Differences in Placental Pathologic Features by Trimester of Infection with SARS-CoV-2.

IF 1.3 4区医学 Q3 PATHOLOGY

Pediatric and Developmental Pathology Pub Date : 2025-05-16 DOI:10.1177/10935266251332697

Payu Raval, Paige M K Larkin, Kathy A Mangold, Sunitha Suresh, Alexa Freedman, Erica Price, Junguen Lee, Ena Basic, Linda M Sabatini, Linda M Ernst

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引用次数: 0

Abstract

Introduction: We describe placental findings associated with SARS-CoV-2 infection in pregnancy and any differences between trimester of infection.

Methods: We included 314 pregnant patients who tested positive for SARS-CoV-2 during pregnancy and had their placenta submitted for pathology examination. Trimester of infection was based on the gestational age at the time of infection. Placental pathology was categorized into acute inflammation (AI), chronic inflammation (CI), maternal vascular malperfusion (MVM), fetal vascular malperfusion (FVM), and divided into none, low-grade, and high-grade. RT-PCR for SARS-CoV-2 was performed on placenta tissue in 238/314 (75%) cases.

Results: The prevalence of AI, CI, FVM, and MVM did not differ by trimester of infection. However, high-grade inflammatory and/or vascular pathology were more prevalent with earlier infection in pregnancy (1st trimester (27/40, 67.5%), 2nd trimester (37/67, 55.2%), and 3rd trimester (82/207, 39.6%, P < .01). Third trimester infection ≤10 days before delivery was associated with a higher prevalence of FVM compared to infection more remote from delivery (46/134, 34.3% vs 14/73, 19.2%; P < .02). We detected SARS-CoV-2 RNA in placenta, in 8/238 (3.4%) of cases.

Conclusion: High-grade inflammatory and/or vascular placental pathology are more prevalent with earlier SARS-CoV-2 infection in pregnancy.

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SARS-CoV-2感染不同妊娠期胎盘病理特征的差异

简介：我们描述了妊娠期与SARS-CoV-2感染相关的胎盘发现，以及感染三个月之间的任何差异。方法：纳入314例妊娠期SARS-CoV-2阳性孕妇，并将其胎盘提交病理检查。感染的三个月以感染时的胎龄为依据。胎盘病理分为急性炎症（AI）、慢性炎症（CI）、母体血管灌注不良（MVM）、胎儿血管灌注不良（FVM），并分为无、低级别、高级别。对238/314例（75%）患者的胎盘组织进行了SARS-CoV-2的RT-PCR检测。结果：AI、CI、FVM和MVM的患病率没有因感染的三个月而不同。妊娠早期感染的胎盘高度炎症和/或血管病变发生率较高(妊娠早期（27/40,67.5%），妊娠中期（37/67,55.2%），妊娠晚期（82/207,39.6%），P P结论：妊娠早期感染的胎盘高度炎症和/或血管病变发生率较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric and Developmental Pathology 医学-病理学

CiteScore

3.70

自引率

5.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal covers the spectrum of disorders of early development (including embryology, placentology, and teratology), gestational and perinatal diseases, and all diseases of childhood. Studies may be in any field of experimental, anatomic, or clinical pathology, including molecular pathology. Case reports are published only if they provide new insights into disease mechanisms or new information.