Progress in Neuro-Psychopharmacology & Biological Psychiatry最新文献

{"title":"Sex-specific association between schizophrenia polygenic risk and subclinical schizophrenia-related traits","authors":"Patricia Mas-Bermejo ,&nbsp;Sergi Papiol ,&nbsp;Pilar Torrecilla ,&nbsp;Valeria Lavín ,&nbsp;Thomas R. Kwapil ,&nbsp;Neus Barrantes-Vidal ,&nbsp;Araceli Rosa","doi":"10.1016/j.pnpbp.2024.111161","DOIUrl":"10.1016/j.pnpbp.2024.111161","url":null,"abstract":"<div><h3>Background</h3><div>According to the dimensional view of psychiatric disorders, psychosis is expressed as a continuum in the general population. However, the investigation of the putative genetic aetiological continuity between its clinical and subclinical phenotypes has yielded mixed results. We aimed to replicate previous findings regarding the association of polygenic risk for schizophrenia with subclinical traits (i.e., schizotypy traits and psychotic-like experiences), and to examine the role of sex in this association in a large nonclinical sample.</div></div><div><h3>Methods</h3><div>The Multidimensional Schizotypy Scale and the Community Assessment of Psychic Experiences were assessed in 919 nonclinical participants. Polygenic Risk Scores for schizophrenia (SZ-PRSs) were computed using the PRS-CS method based on the latest genome-wide association study of schizophrenia. Summary statistics derived from the total GWAS sample and stratified by sex were used. Linear regression analyses tested the associations of the SZ-PRSs with the psychometric variables, both in the total sample and by sex.</div></div><div><h3>Results</h3><div>No associations were found between the SZ-PRSs and the positive, negative or disorganized dimensions of schizotypy in the total sample. Likewise, no associations were found with psychotic-like experiences. However, the sex-stratified analyses revealed a male-specific association with positive schizotypy. Similar results were obtained with the PRSs derived from the sex-stratified summary statistics.</div></div><div><h3>Discussion</h3><div>Our results are consistent with the lack of clear evidence of an association between SZ common genetic risk and its subclinical phenotypes. Nevertheless, the male-specific association found suggests that this PRS might explain better the male phenotype, as reported in previous studies. Future studies should put a focus on the role of sex in this association to unravel its sex specificities.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"136 ","pages":"Article 111161"},"PeriodicalIF":5.3,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aberrant individual large-scale functional network connectivity and topology in chronic insomnia disorder with and without depression","authors":"Meiling Chen ,&nbsp;Heng Shao ,&nbsp;Libo Wang ,&nbsp;Jianing Ma ,&nbsp;Jin Chen ,&nbsp;Junying Li ,&nbsp;Jingmei Zhong ,&nbsp;Baosheng Zhu ,&nbsp;Bin Bi ,&nbsp;Kexuan Chen ,&nbsp;Jiaojian Wang ,&nbsp;Liang Gong","doi":"10.1016/j.pnpbp.2024.111158","DOIUrl":"10.1016/j.pnpbp.2024.111158","url":null,"abstract":"<div><div>Insomnia is increasingly prevalent with significant associations with depression. Delineating specific neural circuits for chronic insomnia disorder (CID) with and without depressive symptoms is fundamental to develop precision diagnosis and treatment. In this study, we examine static, dynamic and network topology changes of individual large-scale functional network for CID with (CID-D) and without depression to reveal their specific neural underpinnings. Seventeen individual-specific functional brain networks are obtained using a regularized nonnegative matrix factorization technique. Disorders-shared and -specific differences in static and dynamic large-scale functional network connectivities within or between the cognitive control network, dorsal attention network, visual network, limbic network, and default mode network are found for CID and CID-D. Additionally, CID and CID-D groups showed compromised network topological architecture including reduced small-world properties, clustering coefficients and modularity indicating decreased network efficiency and impaired functional segregation. Moreover, the altered neuroimaging indices show significant associations with clinical manifestations and could serve as effective neuromarkers to distinguish among healthy controls, CID and CID-D. Taken together, these findings provide novel insights into the neural basis of CID and CID-D, which may facilitate developing new diagnostic and therapeutic approaches.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"136 ","pages":"Article 111158"},"PeriodicalIF":5.3,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA methylation of serotonin genes as predictive biomarkers of antidepressant treatment response","authors":"Silvia Elisabetta Portis Bruzzone ,&nbsp;Brice Ozenne ,&nbsp;Patrick MacDonald Fisher ,&nbsp;Gabriela Ortega ,&nbsp;Martin Balslev Jørgensen ,&nbsp;Gitte Moos Knudsen ,&nbsp;Klaus-Peter Lesch ,&nbsp;Vibe Gedsoe Frokjaer","doi":"10.1016/j.pnpbp.2024.111160","DOIUrl":"10.1016/j.pnpbp.2024.111160","url":null,"abstract":"<div><div>Selective serotonin reuptake inhibitors (SSRI) are frequently ineffective in treating depressive episodes and biomarkers are needed to optimize antidepressant treatment outcomes. DNA methylation levels of serotonin transporter (<em>SLC6A4</em>) and tryptophan hydroxylase 2 genes (<em>TPH2</em>) have been suggested to predict antidepressant clinical outcomes but their applicability remains uncertain. In this study, we: 1) evaluated <em>SLC6A4</em>/<em>TPH2</em> methylation biomarker potential for predicting clinical outcomes after escitalopram treatment; 2) evaluated whether changes in <em>SLC6A4</em>/<em>TPH2</em> methylation are informative of treatment mechanisms. We used a cohort of 90 unmedicated patients with major depressive disorder that were part of a 12-week open-label longitudinal trial and compared our observations with previous findings. Depressive symptoms were measured at baseline and after 8 and 12 weeks of treatment using the Hamilton Depression Rating Scale (HAMD_6/17). We found an association between baseline <em>TPH2</em> methylation and both clinical response (<em>β</em>:3.43; <em>p</em> = 0.01; 95 % CI:[0.80; 6.06]) and change in depressive symptoms after 8 weeks (<em>β</em>:−45.44; p = 0.01; 95 %CI:[− −78.58; −12.30]). However, we found no evidence for predictive value of any gene (<em>TPH2</em> AUC: 0.74 95 % CI:[0.42;0.79]; <em>SLC6A4</em>: AUC: 0.61; 95 % CI: [0.48–0.78]). Methylation levels changed at the trend level for CpG sites of <em>SLC6A4</em> and <em>TPH2</em> over the course of 12 weeks of treatment. In addition, similar to previous observations, we found a trend for an association between methylation of <em>SLC6A4</em> CpG2 (chr17:30,236,083) and HAMD₁₇ change after 12 weeks. Our findings suggest that although <em>TPH2</em> and <em>SLC6A4</em> methylation may be informative of antidepressant treatment outcome, they are unlikely to prove useful as clinical predictor tools.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"136 ","pages":"Article 111160"},"PeriodicalIF":5.3,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain structural differences in cocaine use disorder: Insights from multivariate and neurotransmitter analyses","authors":"Zhenzhen Yang ,&nbsp;Benjamin Klugah-Brown ,&nbsp;Guobin Ding ,&nbsp;Wenchao Zhou ,&nbsp;Bharat B. Biswal","doi":"10.1016/j.pnpbp.2024.111159","DOIUrl":"10.1016/j.pnpbp.2024.111159","url":null,"abstract":"<div><div>Cocaine use disorder (CUD) is a chronic and relapsing neuropsychiatric disorder characterized by structural and functional brain lesions, posing a significant public health challenge. While the disruptive effects of cocaine on neurotransmitter systems (receptors/transporters) have been well established, the patterns of brain structural abnormalities in CUD and its interaction with other factors remain an ongoing topic of investigation. We employed source-based morphometry (SBM), a multivariate approach on 50 CUD participants and 50 matched healthy controls from the public SUDMEX CONN dataset. This method allowed us to identify co-varying patterns of brain tissue volume differences, and further explore the effect of average cocaine dosage through moderation analysis. Spatial correlation analysis was also performed to examine micro-macro structural consistency between tissue volume variations and chemoarchitectural distribution of dopamine and serotonin. Our SBM analysis findings were consistent with reward-related neuroadaptations in the striato-thalamo-cortical and limbic pathways and also exhibited co-localization with the distribution of dopamine and serotonin systems. The moderation analysis suggested that the average dosage positively strengthens cocaine consumption years' effect on brain structures. By integrating our findings of gray and white matter volume differences and corresponding neurotransmitter profiles, this comprehensive view not only strengthens our understanding of the brain's structural abnormalities in CUD, but also reveals potential mechanisms underlying its development and progression.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"136 ","pages":"Article 111159"},"PeriodicalIF":5.3,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing psilocybin to metformin as neuroprotective agents against Parkinson's dementia: A systematic review of evidence and efficacy.","authors":"Randall D Ordovich-Clarkson, Maurice Jabbour, Daniel Arteaga Pelayo, Daniel Lara, Sebastian La Croix, Macie Mumman, Shoshanah Stukas, Reagan Anderson, David Meraz, Anthony Bangura, Brooklyn Anderson, Luke Bamrud, Caleb Blake","doi":"10.1016/j.pnpbp.2024.111155","DOIUrl":"10.1016/j.pnpbp.2024.111155","url":null,"abstract":"<p><strong>Background & aim: </strong>Treatment of Parkinson's disease (PD) has remained largely unchanged and focuses primarily on symptomatic relief through activation of dopaminergic pathways. Currently, there are no proven prophylactic approaches to the prevention of PD. This systematic review seeks to compare two separate compounds, metformin (MTF) and psilocybin, as potential prophylactic therapeutics against the development of PD.</p><p><strong>Methods: </strong>The authors conducted a systematic review focusing on primary studies that test these compounds on cell and animal models to determine if they might have any neuroprotective or neuroplastic effects.</p><p><strong>Results: </strong>The results of this review found that MTF may halt the progression of diseases such as PD through multiple mechanisms including reduced oxidative stress at the level of the mitochondria, thereby reducing α-synuclein related damage. Psilocybin, on the other hand, may increase repair of damaged neurons through psychoplastogenic activation of serotonergic pathways, particularly 5-HT_2A receptor activation, ultimately increasing the release of brain derived neurotropic factor (BDNF) and the reduction of α-synuclein accumulation.</p><p><strong>Conclusion: </strong>Implications of this study include a need for further research in off-label use of MTF as well as further research into serotonergic compounds such as psilocybin for the treatment and prevention of neurodegenerative diseases.</p>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":" ","pages":"111155"},"PeriodicalIF":5.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined cognitive assessment and automated MRI volumetry improves the diagnostic accuracy of detecting MCI due to Alzheimer's disease","authors":"Michaela Defrancesco ,&nbsp;Josef Marksteiner ,&nbsp;Lukas Lenhart ,&nbsp;Paul Klingler ,&nbsp;Ruth Steiger ,&nbsp;Elke R. Gizewski ,&nbsp;Georg Goebel ,&nbsp;Eberhard A. Deisenhammer ,&nbsp;Christoph Scherfler","doi":"10.1016/j.pnpbp.2024.111157","DOIUrl":"10.1016/j.pnpbp.2024.111157","url":null,"abstract":"<div><h3>Background</h3><div>Mild cognitive impairment (MCI) confers a high annual risk of 10–15 % of conversion to Alzheimer's disease (AD) dementia. MRI atrophy patterns derived from automated ROI analysis, particularly hippocampal subfield volumes, were reported to be useful in diagnosing early clinical stages of Alzheimer's disease.</div></div><div><h3>Objective</h3><div>The aim of the present study was to combine automated ROI MRI morphometry of hippocampal subfield volumes and cortical thickness estimates using FreeSurfer 6.0 with cognitive measures to predict disease progression and time to conversion from MCI to AD dementia.</div></div><div><h3>Methods</h3><div>Baseline (Neuropsychology, MRI) and clinical follow-up data from 62 MCI patients were analysed retrospectively. Individual cortical thickness and volumetric measures were obtained from T1-weighted MRI. Linear discriminant analysis (LDA) of both, cognitive measures and MRI measures (hippocampal subfields, temporal and parietal lobe volumes), were performed to differentiate MCI converters from stable MCI patients.</div></div><div><h3>Results</h3><div>Out of 62 MCI patients 21 (34 %) converted to AD dementia within a mean follow-up time of 74.7 ± 36.8 months (mean ± SD, range 12 to 130 months). LDA identified temporal lobe atrophy and hippocampal subfield volumes in combination with cognitive measures of verbal memory, verbal fluency and executive functions to correctly classify 71.4.% of MCI subjects converting to AD dementia and 92.7 % with stable MCI. Lower baseline GM volume of the subiculum and the superior temporal gyrus was associated with faster disease progression of MCI converters.</div></div><div><h3>Conclusion</h3><div>Combining cognitive assessment with automated ROI MRI morphometry is superior to using a single test in order to distinguish MCI due to AD from non converting MCI patients.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"136 ","pages":"Article 111157"},"PeriodicalIF":5.3,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal developmental of hippocampal subfields and amygdalar subnuclei volumes in young adults with heavy cannabis use: A three-year longitudinal study","authors":"Xueyi Zhang ,&nbsp;Zhengju Chen ,&nbsp;Benjamin Becker ,&nbsp;Tong Shan ,&nbsp;Taolin Chen ,&nbsp;Qiyong Gong","doi":"10.1016/j.pnpbp.2024.111156","DOIUrl":"10.1016/j.pnpbp.2024.111156","url":null,"abstract":"<div><h3>Background</h3><div>Differences in the volumes of the hippocampus and amygdala have consistently been observed between young adults with heavy cannabis use relative to their non-using counterparts. However, it remains unclear whether the subfields of these functionally and structurally heterogenous regions exhibit similar patterns of change in young adults with long-term heavy cannabis use disorder (CUD).</div></div><div><h3>Objectives</h3><div>This study aims to investigate the effects of long-term heavy cannabis use in young adults on the subregional structures of the hippocampus and amygdala, as well as their longitudinal alterations.</div></div><div><h3>Methods</h3><div>The study sample comprised 20 young adults with heavy cannabis use and 22 matched non-cannabis using healthy volunteers. All participants completed the Cannabis Use Disorder Identification Test (CUDIT) and underwent two T1-structural magnetic resonance imaging (MRI) scans, one at baseline and another at follow-up 3 years later. The amygdala, hippocampus, and their subregions were segmented on T1-weighted anatomical MRI scans, using a previously validated procedure.</div></div><div><h3>Results</h3><div>At baseline, young adults with heavy CUD exhibited significantly larger volumes in several hippocampal (bilateral presubiculum, subiculum, Cornu Ammonis (CA) regions CA1, CA2-CA3, and right CA4-Dentate Gyrus (DG)) and amygdala (bilateral paralaminar nuclei, right medial nucleus, and right lateral nucleus) subregions compared to healthy controls, but these differences were attenuated at follow-up. Longitudinal analysis revealed an accelerated volumetric decrease in these subregions in young adults with heavy CUD relative to controls. Particularly, compared to healthy controls, significant accelerated volume decreases were observed in the right hippocampal subfields of the parasubiculum, subiculum, and CA4-DG. In the amygdala, similar trends of accelerated volumetric decreases were observed in the left central nucleus, right paralaminar nucleus, right basal nucleus, and right accessory basal nucleus.</div></div><div><h3>Conclusions</h3><div>The current findings suggest that long-term heavy cannabis use impacts maturational process of the amygdala and hippocampus, especially in subregions with high concentrations of cannabinoid type 1 receptors (CB1Rs) and involvement in adult neurogenesis.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"136 ","pages":"Article 111156"},"PeriodicalIF":5.3,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Augmentation of psychiatric symptom onset vulnerability in male mice due to mild traumatic brain injury","authors":"Minori Koga ,&nbsp;Yasushi Satoh ,&nbsp;Masashi Kashitani ,&nbsp;Ryuichi Nakagawa ,&nbsp;Mayumi Sato ,&nbsp;Fumiho Asai ,&nbsp;Toshiaki Ishizuka ,&nbsp;Manabu Kinoshita ,&nbsp;Daizoh Saitoh ,&nbsp;Masanori Nagamine ,&nbsp;Hiroyuki Toda ,&nbsp;Aihide Yoshino","doi":"10.1016/j.pnpbp.2024.111153","DOIUrl":"10.1016/j.pnpbp.2024.111153","url":null,"abstract":"<div><div>Mild traumatic brain injury (mTBI) can induce psychiatric symptoms, including anxiety, depression, and diminished interest. These symptoms can manifest shortly after injury or exhibit delayed onset months or years later, often worsening in severity. Therefore, early intervention and effective treatment are crucial. However, mTBI lacks clear diagnostic markers, making the underlying pathophysiological mechanisms elusive. Additionally, there is a dearth of suitable animal models and a limited understanding of the biochemical changes in the brain that contribute to post-mTBI psychological symptoms. In this study, we hypothesized that mTBI can trigger brain vulnerability mechanisms, which eventually lead to symptom manifestation in response to subsequent stressors. Using a mouse model, we induced very mild blast-induced mTBI without overt trauma or behavioral changes and subsequently subjected the mice to psychological stress. We analyzed the behavioral alterations and gene expression changes in the brain, focusing on microglial and astrocytic markers involved in the immune system and immune responses. The mice exposed to both blast and defeat stress exhibited significantly lower preference scores in the social interaction test than the mice subjected to blast exposure alone, defeat stress alone, or the control condition. Gene expression analysis revealed a distinct set of genes associated with blast exposure during the development of psychiatric symptoms and genes associated with social defeat stress. The results revealed that neither blast exposure nor defeat stress alone significantly affected mouse social behavior; however, their combined influence resulted in noticeable aberrations in social interactions and/or interest. The findings of the present study provide critical insights into the complex interplay between mTBI and psychological stress. Additionally, they provide a novel mouse model for future research aimed at elucidating the pathophysiological mechanisms underlying the psychiatric symptoms associated with mTBI. Ultimately, this knowledge may enhance early intervention and therapeutic strategies for individuals with mTBI-related psychiatric disorders.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"136 ","pages":"Article 111153"},"PeriodicalIF":5.3,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of single and repeated ketamine administration for suicidal ideation in adults with psychiatric disorders: A meta-analysis","authors":"Wanting Feng ,&nbsp;Chengfeng Chen ,&nbsp;Yexian Zeng ,&nbsp;Bin Zhang","doi":"10.1016/j.pnpbp.2024.111152","DOIUrl":"10.1016/j.pnpbp.2024.111152","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies have demonstrated rapid-onset anti-suicidal ideation effects of ketamine. This study aimed to compare the efficacy and duration of anti-suicidal thoughts following single- and repeated-dose ketamine administration.</div></div><div><h3>Methods</h3><div>We retrieved published studies on ketamine for suicidal ideation (SI) from PubMed, OVID (MEDLINE), Web of Science, and Embase, spanning from inception to May 1, 2024. Standardized mean differences (SMD) in the SI scores were calculated for continuous outcomes.</div></div><div><h3>Results</h3><div>This study included 49 independent clinical trials involving 3982 participants. After a single ketamine administration, a significant reduction in SI was observed at 4 h (SMD = −0.607, 95 % confidence interval (CI) = [−0.797, −0.418], I² = 40.69 %), with peak effects observed at 24 h (SMD = −0.955, 95 % CI = [−1.229, −0.682], I² = 63.66 %) and effects persisted for one month (SMD = −0.948, 95 % CI = [−1.611, −0.285], I² = 74.32 %). Similar anti-suicidal effects were observed at the treatment endpoint (SMD = −1.228, 95 % CI = [−1.506, −0.950], I² = 94.56 %) and during a follow-up period of greater than or equal to 1 month (SMD = −1.012, 95 % CI = [−1.695, −0.330], I² = 80.44 %) with multiple doses of ketamine administration.</div></div><div><h3>Conclusions</h3><div>Single ketamine treatment may have a significant and lasting (up to 1 month) beneficial effect on SI. There was no statistical difference in the efficacy and duration of anti-suicidal thoughts between single and serial ketamine administration.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"136 ","pages":"Article 111152"},"PeriodicalIF":5.3,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The brain, rapid eye movement sleep, and major depressive disorder: A multimodal neuroimaging study","authors":"Siyu Liu ,&nbsp;Jingyao Chen ,&nbsp;Lianzi Guan ,&nbsp;Li Xu ,&nbsp;Huanhuan Cai ,&nbsp;Jie Wang ,&nbsp;Dao-min Zhu ,&nbsp;Jiajia Zhu ,&nbsp;Yongqiang Yu","doi":"10.1016/j.pnpbp.2024.111151","DOIUrl":"10.1016/j.pnpbp.2024.111151","url":null,"abstract":"<div><h3>Background</h3><div>Evidence has established the prominent involvement of rapid eye movement (REM) sleep disturbance in major depressive disorder (MDD). However, the neural correlates of REM sleep in MDD and their clinical significance are less clear.</div></div><div><h3>Methods</h3><div>Cross-sectional and longitudinal polysomnography and resting-state functional MRI data were collected from 131 MDD patients and 71 healthy controls to measure REM sleep and voxel-mirrored homotopic connectivity (VMHC). Correlation and mediation analyses were performed to examine the associations between REM sleep, VMHC, and clinical variables. Moreover, we conducted spatial correlations between the neural correlates of REM sleep and a multimodal collection of reference brain maps to facilitate genetic, structural and functional annotations.</div></div><div><h3>Results</h3><div>MDD patients exhibited REM sleep abnormalities manifesting as higher REM sleep latency and lower REM sleep duration, which were correlated with decreased VMHC of the precentral gyrus and inferior parietal lobe and mediated their associations with more severe anxiety symptoms. Longitudinal data showed that VMHC increase of the inferior parietal lobe was related to improvement of depression symptoms in MDD patients. Spatial correlation analyses revealed that the neural correlates of REM sleep in MDD were linked to gene categories primarily involving cellular metabolic process, signal pathway, and ion channel activity as well as linked to cortical microstructure, metabolism, electrophysiology, and cannabinoid receptor.</div></div><div><h3>Conclusion</h3><div>These findings may add important context to the growing literature on the complex interplay between sleep and MDD, and more broadly may inform future treatment for depression via regulating sleep.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"136 ","pages":"Article 111151"},"PeriodicalIF":5.3,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}