{"title":"Engrams, Mnemons, Praxicons, and <i>The Hunting of the Snark</i>: A Conceptual Analysis.","authors":"A J Larner, A P Leff, P Nachev","doi":"10.1353/pbm.2026.a1002730","DOIUrl":"https://doi.org/10.1353/pbm.2026.a1002730","url":null,"abstract":"<p><p>The conception of the engram as \"the enduring though primarily latent modification of the irritable substance produced by a stimulus\" dates back over 100 years to the work of Richard Semon. This conception initiated experimental investigations for the structural embodiment of the engram, most notably pursued by Karl Lashley, as well as formulation of related conceptions, such as mnemons and praxicons. In the past decade, an increasing number of empirical studies have attempted to identify the neural substrates of the engram. However, no conceptual analysis of the coherence of this term has been undertaken hitherto. The authors provide a conceptual analysis of the engram terminology that shows that the conceptual framework is incoherent, and they recommend the abandonment of this terminology.</p>","PeriodicalId":54627,"journal":{"name":"Perspectives in Biology and Medicine","volume":"69 3","pages":"293-305"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What Is the Future of Personalized Medicine? <i>A Review of</i> Tyranny of the Gene <i>by James Tabery</i>.","authors":"Olaf Dammann, Aimee Milliken","doi":"10.1353/pbm.2026.a1002738","DOIUrl":"https://doi.org/10.1353/pbm.2026.a1002738","url":null,"abstract":"<p><p>James Tabery's Tyranny of the Gene: Personalized Medicine and Its Threat to Public Health (2023) offers interesting and timely commentary on the recent history of genomic medicine and raises important questions about the promises and failures of personalized medicine. This Critical Assessment reflects on these questions and offers insights about the role of personalized genomic medicine in the future of health and health care.</p>","PeriodicalId":54627,"journal":{"name":"Perspectives in Biology and Medicine","volume":"69 3","pages":"421-428"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"Wouldn't It Be Easier to Be Burned at the Stake?\": Schizophrenia and Deinstitutionalization in <i>Bitter Medicine</i>.","authors":"Shefali, Preeti Puri","doi":"10.1353/pbm.2026.a985819","DOIUrl":"10.1353/pbm.2026.a985819","url":null,"abstract":"<p><p>This article examines the lived reality of schizophrenia and its treatment as portrayed in Clem and Olivier (Liv) Martini's Bitter Medicine: A Graphic Memoir of Mental Illness (2010), with a focus on how graphic medicine can represent the complexities of subjective experience in the psychiatric health-care system. Drawing on Foucault's critique of disciplinary power in psychiatric institutions, the article explores how the memoir reveals tensions between therapeutic care and systemic control, even after deinstitutionalization. Through El Refaie's idea of visual metaphor and embodiment in comics, Liv's illustrations about his psychiatric suffering are read as more than expressive art that challenges dominant clinical narratives. The article investigates the shift in psychiatric health care in Canada from institutional care to community-based care and the impact of psychopharmaceutical drugs, highlighting the embodied cost of psychiatric treatment. By revealing the social exclusion and economic vulnerability produced by gaps in the implementation of health-care policies, Bitter Medicine critiques the promises of deinstitutionalization. The article illustrates how visual narrative forms can foreground subjective experiences of schizophrenia, while interrogating broader systemic failures in mental health care.</p>","PeriodicalId":54627,"journal":{"name":"Perspectives in Biology and Medicine","volume":"69 1","pages":"143-165"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mark David McGregor Davis, Deborah Lupton, Kerryn Drysdale
{"title":"\"You Are Not Immune from This Virus\": Australian News Reporting During the Early Months of COVID-19.","authors":"Mark David McGregor Davis, Deborah Lupton, Kerryn Drysdale","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immunity narratives have circulated in popular culture and news media since the late 19th century. The emergence of the COVID-19 pandemic instigated a fervent interest in immunity as societies came to terms with the deadly novel coronavirus. In this article, immunity narratives in reports published in the Sydney Morning Herald during the earliest phase of the pandemic are examined for how they expressed biopolitical logics concerning individual responsibility for a strong immune system and the regulation of human populations. In these news reports, there was a blurring of biological, political, and sociolegal meanings. Certain groups were singled out as vulnerable to COVID and therefore requiring protection, including the maintenance of preventive activities by all members of the public. Others-notably elite sports players-were criticized for initially being exempted from the public health restrictions to which most of the public were expected to comply. Overall, the dominant immunitary narrative was that everyone should take action to protect themselves or those people deemed at high risk. Australia could only be immune from the health and economic impacts of the pandemic if all citizens accepted that \"You are not immune from this virus.\"</p>","PeriodicalId":54627,"journal":{"name":"Perspectives in Biology and Medicine","volume":"69 2","pages":"275-291"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marta Fadda, Alessandra Cristaudi, Pietro Majno-Hurst, Martha Montello, Samia Hurst-Majno
{"title":"Preserving Patients' Identities: Patient Biographies Before Major Surgery.","authors":"Marta Fadda, Alessandra Cristaudi, Pietro Majno-Hurst, Martha Montello, Samia Hurst-Majno","doi":"10.1353/pbm.2026.a1002734","DOIUrl":"https://doi.org/10.1353/pbm.2026.a1002734","url":null,"abstract":"<p><p>Since 2019, the authors have implemented the project Knowing Each Other Better Is Better Care, inviting patients scheduled for major surgery to write short biographies to be shared with their care teams. Rooted in the recognition that a strong therapeutic alliance improves treatment outcomes and patient satisfaction, this initiative aims to enhance patient-provider connections by integrating patients' biographies into their care. Analysis of 10 biographies reveals four recurring themes: the desire to be seen as unique individuals, the need for mutual trust with health-care providers, the wish for their hopes to be understood, and gratitude for the opportunity to share their stories. These findings challenge the custom that physicians and hospital staff should rely mainly on family members to bear the moral responsibility for preserving patients' identities. Patients clearly expressed their hope that they can entrust their providers with the responsibility not only to maintain their detailed medical records, but also to hear and absorb their intimate memories, fears, and hopes. This approach has the potential to enhance both the perceived and actual quality of care, ensuring that patients feel heard, valued, and respected throughout their hospital journey.</p>","PeriodicalId":54627,"journal":{"name":"Perspectives in Biology and Medicine","volume":"69 3","pages":"353-366"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Eric Davidson (1937-2015): A Conservative Scientific Revolutionary in Systems Developmental Biology and Evolution.","authors":"Ute Deichmann","doi":"10.1353/pbm.2026.a1002733","DOIUrl":"https://doi.org/10.1353/pbm.2026.a1002733","url":null,"abstract":"<p><p>Using the work of Eric Davidson (1937-2015) as an example, this article challenges the idea that a revolutionary scientific discovery has to change whole scientific frameworks. Instead, it proposes the concept of the conservative revolutionary, which characterizes a scientist whose research leads to groundbreaking changes of theory and methodology, but who continues to work in the frame of their discipline and its epistemologies. The founder of molecular systems developmental biology, Davidson was the first to use large amounts of DNA sequencing in studies on development, and he also developed new mechanistic concepts in evolutionary theory. However, he placed his new methods within the framework of traditional epistemology. His philosophy and practice are of great relevance in the face of increasing use of AI in science.</p>","PeriodicalId":54627,"journal":{"name":"Perspectives in Biology and Medicine","volume":"69 3","pages":"338-352"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Immunity and Freedom.","authors":"Maebh Long, Martin Willis","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54627,"journal":{"name":"Perspectives in Biology and Medicine","volume":"69 2","pages":"174-180"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Mental Health Crisis of Rural America: Understanding Supply and Demand.","authors":"Nadir Al-Saidi","doi":"10.1353/pbm.2026.a985818","DOIUrl":"10.1353/pbm.2026.a985818","url":null,"abstract":"<p><p>This essay examines the rural mental health crisis through the stories of the author's father, an Iraqi immigrant and sole private psychiatric provider in a rural Michigan town. Moving his clinic in 2023 revealed the strain of practicing where demand far exceeds supply and capacity: long days split between a small hospital and an understaffed clinic, chronic underpayment from Medicaid, and a constant backlog of care. These lived experiences are contextualized through the historic failure of US mental health reform after the 1963 Community Mental Health Act, which has left Community Mental Health Centers (CMHCs) under-resourced and, in many rural counties, the only option. Demographic data on psychiatrist shortages, high suicide and illness burdens, and reimbursement disparities are paired with a patient vignette to illustrate how poverty and insurance work together to hinder treatment and precipitate recurrent crises. The essay argues that incremental workforce expansion alone cannot close rural gaps without such structural fixes as raising Medicaid reimbursement, stabilizing and expanding CMHC financing, aligning residency expansion with rural service incentives, and investing in rural infrastructure that addresses social determinants.</p>","PeriodicalId":54627,"journal":{"name":"Perspectives in Biology and Medicine","volume":"69 1","pages":"126-142"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"Post This Coupon for Immunity!\": Early Trends in Immunitary Discourse in the British Empire.","authors":"Maebh Long","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article offers a sociopolitical perspective to histories of immunology by tracing early discourses of immunity as they circulated beyond scientific developments and into public culture. Drawing on newspaper advertisements from Britain, Ireland, Australia, and New Zealand in the late 19th and early 20th centuries, the author identifies earlier conceptualizations of immunity within interconnected colonial and cultural contexts shaped by the British Empire and outlines how immunitary logics of individualism, protection, risk management, labor, and power were formed within marketing media. Advertisements framed immunity as a purchasable and personal asset, offering security against modern anxieties such as disease, environmental instability, social uncertainty, and the loss of power. Foregrounding immunity as an individual responsibility and commercial ideal, these narratives emphasized isolation and defense rather than interdependence, embedding conservative immunitary logics that prioritized the individual over the group, sought to retain power, and presented the nonhuman as threat.</p>","PeriodicalId":54627,"journal":{"name":"Perspectives in Biology and Medicine","volume":"69 2","pages":"197-213"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J Brewer Eberly, Warren Kinghorn, M Therese Lysaught, Abraham M Nussbaum, Farr Curlin, Joseph E Davis, D Brendan Johnson, Mannes Matous, Brett McCarty, Andrew Michel, Jennifer Tu, Margaret S Chisolm
{"title":"\"We Can Run but We Can't Hide\": Applying the Perspectives Model to What Ails Medicine.","authors":"J Brewer Eberly, Warren Kinghorn, M Therese Lysaught, Abraham M Nussbaum, Farr Curlin, Joseph E Davis, D Brendan Johnson, Mannes Matous, Brett McCarty, Andrew Michel, Jennifer Tu, Margaret S Chisolm","doi":"10.1353/pbm.2026.a1002735","DOIUrl":"https://doi.org/10.1353/pbm.2026.a1002735","url":null,"abstract":"<p><p>Contemporary analyses of modern medicine's challenges often oversimplify what medicine has become and the stories physicians tell about themselves and their work. This paper seeks a more fulsome vision of medicine and the lives of medical practitioners by using the \"Perspectives\" model of psychiatry as a form of imaginative inquiry into the state of the profession and physician self-understanding. In The Perspectives of Psychiatry (1998), psychiatrists Paul McHugh and Phillip Slavney described four \"perspectives\" through which clinicians might more fully see and understand those they serve: disease, dimensional, behavior, and life story. While this model was designed for clinical psychiatry, we here apply the model to the practice of medicine itself, looking at medicine and the lives of physicians through the lens of these four perspectives. We pay special attention to the \"life story\" perspective, concluding with a set of conversation starters for students, educators, and clinicians who long to see medicine anew.</p>","PeriodicalId":54627,"journal":{"name":"Perspectives in Biology and Medicine","volume":"69 3","pages":"367-382"},"PeriodicalIF":0.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}