Progress in Biophysics & Molecular Biology最新文献

{"title":"The multifaceted roles of ST3GAL family in cancer: Mechanistic insights and therapeutic implications","authors":"Jingpeng Guo ,&nbsp;Wenxing Jia ,&nbsp;Shengnan Jia","doi":"10.1016/j.pbiomolbio.2025.06.001","DOIUrl":"10.1016/j.pbiomolbio.2025.06.001","url":null,"abstract":"<div><div>Sialylation is a critical glycosylation process involving the covalent attachment of sialic acid residues to the terminal glycans of glycoproteins and glycolipids. This modification is predominantly mediated by sialyltransferases (STs), which play pivotal roles in cell signaling, immune response, and cellular adhesion and migration. Aberrant sialylation, resulting from dysregulated expression of STs, is a hallmark of cancer, frequently observed on the surfaces of both tumor and stromal cells. The ST3GAL family, a key subset of STs, facilitates α-2,3-sialylation and has emerged as a crucial regulator of tumor cell proliferation, motility, drug resistance, and the immunosuppressive tumor microenvironment. Despite its recognized significance, a comprehensive synthesis of the diverse roles and molecular mechanisms of the ST3GAL family in tumor progression is still lacking. This review consolidates current knowledge on the molecular structure, biological functions, and pathological implications of the ST3GAL family in cancer, with a focus on its roles in signal modulation, immune evasion, and therapeutic targeting. By highlighting its potential as a key player in oncogenic processes, this review aims to provide novel insights to inform future research and clinical applications.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"197 ","pages":"Pages 48-59"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The main sources of molecular organization in the cell. Atlas of self-organized and self-regulated dynamic biostructures” [Prog. Biophys. Mol. Biol. 195 (2025) 167–191]","authors":"Ildefonso M. De la Fuente ,&nbsp;Jesus M. Cortes ,&nbsp;Iker Malaina ,&nbsp;Gorka Pérez-Yarza ,&nbsp;Luis Martinez ,&nbsp;José I. López ,&nbsp;Maria Fedetz ,&nbsp;Jose Carrasco-Pujante","doi":"10.1016/j.pbiomolbio.2025.07.004","DOIUrl":"10.1016/j.pbiomolbio.2025.07.004","url":null,"abstract":"","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"197 ","pages":"Page 108"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application progress of cell membrane biomimetic nanoparticles in cancer diagnosis and treatment1","authors":"Baiyan Wang ,&nbsp;Jiayi Li ,&nbsp;Dandan Guo ,&nbsp;Shuxuan Li ,&nbsp;Yalan Li ,&nbsp;Qianqian Wang ,&nbsp;Yi Yang ,&nbsp;Wei Chen ,&nbsp;Shuying Feng","doi":"10.1016/j.pbiomolbio.2025.05.004","DOIUrl":"10.1016/j.pbiomolbio.2025.05.004","url":null,"abstract":"<div><div>Cancer diagnosis and treatment remains challenging, with unresolved issues such as low targeting, drug resistance, and numerous adverse reactions from chemotherapy. Cell membrane biomimetic modified nanoparticles(CMBMNPs), wrapping cell membrane on nanoparticles can achieve homologous cell mimicry, so that it can obtain the functions and properties of the type of cell, with strong targeting ability, strong immune evasion ability, long in vivo circulation time, etc., which is getting more and more attention. This article describes the preparation process of CMBMNPs and the different clinical effects of different types of nanoparticles and mimicking cell membranes in order to select the right match for use. In addition, we list in detail several important features of CMBMNPs as well as the advantages of CMBMNPs in areas related to cancer diagnosis and therapy, and look forward to the future challenges and prospects of cell membrane-generating nanotechnology, which provides new insights into the application of CMBMNPs in cancer diagnosis and therapy.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"197 ","pages":"Pages 21-33"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular heterogeneity and tissue specificity in venous malformations: Implications for pathogenesis and targeted therapies","authors":"Yang He ,&nbsp;Jian Lin ,&nbsp;Yi Li ,&nbsp;Weixing Zeng ,&nbsp;Yongsheng Li","doi":"10.1016/j.pbiomolbio.2025.06.002","DOIUrl":"10.1016/j.pbiomolbio.2025.06.002","url":null,"abstract":"<div><h3>Background</h3><div>Venous malformations (VMs) are common vascular anomalies characterized by abnormal endothelial cell proliferation, a paucity of vascular wall cells, and irregular vascular structures. While pathogenic gene mutations are the genetic basis of VMs, the cellular heterogeneity, tissue specificity, and underlying mechanisms remain poorly understood. VMs are increasingly recognized as vascular anomalies with tumor-like mechanisms, highlighting the critical roles of cellular heterogeneity and tissue specificity in pathogenesis.</div></div><div><h3>Methods</h3><div>This review systematically examines recent advances in VMs research, focusing on cellular heterogeneity and tissue specificity. It summarizes key mutated genes, the roles of various cell types, and their interactions within lesions. By comparing physiological differences between arteries and veins, we explore the tissue-specific origins of VMs. Additionally, we evaluate current cellular and animal models, discussing their strengths and limitations in simulating pathological features, including cellular heterogeneity and tissue specificity.</div></div><div><h3>Results</h3><div>The development of VMs is strongly linked to genetic mutations in endothelial cells, as well as functional alterations in endothelial progenitor cells, vascular wall cells, and other perivascular cells. Lesion tissues exhibit significant heterogeneity in cell function, gene/protein expression, and signal transduction. Tissue specificity is influenced by differences in environmental factors, tissue structure, and gene expression between arteries and veins, explaining why VMs predominantly affect veins.</div></div><div><h3>Conclusions</h3><div>VMs development involves interactions among pathogenic gene mutations, cellular heterogeneity, and tissue specificity. Understanding these mechanisms will elucidate VMs pathogenesis and inform precision therapies. Future research should focus on cell-type interactions, the role of tissue specificity in disease progression, and developing targeted therapeutic strategies.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"197 ","pages":"Pages 34-47"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the mechanisms of HIF-1α-enhanced tumor glycolysis and its relation to dedifferentiation","authors":"Yu Zeng ,&nbsp;Yonggang Tao ,&nbsp;Guotu Du ,&nbsp;Tianyu Huang ,&nbsp;Shicheng Chen ,&nbsp;Longmei Fan ,&nbsp;Neng Zhang","doi":"10.1016/j.pbiomolbio.2025.05.003","DOIUrl":"10.1016/j.pbiomolbio.2025.05.003","url":null,"abstract":"<div><div>Metabolic reprogramming, a hallmark of malignancy, enables tumor cells to adapt to the harsh and dynamic tumor microenvironment (TME) by altering metabolic pathways. Hypoxia, prevalent in solid tumors, activates hypoxia inducible factor 1α (HIF-1α). HIF-1α drives metabolic reprogramming, enhancing glycolysis primarily through the Warburg effect to reduce oxygen dependence and facilitate tumor cell growth/proliferation. The above process is associated with accelerated tumor cell dedifferentiation and enhanced stemness, generating cancer stem cells (CSCs) which possesses the potential for self-renewal and differentiation that can differentiate into a wide range of subtypes of tumor cells and fuel tumor heterogeneity, metastasis, and recurrence, complicating therapy. This review examines the HIF-1α-glycolysis-dedifferentiation crosstalk mechanisms, expecting that indirect inhibition of HIF-1α by targeting metabolic enzymes, metabolites, or their signaling pathways will offer an effective therapeutic strategy to improve the cancer treatment outcomes.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"197 ","pages":"Pages 1-10"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational protein design: Advancing biotechnology through in silico engineering","authors":"Ranjit Ranbhor ,&nbsp;Ruthvik Venkatesan ,&nbsp;Amay Sanjay Redkar ,&nbsp;Vibin Ramakrishnan","doi":"10.1016/j.pbiomolbio.2025.07.003","DOIUrl":"10.1016/j.pbiomolbio.2025.07.003","url":null,"abstract":"<div><div>Currently, computational protein design (CPD) is a disruptive force in biotechnology, changing the paradigm by which proteins are engineered for many applications. In this article, the evolution of CPD has been tracked from its initial forays in the late 1990s to the current advanced and sophisticated domain that it now occupies as one driven by artificial intelligence (AI). It highlights recent advancements that have extended its scope and into which broader elements including protein backbone modeling, energy functions, sampling algorithms, and techniques for sequence optimization were placed. Computer-aided protein design has thus become increasingly accurate and efficient through machine learning, quantum mechanics, and high-throughput virtual screening. In biotechnology, CPD finds applications in developing innovative therapeutics, industrial enzymes, and synthetic biomaterials. Such remarkable successes aside, however, CPD has various challenges, such as energy function, structural predictions, and computational resource requirements. Future predictions in areas such as programmable cellular systems and self-assembling protein-based materials could establish new avenues for growth. Finally, the review points out the need for multidisciplinarity and ethical considerations as well in utilizing CPD to reach its full potential for solving global issues of health, energy, and environmental sustainability. Having moved in that direction, CPD promises to open new avenues of biotechnological development that will enable the creation of proteins with functions and properties never before possible.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"197 ","pages":"Pages 75-83"},"PeriodicalIF":3.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The microelectrode array technique - a crucial tool for studying excitable tissue disorders and drug testing: an update on recent advances","authors":"Andrijana Angelovski ,&nbsp;Markéta Bébarová","doi":"10.1016/j.pbiomolbio.2025.07.005","DOIUrl":"10.1016/j.pbiomolbio.2025.07.005","url":null,"abstract":"<div><div>The microelectrode array (MEA) is an electronic device composed of a varying number of microelectrodes used to detect the extracellular field potential generated by excitable tissues. This technology allows for the measurement of electrical activity without damaging the cell membrane during recording. MEA offers a better way of getting long-term recordings and observing different cellular activities than the invasive patch clamp technique. Recent research demonstrates that MEA technology enables scientists to detect both cellular and subcellular events, allowing them to study cellular properties and reactions across different experimental conditions and even to identify distinct ion currents and their impact on cellular electrophysiology. The paper reviews the historical development of MEA technology along with its modern applications for electrophysiological research. The future advancement of MEA technology will improve our knowledge about neuronal and cardiac excitability and expand its use to additional electrically active tissues, advancing research in pharmacology, neuroscience, cardiology, and other fields.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"197 ","pages":"Pages 97-107"},"PeriodicalIF":4.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of gastric cancer-derived exosomes in the occurrence of metastatic hepatocellular carcinoma","authors":"Jie Zhou ,&nbsp;Yuan-Kun Gou ,&nbsp;Dong Guo ,&nbsp;Ming-Yi Wang ,&nbsp;Peng Liu","doi":"10.1016/j.pbiomolbio.2025.01.005","DOIUrl":"10.1016/j.pbiomolbio.2025.01.005","url":null,"abstract":"<div><div>Gastric cancer (GC), particularly in East Asia, is among the most prevalent cancers with high mortality rates. According to recent epidemiological data, patients with GC account for over a quarter of all cancer incidences and approximately one third of cancer-related deaths in East Asia. Liver metastasis (LM) is not only a common form of GC distant metastasis but also poses a major challenge to the prognosis and treatment of patients with advanced GC. Increasing evidence has shown that the gut-liver axis plays a pivotal role in maintaining the stomach-liver-gut homeostasis. Exosomes are small secreted vesicles enriched with specific proteins, lipids, and nucleic acids. These vesicles exhibit significant activities in signal transmission to adjacent or distant cells in the gut-liver axis, as well as in remodeling the tumor microenvironment. Some research have pointed out that exosomes promote LM of various cancers. However, there still lack of complete and systematic review on how exosomes affect GC-LM. In this article, we present a comprehensive description to explore the role of GC-derived exosomes in the occurrence and development of metastatic hepatocellular carcinoma (HCC).</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"196 ","pages":"Pages 1-7"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of phosphatidylethanolamine-binding protein (PEBP) family in various diseases: Mechanisms and therapeutic potential","authors":"Yeying Teng ,&nbsp;Haiping Xue ,&nbsp;Xiaoliang Deng ,&nbsp;Yanqun Luo ,&nbsp;Tao Wu","doi":"10.1016/j.pbiomolbio.2025.04.002","DOIUrl":"10.1016/j.pbiomolbio.2025.04.002","url":null,"abstract":"<div><div>This article focuses on the phosphatidylethanolamine-binding protein (PEBP) family proteins, detailing PEBP1 and PEBP4 due to limited information on PEBP2 and PEBP3, in cellular signaling pathways and research in a spectrum of pathologies, including diverse cancers, metabolic disorders, immunological diseases and a subset of organ-specific diseases. It outlines the mechanisms through which PEBP1 and PEBP4 regulate essential signaling pathways that are critical for cellular processes such as proliferation, apoptosis, and metastasis. Recent advancements have shown further understanding of these proteins' roles in pathophysiology and their potential as future therapeutic targets. The findings suggest that the impact of PEBP1 and PEBP4 on the course of different diseases has underscored their potential for more in-depth medical research and novel clinically targeted therapies.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"196 ","pages":"Pages 102-113"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skeletogenesis and acupuncture points","authors":"Evgeniy Andreyev,&nbsp;Volodymyr Krasnoholovets","doi":"10.1016/j.pbiomolbio.2025.02.001","DOIUrl":"10.1016/j.pbiomolbio.2025.02.001","url":null,"abstract":"<div><div>The formation of the embryo begins with a “calcium wave” that contributes to the creation of heterogeneities, and then some of them solidify. The further development and a collective information architecture of the embryo is controlled by the so-called morphogenetic field, whose nature is mainly associated with a physical inerton field that is a substructure of the quantum mechanical matter waves, which plays the role of information field in biological systems. The inerton field takes on the function of organising the geometry and topology of the developing system, which we associate with the concept of positional information. Hence, any extended element or system in the body can be specified by certain relative coordinates, or radius vectors drawn from the origin to a given point. Such special points we associate with the patterns of formation of the musculoskeletal system. This work demonstrates an unequivocal correspondence between the functional formations that exist within the bony structures of the skeleton, which we can name ossification centres, or points, and classical acupuncture areas, which involve a number of nerves, muscles, vessels, and tendons. Histologically, there are various kinds of endings around the acupoints and their complexity is responsible for the acupuncture sensation in these places. It is shown that each ossification centre can be associated with a multiple of two number of acupuncture areas located in the immediate vicinity of the ossification centre. With this approach, all 1112 generally recognised acupuncture points find their ossification centres on the tubular bones and axial skeleton.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"196 ","pages":"Pages 33-49"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}