QoL 明显低于儿童和青少年（MD -5.60，95% CI [-8.06; -3.15]；P < 0.00001）。在成人中，没有观察到坚持 GFD 对 QoL 影响的明显差异（MD 3.68，95% CI [-0.53; 7.88]；P = 0.09）。
Assessment of the impact of adherence to gluten-free diet and other determinants on quality of life in children, adolescents and adults with celiac disease using specific instruments: A systematic review with meta-analysis
Objectives
Celiac disease (CD) is an autoimmune disease that affects many aspects of patients including their quality of life (QoL). The aim of this meta-analysis was to highlight the impact of gluten-free diet (GFD) adherence on QoL using specific instruments.
Materials and methods
The included studies should meet to PRISMA guidelines. Thirty-nine studies using developed or adapted specific instruments were included in review, and 25 of them were included in meta-analysis.
Results
In overall, the results showed a neutral QoL both in children and adolescents (47.81, 95% CI [40.50; 55.12]), and in adults (45.12, 95% CI [38.24; 52.00]). The QoL was low in subscales related to GFD such as “Diet” in CD-Dux, “Inadequate treatment” in CD-QoL and in “Dietary burden” in CD-AQ instruments. In children, the QoL was higher in patients adhering to GFD, with mean difference (MD) estimated at 8.24 (95% CI [5.11; 11.37]; P < 0.00001). All studies used CD-Dux as specific instrument and the results showed that the QoL was significantly lower in proxies than their children and adolescents (MD −5.60, 95% CI [−8.06; −3.15]; P < 0.00001). In adults, no significant difference was observed regarding the impact of GFD adherence on QoL (MD 3.68, 95% CI [−0.53; 7.88]; P = 0.09).
Conclusion
Using specific instruments, this meta-analysis highlighted a reduced QoL in subscales related to GFD, and has been improved after GFD adherence.
期刊介绍：
Nutrition Clinique et Métabolisme is the journal of the French-speaking Society of Enteral and Parenteral Nutrition. Associating clinicians, biologists, pharmacists, and fundamentalists, the articles presented in the journal concern man and animals, and deal with organs and cells. The goal is a better understanding of the effects of artificial nutrition and human metabolism. Original articles, general reviews, update articles, technical notes and communications are published, as well as editorials and case reports.
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