Progress in Neuro-Psychopharmacology & Biological Psychiatry最新文献

{"title":"Negative impacts of social isolation on behavior and neuronal functions are recovered after short-term social reintroduction in zebrafish","authors":"Talise E. Müller ,&nbsp;Matheus M. Dos Santos ,&nbsp;Sabrina A. Ferreira ,&nbsp;Mariana T. Claro ,&nbsp;Gabriel T. de Macedo ,&nbsp;Barbara D. Fontana ,&nbsp;Nilda V. Barbosa","doi":"10.1016/j.pnpbp.2024.111038","DOIUrl":"https://doi.org/10.1016/j.pnpbp.2024.111038","url":null,"abstract":"<div><p>Recently, social isolation measures were crucial to prevent the spread of the coronavirus pandemic. However, the lack of social interactions affected the population mental health and may have long-term consequences on behavior and brain functions. Here, we evaluated the behavioral, physiological, and molecular effects of a social isolation (SI) in adult zebrafish, and whether the animals recover such changes after their reintroduction to the social environment. Fish were submitted to 12 days of SI, and then reintroduced to social context (SR). Behavioral analyses to evaluate locomotion, anxiety-like and social-related behaviors were performed after SI protocol, and 3 and 6 days after SR. Cortisol and transcript levels from genes involved in neuronal homeostasis (<em>c-fos</em>, <em>egr</em>, <em>bdnf</em>), and serotonergic (5-HT) and dopaminergic (DA) neurotransmission (<em>thp</em>, <em>th</em>) were also measured. <strong>SI altered social behaviors in zebrafish such as aggression, social preference, and shoaling.</strong> Fish submitted to SI also presented changes in the transcript levels of genes related to neural activity, and 5-HT/DA signaling. Interestingly, most of the behavioral and molecular changes induced by SI were not found again 6 days after SR. Thus, we highlight that SR of zebrafish to their conspecifics played a positive role in social behaviors and in the expression of genes involved in different neuronal signaling pathways that were altered after 12 days of SI. This study brings unprecedented data on the effects of SR in the recovery from SI neurobehavioral alterations, and reinforces the role of zebrafish as a translational model for understanding the neurobiological mechanisms adjacent to SI and resocialization.</p></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141164192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T1w/T2w ratio maps identify children with autism spectrum disorder and the relationships between myelin-related changes and symptoms","authors":"Shujun Zhang ,&nbsp;Liping Jiang ,&nbsp;Zhe Hu ,&nbsp;Wenjing Liu ,&nbsp;Hao Yu ,&nbsp;Yao Chu ,&nbsp;Jiehuan Wang ,&nbsp;Yueqin Chen","doi":"10.1016/j.pnpbp.2024.111040","DOIUrl":"10.1016/j.pnpbp.2024.111040","url":null,"abstract":"<div><h3>Background</h3><p>Modern neuroimaging methods have revealed that autistic symptoms are associated with abnormalities in brain morphology, connectivity, and activity patterns. However, the changes in brain microstructure underlying the neurobiological and behavioral deficits of autism remain largely unknown.</p></div><div><h3>Methods</h3><p>we characterized the associated abnormalities in intracortical myelination pattern by constructing cortical T1-weighted/T2-weighted ratio maps. Voxel-wise comparisons of cortical myelination were conducted between 150 children with autism spectrum disorder (ASD) and 139 typically developing (TD) children. Group differences in cortical T1-weighted/T2-weighted ratio and gray matter volume were then examined for associations with autistic symptoms. A convolutional neural network (CNN) model was also constructed to examine the utility of these regional abnormalities in cortical myelination for ASD diagnosis.</p></div><div><h3>Results</h3><p>Compared to TD children, the ASD group exhibited widespread reductions in cortical myelination within regions related to default mode, salience, and executive control networks such as the inferior frontal gyrus, bilateral insula, left fusiform gyrus, bilateral hippocampus, right calcarine sulcus, bilateral precentral, and left posterior cingulate gyrus. Moreover, greater myelination deficits in most of these regions were associated with more severe autistic symptoms. In addition, children with ASD exhibited reduced myelination in regions with greater gray matter volume, including left insula, left cerebellum_4_5, left posterior cingulate gyrus, and right calcarine sulcus. Notably, the CNN model based on brain regions with abnormal myelination demonstrated high diagnostic efficacy for ASD.</p></div><div><h3>Conclusions</h3><p>Our findings suggest that microstructural abnormalities in myelination contribute to autistic symptoms and so are potentially promising therapeutic targets as well as biomarkers for ASD diagnosis.</p></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabidiol in the dorsal hippocampus attenuates emotional and cognitive impairments related to neuropathic pain: The role of prelimbic neocortex-hippocampal connections","authors":"Ana Carolina Medeiros ,&nbsp;Priscila Medeiros ,&nbsp;Glauce Regina Pigatto ,&nbsp;Sabatino Maione ,&nbsp;Norberto Cysne Coimbra ,&nbsp;Renato Leonardo de Freitas","doi":"10.1016/j.pnpbp.2024.111039","DOIUrl":"10.1016/j.pnpbp.2024.111039","url":null,"abstract":"<div><h3>Background and purpose</h3><p>Chronic neuropathic pain (NP) is commonly associated with cognitive and emotional impairments. Cannabidiol (CBD) presents a broad spectrum of action with a potential analgesic effect. This work investigates the CBD effect on comorbidity between chronic NP, depression, and memory impairment.</p></div><div><h3>Experimental approach</h3><p>The connection between the neocortex and the hippocampus was investigated with biotinylated dextran amine (BDA) deposits in the prelimbic cortex (PrL). Wistar rats were submitted to chronic constriction injury (CCI) of the sciatic nerve and CA₁ treatment with CBD (15, 30, 60 nmol).</p></div><div><h3>Key results</h3><p>BDA-labeled perikarya and terminal buttons were found in CA₁ and dentate gyrus. CCI-induced mechanical and cold allodynia increased c-Fos protein expression in the PrL and CA₁. The number of astrocytes in PrL and CA₁ increased, and the number of neuroblasts decreased in CA₁. Animals submitted to CCI procedure showed increasing depressive-like behaviors, such as memory impairment. CBD (60 nmol) treatment decreased mechanical and cold allodynia, attenuated depressive-associated behaviors, and improved memory performance. Cobalt chloride (CoCl₂: 1 nM), WAY-100635 (0.37 nmol), and AM251 (100 nmol) intra-PrL reversed the effect of CA₁ treatment with CBD (60 nmol) on nociceptive, cognitive, and depressive behaviors.</p></div><div><h3>Conclusion</h3><p>CBD represents a promising therapeutic perspective in the pharmacological treatment of chronic NP and associated comorbidities such as depression and memory impairments. The CBD effects possibly recruit the CA₁-PrL pathway, inducing neuroplasticity. CBD acute treatment into the CA₁ produces functional and molecular morphological improvements.</p></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141134277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural basis responsible for effect of grit on procrastination: The interaction between the self-regulation and motivation neural pathways","authors":"Youling Bai ,&nbsp;Biying Zhang ,&nbsp;Tingyong Feng","doi":"10.1016/j.pnpbp.2024.111037","DOIUrl":"10.1016/j.pnpbp.2024.111037","url":null,"abstract":"<div><p>Procrastination has a detrimental impact on academic performance, health, and subjective well-being. Previous studies indicated that grit was negatively related to procrastination. However, the underlying neural basis of this relationship remains unclear. To address this issue, we utilized voxel-based morphometry (VBM) and resting-state functional connectivity (RSFC) analysis to identify the neural substrates of how is grit linked to procrastination. Behavioral results showed that procrastination was negatively associated with grit. VBM analysis revealed that gray matter volume (GMV) in the left precuneus was positively associated with the <em>consistency of interest</em> (CI), a subcomponent of grit, while the right medial orbital frontal cortex (mOFC) was positively correlated with the <em>perseverance of effort</em> (PE), another subcomponent of grit. Moreover, the RSFC analysis indicated that both precuneus-medial superior frontal gyrus (mSFG) and precuneus-insula connectivity were positively related to CI, while the functional coupling of right mOFC with left anterior cingulate cortex (ACC) was positively related to PE. Importantly, the structural equation modeling (SEM) results were well suited for the influence of grit on procrastination via both self-regulation (mOFC-ACC) and motivation pathways (precuneus-mSFG, precuneus-insula). Together, these findings imply that self-regulation and motivation could be two neural circuits underlying the impact of grit on procrastination.</p></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141135769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impairment of olfactory identification ability in ultra-high risk for psychosis and drug-naïve first episode psychosis","authors":"Lijun Ouyang ,&nbsp;Xiaoqian Ma ,&nbsp;Liu Yuan ,&nbsp;Lejia Fan ,&nbsp;Aijun Liao ,&nbsp;David Li ,&nbsp;Zihao Yang ,&nbsp;Zhenmei Zhang ,&nbsp;Weiqing Liu ,&nbsp;Xiaogang Chen ,&nbsp;Zongchang Li ,&nbsp;Ying He","doi":"10.1016/j.pnpbp.2024.111035","DOIUrl":"10.1016/j.pnpbp.2024.111035","url":null,"abstract":"<div><h3>Objective</h3><p>Patients with psychotic diseases have been reported to exhibit abnormalities in their olfactory discrimination. These alterations have also been identified in people at high genetic or clinical risk for psychosis, suggesting olfactory discrimination dysfunction may be a potential risk factor for developing psychosis. Thus, the purpose of our study is to explore the difference in olfactory discrimination ability in the prosal stage and early stage of psychosis and to explore the potential risk factor of developed psychosis.</p></div><div><h3>Methods</h3><p>We compared olfactory identification and cognitive function in 89 ultra-high-risk (UHR) individuals, 103 individuals with Drug-naïve first-episode schizophrenia (FES), 81 genetic high-risk (GHR) individuals, and 97 healthy controls (HC). Additionally, we compared olfactory identification and cognitive function between two groups; UHR individuals who later transitioned to psychosis (UHR-T; <em>n</em> = 33) and those who did not transition (UHR-NT; <em>n</em> = 42)). Furthermore, we analyzed the correlations between olfactory discrimination ability and cognitive function and symptoms and compared the olfactory function between men and women.</p></div><div><h3>Results</h3><p>Patients with first-episode schizophrenia (FES) and those at ultra-high risk (UHR) for psychosis exhibited more significant deficits in olfactory identification than healthy controls (HC), while no differences in olfactory identification dysfunction were observed between the genetic high risk (GHR) and HC groups. Notably, individuals in the UHR group who later developed psyhchosis displayed a steeper marked decline in their baseline olfactory identification ability than that of those in the UHR group who did not develop psychosis. Cognitive dysfunction is widely observed in both the FES and UHR groups, with a distinct correlation identified between olfactory discrimination function and cognitive performance. Finally, overall, women exhibit significantly superior olfactory function than men.</p></div><div><h3>Conclusion</h3><p>In conclusion, these findings suggest that impairment of olfactory identification exists in the early stage of psychosis. Olfactory identification dysfunction may therefore be a potential marker of predicting the transition to schizophrenia.</p></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141142799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-dependent behavioral effects of chronic nicotine during adolescence evaluated in young adult rats tested in Hole-Board","authors":"Maurizio Casarrubea ,&nbsp;Stefania Aiello ,&nbsp;Giuseppe Crescimanno ,&nbsp;Daniel Cassar ,&nbsp;Zachary Busuttil ,&nbsp;Fabiana Faulisi ,&nbsp;Antonio Iacono ,&nbsp;Giuseppe Di Giovanni","doi":"10.1016/j.pnpbp.2024.111034","DOIUrl":"10.1016/j.pnpbp.2024.111034","url":null,"abstract":"<div><p>As one of the leading causes of death and serious illnesses, tobacco smoking remains a significant issue in modern societies. Many individuals smoke during adolescence, a trend that has been exacerbated by the prevalence of vaping among young people. In this context, studying the behavioral effects induced by nicotine administration in male and female rats, during the adolescent period, assumes great importance because it can help to better understand the dynamics underlying tobacco use in the two sexes. For this purpose, we employed 4 groups of rats, 2 male and 2 female groups, chronically treated with saline or nicotine 3 mg/kg i.p. for 30 days, spanning from postnatal day 30 to postnatal day 60. Utilizing quantitative analyses and T-pattern detection and analysis, our findings revealed a complex and multifaceted behavioral reorganization in adolescent rats subjected to chronic nicotine administration. Specifically, we observed an increase of anxiety in males and a reduction in females. The distinctive structural changes, induced by chronic nicotine in both sexes, have significant implications, from a translational perspective, for studies on nicotine dependence disorders.</p></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141142526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between BDNF and physical activity on depression","authors":"Juan Antonio Zarza-Rebollo ,&nbsp;Elena López-Isac ,&nbsp;Margarita Rivera ,&nbsp;Laura Gómez-Hernández ,&nbsp;Ana M. Pérez-Gutiérrez ,&nbsp;Esther Molina","doi":"10.1016/j.pnpbp.2024.111033","DOIUrl":"10.1016/j.pnpbp.2024.111033","url":null,"abstract":"<div><h3>Background/objective</h3><p>Major depressive disorder (MDD) is one of the leading causes of disease burden and disability worldwide. Brain-derived neurotrophic factor (BDNF) seems to have an important role in the molecular mechanisms underlying MDD aetiology, given its implication in regulating neuronal plasticity. There is evidence that physical activity (PA) improves depressive symptoms, with a key role of BDNF in this effect. We aim to perform a systematic review examining the relationship between the <em>BDNF</em> Val66Met polymorphism and the BDNF protein, PA and MDD.</p></div><div><h3>Methods</h3><p>Both observational and experimental design original articles or systematic reviews were selected, according to the PRISMA statement.</p></div><div><h3>Results</h3><p>Six studies evaluated the Val66Met polymorphism, suggesting a greater impact of physical activity on depression depending on the Val66Met genotype. More discordant findings were observed among the 13 studies assessing BDNF levels with acute or chronic exercise interventions, mainly due to the high heterogeneity found among intervention designs, limited sample size, and potential bias.</p></div><div><h3>Conclusions</h3><p>Overall, there is cumulative evidence supporting the potential role of BDNF in the interaction between PA and MDD. However, this review highlights the need for further research with more homogeneous and standardised criteria, and pinpoints important confounding factors that must be considered in future studies to provide robust conclusions.</p></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0278584624001015/pdfft?md5=caa5329108e48f65b5fc22fbe93d9c1a&pid=1-s2.0-S0278584624001015-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral serotonin levels as a predictor of antidepressant treatment response: A systematic review","authors":"Amanda Holck ,&nbsp;Pouya Movahed ,&nbsp;Åsa Westrin ,&nbsp;Owen M. Wolkowitz ,&nbsp;Daniel Lindqvist ,&nbsp;Marie Asp","doi":"10.1016/j.pnpbp.2024.111031","DOIUrl":"10.1016/j.pnpbp.2024.111031","url":null,"abstract":"<div><p>There are currently no reliable biomarkers to predict clinical response to pharmacological treatments of depressive disorders. Peripheral blood 5-hydroxytryptamine (5-HT; serotonin) has been suggested as a biomarker of antidepressant treatment response, but there has not been an attempt to systematically summarize and evaluate the scientific evidence of this hypothesis. In this systematic review we searched MEDLINE, Embase, PsycINFO, and the Cochrane Central Register of Controlled Trials. Twenty-six relevant studies investigating peripheral 5-HT as an antidepressant biomarker were identified. In all, we did not find robust support for an association between baseline 5-HT and treatment response. Several larger studies with lower risk of bias, however, showed that higher baseline 5-HT was associated with a greater antidepressant response to SSRIs, prompting future studies to investigate this hypothesis. Our results also confirm previous reports that SSRI treatment is associated with a decrease in peripheral 5-HT levels; however, we were not able to confirm that larger decreases of 5-HT are associated with better treatment outcome as results were inconclusive.</p></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S027858462400099X/pdfft?md5=c017e5acbce3b7e48d4f1be399e59862&pid=1-s2.0-S027858462400099X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of pregnancy on the pharmacokinetics of antiseizure medications: A systematic review and meta-analysis of data from 674 pregnancies","authors":"Georgios Schoretsanitis ,&nbsp;Kristina M. Deligiannidis ,&nbsp;Nicholas Kasperk ,&nbsp;Chiara Theresa Schmidt ,&nbsp;Sarah Kittel-Schneider ,&nbsp;Peter Ter Horst ,&nbsp;Maya Berlin ,&nbsp;Elkana Kohn ,&nbsp;Eline M.P. Poels ,&nbsp;Deepti Zutshi ,&nbsp;Torbjörn Tomson ,&nbsp;Olav Spigset ,&nbsp;Michael Paulzen","doi":"10.1016/j.pnpbp.2024.111030","DOIUrl":"10.1016/j.pnpbp.2024.111030","url":null,"abstract":"<div><h3>Objective</h3><p>Increasing evidence suggests that the physiological changes of pregnancy may impact pharmacokinetics of antiseizure medications (ASM), and this may affect treatment outcomes. The aim of this study was to quantify the pregnancy impact on the ASM pharmacokinetics.</p></div><div><h3>Methods</h3><p>A systematic literature search was conducted in PubMed/EMBASE in November 2022 and updated in August 2023 for studies comparing levels of ASM in the same individuals during pregnancy and in the preconception/postpartum period. Alteration ratios between the 3rd trimester and baseline were estimated. We also performed a random-effects meta-analysis calculating between-timepoint differences in mean differences (MDs) and 95% confidence intervals (95%CIs) for dose-adjusted plasma concentrations (C/D ratios). Study quality was assessed using the ClinPK guidelines.</p></div><div><h3>Results</h3><p>A total of 65 studies investigating 15 ASMs in 674 pregnancies were included. The largest differences were reported for lamotrigine, oxcarbazepine and levetiracetam (alteration ratio 0.42, range 0.07–2.45, 0.42, range 0.08–0.82 and 0.52, range 0.04–2.77 respectively): accordingly, C/D levels were lower in the 3rd trimester for lamotrigine, levetiracetam and the main oxcarbazepine metabolite monohydroxycarbazepine (MD = -12.33 × 10⁻³, 95%CI = -16.08 to −8.58 × 10⁻³ (μg/mL)/(mg/day), <em>p</em> &lt; 0.001, MD = -7.16 (μg/mL)/(mg/day), 95%CI = -9.96 to −4.36, p &lt; 0.001, and MD = -4.87 (μg/mL)/(mg/day), 95%CI = -9.39 to −0.35, <em>p</em> = 0.035, respectively), but not for oxcarbazepine (MD = 1.16 × 10⁻³ (μg/mL)/(mg/day), 95%CI = -2.55 to 0.24 × 10⁻³, <em>p</em> = 0.10). The quality of studies was acceptable with an average rating score of 11.5.</p></div><div><h3>Conclusions</h3><p>Data for lamotrigine, oxcarbazepine (and monohydroxycarbazepine) and levetiracetam demonstrate major changes in pharmacokinetics during pregnancy, suggesting the importance of therapeutic drug monitoring to assist clinicians in optimizing treatment outcomes.</p></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0278584624000988/pdfft?md5=5bc2e46ab23bcb8d86eae3dfa585866a&pid=1-s2.0-S0278584624000988-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141045847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal stress modulates glutamatergic functional connectivity: A post-synaptic density immediate early gene-based network analysis","authors":"Licia Vellucci ,&nbsp;Giuseppe De Simone ,&nbsp;Sara Morley-Fletcher ,&nbsp;Elisabetta Filomena Buonaguro ,&nbsp;Camilla Avagliano ,&nbsp;Annarita Barone ,&nbsp;Stefania Maccari ,&nbsp;Felice Iasevoli ,&nbsp;Andrea de Bartolomeis","doi":"10.1016/j.pnpbp.2024.111032","DOIUrl":"10.1016/j.pnpbp.2024.111032","url":null,"abstract":"<div><p>Early life stress may induce synaptic changes within brain regions associated with behavioral disorders. Here, we investigated glutamatergic functional connectivity by a postsynaptic density immediate-early gene-based network analysis. Pregnant female Sprague–Dawley rats were randomly divided into two experimental groups: one exposed to stress sessions and the other serving as a stress-free control group. <em>Homer1</em> expression was evaluated by in situ hybridization technique in eighty-eight brain regions of interest of male rat offspring. Differences between the perinatal stress exposed group (PRS) (<em>n</em> = 5) and the control group (CTR) (n = 5) were assessed by performing the Student's <em>t-</em>test via SPSS 28.0.1.0 with Bonferroni correction. Additionally, all possible pairwise Spearman's correlations were computed as well as correlation matrices and networks for each experimental group were generated via RStudio and Cytoscape. Perinatal stress exposure was associated with <em>Homer1a</em> reduction in several cortical, thalamic, and striatal regions. Furthermore, it was found to affect functional connectivity between: the lateral septal nucleus, the central medial thalamic nucleus, the anterior part of the paraventricular thalamic nucleus, and both retrosplenial granular b cortex and hippocampal regions; the orbitofrontal cortex, amygdaloid nuclei, and hippocampal regions; and lastly, among regions involved in limbic system. Finally, the PRS networks showed a significant reduction in multiple connections for the ventrolateral part of the anteroventral thalamic nucleus after perinatal stress exposure, as well as a decrease in the centrality of ventral anterior thalamic and amygdaloid nuclei suggestive of putative reduced cortical control over these regions.</p><p>Within the present preclinical setting, perinatal stress exposure is a modifier of glutamatergic early gene-based functional connectivity in neuronal circuits involved in behaviors relevant to model neurodevelopmental disorders.</p></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0278584624001003/pdfft?md5=8b571b67c4ea8389e16a789e52ebdb34&pid=1-s2.0-S0278584624001003-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141039358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}