Pediatric AnnalsPub Date : 2025-05-01DOI: 10.3928/19382359-20250307-02
Anusha Panjwani, Jennifer S Katz, Robert K Katz
{"title":"Nirsevimab and Maternal Respiratory Syncytial Virus Vaccine Recommendations for the Pediatric Population.","authors":"Anusha Panjwani, Jennifer S Katz, Robert K Katz","doi":"10.3928/19382359-20250307-02","DOIUrl":"https://doi.org/10.3928/19382359-20250307-02","url":null,"abstract":"<p><p>For infants up to age 12 months, there is an urgent need for protection against respiratory tract infection caused by respiratory syncytial virus (RSV). Nirsevimab (Beyfortus [Sanofi (Bridgewater, NJ), AstraZeneca (Wilmington, DE)], a long-acting monoclonal antibody for infants, and the bivalent RSV prefusion F (RSVpreF) vaccine (ABRYSVO [Pfizer (New York, NY)]) for pregnant women are the current recommendations for protection against RSV. This review summarizes current evidence-based practices for these interventions, highlights recommendations for delivery, and addresses challenges faced by providers during the RSV season. <b>[<i>Pediatr Ann</i>. 2025;54(5):e160-e166.]</b>.</p>","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 5","pages":"e160-e166"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pediatric AnnalsPub Date : 2025-05-01DOI: 10.3928/19382359-20250317-01
David E Solano, Magda Mendez
{"title":"A Review of the Literature on Cow Milk Protein Allergy Management.","authors":"David E Solano, Magda Mendez","doi":"10.3928/19382359-20250317-01","DOIUrl":"https://doi.org/10.3928/19382359-20250317-01","url":null,"abstract":"<p><p>Cow milk allergy (CMA) is an immune-mediated condition affecting infants and young children, leading to a range of gastrointestinal, respiratory, and skin-related symptoms. This review explores the epidemiology, etiology and pathogenesis, clinical manifestations, diagnosis, treatment, and prognosis of CMA. CMA's prevalence varies geographically and is influenced by genetic and environmental factors. In this article, we review how to accurately diagnose CMA to avoid unnecessary dietary restrictions, as well as provide an overview of treatment options that highlight the importance of tailored dietary management and the potential for developing tolerance in affected children. <b>[<i>Pediatr Ann</i>. 2025;54(5):e179-e181.]</b>.</p>","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 5","pages":"e179-e181"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pediatric AnnalsPub Date : 2025-05-01DOI: 10.3928/19382359-20250307-03
Sara Popofsky, José R Romero
{"title":"Measles: An Ongoing Threat.","authors":"Sara Popofsky, José R Romero","doi":"10.3928/19382359-20250307-03","DOIUrl":"https://doi.org/10.3928/19382359-20250307-03","url":null,"abstract":"<p><p>Measles is an acute, serious, highly contagious viral infection. Despite the existence of an effective and safe vaccine for more than half a century, measles outbreaks continue in the United States and cases are increasing worldwide. Further, there is a decreasing trend in national measles, mumps, and rubella vaccination coverage among kindergarteners. This article is intended to provide practitioners caring for children with an overview of the history of measles, its current national and international epidemiology, clinical picture, and important complications, as well as methods for prevention. Readers are directed to in-depth reviews for specific detailed recommendations regarding vaccines and biologics mentioned herein. <b>[<i>Pediatr Ann</i>. 2025;54(5):e167-e173.]</b>.</p>","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 5","pages":"e167-e173"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pediatric AnnalsPub Date : 2025-05-01DOI: 10.3928/19382359-20250307-01
Kirsten Gilliland, Alexandra Kilinsky
{"title":"Vaccine Hesitancy: Where Are We Now?","authors":"Kirsten Gilliland, Alexandra Kilinsky","doi":"10.3928/19382359-20250307-01","DOIUrl":"https://doi.org/10.3928/19382359-20250307-01","url":null,"abstract":"<p><p>Vaccine hesitancy is the delay in acceptance or outright refusal of immunizations, which has evolved into a growing public health threat. In this article, we explore recent trends in vaccine hesitancy in the setting of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pandemic, vaccine-specific variations, social media influence, and sociodemographic factors. During the coronavirus disease 2019 pandemic, the antivaccine movement gained increasing support and generated widespread conspiracy theories and mistrust. This highlighted the importance of enhancing communication between the health care field and general public. While the impact of antivaccine social media is widespread, physicians have also begun to use technology to spread factual information and increase vaccination uptake. There is a growing body of evidence regarding sociodemographic data, including the pervasive impact of medical racism on vaccine hesitancy, with additional studies on age, education, income, and more. Providers must serve as communicators and focus on presumptive language, strong recommendations, and tailored conversations with families who are hesitant about vaccines. <b>[<i>Pediatr Ann</i>. 2025;54(5):e154-e159.]</b>.</p>","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 5","pages":"e154-e159"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pediatric AnnalsPub Date : 2025-05-01DOI: 10.3928/19382359-20250307-04
José R Romero, Henry H Bernstein
{"title":"Vaccinations Matter.","authors":"José R Romero, Henry H Bernstein","doi":"10.3928/19382359-20250307-04","DOIUrl":"https://doi.org/10.3928/19382359-20250307-04","url":null,"abstract":"","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 5","pages":"e152-e153"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pediatric AnnalsPub Date : 2025-05-01DOI: 10.3928/19382359-20250307-06
Alexander P Vasilakopoulos, Mundeep K Kainth
{"title":"A Review of Pediatric Influenza.","authors":"Alexander P Vasilakopoulos, Mundeep K Kainth","doi":"10.3928/19382359-20250307-06","DOIUrl":"https://doi.org/10.3928/19382359-20250307-06","url":null,"abstract":"<p><p>Influenza remains a significant public health concern, particularly among children. This comprehensive review focuses on pathophysiology, epidemiology, clinical presentation, treatment, and vaccines for pediatric influenza. Key genetic and immune-related factors, as well as excessive neutrophil activation, contribute to severe disease and outcomes. Epidemiologically, influenza affects 8% to 10% of children in the United States annually, with higher hospitalization rates among children who are Black, Hispanic, Native American and Alaska Native, and Asian and Pacific Islander. Clinically, children exhibit more severe symptoms and higher rates of gastrointestinal manifestations compared with adults. Treatment primarily involves neuraminidase inhibitors, like oseltamivir; although, therapies, such as baloxavir marboxil, are also effective. Vaccination remains the cornerstone of prevention, yet declining rates of uptake and increasing vaccine hesitancy pose challenges for population immunity. Universal influenza vaccine research offers hope for broader protection. This review aims to inform evidence-based practices in managing pediatric influenza and highlights areas for future research. <b>[<i>Pediatr Ann</i>. 2025;54(5):e174-e178.]</b>.</p>","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 5","pages":"e174-e178"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pediatric AnnalsPub Date : 2025-05-01DOI: 10.3928/19382359-20250401-01
Joseph R Hageman, Lolita Alcocer Alkureishi
{"title":"From Screening to Saving Lives: The New Era of Critical Congenital Heart Disease Detection.","authors":"Joseph R Hageman, Lolita Alcocer Alkureishi","doi":"10.3928/19382359-20250401-01","DOIUrl":"https://doi.org/10.3928/19382359-20250401-01","url":null,"abstract":"","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 5","pages":"e150-e151"},"PeriodicalIF":1.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pediatric AnnalsPub Date : 2025-04-01DOI: 10.3928/19382359-20250206-01
Jyodi Mohole, Miriam Beyder, Yamini Sharma
{"title":"Guiding Light: How the Updated AAP Clinical Guidelines for Hyperbilirubinemia Impacted Management of a Case of Severe and Persistent Hemolytic Disease of the Newborn.","authors":"Jyodi Mohole, Miriam Beyder, Yamini Sharma","doi":"10.3928/19382359-20250206-01","DOIUrl":"10.3928/19382359-20250206-01","url":null,"abstract":"<p><p>A full-term newborn is found to have clinically significant hyperbilirubinemia in the first 24 hours of life secondary to maternal anti-Rhesus (Rh) (E) immunization in this illustrative case. Rh(E) is a minor non-Rh(D) antigen that is less commonly implicated in hemolytic disease of the fetus and newborn (HDFN). The infant had both a severe and prolonged course of HDFN and hemolytic anemia requiring a combination of phototherapy, intravenous immunoglobulin (IVIG), and blood transfusions during the course of 2 weeks. By following the 2022 American Academy of Pediatrics' Clinical Practice Guidelines for hyperbilirubinemia, we demonstrate that rapid identification and adjuvant therapy with IVIG successfully avoids exchange transfusion in a case of severe immune-mediated HDFN. This case also specifically highlights the importance of minor antigens, such as Rh(E) in newborn hemolytic conditions. <b>[<i>Pediatr Ann</i>. 2025;54(4):e125-e129.]</b>.</p>","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 4","pages":"e125-e129"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pediatric AnnalsPub Date : 2025-04-01DOI: 10.3928/19382359-20250206-04
Courtney W Tam, Shivani Patel, Jasmine Massoumi, Aditya Manuel, Amy Yeh, Hemananda Muniraman
{"title":"Atypical Presentation of Duodenal Atresia in a Newborn With Trisomy 21: A Simulated Case Report and Narrative Review.","authors":"Courtney W Tam, Shivani Patel, Jasmine Massoumi, Aditya Manuel, Amy Yeh, Hemananda Muniraman","doi":"10.3928/19382359-20250206-04","DOIUrl":"10.3928/19382359-20250206-04","url":null,"abstract":"<p><p>Duodenal atresia has a strong association with chromosomal anomalies, particularly trisomy 21. Duodenal atresia is identified prenatally in up to 60% of cases, and intestinal obstructions often present with signs, including difficulty feeding, emesis (particularly in the first 24 to 48 hours of life), abdominal distension, and inability to pass meconium in the immediate postnatal period. In this article, we present a simulated case of a neonate with trisomy 21 who presented at age 2 weeks for evaluation of poor weight gain and feeding intolerance and was diagnosed with duodenal atresia. Imaging is the mainstay of diagnosis and imaging modalities, such as abdominal radiographs or upper gastrointestinal studies, will reveal a \"double bubble\" sign. This sign indicates proximal dilation of the duodenum and stomach, suggesting duodenal atresia. Management often involves surgical correction to bypass the obstruction and parenteral nutrition, as enteral feeds are often introduced slowly postoperatively. Early diagnosis and a collaborative multidisciplinary approach are vital to successful treatment. <b>[<i>Pediatr Ann</i>. 2025;54(4):e139-e143.]</b>.</p>","PeriodicalId":54633,"journal":{"name":"Pediatric Annals","volume":"54 4","pages":"e139-e143"},"PeriodicalIF":1.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}