{"title":"French protocol for the diagnosis and management of systemic lupus erythematosus","authors":"","doi":"10.1016/j.revmed.2024.07.006","DOIUrl":"10.1016/j.revmed.2024.07.006","url":null,"abstract":"<div><p>Because Systemic Lupus Erythematosus (SLE) is a rare disease, and due to the significant prognostic impact of early management, a diagnosis confirmed by a physician with experience in SLE is recommended, for example from an expert center. Once the diagnosis is confirmed, existing manifestations should be identified in particular, renal involvement by an assessment of proteinuria, disease activity and severity should be determined, potential complications anticipated, associated diseases searched for, and the patient's socioprofessional and family context noted. Therapeutic management of SLE includes patient education on recognizing symptoms, understanding disease progression as well as when they should seek medical advice. Patients are informed about routine checkups, treatment side effects, and the need for regular vaccinations, especially if they are receiving immunosuppressive treatment. They are also advised on lifestyle factors such as the risks of smoking, sun exposure, and dietary adjustments, especially when they are receiving corticosteroids. The importance of contraception, particularly when teratogenic medications are being used, and regular cancer screening are emphasized. Support networks can help relieve a patient's isolation. The first-line medical treatment of SLE is hydroxychloroquine (HCQ), possibly combined with an immunosuppressant and/or low-dose corticosteroid therapy. The treatment of flares depends on their severity, and typically involves HCQ and NSAIDs, but may be escalated to corticosteroid therapy with immunosuppressants or biologic therapies in moderate to severe cases. Because there is no curative treatment, the goals of therapy are patient comfort, preventing progression and flares, and preserving overall long-term health and fertility. The frequency of follow-up visits depends on disease severity and any new symptoms. Regular specialized assessments are necessary, especially when treatment changes, but a frequency of every 3 to 6 months is recommended during periods of remission and monthly during active or severe disease, especially in children. These assessments include both clinical and laboratory tests to monitor complications and disease activity, with specific attention to proteinuria.</p></div>","PeriodicalId":54458,"journal":{"name":"Revue De Medecine Interne","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142083013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prise en charge personnalisée du PTI de l'adulte : enjeux et considérations pratiques","authors":"","doi":"10.1016/S0248-8663(24)00773-2","DOIUrl":"10.1016/S0248-8663(24)00773-2","url":null,"abstract":"","PeriodicalId":54458,"journal":{"name":"Revue De Medecine Interne","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Screening for primary immune deficiency among patients with bronchiectasis","authors":"","doi":"10.1016/j.revmed.2024.06.010","DOIUrl":"10.1016/j.revmed.2024.06.010","url":null,"abstract":"<div><h3>Introduction</h3><p>To assess frequency and methods of PID (primary immune deficiency) screening among patients with bronchiectasis by pneumologists in clinical practice.</p></div><div><h3>Methods</h3><p>All the patients hospitalized in the department of pneumology of the Poitiers University Hospital between April 2013 and April 2020 with a diagnosis of bronchiectasis on chest computerized tomography were included. Patients aged 70 and over and those with already known PID were excluded. Primary endpoint was the proportion of patients having had serum immunoglobulin (Ig) assay and serum protein electrophoresis (SPE) analysis. Secondary endpoints were factors associated with prescription of SPE and/or Ig assay, proportion of patients with newly diagnosed PID and their characteristics and factors associated with repeated courses of antibiotics.</p></div><div><h3>Results</h3><p>Among the 133 patients included, 43% had SPE<!--> <!-->+<!--> <!-->Ig assay, 34% SPE only and 23% neither. The proportion of patients with asthma was higher in the “SPE<!--> <!-->+<!--> <!-->Ig assay” group (33.3%) compared to the “SPE only” (11.1%) and the “Neither SPE nor Ig assay” groups (6.4%) (<em>P</em> <!-->=<!--> <!-->0.002). Four patients were newly diagnosed for PID of whom 3 had subclass IgG deficiency. Factors associated with repeated courses of antibiotics were generalized bronchiectasis (<em>P</em> <!-->=<!--> <!-->0.02) and asthma (<em>P</em> <!-->=<!--> <!-->0.04).</p></div><div><h3>Conclusion</h3><p>PID is underscreened by pneumologists among patients with bronchiectasis. Association of SPE<!--> <!-->+<!--> <!-->Ig assay<!--> <!-->+<!--> <!-->IgG subclass assay appears as the most accurate combination.</p></div>","PeriodicalId":54458,"journal":{"name":"Revue De Medecine Interne","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pr Bertrand Godeau, PU-PH en médecine interne au CHU Henri-Mondor, Président du Conseil national des universités, sous-section 5301 – médecine interne ; gériatrie et biologie du vieillissement ; addictologie","authors":"","doi":"10.1016/j.revmed.2024.07.007","DOIUrl":"10.1016/j.revmed.2024.07.007","url":null,"abstract":"","PeriodicalId":54458,"journal":{"name":"Revue De Medecine Interne","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0248866324007057/pdfft?md5=a559e0bfbdf812a5b128faa69befc32d&pid=1-s2.0-S0248866324007057-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plénière de l'Amicale des jeunes internistes – Médecine spatiale","authors":"","doi":"10.1016/S0248-8663(24)00777-X","DOIUrl":"10.1016/S0248-8663(24)00777-X","url":null,"abstract":"","PeriodicalId":54458,"journal":{"name":"Revue De Medecine Interne","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Maladies infectieuses émergentes dans le contexte du changement climatique et des migrations des populations","authors":"","doi":"10.1016/S0248-8663(24)00774-4","DOIUrl":"10.1016/S0248-8663(24)00774-4","url":null,"abstract":"","PeriodicalId":54458,"journal":{"name":"Revue De Medecine Interne","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hommage au Prof. Pierre Fesler (1970–2024)","authors":"","doi":"10.1016/j.revmed.2024.07.012","DOIUrl":"10.1016/j.revmed.2024.07.012","url":null,"abstract":"","PeriodicalId":54458,"journal":{"name":"Revue De Medecine Interne","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0248866324007331/pdfft?md5=39c048e0fec41ee83b342f62cee1c4a9&pid=1-s2.0-S0248866324007331-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}