Pediatric and Developmental Pathology最新文献_第2页

CD163 Expression in Chronic Intervillositis of Unknown Etiology and SARS-CoV-2 Placentitis. 病因不明的慢性间质性肺炎和 SARS-CoV-2 胎盘炎中的 CD163 表达

IF 1.3 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-11-08 DOI: 10.1177/10935266241291107

Jefferson Terry

{"title":"CD163 Expression in Chronic Intervillositis of Unknown Etiology and SARS-CoV-2 Placentitis.","authors":"Jefferson Terry","doi":"10.1177/10935266241291107","DOIUrl":"https://doi.org/10.1177/10935266241291107","url":null,"abstract":"Chronic intervillositis of unknown etiology (CIUE) is an aberrant maternal inflammatory infiltrate comprised primarily of macrophages that collect in the intervillus space and is associated with poor outcomes including recurrent pregnancy loss. An abnormal maternal Th1-type response to pregnancy may be the basis for pathogenesis of CIUE but macrophage in the maternal infiltrate of CIUE have been reported to have an anti-inflammatory M2 phenotype characterized by increased expression of CD163. This study assesses expression of CD163 in CIUE and SARS-CoV-2 placentitis, which has a similar histopathological presentation, using an automated approach to minimize observer-related variability. The data show that the maternal inflammatory infiltrate of CIUE contains a blended population of high and low CD163 expressing macrophage with a prominent bias towards an anti-inflammatory M2 phenotype when compared to normal control tissue. A similar pattern is seen in SARS-CoV-2 placentitis, suggesting pathophysiologic similarity with CIUE, although SARS-CoV-2 also appears to promote decreased CD163 expression in Hofbauer cells, which is not seen in CIUE.","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"10935266241291107"},"PeriodicalIF":1.3,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cord Hemangioma Versus Angiomyxoma: How Many Angels Can Dance on the Head of a Pin? 脐带血管瘤与血管肌瘤：针尖上能舞出多少天使？

IF 1.3 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-11-07 DOI: 10.1177/10935266241297330

James R Wright

引用次数: 0

Interferon γ Expressing Mucosal Cells in Pediatric Chronic Inflammatory Bowel Disease. 小儿慢性炎症性肠病中表达干扰素 γ 的黏膜细胞

IF 1.3 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-11-01 Epub Date: 2024-07-31 DOI: 10.1177/10935266241265767

Jefferson Terry

{"title":"Interferon γ Expressing Mucosal Cells in Pediatric Chronic Inflammatory Bowel Disease.","authors":"Jefferson Terry","doi":"10.1177/10935266241265767","DOIUrl":"10.1177/10935266241265767","url":null,"abstract":"The pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC) is multifactorial and includes aberrations in the composition of gastrointestinal mucosal inflammatory cells. Accurate identification of CD and UC is important as treatment and prognosis differs; however, CD and UC may be difficult to differentiate. Interferon γ (IFNγ) expression appears to be increased in ileal mucosa from CD patients, implying that IFNγ could be a diagnostically useful marker to differentiate CD from UC. This study uses automated assessment of IFNγ immunohistochemical expression in archival GI mucosal biopsies from stomach, duodenum, terminal ileum, and colon in a pediatric population to address this possibility. IFNγ positive mucosal cells are increased in the colon in both CD and UC compared to normal colon and in the ileum of CD compared to normal and UC. The abundance of IFNγ positive cells is not correlated with the presence of active inflammation, indicating that active inflammation is not responsible for the variance in abundance of IFNγ positive cells between cohorts and sites. Overlap between CD, UC, and normal suggests that IFNγ immunohistochemistry may only be clinically useful in select situations such as undetermined inflammatory bowel disease and additional study in these areas is warranted.","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"576-581"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding BCOR-ITD Sarcomas: Case Report of a Rare Pediatric Tumor With Challenges in Diagnosis. 解码 BCOR-ITD 肉瘤：一种罕见儿科肿瘤的病例报告与诊断挑战。

IF 1.3 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-11-01 Epub Date: 2024-05-19 DOI: 10.1177/10935266241249344

Emilio Medina-Ceballos, María Niveiro, Laura Ureña-Horno, Marta Sesé, María Tasso, Samuel Navarro, Marta Garrido-Pontnou

{"title":"Decoding BCOR-ITD Sarcomas: Case Report of a Rare Pediatric Tumor With Challenges in Diagnosis.","authors":"Emilio Medina-Ceballos, María Niveiro, Laura Ureña-Horno, Marta Sesé, María Tasso, Samuel Navarro, Marta Garrido-Pontnou","doi":"10.1177/10935266241249344","DOIUrl":"10.1177/10935266241249344","url":null,"abstract":"Sarcomas characterized by BCOR gene alterations, are a distinct clinico-pathological group of high-grade tumors, that represent 5% of small round cell tumors without EWSR or FUS fusion. Diverse genetic alterations characterize this group, including BCOR-CCNB3 gene fusion being the most common alteration and less frequently internal tandem duplications (ITDs). We present a compelling case of a 3-year-old girl diagnosed with a high-grade nasoethmoidal sarcoma exhibiting BCOR-ITD. The diagnostic process illustrates the histological and immunophenotypic spectrum, requiring an extensive immunohistochemical panel and diverse molecular tests for accurate classification. Additionally, this case highlights the challenges in detecting BCOR-ITDs using different NGS panels, advocating for alternative molecular approaches. Our patient after 10 months since diagnosis is alive with progressive disease. This emphasizes the urgency for ongoing research to refine diagnostic methods and develop effective therapeutic strategies for these rare and aggressive tumors.","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"582-586"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Early T-Precursor Lymphoblastic Lymphoma (ETP-LBL) in a Child With Nijmegen Breakage Syndrome. 奈梅亨断裂综合征患儿罕见的早期 T 前体淋巴母细胞淋巴瘤（ETP-LBL）病例。

IF 1.3 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-11-01 Epub Date: 2024-05-25 DOI: 10.1177/10935266241255277

Kristina R Brannock, Samir B Kahwash

引用次数: 0

Maude Abbott: "A Feminine Misfit in an Exclusive Male Environment" and Her Strategies for Success. 莫德-阿博特："男性专属环境中的女性不适应者 "及其成功策略。

IF 16.4 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-11-01 Epub Date: 2024-10-01 DOI: 10.1177/10935266241281786

James R Wright

{"title":"Maude Abbott: \"A Feminine Misfit in an Exclusive Male Environment\" and Her Strategies for Success.","authors":"James R Wright","doi":"10.1177/10935266241281786","DOIUrl":"10.1177/10935266241281786","url":null,"abstract":"Maude Abbott was a pioneering female Canadian physician who became a world authority on medical museums and congenital heart disease. Abbott spent almost all her career in highly sexist, discriminatory work environments. This paper reviews Abbott's life and accomplishments, but, more importantly, analyzes her pathway to success in the masculine world of early 20th-century academic pathology. Abbott, though well-trained as a pathologist, never provided clinical service, but instead worked as museum curator at McGill University. She established the International Association of Medical Museums (predecessor to the International Academy of Pathology), edited its journal, and essentially ran the organization. Abbott, surrounded by influential males, dealt differently with each. In general, she recognized that male doctors believed women lacked the gravitas to lead major initiatives but that she could circumnavigate this supposed impediment by co-leading projects with male counterparts, preferably ones too busy to get in her way. She repeatedly used this approach, and by doing most of the work but sharing credit, succeeded in gaining reputation, accomplishment, and advancement. Abbott's pioneering work on congenital heart disease established her as one of the founders of pediatric pathology, and, overall, her career promoted the entry of women physicians into the pathology profession.","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"513-529"},"PeriodicalIF":16.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Variable Definition of "Negative Appendicitis" Remains a Surgical Challenge. 阴性阑尾炎 "的多变定义仍是外科手术的挑战。

IF 1.3 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-11-01 Epub Date: 2024-06-06 DOI: 10.1177/10935266241255281

Hetal Patel, Mohamed Kamel, Eden Cooper, Claire Bowen, Ingo Jester

{"title":"The Variable Definition of \"Negative Appendicitis\" Remains a Surgical Challenge.","authors":"Hetal Patel, Mohamed Kamel, Eden Cooper, Claire Bowen, Ingo Jester","doi":"10.1177/10935266241255281","DOIUrl":"10.1177/10935266241255281","url":null,"abstract":"Aim: Acute appendicitis (AA) is treated primarily surgically with histopathology being the gold standard for confirmation of appendicitis and reported rates of negative appendicectomies (NA) ranging between 3.2% and 19% worldwide and 15.9-20.6% in the UK. NA rates are frequently used to identify poor performing centers as part of a Model Health System and form an integral part of appendicitis scoring systems. This study aims to evaluate the prevalence of negative appendicectomies within our institution and critically analyze the appropriateness of its use as a quality metric and its impact on clinical practice and research.Patients and methods: Data analysis from a prospective dataset of pediatric appendicitis patients between 2015 and 2021 in a tertiary center in the UK was performed. Detailed analysis of negative appendicectomies was performed and further stratified by two distinct age and gender groups looking at the incidence of NA and the classification of non-histologically normal appendix specimens.Results: In our series, 819 patients met inclusion criteria, 736 (89.9%) had acute appendicitis. Our overall institutional negative appendicectomy rate was 10.1% (83 patients) with the breakdown as follows: 65 histologically normal appendix (7.9%), 10 Enterobius vermicularis, 3 eosinophilic appendicitis, 2 neoplasms, 1 isolated faecolith, 1 fibrous obliteration of the lumen, and 1 peri-appendiceal inflammation.Conclusion: Our negative appendicectomy rate is below established UK pediatric NA rates. This rate ranges from 7.9% to 10.1% depending on the definition of NA utilized. A single standard pathological definition for histological acute appendicitis is required when being used as a comparative quality metric. Centers engaged in clinical research should be aware of variations in NA definitions both in scoring systems and individual centers to avoid skewing derived results.","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"552-558"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TTF-1 Immunoreactivity in the Germinal Matrix: A Brief Case Study. 胚芽基质中的 TTF-1 免疫活性：简要案例研究。

IF 1.3 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-11-01 Epub Date: 2024-07-26 DOI: 10.1177/10935266241264603

Sumit Das

引用次数: 0

Triaging and Evaluation of Products of Conception in Abortions and Post-Partum Hemorrhage. 人工流产和产后出血受孕产物的分流和评估。

IF 1.3 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-11-01 Epub Date: 2024-05-25 DOI: 10.1177/10935266241255981

Philip J Katzman, Jonathan L Hecht

引用次数: 0

The First Fetal Case of Shwachman-Diamond Syndrome Mimicking Vascular Growth Restriction. 首例模仿血管生长受限的舒瓦赫曼-钻石综合征胎儿病例

IF 1.3 4区医学

Pediatric and Developmental Pathology Pub Date : 2024-11-01 Epub Date: 2024-08-31 DOI: 10.1177/10935266241272735

Nicoleta-Andreea Bobric, Julie Grevoul-Fesquet, Luc Rigonnot, Detlef Trost, Aïcha Boughalem, Jelena Martinovic

{"title":"The First Fetal Case of Shwachman-Diamond Syndrome Mimicking Vascular Growth Restriction.","authors":"Nicoleta-Andreea Bobric, Julie Grevoul-Fesquet, Luc Rigonnot, Detlef Trost, Aïcha Boughalem, Jelena Martinovic","doi":"10.1177/10935266241272735","DOIUrl":"10.1177/10935266241272735","url":null,"abstract":"Shwachman-Diamond Syndrome (SDS) is a rare autosomal recessive genetic condition with 90% of cases associated with biallelic pathogenic variants in the Shwachman-Bodian-Diamond Syndrome (SBDS) gene on chromosome 7q.11.21. SDS belongs to ribosomopathies since SBDS gene encodes a protein involved in ribosomal maturation. Its phenotypic postnatal hallmark features include growth delay, bone marrow failure, exocrine pancreatic insufficiency, and skeletal abnormalities. We report a first fetal case of Shwachman-Diamond syndrome and extend its phenotype before birth. The clinical features mimicked vascular growth restriction with FGR and shortened long bones, associated with abnormal Doppler indices. Non-restricted fetal autopsy after termination of pregnancy allowed deep phenotyping disclosing the features of fetal skeletal dysplasia. Post-fetopathological trio exome sequencing identified biallelic pathogenic variants in the SBDS gene. Genotype-phenotype correlations confirmed the diagnosis and enabled an adequate genetic counseling of the parents. Our case is another example of the positive impact of fetal autopsy coupled with post-fetopathological genomic studies, even in the cases that were hitherto classified as maternal or fetal vascular malperfusion.","PeriodicalId":54634,"journal":{"name":"Pediatric and Developmental Pathology","volume":" ","pages":"603-607"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0