{"title":"Comment prendre en charge une hypomagnésémie ?","authors":"Geoffrey Cheminet , Aude Ritter , Pascal Houillier , Caroline Prot-Bertoye","doi":"10.1016/j.revmed.2025.06.016","DOIUrl":"10.1016/j.revmed.2025.06.016","url":null,"abstract":"<div><div>Magnesium is essential to many enzymatic processes, using it in the form of adenosine or guanosine triphosphate (ATP/GTP)-Mg. Hypomagnesemia should be screened for more frequently. It can be due to multiple causes that need to be diagnosed. In this review, we provide a “practical” view of the management of hypomagnesemia: (patho)physiological concepts, clinical and biological manifestations, causes, diagnostic approach, and treatments.</div></div>","PeriodicalId":54458,"journal":{"name":"Revue De Medecine Interne","volume":"46 9","pages":"Pages 529-541"},"PeriodicalIF":0.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick Mercié , Visal Keo , Anne Contis , Étienne Rivière , Noémie Gensous , Guillaume Vial , Vivien Guillotin , Estibaliz Lazaro , Valérie Aurillac , Pierre Duffau , Emmanuel Richard , Emmanuel Ribeiro
{"title":"Place de la chitotriosidase au sein des biomarqueurs sériques de la sarcoïdose : une revue narrative de la littérature","authors":"Patrick Mercié , Visal Keo , Anne Contis , Étienne Rivière , Noémie Gensous , Guillaume Vial , Vivien Guillotin , Estibaliz Lazaro , Valérie Aurillac , Pierre Duffau , Emmanuel Richard , Emmanuel Ribeiro","doi":"10.1016/j.revmed.2025.06.014","DOIUrl":"10.1016/j.revmed.2025.06.014","url":null,"abstract":"<div><div>Sarcoidosis is an inflammatory systemic disease characterized by epithelio-gigantocellular granulomatosis without cell necrosis. The diagnosis is pathologic. There are many biomarkers of sarcoidosis. The oldest and most widely used in routine medical practice is angiotensin-converting enzyme (ACE) since 1975. However, it is a marker of low diagnostic value. The other most frequently studied biomarkers of interest are chitotriosidase (CTO), soluble IL-2 receptor (rsIL-2), neopterin, lysozyme, and SAA protein. In this work, we propose a review of the serum biomarkers of sarcoidosis. The studies are heterogeneous, and the results are difficult to conclude. Pathology remains the gold standard for the definitive diagnosis. In the context of evolutionary follow-up and relapse, we can select a priori 3 markers of interest: ACE (sensitivity [Se]: from 22 to 77% and specificity [Sp]: from 54 to 99%), CTO (Se: from 45 to 89% and Sp from 70 to 100%), and rsIL-2 (Se: from 52 to 82% and Sp: from 57 to 94%). The most rational association for a particular disease phenotype has yet to be determined. Future advances will come from an in-depth knowledge of granuloma, its mechanisms of formation, growth, and regression in the context of a still partially unknown inflammatory and immune response. Recent substantial progress has been made through radiological examinations. Multi-omics technologies will undoubtedly complement the arsenal of physiopathological and diagnostic research that will make it possible to move away from pathological examination and ensure better monitoring of the disease.</div></div>","PeriodicalId":54458,"journal":{"name":"Revue De Medecine Interne","volume":"46 9","pages":"Pages 517-528"},"PeriodicalIF":0.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Portrait du Dr. Delphine Gobert, praticien hospitalier à l’hôpital Saint-Antoine à Paris","authors":"Aïcha Kante , Jonathan Sormani , Anaïs Roeser","doi":"10.1016/j.revmed.2025.06.013","DOIUrl":"10.1016/j.revmed.2025.06.013","url":null,"abstract":"","PeriodicalId":54458,"journal":{"name":"Revue De Medecine Interne","volume":"46 9","pages":"Pages 563-565"},"PeriodicalIF":0.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Étienne Rivière , Yann Nguyen , Noëlle Bernard , Nathalie Costedoat-Chalumeau , groupe Greenternist
{"title":"Connaître le coût financier et écologique pour rationaliser les prescriptions d’examens complémentaires ou de médicaments","authors":"Étienne Rivière , Yann Nguyen , Noëlle Bernard , Nathalie Costedoat-Chalumeau , groupe Greenternist","doi":"10.1016/j.revmed.2025.06.012","DOIUrl":"10.1016/j.revmed.2025.06.012","url":null,"abstract":"","PeriodicalId":54458,"journal":{"name":"Revue De Medecine Interne","volume":"46 7","pages":"Pages 365-368"},"PeriodicalIF":0.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julie Moreau , Liticia Chikhoune , Claire Poggi , Sarah Stabler , Jean-Guillaume Letarouilly , Éric Hachulla , David Launay
{"title":"Safety profile of JAK inhibitors in inflammatory or autoimmune diseases","authors":"Julie Moreau , Liticia Chikhoune , Claire Poggi , Sarah Stabler , Jean-Guillaume Letarouilly , Éric Hachulla , David Launay","doi":"10.1016/j.revmed.2025.06.003","DOIUrl":"10.1016/j.revmed.2025.06.003","url":null,"abstract":"<div><div>Over the past decade, Janus kinase inhibitors (JAKi) have emerged as a promising treatment for inflammatory and autoimmune diseases. Concurrently, there has been increasing attention to their potential side effects, particularly infectious and cardiovascular risks. In this review, we outline the various adverse effects of these treatments and emphasize the importance of their prevention. First, we examine the risk of infection and the preventive measures through screening, vaccination, and prophylaxis. Subsequently, we explore the risk of developing malignant tumors, venous thromboembolism, and major cardiovascular events. Although the data are sometimes inconsistent, they indicate the existence of a subpopulation at increased risk of JAKi side effects, including patients over 65<!--> <!-->years of age, those with cardiovascular and malignancy risk factors, and smokers. Finally, we discuss the risk and prevention strategies for gastrointestinal perforation, as well as the risk of biological abnormalities, such as cytopenias, cytolysis, dyslipidemia, and elevated CPK levels.</div></div>","PeriodicalId":54458,"journal":{"name":"Revue De Medecine Interne","volume":"46 7","pages":"Pages 386-396"},"PeriodicalIF":0.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}