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From Genes to Gut: Understanding Diagnosis and Treatment in Very Early Onset Inflammatory Bowel Disease. 从基因到肠道：了解极早发性炎症性肠病的诊断和治疗。
IF 1 4区 医学
Pediatric Annals Pub Date : 2025-08-01 DOI: 10.3928/19382359-20250612-04
Casey Konys, Yusuf Usman, Joseph Runde
{"title":"From Genes to Gut: Understanding Diagnosis and Treatment in Very Early Onset Inflammatory Bowel Disease.","authors":"Casey Konys, Yusuf Usman, Joseph Runde","doi":"10.3928/19382359-20250612-04","DOIUrl":"https://doi.org/10.3928/19382359-20250612-04","url":null,"abstract":"<p><p>Very early onset inflammatory bowel disease (VEO-IBD), defined by a diagnosis of IBD before age 6 years, poses unique clinical and therapeutic challenges. This review examines differences in clinical manifestations and management for this population, noting important considerations between polygenic and monogenic forms of VEO-IBD. In general, a younger age of onset of IBD is associated with more extensive disease burden and more guarded outcomes compared with adults. For this reason, a comprehensive and multidisciplinary approach involving pediatricians, gastroenterologists, dietitians, and immunologists, among other subspecialties, is vital. Early identification of monogenic disease may allow for targeted therapy selection and improved prognosis, so a high index of suspicion from caretakers is needed. Moving forward, more real-world descriptions, prospective trials, and emerging studies on gene therapy and new mechanisms of action offer promise with a goal for a precision-based approach in this unique population.</p>","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 8","pages":"e280-e285"},"PeriodicalIF":1.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Should Pediatricians Learn About Therapy Chatbots and Recommend to Their Patients? 儿科医生是否应该了解治疗聊天机器人并向患者推荐？
IF 1 4区 医学
Pediatric Annals Pub Date : 2025-08-01 DOI: 10.3928/19382359-20250702-03
Joseph R Hageman, Lolita Alcocer Alkureishi, John Sullivan
{"title":"Should Pediatricians Learn About Therapy Chatbots and Recommend to Their Patients?","authors":"Joseph R Hageman, Lolita Alcocer Alkureishi, John Sullivan","doi":"10.3928/19382359-20250702-03","DOIUrl":"https://doi.org/10.3928/19382359-20250702-03","url":null,"abstract":"","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 8","pages":"e254-e255"},"PeriodicalIF":1.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response: Koplik, Comby, and Stimson: Three Observed Physical Signs in Measles. 回应：Koplik， Comby和Stimson：麻疹中观察到的三种体征。
IF 1 4区 医学
Pediatric Annals Pub Date : 2025-08-01 DOI: 10.3928/19382359-20250702-02
Sara Popofsky, José R Romero
{"title":"Response: Koplik, Comby, and Stimson: Three Observed Physical Signs in Measles.","authors":"Sara Popofsky, José R Romero","doi":"10.3928/19382359-20250702-02","DOIUrl":"https://doi.org/10.3928/19382359-20250702-02","url":null,"abstract":"","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 8","pages":"e256"},"PeriodicalIF":1.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and Opportunities for Restoring Health in Pediatric Digestive Disease. 儿童消化系统疾病恢复健康的挑战与机遇。
IF 1 4区 医学
Pediatric Annals Pub Date : 2025-08-01 DOI: 10.3928/19382359-20250612-01
Mora Mocanu, Joseph Runde
{"title":"Challenges and Opportunities for Restoring Health in Pediatric Digestive Disease.","authors":"Mora Mocanu, Joseph Runde","doi":"10.3928/19382359-20250612-01","DOIUrl":"https://doi.org/10.3928/19382359-20250612-01","url":null,"abstract":"","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 8","pages":"e261-e262"},"PeriodicalIF":1.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding Celiac Disease for the General Pediatrician. 为普通儿科医生了解乳糜泻。
IF 1 4区 医学
Pediatric Annals Pub Date : 2025-08-01 DOI: 10.3928/19382359-20250612-02
Andrea Berkemeyer
{"title":"Understanding Celiac Disease for the General Pediatrician.","authors":"Andrea Berkemeyer","doi":"10.3928/19382359-20250612-02","DOIUrl":"10.3928/19382359-20250612-02","url":null,"abstract":"<p><p>Celiac disease is an autoimmune disease caused by a permanent sensitivity to gluten. It manifests as small intestinal enteropathy, which is ongoing intestinal damage, irritation, and swelling. Celiac disease can occur at any age and can present with both gastrointestinal and extraintestinal symptoms, making it challenging to diagnose. Lifelong, strict adherence to a gluten-free diet is currently the only treatment option. After diagnosis, multidisciplinary care, including regular visits with a gastroenterology physician or a dietitian, are useful to help families manage dietary modifications, lifestyle changes, and the psychological burden that adherence to a lifelong treatment regimen can incur. Children often first present with symptoms to their pediatrician, and it is reasonable for pediatricians to initiate celiac serology screening in the appropriate clinical scenario and consider referral to gastroenterology for ongoing care. Knowledge in the primary care setting regarding the presentation of celiac disease, identifying patient populations who are at risk, and ordering the appropriate tests are paramount to prevent diagnostic delay.</p>","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 8","pages":"e263-e268"},"PeriodicalIF":1.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reaching for Remission: Integrating Complementary and Alternative Strategies into Inflammatory Bowel Disease Management. 达到缓解：将补充和替代策略整合到炎症性肠病管理中。
IF 1 4区 医学
Pediatric Annals Pub Date : 2025-08-01 DOI: 10.3928/19382359-20250612-07
Kelsey Ryan, Asha Cunningham, Joseph Runde
{"title":"Reaching for Remission: Integrating Complementary and Alternative Strategies into Inflammatory Bowel Disease Management.","authors":"Kelsey Ryan, Asha Cunningham, Joseph Runde","doi":"10.3928/19382359-20250612-07","DOIUrl":"https://doi.org/10.3928/19382359-20250612-07","url":null,"abstract":"<p><p>Pediatric inflammatory bowel disease (IBD) is increasing in prevalence in the United States. While medical therapy options continue to expand, patients and their families often inquire about applications of complementary and alternative medicine (CAM). In this article, we review the existing literature for a wide variety of CAMs, including mind-body practices, modulation of the gut microbiome, and herbal supplements, which can be integrated into traditional medical treatments. Mind-body practices, particularly cognitive behavioral therapy, yoga, and acupuncture, have promising data for improved quality of life and potential for disease modification. Methods for gut microbiome modulation, such as probiotics and fecal microbiota transplant, have potential for modifying disease in IBD but need more studies evaluating safety and efficacy. Plant-based traditional remedies with anti-inflammatory properties, including curcumin and Indigo naturalis (Qing dai), have shown promising results in clinical trials demonstrating improvements in ulcerative colitis disease activity, although more pediatric trials are needed.</p>","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 8","pages":"e274-e279"},"PeriodicalIF":1.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Impact of Inpatient Practice and Gender on Physician Well-Being. 探索住院实践和性别对医生幸福感的影响。
IF 1.1 4区 医学
Pediatric Annals Pub Date : 2025-07-01 DOI: 10.3928/19382359-20250418-01
Kelci B Butler, Lauren J Amendola, Sonali Mehta Patel, Ashley N Czworniak, Rani Ganesan
{"title":"Exploring the Impact of Inpatient Practice and Gender on Physician Well-Being.","authors":"Kelci B Butler, Lauren J Amendola, Sonali Mehta Patel, Ashley N Czworniak, Rani Ganesan","doi":"10.3928/19382359-20250418-01","DOIUrl":"https://doi.org/10.3928/19382359-20250418-01","url":null,"abstract":"<p><p>This article aims to describe the evolution of physician well-being. Ensuring professional fulfillment and mitigating the risk for burnout are priorities for all physicians. However, the threats and obstacles to preserving well-being are not universal. In both the inpatient and ambulatory settings, there are growing administrative burdens, increased clinical workload, and insufficient time per patient encounter. Among inpatient pediatric subspecialties, particularly high rates of burnout are reported within the field of pediatric critical care. The obstacles to career satisfaction and well-being in both areas are complex and myriad. The demands unique to women in medicine are different than those for men in medicine. Caregiving and gender-based inequities force women out of health care at rates higher than men. A career in medicine risks a woman's fertility and health. Despite increased prevalence of women-dominated subspecialties (eg, pediatrics), their presence in leadership roles continues to be relatively low. We have chosen to focus this article on issues facing inpatient physicians and the unique difficulties of being a woman provider in health care. <b>[<i>Pediatr Ann</i>. 2025;54(7):e244-e248.]</b>.</p>","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 7","pages":"e244-e248"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment and Stabilization of Status Epilepticus in the Primary Care Office. 初级保健办公室对癫痫持续状态的评估和稳定。
IF 1.1 4区 医学
Pediatric Annals Pub Date : 2025-07-01 DOI: 10.3928/19382359-20250421-01
Rebecca Wingerter, Erica Iafelice
{"title":"Assessment and Stabilization of Status Epilepticus in the Primary Care Office.","authors":"Rebecca Wingerter, Erica Iafelice","doi":"10.3928/19382359-20250421-01","DOIUrl":"10.3928/19382359-20250421-01","url":null,"abstract":"<p><p>Status epilepticus (SE) is a prolonged seizure episode. Prompt recognition and management of SE is essential in preventing morbidity and mortality associated with the condition. The longer SE persists the less responsive it becomes to first-line interventions. Additionally, a seizure episode that is longer than 30 minutes has increased risk of neuronal death and sequelae of SE. If the primary care clinician is confronted with a patient in SE, the evaluation and subsequent management should occur in a systematic, stepwise approach focusing on the patient's airway, breathing, circulation, and disability. Primary care clinicians and staff should be trained in supporting the pediatric airway, including the proper bag-valve-mask ventilation technique. Benzodiazepines are the first-line rescue medications for SE and should be promptly administered at the appropriate dose. <b>[<i>Pediatr Ann</i>. 2025;54(7):e233-e237.]</b>.</p>","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 7","pages":"e233-e237"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding Diabetic Ketoacidosis: What a Pediatrician Needs to Know. 解读糖尿病酮症酸中毒：儿科医生需要知道的事情。
IF 1.1 4区 医学
Pediatric Annals Pub Date : 2025-07-01 DOI: 10.3928/19382359-20250418-03
Nicole Cyrus, Ian Cacho-Santana, Heather Fagan, Sindy Villacres
{"title":"Decoding Diabetic Ketoacidosis: What a Pediatrician Needs to Know.","authors":"Nicole Cyrus, Ian Cacho-Santana, Heather Fagan, Sindy Villacres","doi":"10.3928/19382359-20250418-03","DOIUrl":"10.3928/19382359-20250418-03","url":null,"abstract":"<p><p>Diabetic ketoacidosis (DKA) is often considered a critical care topic, but since many patients will initially present with new onset type 1 diabetes mellitus in DKA, it is essential that general pediatric providers are aware of the risk factors and variable symptoms. Many providers feel comfortable recognizing typical symptoms of diabetes mellitus but may not be aware of the different presentations of DKA, particularly in patients in whom the typical symptoms are difficult to discern from their history. In this article, we describe a patient with tachypnea as their initial symptom of DKA and type 1 diabetes mellitus. We discuss the background of DKA, presentation and differential diagnosis, and important management steps of which the general pediatrician should be aware. Our aim is to increase the general pediatrician's awareness of DKA and improve the time to diagnosis and critical treatment. <b>[<i>Pediatr Ann</i>. 2025;54(7):e227-e232.]</b>.</p>","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 7","pages":"e227-e232"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Ethical Complexities of Anorexia Nervosa Treatment. 神经性厌食症治疗的伦理复杂性。
IF 1.1 4区 医学
Pediatric Annals Pub Date : 2025-07-01 DOI: 10.3928/19382359-20250604-01
Kelly Horn, Kathryn Moton-Ospino, Gregg J Montalto
{"title":"The Ethical Complexities of Anorexia Nervosa Treatment.","authors":"Kelly Horn, Kathryn Moton-Ospino, Gregg J Montalto","doi":"10.3928/19382359-20250604-01","DOIUrl":"https://doi.org/10.3928/19382359-20250604-01","url":null,"abstract":"","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 7","pages":"e222-e224"},"PeriodicalIF":1.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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