Progress in Neuro-Psychopharmacology & Biological Psychiatry最新文献

{"title":"Sex-specific metabolic and inflammatory alterations in adult animals vulnerable to prenatal stress exposure","authors":"Ilari D'Aprile ,&nbsp;Giulia Petrillo ,&nbsp;Valentina Zonca ,&nbsp;Monica Mazzelli ,&nbsp;Floriana De Cillis ,&nbsp;Maria Grazia Di Benedetto ,&nbsp;Marco Andrea Riva ,&nbsp;Annamaria Cattaneo","doi":"10.1016/j.pnpbp.2025.111344","DOIUrl":"10.1016/j.pnpbp.2025.111344","url":null,"abstract":"<div><div>Early life stress (ELS) is a significant risk factor for the development of mood and metabolic disorders later in life, which are often in comorbidity. Although it is well known that not all the exposed individuals develop these conditions, the mechanisms leading to a vulnerable or a resilient phenotype for mood and metabolic disorders, as consequences of ELS exposure, are still not fully understood. In this study, we used a prenatal stress (PNS) model, mimicking perinatal adversities, to investigate the impact of ELS on metabolic function, stress-related and inflammatory markers in adult male and female offspring, with a particular focus on vulnerable or resilient phenotypes. PNS exposure was associated with a dysregulation of stress-related and metabolic markers both in the liver and also in the ventral hippocampus, with vulnerable males exhibiting increased insulin receptor levels and dysregulated expression of adipokine receptors (such as leptin and adiponectin). In contrast, female animals did not exhibit these changes. Additionally, PNS induced a pronounced neuroinflammatory response in the ventral hippocampus of vulnerable male rats, characterized by an upregulation of microglial activation markers. Interestingly, a similar pro-inflammatory status was observed in the liver of PNS-exposed males regardless of the pathologic phenotype; however, anti-inflammatory markers were upregulated only in resilient animals, suggesting an active mechanism of resilience. These findings suggest that specific metabolic and inflammatory changes underlie, with a sex-specific effect, the onset of a vulnerable phenotype to PNS and highlight the importance of targeting these pathways in the treatment of mood disorders and metabolic comorbidities.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"138 ","pages":"Article 111344"},"PeriodicalIF":5.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kynurenine amplifies tetrahydrocannabinol-induced sensorimotor impairment and classic “tetrad” effects in mice","authors":"Sabrine Bilel ,&nbsp;Giorgia Corli ,&nbsp;Edoardo Tiziani ,&nbsp;Daniele Chirenti ,&nbsp;Stefano Dall'Acqua ,&nbsp;Stefano Comai ,&nbsp;Luca Ferraro ,&nbsp;Matteo Marti ,&nbsp;Sarah Beggiato","doi":"10.1016/j.pnpbp.2025.111342","DOIUrl":"10.1016/j.pnpbp.2025.111342","url":null,"abstract":"<div><h3>Background</h3><div>L-kynurenine (KYN), a kynurenine pathway (KP) metabolite, is the main precursor for the neuroactive metabolite kynurenic acid (KYNA). Several studies suggest a patho-physiologically relevant association between increased brain KYNA levels and cognitive dysfunctions in individuals with schizophrenia. Δ⁹-tetrahydrocannabinol (Δ⁹-THC; <em>i.e.</em> the main psychoactive compound of cannabis) can worse schizophrenia-related psychosis, often leads to the development of cannabis use disorder in individuals with schizophrenia, and increases the risk of earlier onset of schizophrenia symptoms in those with a genetic predisposition. A role of KP alterations and, specifically, increased brain KYNA levels in Δ⁹-THC-induced psychotic symptoms has been previously proposed. The aim of the study was to investigate on the possible involvement of KP alterations in Δ⁹-THC-induced sensorimotor and “tetrad” responses in mice.</div></div><div><h3>Methods</h3><div>Adult male CD-1 mice were treated with Δ⁹-THC (30 mg/ kg; i.p.) and KYN (20 mg/kg; i.p.), alone or in combination, and body temperature, acute mechanical and thermal analgesia, motor activity and sensorimotor responses were evaluated. Furthermore, brain KYNA levels as well as plasma Δ⁹-THC and its metabolites concentrations after the treatments were also evaluated.</div></div><div><h3>Results</h3><div>Brain KYNA levels were significantly increased 1 h, but not 4 h, after KYN and KYN + Δ⁹-THC administration. KYN administration amplified the Δ⁹-THC-induced impairment of sensorimotor responses (visual placing, acoustic and tactile responses). Furthermore, KYN significantly increased Δ⁹-THC-induced motor activity impairment (bar test, drag test and rotarod test) and hypothermia (core and surface body temperature), but not Δ⁹-THC-induced analgesia. Finally, 1 h after Δ⁹-THC administration, Δ⁹-THC and its psychoactive metabolite 11-OH-THC plasma levels were higher in mice pretreated with KYN than in control mice.</div></div><div><h3>Conclusions</h3><div>The present data indicate for the first time that KYN amplifies the THC-induced sensorimotor impairment and classic “tetrad” response possibly through a pharmacokinetic interaction.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"138 ","pages":"Article 111342"},"PeriodicalIF":5.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neochlorogenic acid ameliorates Alzheimer's disease-like pathology via scavenging oxidative stress and restoring blood-brain barrier function in zebrafish","authors":"Li Gao ,&nbsp;Baokun Wang ,&nbsp;Xiaotong Cui ,&nbsp;Lijie Xia ,&nbsp;Xinjia Li ,&nbsp;Yanier Nuñez Figueredo ,&nbsp;Dong Li ,&nbsp;Kechun Liu ,&nbsp;Haitao Wang ,&nbsp;Meng Jin","doi":"10.1016/j.pnpbp.2025.111334","DOIUrl":"10.1016/j.pnpbp.2025.111334","url":null,"abstract":"<div><div>Alzheimer's disease is the most widespread neurodegenerative disease characterized by insidious onset and slow progression. At present, most available medications serve to attenuate the progression of Alzheimer's disease with side effects and drug resistance. Neochlorogenic acid is a natural polyphenolic compound with excellent antioxidant properties. Based on zebrafish Alzheimer's disease model induced by AlCl₃, we found that neochlorogenic acid significantly improved motor dysfunction, reduced brain cell apoptosis, and Aβ plaque. Because of antioxidant stress and improvement of blood-brain barrier dysfunction are important in treating Alzheimer's disease, we explored the interaction between these two mechanisms in alleviating the pathological course of Alzheimer's disease. Neochlorogenic acid inhibited the overproduction of reactive oxygen species, suppressed the gene expression encoding antioxidant-related proteins, and protected brain cell integrity while enhancing Nrf2, improving blood-brain barrier nerve resilience. Meanwhile, neochlorogenic acid attenuated blood-brain barrier dysfunction in Alzheimer's disease zebrafish by reducing blood hemoglobin leakage and upregulating the gene expression encoding blood-brain barrier endothelial cell-related proteins, resulting in reactive oxygen species in a controllable state. In conclusion, our research suggests that neochlorogenic acid ameliorates Alzheimer's disease-like pathology by inhibiting oxidative stress and restoring blood-brain barrier function, indicating that neochlorogenic acid may be a potential drug for treating Alzheimer's disease.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"138 ","pages":"Article 111334"},"PeriodicalIF":5.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoustic biomarkers for schizophrenia spectrum disorders and their associations with symptoms and cognitive functioning","authors":"Kangwook Jang ,&nbsp;Ling Li ,&nbsp;Thi-Hung Le ,&nbsp;Ariana Setiani ,&nbsp;Fatima Zahra Rami ,&nbsp;Hoirin Kim ,&nbsp;Young Chul Chung","doi":"10.1016/j.pnpbp.2025.111339","DOIUrl":"10.1016/j.pnpbp.2025.111339","url":null,"abstract":"<div><h3>Backgrounds</h3><div>Acoustic biomarkers for schizophrenia spectrum disorders (SSDs) hold great promise due to their capacity to capture emotional information, which is often impaired in these patients. These biomarkers are easily accessible, noninvasive, objective, and cost-effective. This study investigated the accuracy of different machine learning (ML) models in classifying patients with SSDs or schizophrenia (SZ) versus healthy controls (HCs), as well as patients with cognitive-deficit (Cog-D) versus cognitive-non-deficit (Cog-ND) versus HCs. Additionally, correlations of the top 25 features contributing to these classifications with psychopathology and cognitive functioning were explored.</div></div><div><h3>Methods</h3><div>Speech data were collected from patients with SSDs (<em>n</em> = 238) and HCs (<em>n</em> = 157) using multiple tasks, including the reading of emotional sentences. The Extrapyramidal Symptom Rating Scale (ESRS) was used to control for potential medication effects on speech. Acoustic features were extracted using the openSMILE toolkit, and models were trained with 10-fold cross-validation. Partial correlation analysis, adjusted for ESRS and chlorpromazine (CPZ) equivalent, was conducted between the top 25 features and measures of psychopathology and cognitive functioning.</div></div><div><h3>Results</h3><div>Among the five ML models, accuracy of support vector machine (SVM) model was the best. It classified SSDs versus HCs with 83 % accuracy when using all 7 tasks, and 85 % when using only the happy sentences task. The SVM classification accuracy for Cog-D versus Cog-ND within SSDs was poor across all tasks; however, the accuracy for Cog-D versus HCs was 79 % when using free speech or happy sentences. The accuracy for classifying SZ versus HCs and Cog-D versus Cog-ND versus HCs exhibited variations. Several of the top 25 acoustic features correlated significantly with attention and verbal memory in patients with SSDs.</div></div><div><h3>Conclusions</h3><div>Our findings suggested that acoustic analysis, combined with a ML approach, could be used to classify successfully SSDs or the Cog-D subtype versus HCs. Features related to pitch, loudness, and timbre were particularly associated with attention in patients with SSDs. Future research should explore further the potential applications of acoustic biomarkers in multi-class classification, treatment response, and relapse detection in patients with SSDs.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"138 ","pages":"Article 111339"},"PeriodicalIF":5.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioenergetic markers in cerebrospinal fluid in first-episode psychosis: Are they predictors of early antipsychotic response and 1-year outcomes?","authors":"Eloi Giné-Servén ,&nbsp;Ester Boix-Quintana ,&nbsp;Alejandro Ballesteros ,&nbsp;Eva Daví-Loscos ,&nbsp;Nicolau Guanyabens ,&nbsp;Virginia Casado ,&nbsp;María Martínez-Ramírez ,&nbsp;Benedicto Crespo-Facorro ,&nbsp;Manuel J. Cuesta ,&nbsp;Javier Labad","doi":"10.1016/j.pnpbp.2025.111336","DOIUrl":"10.1016/j.pnpbp.2025.111336","url":null,"abstract":"<div><div>Psychotic disorders involve complex pathophysiological mechanisms, and identification of biomarkers for treatment response remains a major challenge. We aimed to study whether routine cerebrospinal fluid (CSF) parameters measured at baseline predict poor early response at 2 weeks with optimal antipsychotic treatment doses in patients with first-episode psychosis (FEP). We also explored whether these parameters could predict changes in social functioning and psychopathology over a 1-year follow-up. Ninety-eight inpatients with FEP who had received less than 6 weeks of antipsychotic treatment were included in the study. A lumbar puncture was performed at the index admission to measure CSF parameters (glucose, total protein, and lactate dehydrogenase [LDH]). The Positive and Negative Syndrome Scale (PANSS) was administered. A poor early treatment response at week 2 was defined as a &lt; 20 % reduction in the PANSS positive subscore of a consensus factor. Social functioning was assessed using the Personal and Social Performance Scale (PSP) at baseline and 2, 4, 6, 9, and 12 months. Statistical analyses explored the role of CSF biomarkers in early treatment response using logistic regression and long-term social functioning and psychopathology using mixed linear regression analyses. Eighteen patients with FEP (18.4 %) were nonresponders at week 2. The CSF LDH concentration was a predictor of early treatment nonresponse. Higher CSF LDH concentrations were associated with a reduced improvement in social functioning at month 2, and higher CSF glucose concentrations were associated with lower reductions in the PANSS total scores at all visits. These findings suggest that specific bioenergetic parameters in the CSF, such as LDH and glucose, may serve as prognostic biomarkers for early treatment response and 1-year social and psychopathological outcomes in patients with FEP.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"138 ","pages":"Article 111336"},"PeriodicalIF":5.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-dependent effects of stress on aIC-NAc circuit neuroplasticity: Role of the endocannabinoid system","authors":"Manon Gauthier ,&nbsp;Léo-Paul Hebert ,&nbsp;Emilie Dugast ,&nbsp;Virginie Lardeux ,&nbsp;Kevin Letort ,&nbsp;Nathalie Thiriet ,&nbsp;Laure Belnoue ,&nbsp;Eric Balado ,&nbsp;Marcello Solinas ,&nbsp;Pauline Belujon","doi":"10.1016/j.pnpbp.2025.111335","DOIUrl":"10.1016/j.pnpbp.2025.111335","url":null,"abstract":"<div><div>Stress is a major risk factor for psychiatric disorders and affects neuroplasticity in brain areas like the nucleus accumbens core (NAcC) and the insular cortex (IC). This study examined neuroplasticity changes in the aIC-NAcC circuit after restraint stress in male and female rats, and explored the role of the endocannabinoid system.</div><div>Male and female rats underwent 2 h of acute restraint stress. Behavioral tests and <em>in vivo</em> electrophysiological recordings were performed immediately and 24 h after stress exposure. cFos was performed immediately after stress. Since stress effects were observed only in males, we evaluated the systemic and intra-NAc blockade of CB1 receptors in male rats.</div><div>We found increased c-Fos expression in the hypothalamus but not in the IC in both sexes after acute restraint stress, along with heightened anxiety and reduced exploratory behavior. Males and females exhibited different neuronal plasticity in the aIC-NAcC pathway. Under basal conditions, males showed equal proportions of long-term potentiation (LTP) and long-term depression (LTD), whereas females predominantly exhibited LTP. Stress disrupted synaptic plasticity in males by eliminating LTD in the aIC-NAcC pathway 24 h after exposure. This effect was reversed by systemic and local CB1 receptor blockade.</div><div>These findings suggest that integration of aIC information into NAcC differs by sex, with stress-induced neuroplasticity changes occurring only in males, dependent on the endocannabinoid system. This study provides insight into sex differences in stress reactivity, which may relate to stress-related psychiatric disorders.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"138 ","pages":"Article 111335"},"PeriodicalIF":5.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurological soft signs and thyroid hormones in schizophrenia spectrum disorders","authors":"Michael Carl Treiber ,&nbsp;Eva-Maria Tsapakis ,&nbsp;Sophia Athanasiou ,&nbsp;Kostas Chovardas ,&nbsp;Theocharis Kyziridis ,&nbsp;Konstantinos N. Fountoulakis","doi":"10.1016/j.pnpbp.2025.111338","DOIUrl":"10.1016/j.pnpbp.2025.111338","url":null,"abstract":"<div><h3>Background</h3><div>Neurological soft signs (NSS) are minor sensory and motor deviations linked to neurodevelopmental disorders and schizophrenia spectrum disorders (SSD). Thyroid hormones (TH) are essential for neurodevelopment and are suggested to be altered in SSD. Yet, the relationship between NSS and TH is unclear.</div></div><div><h3>Objectives</h3><div>We evaluated the relationship between NSS and TH in individuals with SSD.</div></div><div><h3>Methods</h3><div>We examined a total of 72 individuals with SSD. We assessed NSS using the Neurological Evaluation Scale (NES) and clinical symptoms using the Positive and Negative Syndrome Scale (PANSS). We collected fasting blood samples to measure serum levels of thyroid-stimulating hormone (TSH), free thyroxine (fT4), and free triiodothyronine (fT3). We used the <em>t</em>-test to compare differences between sex and the Pearson correlation to test for correlations between NSS, TH and psychopathology separately for males and females.</div></div><div><h3>Results</h3><div>We observed a negative correlation between fT4 and NES total score (<em>r</em> = −0.374, <em>p</em> = .032), and NES subdomain “sensory integration” (<em>r</em> = −0.372, <em>p</em> = .033). The correlation between fT4 and “sensory integration” remained largely unchanged when controlling for age, DOI, and antipsychotic dose in OLZ equivalents by performing partial correlation analyses (<em>r</em> = −0.424, <em>p</em> = .049). Serum fT3 and TSH levels exhibited no significant correlation with NES scores but the PANSS negative symptoms score was negatively associated with fT3 (<em>r</em> = −0.472, <em>p</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>Lower fT4 levels were associated with NSS severity and specific NSS subdomains only in male individuals. In the overall sample, we detected a significant negative correlation between fT3 and negative symptoms. Future studies should examine a larger sample of drug-naïve individuals with SSDs, followed-up longitudinally in time to infer causality.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"138 ","pages":"Article 111338"},"PeriodicalIF":5.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of sex and complex PTSD comorbidity on pharmacological treatment response in bipolar disorder patients","authors":"Luca Steardo Jr. ,&nbsp;Michele Fornaro ,&nbsp;Martina D'Angelo ,&nbsp;Valeria Di Stefano ,&nbsp;Francesco Monaco ,&nbsp;Caterina Scuderi ,&nbsp;Luca Steardo ,&nbsp;Marta Valenza","doi":"10.1016/j.pnpbp.2025.111337","DOIUrl":"10.1016/j.pnpbp.2025.111337","url":null,"abstract":"<div><h3>Background</h3><div>The prevalence of bipolar disorder (BD) is similar in men and women. However, factors such as sex and comorbid psychiatric conditions can influence its clinical presentation and treatment outcomes, including complex PTSD (cPTSD), a newly categorized trauma-related condition. Little is known about how sex and cPTSD comorbidity affect the response to mood stabilizers, a cornerstone treatment for BD. This observational, cross-sectional study examines the impact of sex and cPTSD comorbidity on clinical and behavioral BD features as well as their interplay in influencing pharmacological treatment response.</div></div><div><h3>Methods</h3><div>A cohort of BD patients (females = 177, males = 166, age range: 19–76; BD-I = 253, BD-II = 90) was recruited over three years. Clinical assessments were conducted, and patients were administered the International Trauma Questionnaire to evaluate cPTSD comorbidity and the Alda Scale to assess response to mood stabilizers.</div></div><div><h3>Results</h3><div>Our results show distinct clinical profiles based on sex and cPTSD. Female BD patients exhibit more hypomanic episodes, antidepressant-induced mania, and longer periods of untreated illness than males. Comorbid cPTSD was diagnosed in 154 patients (44.8 %), among which 69 were females. Patients with cPTSD display more severe BD symptoms, including earlier onset, more frequent episodes, and a higher prevalence of psychosis and suicidality. Importantly, comorbid cPTSD was associated with poorer mood stabilizer response, particularly in males, who otherwise responded better to treatment than females.</div></div><div><h3>Conclusions</h3><div>These findings underscore the importance of addressing trauma symptoms in BD treatment and highlight the need for individualized approaches considering both sex and comorbid trauma, as standard mood stabilizers may be insufficient for certain subgroups.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"138 ","pages":"Article 111337"},"PeriodicalIF":5.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial patterns of individual morphological deformation in schizophrenia: Putative cortical compensatory of unaffected sibling","authors":"Pan Yunzhi ,&nbsp;Zhong Mingjun ,&nbsp;Chen Yuqing ,&nbsp;Han Lin ,&nbsp;Huang Weiqing ,&nbsp;Tan Wenjian ,&nbsp;Huang Danqing ,&nbsp;Yang Jun ,&nbsp;Cheng Yixing ,&nbsp;Chen Xudong","doi":"10.1016/j.pnpbp.2025.111329","DOIUrl":"10.1016/j.pnpbp.2025.111329","url":null,"abstract":"<div><h3>Background</h3><div>Neuroimaging advancements have revealed morphological deformation across various indicators, illuminating the neuropathological origins of schizophrenia. However, consolidating the findings across indicators and assessing regional global deformation at individual-level poses a significant challenge.</div></div><div><h3>Methods</h3><div>We propose individual morphological deformation index (IMDI) as potential biomarker for schizophrenia leveraging a distance algorithm that incorporates three key indicators (cortical thickness, gyrification, and volume), and applied it for 199 schizophrenia patients, 218 healthy controls, and 47 unaffected siblings. Additionally, we studied the relationships between polygenic risks, symptomology, cognition, social functioning and regional IMDI.</div></div><div><h3>Results</h3><div>Our findings reveal significantly higher IMDI in specific brain regions (bilateral pars opercularis, lateral orbitofrontal, left superior parietal, right pars orbitalis, and superior temporal) in patients, demonstrating two distinct spatial patterns linked to either isolated indicator reduction or concurrent declines across multiple indicators. Notably, unaffected siblings exhibited higher IMDI than controls, primarily due to cortical volume expansion in the right pars opercularis and superior temporal regions. Patients with higher IMDI had more severe positive symptoms, impaired cognition, reduced social functioning and selfcare ability. Participants with higher polygenic scores showed higher IMDI specifically in left caudal middle frontal regions.</div></div><div><h3>Conclusions</h3><div>The proposed IMDI biomarker offers an objective, interpretable way to quantify global regional deformation and integrate disparate neuroimaging indicators. Our results indicate that schizophrenia-related cortical deformations encompass sensorimotor, attention, default mode, and frontoparietal networks, exhibiting at least two spatial patterns. Moreover, siblings may exhibit compensation in cortical volume. These insights offer a novel perspective on the neuroanatomical underpinnings of schizophrenia.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"138 ","pages":"Article 111329"},"PeriodicalIF":5.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The underlying neurobiological basis of gray matter volume alterations in schizophrenia with auditory verbal hallucinations: A meta-analytic investigation","authors":"Yuanjun Xie ,&nbsp;Tian Zhang ,&nbsp;Chaozong Ma ,&nbsp;Muzhen Guan ,&nbsp;Chenxi Li ,&nbsp;Lingling Wang ,&nbsp;Xinxin Lin ,&nbsp;Yijun Li ,&nbsp;Zhongheng Wang ,&nbsp;Huaning Wang ,&nbsp;Peng Fang","doi":"10.1016/j.pnpbp.2025.111331","DOIUrl":"10.1016/j.pnpbp.2025.111331","url":null,"abstract":"<div><div>Schizophrenia patients with auditory verbal hallucinations (AVH) frequently exhibit brain structural alterations, particularly reductions in gray matter volume (GMV).Understanding the neurobiological mechanisms underlying the changes is essential for advancing treatment strategies. To address this, a meta-analysis was conducted to identify GMV changes in schizophrenia patients with AVH and their associations with gene expression and neurotransmitter receptor profiles. The results indicated significant GMV reductions in the left and the right insula, as well as the left anterior cingulate cortex. Ontology analysis of genes associated with GMV alternations revealed enrichment in biological processes related to ion transport and synaptic transmission. Hub genes from the KCN, SCN, GN, and PRK families, along with neurotransmitter receptors such as D2, VAChT, and mGluR5, showed significant correlations with GMV changes. Furthermore, multivariate linear regression analysis demonstrated that GNB2, GNB4, PRKCG, D2, and mGluR5 significantly predicted GMV alternations. These findings suggest that GMV reductions in schizophrenia with AVH are linked to disruptions in neurobiological processes involving specific genes and neurotransmitter systems, highlighting the potential targets for therapeutic intervention.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"138 ","pages":"Article 111331"},"PeriodicalIF":5.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}