Progress in Biophysics & Molecular Biology最新文献_第4页

Electromagnetic radiation and biophoton emission in neuronal communication and neurodegenerative diseases 电磁辐射和光子发射在神经元通讯和神经退行性疾病中的作用。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-12-26 DOI: 10.1016/j.pbiomolbio.2024.12.004

Aysin Erboz , Elif Kesekler , Pier Luigi Gentili , Vladimir N. Uversky , Orkid Coskuner-Weber

{"title":"Electromagnetic radiation and biophoton emission in neuronal communication and neurodegenerative diseases","authors":"Aysin Erboz , Elif Kesekler , Pier Luigi Gentili , Vladimir N. Uversky , Orkid Coskuner-Weber","doi":"10.1016/j.pbiomolbio.2024.12.004","DOIUrl":"10.1016/j.pbiomolbio.2024.12.004","url":null,"abstract":"<div><div>The intersection of electromagnetic radiation and neuronal communication, focusing on the potential role of biophoton emission in brain function and neurodegenerative diseases is an emerging research area. Traditionally, it is believed that neurons encode and communicate information via electrochemical impulses, generating electromagnetic fields detectable by EEG and MEG. Recent discoveries indicate that neurons may also emit biophotons, suggesting an additional communication channel alongside the regular synaptic interactions. This dual signaling system is analyzed for its potential in synchronizing neuronal activity and improving information transfer, with implications for brain-like computing systems. The clinical relevance is explored through the lens of neurodegenerative diseases and intrinsically disordered proteins, where oxidative stress may alter biophoton emission, offering clues for pathological conditions, such as Alzheimer's and Parkinson's diseases. The potential therapeutic use of Low-Level Laser Therapy (LLLT) is also examined for its ability to modulate biophoton activity and mitigate oxidative stress, presenting new opportunities for treatment. Here, we invite further exploration into the intricate roles the electromagnetic phenomena play in brain function, potentially leading to breakthroughs in computational neuroscience and medical therapies for neurodegenerative diseases.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"195 ","pages":"Pages 87-99"},"PeriodicalIF":3.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trees suck. Notes on the physics of transpiration in trees 树木吸收。关于树木蒸腾作用的物理学注释。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-12-25 DOI: 10.1016/j.pbiomolbio.2024.12.002

Harvey R. Brown, Adrian P. Sutton

引用次数: 0

Research progress on N6-Methyladenosine modification in angiogenesis, vasculogenic mimicry, and therapeutic implications in breast cancer n6 -甲基腺苷修饰在乳腺癌血管生成、血管生成模拟及其治疗意义的研究进展。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-12-20 DOI: 10.1016/j.pbiomolbio.2024.12.003

Jiachen Weng , Yisi Shan , Qingyu Chang, Chenyan Cao, Xuemin Liu

引用次数: 0

Transforming agents: The power of structural modifications in glioblastoma multiforme therapy 转化剂：结构改变在胶质母细胞瘤多形性治疗中的作用。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-12-17 DOI: 10.1016/j.pbiomolbio.2024.12.001

Seyedeh Elham Norollahi , Saman Morovat , Arman Keymoradzadeh , Arman Hamzei , Morteza Modaeinama , Nazanin Soleimanmanesh , Yasaman Soleimanmanesh , Ali Najafizadeh , Elahe Bakhshalipour , Babak alijani , Ali Akbar Samadani

{"title":"Transforming agents: The power of structural modifications in glioblastoma multiforme therapy","authors":"Seyedeh Elham Norollahi , Saman Morovat , Arman Keymoradzadeh , Arman Hamzei , Morteza Modaeinama , Nazanin Soleimanmanesh , Yasaman Soleimanmanesh , Ali Najafizadeh , Elahe Bakhshalipour , Babak alijani , Ali Akbar Samadani","doi":"10.1016/j.pbiomolbio.2024.12.001","DOIUrl":"10.1016/j.pbiomolbio.2024.12.001","url":null,"abstract":"<div><div>Glioblastoma (GBM) is a very deadly type of brain tumor with a poor prognosis and a short survival rate. Recent advancements in understanding GBM's molecular and genetic characteristics have led to the development of various therapeutic and diagnostic strategies. Key elements such as microRNAs, lncRNAs, exosomes, angiogenesis, and chromatin modifications are highlighted, alongside significant epigenetic alterations that impact therapy and diagnosis. Despite these advancements, molecular classifications have not improved patient outcomes due to intratumoral diversity complicating targeted therapies. In this article, it is tried to emphasize the potential of investigating the epigenetic landscape of GBM, particularly identifying patients with diffuse hypermethylation at gene promoters associated with better outcomes. Integrating epigenetic and genetic data has enhanced the identification of glioma subtypes with high diagnostic precision. The reversibility of epigenetic changes offers promising therapeutic prospects, as recent insights into the “epigenetic orchestra” suggest new avenues for innovative treatment modalities for this challenging cancer. In this review article, we focus on the roles of translational elements and their alterations in the context of GBM diagnosis and therapy.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"195 ","pages":"Pages 41-56"},"PeriodicalIF":3.2,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro regulation of collective cell migration: Understanding the role of physical and chemical microenvironments 细胞集体迁移的体外调控：理解物理和化学微环境的作用。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-11-28 DOI: 10.1016/j.pbiomolbio.2024.11.005

Chang-Xing Li, Zi-Xu Zhao, Dan-Bo Su, Da-Chuan Yin, Ya-Jing Ye

{"title":"In vitro regulation of collective cell migration: Understanding the role of physical and chemical microenvironments","authors":"Chang-Xing Li, Zi-Xu Zhao, Dan-Bo Su, Da-Chuan Yin, Ya-Jing Ye","doi":"10.1016/j.pbiomolbio.2024.11.005","DOIUrl":"10.1016/j.pbiomolbio.2024.11.005","url":null,"abstract":"<div><div>Collective cell migration is the primary mode of cellular movement during embryonic morphogenesis, tissue repair and regeneration, and cancer invasion. Distinct from single-cell migration, collective cell migration involves complex intercellular signaling cascades and force transmission. Consequently, cell collectives exhibit intricate and diverse migration patterns under the influence of the microenvironment <em>in vivo</em>. Investigating the patterns and mechanisms of collective cell migration within complex environmental factors <em>in vitro</em> is essential for elucidating collective cell migration <em>in vivo</em>. This review elucidates the influence of physical and chemical factors <em>in vitro</em> microenvironment on the migration patterns and efficiency of cell collectives, thereby enhancing our comprehension of the phenomenon. Furthermore, we concisely present the effects of characteristic properties of common biomaterials on collective cell migration during tissue repair and regeneration, as well as the features and applications of tumor models of different dimensions (2D substrate or 3D substrate) <em>in vitro</em>. Finally, we highlight the challenges facing the research of collective cell migration behaviors <em>in vitro</em> microenvironment and propose that modulating collective cell migration may represent a potential strategy to promote tissue repair and regeneration and to control tumor invasion and metastasis.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"195 ","pages":"Pages 23-40"},"PeriodicalIF":3.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on salt-induced DNA compaction and charge inversion 盐诱导 DNA 压实和电荷反转综述

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-11-20 DOI: 10.1016/j.pbiomolbio.2024.11.003

Khadka B. Chhetri

引用次数: 0

Electrical impedance sensing in stem cell research: Insights, applications, and future directions 干细胞研究中的电阻抗传感：见解、应用和未来方向。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-11-16 DOI: 10.1016/j.pbiomolbio.2024.11.004

Hassan Moghtaderi , Saeed Mohahammadi , Golfam Sadeghian , Mahua Choudhury , Ahmed Al-Harrasi , Shaikh Mizanoor Rahman

{"title":"Electrical impedance sensing in stem cell research: Insights, applications, and future directions","authors":"Hassan Moghtaderi , Saeed Mohahammadi , Golfam Sadeghian , Mahua Choudhury , Ahmed Al-Harrasi , Shaikh Mizanoor Rahman","doi":"10.1016/j.pbiomolbio.2024.11.004","DOIUrl":"10.1016/j.pbiomolbio.2024.11.004","url":null,"abstract":"<div><div>The exceptional differentiation abilities of stem cells make them ideal candidates for cell replacement therapies. Considering their great potential, researchers should understand how stem cells interact with other cell types. The production of high-quality differentiated cells is crucial for favorable treatment and makes them an ideal choice for clinical applications. Label-free stem cell monitoring approaches are anticipated to be more effective in this context, as they ensure quality of differentiation while preserving the therapeutic potential. Electric cell-substrate impedance sensing (ECIS) is a nonintrusive technique that enables cell quantification through continuous monitoring of adherent cell behavior using electronic transcellular impedance measurements. This technique also facilitates the study of cell growth, motility, differentiation, drug effects, and cell barrier functions. Therefore, numerous studies have identified ECIS as an effective method for monitoring stem cell quality and differentiation. In this review, we discuss the current understanding of ECIS's achievements in examining cell behaviors and the potential applications of ECIS arrays in preclinical stem cell research. Moreover, we highlight our present knowledge concerning ECIS's contributions in examining cell behaviors and speculate about the future uses of ECIS arrays in preclinical stem cell research. This review also aims to stimulate research on electrochemical biosensors for future applications in regenerative medicine.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"195 ","pages":"Pages 1-14"},"PeriodicalIF":3.2,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A physical perspective on lithium therapy 从物理角度看锂疗法

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-11-14 DOI: 10.1016/j.pbiomolbio.2024.11.002

Dana Kamp

{"title":"A physical perspective on lithium therapy","authors":"Dana Kamp","doi":"10.1016/j.pbiomolbio.2024.11.002","DOIUrl":"10.1016/j.pbiomolbio.2024.11.002","url":null,"abstract":"<div><div>Lithium salts have strong medical properties in neurological disorders such as bipolar disorder and lithium-responsive headaches. They have recently gathered attention due to their potential preventive effect in viral infections. Though the therapeutic effect of lithium was documented by Cade in the late 1940s, its underlying mechanism of action is still disputed. Acute lithium exposure has an activating effect on excitable organic tissue and organisms, and is highly toxic. Lithium exposure is associated with a strong metabolic response in the organism, with large changes in phospholipid and cholesterol expression. Opposite to acute exposure, this metabolic response alleviates excessive cellular activity. The presence of lithium ions strongly affects lipid conformation and membrane phase unlike other alkali ions, with consequences for membrane permeability, buffer property and excitability. This review investigates how lithium ions affect lipid membrane composition and function, and how lithium response might in fact be the body’s attempt to counteract the physical presence of lithium ions at cell level. Ideas for further research in microbiology and drug development are discussed.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"194 ","pages":"Pages 55-74"},"PeriodicalIF":3.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measurement methods, influencing factors and applications of intercellular receptor-ligand binding kinetics in diseases 细胞间受体-配体结合动力学在疾病中的测量方法、影响因素和应用。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-11-02 DOI: 10.1016/j.pbiomolbio.2024.11.001

Qian Wu, Liangchao Li, Yuyan Zhang, Xiaozhi Ming, Nianjie Feng

{"title":"Measurement methods, influencing factors and applications of intercellular receptor-ligand binding kinetics in diseases","authors":"Qian Wu, Liangchao Li, Yuyan Zhang, Xiaozhi Ming, Nianjie Feng","doi":"10.1016/j.pbiomolbio.2024.11.001","DOIUrl":"10.1016/j.pbiomolbio.2024.11.001","url":null,"abstract":"<div><div>Receptor-ligand binding on contacting cells dictates the extent of transmembrane signaling through membrane receptors during cell communication, influencing both the physiological and pathological activities of cells. This process is integral to fundamental biological mechanisms including signal transduction, cancer metastasis, immune responses, and inflammatory cascades, all of which are profoundly influenced by the cell microenvironment. This article provides an overview of the kinetic theory of receptor-ligand binding and examines methods for measuring this interaction, along with their respective advantages and disadvantages. Furthermore, it comprehensively explores the factors that impact receptor-ligand binding, encompassing protein-membrane interactions, the bioelectric microenvironment, auxiliary factors, hydrogen bond strength, pH levels, cis and trans interactions between ligands and receptors. The application of receptor-ligand binding kinetics in various diseases such as immunity, cancer, and inflammation are also discussed. Additionally, the investigation into how functional substances alter receptor-ligand binding dynamics within specific cellular microenvironments presents a promising new approach to treating related diseases.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"194 ","pages":"Pages 43-54"},"PeriodicalIF":3.2,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

m6A methylation regulators and ncRNAs in osteosarcoma: Potential therapeutic strategies 骨肉瘤中的 m6A 甲基化调节因子和 ncRNA：潜在的治疗策略

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-10-25 DOI: 10.1016/j.pbiomolbio.2024.10.003

Ce Shi , Lei Chen , Kui Huang , Guanghui Yang , Tingting Shi , Jinshuang Li , Hongbing Zheng

{"title":"m6A methylation regulators and ncRNAs in osteosarcoma: Potential therapeutic strategies","authors":"Ce Shi , Lei Chen , Kui Huang , Guanghui Yang , Tingting Shi , Jinshuang Li , Hongbing Zheng","doi":"10.1016/j.pbiomolbio.2024.10.003","DOIUrl":"10.1016/j.pbiomolbio.2024.10.003","url":null,"abstract":"<div><div>Osteosarcoma (OS) represents the primary form of bone cancer observed in paediatric and adolescent populations. Nearly 10%–15% of patients have metastases at diagnosis, and the 5-year survival rate was less than 20%. Although numerous investigators have offered significant efforts, the survival rates for patients with OS have remained almost unchanged over the past three decades. The most pervasive and abundant modification of internal transcripts in eukaryotic messenger RNAs (mRNAs) is N6-methyladenosine (m6A), and it is regulated by m6A methylation regulators. A number of recent studies have demonstrated that m6A modifications can regulate the biological activities of tumour cells and are intimately linked with cancer development, prognosis, drug resistance, and therapy. N6-methyladenosine modification of Non-coding RNA (ncRNA) has likewise shown a broad potential in gene regulation and tumor biology. Epigenetic changes induced by mRNAs and ncRNAs methylation are important for a better understanding of OS development and targeted drug development. Therefore, this paper summarises the biological functions of m6A-modified regulators in osteosarcoma and the role of mutual regulation between m6A and ncRNAs in osteosarcoma. Furthermore, the potential clinical applications of m6A modifications in OS are presented for consideration. It provides new directions for the future research and clinical treatment strategies of osteosarcoma.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"194 ","pages":"Pages 34-42"},"PeriodicalIF":3.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0