Progress in Biophysics & Molecular Biology最新文献_第4页

Diagnostic use of circulating cells and sub-cellular bio-particles 循环细胞和亚细胞生物颗粒的诊断用途。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-08-17 DOI: 10.1016/j.pbiomolbio.2024.08.002

Atakan Tevlek

{"title":"Diagnostic use of circulating cells and sub-cellular bio-particles","authors":"Atakan Tevlek","doi":"10.1016/j.pbiomolbio.2024.08.002","DOIUrl":"10.1016/j.pbiomolbio.2024.08.002","url":null,"abstract":"<div><p>In the bloodstream or other physiological fluids, \"circulating cells and sub-cellular bio-particles\" include many microscopic biological elements such as circulating tumor cells (CTCs), cell-free DNA (cfDNA), exosomes, microRNAs, platelets, immune cells, and proteins are the most well-known and investigated. These structures are crucial biomarkers in healthcare and medical research for the early detection of cancer and other disorders, enabling treatment to commence before the onset of clinical symptoms and enhancing the efficacy of treatments. As the size of these biomarkers to be detected decreases and their numbers in body fluids diminishes, the detection materials, ranging from visual inspection to advanced microscopy techniques, begin to become smaller, more sensitive, faster, and more effective, thanks to developing nanotechnology. This review first defines the circulating cells and subcellular bio-particles with their biological, physical, and mechanical properties and second focuses on their diagnostic importance, including their most recent applications as biomarkers, the biosensors that are utilized to detect them, the present obstacles that must be surmounted, and prospective developments in the domain. As technology advances and biomolecular pathways are deepens, diagnostic tests will become more sensitive, specific, and thorough. Finally, integrating recent advances in the diagnostic use of circulating cells and bioparticles into clinical practice is promising for precision medicine and patient outcomes.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"192 ","pages":"Pages 19-36"},"PeriodicalIF":3.2,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological evolution is dead in the water of Darwin's warm little pond 生物进化在达尔文温暖的小池塘里已经死了。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-08-15 DOI: 10.1016/j.pbiomolbio.2024.08.003

Olen R. Brown , David A. Hullender

{"title":"Biological evolution is dead in the water of Darwin's warm little pond","authors":"Olen R. Brown , David A. Hullender","doi":"10.1016/j.pbiomolbio.2024.08.003","DOIUrl":"10.1016/j.pbiomolbio.2024.08.003","url":null,"abstract":"<div><p>The origin of life and its evolution are generally taught as occurring by abiogenesis and gene-centric neo-Darwinism. Significant biological evolutionary changes are preserved and given direction (descent with modification) by Darwin's (Spencer's) natural selection by survival of the fittest. Only survival of the fittest (adapted/broadened) is available to provide a ‘naturalistic’ direction to prefer one outcome/reaction over another for abiogenesis. Thus, assembly of first life must reach some threshold (the first minimal cell) before ‘survival of the fittest’ (the only naturalistic explanation available) can function as Darwin proposed for biological change. We propose the novel concept that the requirement for co-origination of vitamins with enzymes is a fundamental, but overlooked, problem that survival of the fittest (even broadly redefined beyond Darwin) cannot reasonably overcome. We support this conclusion with probability calculations. We focus on the stage of evolution involving the transition from non-life to the first, minimal living cell. We show that co-origination of required biochemical processes makes the origin of life probabilistically absurdly improbable even when all assumptions are chosen to unreasonably favor evolutionary theories.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"193 ","pages":"Pages 1-6"},"PeriodicalIF":3.2,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in the study of glucose metabolism in relation to tumor progression and treatment 葡萄糖代谢与肿瘤进展和治疗的关系研究取得进展。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-08-05 DOI: 10.1016/j.pbiomolbio.2024.08.001

Meng Zhao , Yu-long Chen , Lian-He Yang

{"title":"Advancements in the study of glucose metabolism in relation to tumor progression and treatment","authors":"Meng Zhao , Yu-long Chen , Lian-He Yang","doi":"10.1016/j.pbiomolbio.2024.08.001","DOIUrl":"10.1016/j.pbiomolbio.2024.08.001","url":null,"abstract":"<div><p>Sugar serves as the primary energy source for mammals, with glucose metabolism facilitating energy acquisition in human cells. The proper functioning of intracellular glucose metabolism is essential for the maintenance of orderly and healthy physiological activities. Tumor cells, characterized by uncontrolled growth, exhibit dysregulated proliferation and apoptosis processes, leading to abnormal alterations in glucose metabolism. Specifically, tumor cells exhibit a shift towards aerobic glycolysis, resulting in the production of lactic acid that can be utilized as a metabolic intermediate for sustained tumor cell growth. This article provides a comprehensive overview of the enzymes involved in glucose metabolism and the alterations in gene expression that occur during tumor progression. It also examines the current research on targeting abnormal glucose metabolism processes for tumor treatment and discusses potential future directions for utilizing glucose metabolism as a therapeutic target.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"192 ","pages":"Pages 11-18"},"PeriodicalIF":3.2,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0079610724000762/pdfft?md5=50cba58d49676ad569320a7cbef073d5&pid=1-s2.0-S0079610724000762-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angio-microRNAs in diabetic foot ulcer-: Mechanistic insights and clinical perspectives 糖尿病足溃疡中的血管微核糖核酸：机理认识与临床展望。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-07-27 DOI: 10.1016/j.pbiomolbio.2024.07.006

Mohammad Hasan Soheilifar , Nastaran Masoudi-Khoram , Mahmoud Hassani , Amirhossein Hajialiasgary Najafabadi , Mahdieh Khojasteh , Hoda Keshmiri Neghab , Zahra Jalili

引用次数: 0

Symbiogenesis redicts the monism of the cosmos 共生重新揭示了宇宙一元论。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-07-06 DOI: 10.1016/j.pbiomolbio.2024.07.004

John S. Torday

{"title":"Symbiogenesis redicts the monism of the cosmos","authors":"John S. Torday","doi":"10.1016/j.pbiomolbio.2024.07.004","DOIUrl":"10.1016/j.pbiomolbio.2024.07.004","url":null,"abstract":"<div><p>Symbiogenesis has been systematically exploited to understand consciousness as the aggregate of our physiology. The Symbiogenic mechanism for assimilation of factors in the environment formulates the continuum from inside the cell to the Cosmos, both consciousness and cosmology complying with the Laws of Nature. Since Symbiogenesis is ‘constructive’, whereas eliminating what threatens us is ‘destructive’, why do we largely practice Symbiogenesis? Hypothetically, Symbiogenesis recursively simulates the monism of our origin, recognizing ‘something bigger than ourselves’. That perspective explains many heretofore unexplained aspects of consciousness, such as mind, epigenetic inheritance, physiology, behaviors, social systems, mathematics, the Arts, from an <em>a priori</em> perspective. Moreover, there is an energetic continuum from Newtonian to Quantum Mechanics, opening up to a novel way of understanding the ‘true nature of our being’, not as ‘materialism’, but instead being the serial homeostatic control of energy. The latter is consistent with the spirit of Claude Bernard and Walter B. Cannon's perspectives on physiology. Such a paradigm shift is overdue, given that materialism is causing the destruction of the Earth and ourselves.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"191 ","pages":"Pages 58-62"},"PeriodicalIF":3.2,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioelectric pharmacology of cancer: A systematic review of ion channel drugs affecting the cancer phenotype 癌症生物电药理学》：影响癌症表型的离子通道药物系统综述》。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-07-05 DOI: 10.1016/j.pbiomolbio.2024.07.005

Karina Kofman , Michael Levin

{"title":"Bioelectric pharmacology of cancer: A systematic review of ion channel drugs affecting the cancer phenotype","authors":"Karina Kofman , Michael Levin","doi":"10.1016/j.pbiomolbio.2024.07.005","DOIUrl":"10.1016/j.pbiomolbio.2024.07.005","url":null,"abstract":"<div><p>Cancer is a pernicious and pressing medical problem; moreover, it is a failure of multicellular morphogenesis that sheds much light on evolutionary developmental biology. Numerous classes of pharmacological agents have been considered as cancer therapeutics and evaluated as potential carcinogenic agents; however, these are spread throughout the primary literature. Here, we briefly review recent work on ion channel drugs as promising anti-cancer treatments and present a systematic review of the known cancer-relevant effects of 109 drugs targeting ion channels. The roles of ion channels in cancer are consistent with the importance of bioelectrical parameters in cell regulation and with the functions of bioelectric signaling in morphogenetic signals that act as cancer suppressors. We find that compounds that are well-known for having targets in the nervous system, such as voltage-gated ion channels, ligand-gated ion channels, proton pumps, and gap junctions are especially relevant to cancer. Our review suggests further opportunities for the repurposing of numerous promising candidates in the field of cancer electroceuticals.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"191 ","pages":"Pages 25-39"},"PeriodicalIF":3.2,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Major evolutionary transitions before cells: A journey from molecules to organisms 细胞之前的重大进化转变：从分子到生物的旅程。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-07-05 DOI: 10.1016/j.pbiomolbio.2024.07.002

Francisco Prosdocimi , Sávio Torres de Farias

{"title":"Major evolutionary transitions before cells: A journey from molecules to organisms","authors":"Francisco Prosdocimi , Sávio Torres de Farias","doi":"10.1016/j.pbiomolbio.2024.07.002","DOIUrl":"10.1016/j.pbiomolbio.2024.07.002","url":null,"abstract":"<div><p>Basing on logical assumptions and necessary steps of complexification along biological evolution, we propose here an evolutionary path from molecules to cells presenting four ages and three major transitions. At the first age, the basic biomolecules were formed and become abundant. The first transition happened with the event of a chemical symbiosis between nucleic acids and peptides worlds, which marked the emergence of both life and the process of organic encoding. FUCA, the first living process, was composed of self-replicating RNAs linked to amino acids and capable to catalyze their binding. The second transition, from the age of FUCA to the age of progenotes, involved the duplication and recombination of proto-genomes, leading to specialization in protein production and the exploration of protein to metabolite interactions in the prebiotic soup. Enzymes and metabolic pathways were incorporated into biology from protobiotic reactions that occurred without chemical catalysts, step by step. Then, the fourth age brought origin of organisms and lineages, occurring when specific proteins capable to stackle together facilitated the formation of peptidic capsids. LUCA was constituted as a progenote capable to operate the basic metabolic functions of a cell, but still unable to interact with lipid molecules. We present evidence that the evolution of lipid interaction pathways occurred at least twice, with the development of bacterial-like and archaeal-like membranes. Also, data in literature suggest at least two paths for the emergence of DNA biosynthesis, allowing the stabilization of early life strategies in viruses, archaeas and bacterias. Two billion years later, the eukaryotes arouse, and after 1,5 billion years of evolution, they finally learn how to evolve multicellularity via tissue specialization.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"191 ","pages":"Pages 11-24"},"PeriodicalIF":3.2,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the regulatory role of tsRNAs in the TNF signaling pathway: Implications for cancer and non-cancer diseases 探索 tsRNA 在 TNF 信号通路中的调控作用：对癌症和非癌症疾病的影响。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-07-04 DOI: 10.1016/j.pbiomolbio.2024.07.003

Qurui Wang , Qinyuan Huang , Xiaowei Ying , Yang Zhou , Shiwei Duan

{"title":"Exploring the regulatory role of tsRNAs in the TNF signaling pathway: Implications for cancer and non-cancer diseases","authors":"Qurui Wang , Qinyuan Huang , Xiaowei Ying , Yang Zhou , Shiwei Duan","doi":"10.1016/j.pbiomolbio.2024.07.003","DOIUrl":"10.1016/j.pbiomolbio.2024.07.003","url":null,"abstract":"<div><p>Transfer RNA-derived small RNAs (tsRNAs), a recently identified subclass of small non-coding RNAs (sncRNAs), emerge through the cleavage of mature transfer RNA (tRNA) or tRNA precursors mediated by specific enzymes. The tumor necrosis factor (TNF) protein, a signaling molecule produced by activated macrophages, plays a pivotal role in systemic inflammation. Its multifaceted functions include the capacity to eliminate or hinder tumor cells, enhance the phagocytic capabilities of neutrophils, confer resistance against infections, induce fever, and prompt the production of acute phase proteins. Notably, four TNF-related tsRNAs have been conclusively linked to distinct diseases. Examples include 5′tiRNA-Gly in skeletal muscle injury, tsRNA-21109 in systemic lupus erythematosus (SLE), tRF-Leu-AAG-001 in endometriosis (EMs), and tsRNA-04002 in intervertebral disk degeneration (IDD). These tsRNAs exhibit the ability to suppress the expression of TNF-α. Additionally, KEGG analysis has identified seven tsRNAs potentially involved in modulating the TNF pathway, exerting their influence across a spectrum of non-cancerous diseases. Noteworthy instances include aberrant tiRNA-Ser-TGA-001 and tRF-Val-AAC-034 in intrauterine growth restriction (IUGR), irregular tRF-Ala-AGC-052 and tRF-Ala-TGC-027 in obesity, and deviant tiRNA-His-GTG-001, tRF-Ser-GCT-113, and tRF-Gln-TTG-035 in irritable bowel syndrome with diarrhea (IBS-D). This comprehensive review explores the biological functions and mechanisms of tsRNAs associated with the TNF signaling pathway in both cancer and other diseases, offering novel insights for future translational medical research.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"191 ","pages":"Pages 1-10"},"PeriodicalIF":3.2,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein folding, cellular stress and cancer 蛋白质折叠、细胞压力和癌症。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-07-03 DOI: 10.1016/j.pbiomolbio.2024.07.001

Armando Aranda-Anzaldo, Myrna A.R. Dent, Edith Segura-Anaya, Alejandro Martínez-Gómez

{"title":"Protein folding, cellular stress and cancer","authors":"Armando Aranda-Anzaldo, Myrna A.R. Dent, Edith Segura-Anaya, Alejandro Martínez-Gómez","doi":"10.1016/j.pbiomolbio.2024.07.001","DOIUrl":"10.1016/j.pbiomolbio.2024.07.001","url":null,"abstract":"<div><p>Proteins are acknowledged as the phenotypical manifestation of the genotype, because protein-coding genes carry the information for the strings of amino acids that constitute the proteins. It is widely accepted that protein function depends on the corresponding “native” structure or folding achieved within the cell, and that native protein folding corresponds to the lowest free energy minimum for a given protein. However, protein folding within the cell is a non-deterministic dissipative process that from the same input may produce different outcomes, thus conformational heterogeneity of folded proteins is the rule and not the exception. Local changes in the intracellular environment promote variation in protein folding. Hence protein folding requires “supervision” by a host of chaperones and co-chaperones that help their client proteins to achieve the folding that is most stable according to the local environment. Such environmental influence on protein folding is continuously transduced with the help of the cellular stress responses (CSRs) and this may lead to changes in the rules of engagement between proteins, so that the corresponding protein interactome could be modified by the environment leading to an alternative cellular phenotype. This allows for a phenotypic plasticity useful for adapting to sudden and/or transient environmental changes at the cellular level. Starting from this perspective, hereunder we develop the argument that the presence of sustained cellular stress coupled to efficient CSRs may lead to the selection of an aberrant phenotype as the resulting adaptation of the cellular proteome (and the corresponding interactome) to such stressful conditions, and this can be a common epigenetic pathway to cancer.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"191 ","pages":"Pages 40-57"},"PeriodicalIF":3.2,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Appreciation of Sir Tom Blundell 汤姆-布伦德尔爵士赏析。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-05-31 DOI: 10.1016/j.pbiomolbio.2024.05.004

Denis Noble (Editor in Chief), Delphine Dean (Editor in Chief)

引用次数: 0