Understanding and Caring for Adolescents and Young Adults Who Are Considering or Pursuing a Detransition Process.

Detransition refers to stopping, shifting, or reversing an initial gender transition. It often involves changes in self-identity and decisional regret with prior transition-related medical or surgical treatments. There are currently no formal care guidelines available to assist clinicians in discussing detransition with patients and their families or for supporting young people navigating the process. The aim of this article is to examine contemporary detransition research published between 2020 and 2025 to enhance evidence-informed care for adolescents and young adults who are transgender and gender diverse, as well as individuals who opt to detransition. Detransition often occurs in the context of health concerns or complications with treatments, transgender discrimination, complex mental health challenges and neurodivergence, and identity shifts. Recommendations for care and support for patients contemplating or engaging in a detransition process are discussed.