Pediatric Annals最新文献_第2页

Hemoglobinopathies and Cellular Therapy: What Pediatricians Need to Know About Indications and Counseling. 血红蛋白病和细胞治疗：儿科医生需要了解的适应症和咨询。

IF 0.9 4区医学

Pediatric Annals Pub Date : 2026-09-01 DOI: 10.3928/19382359-20260629-01

Obadah Alquadan, Rasha Deebaja, Avanti Gupte, Eman T Al-Antary

引用次数: 0

Pediatric Nonmalignant Hematopoietic Cell Transplantation in the Era of Precision Conditioning and Gene Therapy. 精准调理与基因治疗时代的儿童非恶性造血细胞移植。

IF 0.9 4区医学

Pediatric Annals Pub Date : 2026-09-01 DOI: 10.3928/19382359-20260628-01

Eman M Elsabbagh, Ahmed A Shawky, Christopher C Dvorak

{"title":"Pediatric Nonmalignant Hematopoietic Cell Transplantation in the Era of Precision Conditioning and Gene Therapy.","authors":"Eman M Elsabbagh, Ahmed A Shawky, Christopher C Dvorak","doi":"10.3928/19382359-20260628-01","DOIUrl":"https://doi.org/10.3928/19382359-20260628-01","url":null,"abstract":"The landscape of pediatric hematopoietic cell transplantation for nonmalignant disorders has evolved through disease-adapted conditioning, pharmacokinetic-guided dosing, expanded donor options, and gene therapy (GT). These advances have transformed curative strategies for children with select inborn errors of immunity, hemophagocytic lymphohistiocytosis, hemoglobinopathies, bone marrow failure syndromes, and select metabolic disorders. Early diagnosis, especially newborn screening for severe combined immunodeficiency, enables timely intervention, with contemporary series reporting more than 90% survival in select early-treated infants. Similarly, modern matched related donor transplantation for pediatric severe aplastic anemia approaches 98% 3-year survival. Fludarabine-based platforms combined with busulfan, melphalan, or treosulfan support durable engraftment with reduced toxicity, while matched unrelated, haploidentical, and cord blood donors expand access. GT now offers a parallel curative platform for select sickle cell disease, transfusion-dependent beta-thalassemia, and immunodeficiencies. For pediatricians, early referral before irreversible complications is critical. This review proposes a five-axis framework to guide referral, treatment selection, and survivorship planning.","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"55 9","pages":"e332-e340"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shared Care After Pediatric Nonmalignant Hematopoietic Cell Transplantation. 儿童非恶性造血细胞移植后的共同护理。

IF 0.9 4区医学

Pediatric Annals Pub Date : 2026-09-01 DOI: 10.3928/19382359-20260630-01

Ahmed A Shawky, Ahmed H Ibrahim, Ahmed A Elhadidy, Augusto D Chiang, Eman M Elsabbagh

{"title":"Shared Care After Pediatric Nonmalignant Hematopoietic Cell Transplantation.","authors":"Ahmed A Shawky, Ahmed H Ibrahim, Ahmed A Elhadidy, Augusto D Chiang, Eman M Elsabbagh","doi":"10.3928/19382359-20260630-01","DOIUrl":"https://doi.org/10.3928/19382359-20260630-01","url":null,"abstract":"Children undergoing hematopoietic cell transplantation (HCT) for nonmalignant disorders are increasingly surviving long-term, shifting the focus from procedural success to durable immune recovery, infection prevention, revaccination, organ health, development, and quality of life. General pediatricians play a central role in shared care after HCT, as children transition from transplant-centered monitoring back to community-based care. Post-HCT immune recovery is heterogeneous and depends on diagnosis, donor source, graft source, conditioning, serotherapy exposure, graft-versus-host disease (GVHD), immunosuppression, and prior infections. Infection risk persists beyond neutro-phil recovery and may be prolonged in children with delayed T-cell or B-cell recovery, chronic GVHD, or ongoing immunosuppression. Revaccination is essential, as pretrans-plant immunity is often lost. This review provides a practical framework for pediatricians caring for children after nonmalignant HCT, with emphasis on infection prevention, immunization, survivorship monitoring, and the emerging role of data-driven tools to support individualized follow-up.","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"55 9","pages":"e358-e367"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inborn Errors of Immunity and Hematopoietic Cell Transplantation: Recognition and Pretransplant Management. 先天性免疫错误和造血细胞移植：识别和移植前处理。

IF 0.9 4区医学

Pediatric Annals Pub Date : 2026-09-01 DOI: 10.3928/19382359-20260628-02

Alyssa M Greenwell, Avanti Gupte, Eman T Al-Antary

{"title":"Inborn Errors of Immunity and Hematopoietic Cell Transplantation: Recognition and Pretransplant Management.","authors":"Alyssa M Greenwell, Avanti Gupte, Eman T Al-Antary","doi":"10.3928/19382359-20260628-02","DOIUrl":"https://doi.org/10.3928/19382359-20260628-02","url":null,"abstract":"Primary immunodeficiencies, now more broadly termed as \"inborn errors of immunity (IEI),\" are rare genetic disorders associated with recurrent infections, immune dysregulation, autoimmunity, lymphoproliferation, and malignancy risk. Early recognition and diagnosis are essential to reduce infection-related morbidity, prevent organ damage, and identify children who may benefit from curative therapy. A comprehensive history, physical examination, targeted immune evaluation, and genetic testing can support diagnosis, while early supportive measures may reduce infection risk before definitive therapy. Treatment may include antimicrobial prophylaxis, immunoglobulin replacement, enzyme replacement, immune-modifying agents, gene-based therapies, and allogeneic hematopoietic cell transplantation (HCT), which can be curative for select IEI. However, HCT requires careful pretransplant evaluation, as outcomes are influenced by disease biology, infection burden, organ function, donor availability, graft-versus-host disease risk, and conditioning toxicity. This review focuses on recognition of IEI, initial evaluation, supportive care, and pre-HCT management for pediatricians.","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"55 9","pages":"e341-e349"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recognition and Management of Ulcerative Infantile Hemangioma: Risk Factors, Diagnosis, and Prognosis. 婴幼儿溃疡性血管瘤的识别和治疗：危险因素、诊断和预后。

IF 0.9 4区医学

Pediatric Annals Pub Date : 2026-09-01 DOI: 10.3928/19382359-20260701-01

Elvina Veronica, Qiushuang Cai, Qin Shen, Yijing Jiang, Renfang Mao

{"title":"Recognition and Management of Ulcerative Infantile Hemangioma: Risk Factors, Diagnosis, and Prognosis.","authors":"Elvina Veronica, Qiushuang Cai, Qin Shen, Yijing Jiang, Renfang Mao","doi":"10.3928/19382359-20260701-01","DOIUrl":"https://doi.org/10.3928/19382359-20260701-01","url":null,"abstract":"Infantile hemangioma (IH) is a benign tumor that appears in the first year of life and typically involutes within 3 to 4 years. Ulcerative IH, the most common complication, poses a significant burden to patients. Early referral of high-risk cases reduces morbidity. Current literature on risk factors and prognosis is limited. Segmental and mixed IH in urogenital, head, neck, and lip areas show higher ulceration risk. Diagnosis is typically clinical; histopathology is rarely performed. Atypical cases require positive glucose transporter-1 immunohistochemistry. Larger lesions, delayed intervention, and bacterial infection worsen prognosis, prolong healing, and increase recurrence. Condition-dependent treatments, including oral propranolol (starting at 1 mg/kg or less daily, maintenance at 2 to 3 mg/kg daily), timolol prophylaxis, and wound management care combined with laser therapy, shorten therapy duration and minimize recurrence. Empiric antibiotics are indicated for infected ulcerative IH. Surgery is indicated for life-threatening cases (eg, chest wall hemangiomas requiring transfusion or airway obstruction) and high-morbidity cases (eg, lip lesions affecting speech or periorbital lesions impairing vision). The Infantile Hemangioma Referral Score helps clinicians identify high-risk patients who require prompt referral, thereby preventing delayed treatment.","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"55 9","pages":"e368-e373"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Hematopoietic Cell Transplantation for Nonmalignant Disorders: A Contemporary Guide for General Pediatricians. 非恶性疾病的儿童造血细胞移植：普通儿科医生的当代指南。

IF 0.9 4区医学

Pediatric Annals Pub Date : 2026-09-01 DOI: 10.3928/19382359-20260701-02

Eman M Elsabbagh

引用次数: 0

Summer (and Every Season) Water Safety. 夏季（和每个季节）水上安全。

IF 0.9 4区医学

Pediatric Annals Pub Date : 2026-08-01 DOI: 10.3928/19382359-20260708-02

Tyler K Smith, Erica L Singleton

引用次数: 0

Suicide Screening, Evaluation, and Management: A Trauma-Informed Approach for Primary Care. 自杀筛查，评估和管理：创伤知情的初级保健方法。