Pediatric Allergy Immunology and Pulmonology最新文献

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Could Age and Oral Challenge Outcomes Identify High-Risk Patients During Cow's Milk Oral Immunotherapy? 在牛奶口服免疫治疗过程中,年龄和口腔挑战结果能否识别高危患者?
IF 0.9 4区 医学
Pediatric Allergy Immunology and Pulmonology Pub Date : 2022-06-08 DOI: 10.1089/ped.2022.0003
H. Duman Şenol, E. Topyıldız, E. Ulusoy Severcan, Sanem Eren Akercan, Nursen Cigerci Gunaydin, F. Gulen, E. Demir
{"title":"Could Age and Oral Challenge Outcomes Identify High-Risk Patients During Cow's Milk Oral Immunotherapy?","authors":"H. Duman Şenol, E. Topyıldız, E. Ulusoy Severcan, Sanem Eren Akercan, Nursen Cigerci Gunaydin, F. Gulen, E. Demir","doi":"10.1089/ped.2022.0003","DOIUrl":"https://doi.org/10.1089/ped.2022.0003","url":null,"abstract":"Objective: Severe immunglobuline E (IgE)-mediated reactions during oral immunotherapy (OIT) are major obstacles to treatment. The present study aimed to evaluate and identify clinical and laboratory biomarkers of adverse events during OIT among children with cow's milk (CM) allergy. Study Design: Eighty-six children older than 36 months who had undergone OIT with milk were enrolled. Clinical data, oral food challenge (OFC) test results, and laboratory data were recorded retrospectively. Results: The median duration of the build-up phase of OIT was 19 weeks (min 10-max 40) and the duration of the maintenance phase was 86.5 (min 1-max 132) months. A total of 11,767 CM doses were administered during the build-up phase and adverse reactions were seen in 62 (73.8%) patients with reactions registered for 157 doses among 11,767 (1/75 doses). The number of reactions during the maintenance phase was 41 (47.6%) in 24 (27.9%) patients. There was a significant reduction in the number of reactions (P = 0.000) between the build-up phase and maintenance phase. Adverse reactions and anaphylaxis were higher for patients who had cough during OFC (P = 0.003, P = 0.002, respectively) during the build-up phase and also during the maintenance phase too (P = 0.000). Evaluation for all reactions and anaphylaxis (during build-up and maintenance) with Kaplan-Meier and Cox regression analysis showed class IV-VI of CM-specific immunoglobulin E (sIgE), casein-sIgE and cough during OFC were significantly associated with increased probability of reaction and anaphylaxis. Younger age at onset of OIT was associated with risk reduction (0.017). Conclusion: Laboratory data and reactions during the OFC (especially cough) can help to identify high-risk patients during OIT.","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46936298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Care Coordinators for Children with Respiratory Technologies and Home Nursing. 儿童呼吸技术和家庭护理护理协调员的角色。
IF 0.9 4区 医学
Pediatric Allergy Immunology and Pulmonology Pub Date : 2022-06-01 DOI: 10.1089/ped.2021.0236
Sarah A Sobotka, Emma Lynch, Rishi Agrawal
{"title":"The Role of Care Coordinators for Children with Respiratory Technologies and Home Nursing.","authors":"Sarah A Sobotka,&nbsp;Emma Lynch,&nbsp;Rishi Agrawal","doi":"10.1089/ped.2021.0236","DOIUrl":"https://doi.org/10.1089/ped.2021.0236","url":null,"abstract":"<p><p><b><i>Background:</i></b> Children with respiratory technologies, particularly those with mechanical ventilation, represent a growing population that require complex home nursing, medical equipment, outpatient medical and habilitative supports to live and thrive in their community. Care coordination is essential to support these children and their families to navigate and integrate key community-based health and educational services, however, care is often fragmented and care coordination needs unmet. Therefore, to fully support children with respiratory technologies, it is critical to understand the role of care coordinators (CCs) and how to sustain this workforce. The aim of this article is to describe CCs' perspective on (1) their role in supporting families in a home care program for children with respiratory technologies and home nursing, and (2) the core components of recruiting into and sustaining the CC workforce. <b><i>Methods:</i></b> Semistructured interviews were conducted with 15 CC from the Division of Specialized Care for Children (DSCC) Home Care program for children with technology dependence and home nursing in Illinois. Two independent coders utilized a modified template approach and discussed to agreement to analyze transcripts. <b><i>Results:</i></b> CC averaged 6.6 years of CC experience; the majority had social work or nursing backgrounds. CCs' job satisfaction was derived from their role supporting hospital discharge, seeing children improve over time, and navigating challenges with families. CCs enjoyed working in a collaborative environment where they could draw from their colleagues' experience to solve problems. Job dissatisfaction and job turnover stemmed from difficult family interactions, high caseloads, and redundant and time-intensive administrative tasks, which interfered with family engagement. <b><i>Conclusions:</i></b> CCs for children with respiratory technologies require diverse skills, but interdisciplinary teams enable collaborative support of families. Seeing children thrive can sustain the workforce, however, CCs report challenges due to high caseloads and administrative tasks, which impede direct family involvement.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"35 2","pages":"49-57"},"PeriodicalIF":0.9,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247673/pdf/ped.2021.0236.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9555321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Evaluation of Frequency and Characteristics of Drug Allergy in Pediatric Patients with Cystic Fibrosis. 儿童囊性纤维化患者药物过敏的频率和特点评价。
IF 0.9 4区 医学
Pediatric Allergy Immunology and Pulmonology Pub Date : 2022-06-01 DOI: 10.1089/ped.2021.0165
Zeynep Şengül Emeksiz, Pınar Metbulut, Şule Selin Akyan Soydaş, Gökçen Tuğcu, Güzin Cinel, Emine Dibek Mısırlıoğlu
{"title":"Evaluation of Frequency and Characteristics of Drug Allergy in Pediatric Patients with Cystic Fibrosis.","authors":"Zeynep Şengül Emeksiz,&nbsp;Pınar Metbulut,&nbsp;Şule Selin Akyan Soydaş,&nbsp;Gökçen Tuğcu,&nbsp;Güzin Cinel,&nbsp;Emine Dibek Mısırlıoğlu","doi":"10.1089/ped.2021.0165","DOIUrl":"https://doi.org/10.1089/ped.2021.0165","url":null,"abstract":"<p><p><b><i>Background:</i></b> Previous studies reported that the prevalence of drug allergy is higher in patients with cystic fibrosis (CF) than in the general population. It is important to exclude or confirm the drug allergy diagnosis with detailed allergic evaluation for preventing drug allergy overdiagnosis. Our study aims to determine the actual frequency of drug allergy proven by diagnostic tests in children with CF and to compare it with the control group. <b><i>Methods:</i></b> Patients diagnosed with CF who were followed up in the Pediatric Pulmonology Clinic were included in the study group. Children with similar gender and age characteristics who did not have any chronic diseases and who applied to the Pediatric Polyclinics were included in the control group. We reviewed the medical data of patients with CF. Also, we evaluated the parents of the patients via phone conversation and/or during the control of the outpatient clinic and questioned them in terms of drug allergy. In addition, we assessed those with suspected drug allergies in the pediatric allergy clinic for diagnostic tests and compared it to the control group. <b><i>Results:</i></b> CF patients (<i>n</i> = 44) and control group (<i>n</i> = 100) were included in the study. Only 1 patient (2.2%) out of the 44 patients in the study group had a suspicion of drug-related hypersensitivity history. In the control group, 1 patient had a history of rash, provocation test was performed to rule out drug hypersensitivity reaction, and it was evaluated as a negative result. <b><i>Conclusions:</i></b> The result of our study showed that the frequency of drug allergy in children diagnosed with CF was not different from the control group. However, it will be useful to confirm the data of pediatric patients with CF in larger groups. In the presence of suspicion of drug allergy, a diagnostic evaluation can prevent unnecessary drug allergy diagnoses.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"35 2","pages":"74-78"},"PeriodicalIF":0.9,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247676/pdf/ped.2021.0165.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9911713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Comparison of Two Weaning Methods from Heated Humidified High-Flow Nasal Cannula Therapy in Pediatric Intensive Care Unit. 儿童重症监护病房加热加湿高流量鼻插管两种脱机方法的比较。
IF 0.9 4区 医学
Pediatric Allergy Immunology and Pulmonology Pub Date : 2022-06-01 DOI: 10.1089/ped.2021.0229
Muhammed Udurgucu, Hatice Albayrak, Hatice Elif Kinik Kaya, Nazik Yener
{"title":"Comparison of Two Weaning Methods from Heated Humidified High-Flow Nasal Cannula Therapy in Pediatric Intensive Care Unit.","authors":"Muhammed Udurgucu,&nbsp;Hatice Albayrak,&nbsp;Hatice Elif Kinik Kaya,&nbsp;Nazik Yener","doi":"10.1089/ped.2021.0229","DOIUrl":"https://doi.org/10.1089/ped.2021.0229","url":null,"abstract":"<p><p><b><i>Background and Objective:</i></b> Although high-flow nasal cannula (HFNC) is widely used in children, there is no consensus on the methods for starting, maintenance, and weaning. The aim of this study was to compare weaning methods in children. <b><i>Methods:</i></b> The study included all patients in pediatric intensive care unit (PICU) who were started on HFNC treatment. The respiratory assessment score was used in the decisions for starting, continuing, and weaning from HFNC. The patients who responded and for whom weaning was planned were randomized by month into 2 groups as directly weaned from HFNC and weaned by reducing the flow. Success rates, treatment, and length of stay (LOS) in weaning methods were compared. <b><i>Results:</i></b> Of the 145 patients initially included in the study, 32 (22%) were excluded, and analysis was made of 113 patients. Successful weaning from HFNC was obtained in 76.9% of the patients, in 82.1% of flow weaning, and 73.6% of direct weaning, with no statistically significant difference determined between the groups (<i>P</i> = 0.286). The median duration of HFNC and the median LOS in PICU were determined to be statistically significantly shorter in direct weaning than in flow weaning [36 h interquartile range (IQR) 24-48 h] versus 60 h (IQR 60-72 h), <i>P</i> < 0.001 and 6 days (4-14 days) versus 9.5 days (5.25-20.75 days, <i>P</i> = 0.043, respectively). <b><i>Conclusion:</i></b> In patients who responded to HFNC in PICU, the responses to direct weaning and flow reduction were seen to be similar. In patients directly weaned off, both the HFNC duration and LOS in PICU were significantly shorter.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"35 2","pages":"79-85"},"PeriodicalIF":0.9,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247675/pdf/ped.2021.0229.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9927963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
School Nurse Perspectives on School-Supervised Asthma Therapy: A Qualitative Study. 校医对学校监督下哮喘治疗的看法:定性研究。
IF 1.1 4区 医学
Pediatric Allergy Immunology and Pulmonology Pub Date : 2022-06-01 DOI: 10.1089/ped.2022.0022
Shushmita Hoque, Janki Luther, Raphael Mizrahi, Lynn B Gerald, Wanda Phipatanakul, Stephenie C Lemon, Milagros C Rosal, Nancy Byatt, Lori Pbert, Michelle Trivedi
{"title":"School Nurse Perspectives on School-Supervised Asthma Therapy: A Qualitative Study.","authors":"Shushmita Hoque, Janki Luther, Raphael Mizrahi, Lynn B Gerald, Wanda Phipatanakul, Stephenie C Lemon, Milagros C Rosal, Nancy Byatt, Lori Pbert, Michelle Trivedi","doi":"10.1089/ped.2022.0022","DOIUrl":"10.1089/ped.2022.0022","url":null,"abstract":"<p><p><b><i>Background:</i></b> School-supervised asthma therapy improves asthma outcomes for children, yet this strategy is not widely utilized. School nurses play a vital role in this intervention, yet their perspectives on school-supervised asthma therapy have not been thoroughly examined. <b><i>Objectives:</i></b> To examine the perspectives of school nurses participating in school-supervised asthma therapy and identify key facilitators, barriers, and proposed solutions that will facilitate the uptake of this strategy. <b><i>Methods:</i></b> We used purposeful sampling to recruit 12 school nurses participating in Asthma Link, a real-world application of school-supervised asthma therapy, between 2017 and 2019. We performed semistructured interviews with school nurses to elicit their perspectives on the facilitators, barriers, and proposed solutions to barriers to Asthma Link implementation. Interview transcripts were analyzed using qualitative descriptive methodology to identify major themes. <b><i>Results:</i></b> School nurses identified facilitators for Asthma Link adoption, including the ease of integrating supervised therapy into school nurse routines, recognition of benefits for families with limited resources, and satisfaction participating in preventive care. School nurses identified barriers, including communication challenges with families and providers, families not reliably bringing medication to school, limited nursing staff in schools, and increased school nurse turnover. School nurses proposed specific solutions to these barriers, including appointing Asthma Link liaisons within pediatric practices, incentivizing families to bring medicine to school, and partnering new school nurses with those experienced in delivering Asthma Link to overcome staffing issues and promote program fidelity. <b><i>Conclusions:</i></b> School nurse perspectives on the facilitators, barriers, and solutions to barriers are important for understanding how to promote real-world implementation of school-supervised asthma therapy. The themes identified in this study will be utilized to refine our protocol for Asthma Link to facilitate real-world adoption of this evidence-based strategy.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"35 2","pages":"65-73"},"PeriodicalIF":1.1,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247674/pdf/ped.2022.0022.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9555320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Is Bronchodilation Testing Routinely Useful in All Asthmatic Children?, by Tosca, et al. Pediatr Allergy Immunol Pulmonol 2022;31(1):8-11; doi: 10.1089/ped.2021.0222. 更正:支气管扩张测试对所有哮喘儿童都有用吗?,Tosca等人,Pediatr Allergy Immunol Pulmonol 2022;31(1):8-11;doi:10.1089/第2021.0222页。
IF 0.9 4区 医学
Pediatric Allergy Immunology and Pulmonology Pub Date : 2022-05-12 DOI: 10.1089/ped.2021.0222.correx
{"title":"Correction to: Is Bronchodilation Testing Routinely Useful in All Asthmatic Children?, by Tosca, et al. Pediatr Allergy Immunol Pulmonol 2022;31(1):8-11; doi: 10.1089/ped.2021.0222.","authors":"","doi":"10.1089/ped.2021.0222.correx","DOIUrl":"https://doi.org/10.1089/ped.2021.0222.correx","url":null,"abstract":"","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45924839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Racial and Ethnic Differences of Influenza-Associated Pediatric Hospitalizations and Deaths, 2008-2017. 2008-2017年流感相关儿童住院和死亡的种族差异
IF 0.9 4区 医学
Pediatric Allergy Immunology and Pulmonology Pub Date : 2022-04-29 DOI: 10.1089/ped.2021.0199
Shelease C O'Bryant, Deepa Dongarwar, H. Salihu, S. Gillespie
{"title":"Racial and Ethnic Differences of Influenza-Associated Pediatric Hospitalizations and Deaths, 2008-2017.","authors":"Shelease C O'Bryant, Deepa Dongarwar, H. Salihu, S. Gillespie","doi":"10.1089/ped.2021.0199","DOIUrl":"https://doi.org/10.1089/ped.2021.0199","url":null,"abstract":"Background: Influenza is one of the most common causes of acute respiratory infections in children; its complications are a leading cause of morbidity and mortality. There is a paucity of pediatric data on influenza disparities among racial/ethnic minorities. Our study assesses if there are racial/ethnic differences in hospitalizations and mortality in children infected with influenza. Methods: This was a retrospective cohort study using the National Inpatient Sample (NIS) from January 1, 2008 to December 31, 2017. We included children 18 years and younger hospitalized with a primary or secondary diagnosis of influenza or its subtypes. We generated adjusted odds ratios (aORs) and 95% confidence intervals (CIs) to evaluate the associations between patient characteristics and influenza hospitalizations and influenza-related mortality. Results: There were 226,535 (0.04%) influenza-associated hospitalizations. When compared with non-Hispanic (NH) White children, minority children were more likely to be hospitalized with an influenza diagnosis [Hispanics (aOR = 1.25; 95% CI, 1.17 to 1.33), NH-Blacks (aOR = 1.21, 95% CI, 1.17 to 1.33) and NH-Others group (aOR = 1.11; 95% CI, 1.04 to 1.19)]. There was no racial/ethnic difference in mortality. Conclusions: Minority children experienced a higher likelihood of influenza-associated hospitalizations but not mortality. Further research is needed to reduce the racial/ethnic disparities of influenza's impact.","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"1 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43312037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Anxiety Levels and Changes in Health and Hygiene Behaviors in Mothers of Children with Asthma in Early COVID-19 Lockdown in Turkey. 土耳其新冠肺炎早期封锁期间哮喘患儿母亲的焦虑水平和健康卫生行为变化。
IF 0.9 4区 医学
Pediatric Allergy Immunology and Pulmonology Pub Date : 2022-03-14 DOI: 10.1089/ped.2021.0113
O. Sancakli, T. Tuncel, S. Eren Akarcan, A. Kanık, G. Özyurt, E. Ozdogru
{"title":"Anxiety Levels and Changes in Health and Hygiene Behaviors in Mothers of Children with Asthma in Early COVID-19 Lockdown in Turkey.","authors":"O. Sancakli, T. Tuncel, S. Eren Akarcan, A. Kanık, G. Özyurt, E. Ozdogru","doi":"10.1089/ped.2021.0113","DOIUrl":"https://doi.org/10.1089/ped.2021.0113","url":null,"abstract":"Objective: The restrictions imposed by the coronavirus disease 2019 (COVID-19) pandemic have caused significant changes in people's lives. This study aimed to investigate anxiety levels and changes in health and hygiene behaviors in mothers of children with asthma in early COVID-19 lockdown in Turkey. Materials and Methods: This study was a cross-sectional survey conducted on children with asthma, 6 to 11 years of age, between June 1 and 30, 2020, in Turkey. A sociodemographic data form, health and hygiene behavior form, childhood asthma control test, and state-trait anxiety inventory were administered to the mothers of the children. Results: The asthma group included 123 children (Female: 39.0%) and median age, interquartile range (IQR) [minimum-maximum]: 8.0 (6) [6-12] years; the control group included 88 children (Female: 47.7%) median age, IQR [minimum-maximum]: 8.0 (7) [5-12] years. Increased hygiene behaviors and high compliance with social isolation measures were recorded in the early lockdown, with no difference between the groups. Before the pandemic, the most frequently used cleaning products were general-purpose cleaners. During the early lockdown, however, the most frequently used product was disinfectants and was similar in both groups. In both groups, the rate of using nutritional supplements increased during the pandemic period, but the rate was higher in children with asthma both before and during the early lockdown (P < 0.001). The anxiety levels of the mothers in asthma and control groups were similar. Conclusion: This study is the first in Turkey demonstrating that, in mothers of children with asthma, lifestyle changes related to health and hygiene and anxiety levels are similar to those of other children and their mothers during the early lockdown period of COVID-19 pandemic.","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48875673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Inhaled Dry Powder Mannitol Treatment in Pediatric Patients with Cystic Fibrosis: Evaluation of Clinical Data in a Real-World Setting. 吸入干粉甘露醇治疗儿童囊性纤维化患者:在现实世界环境下的临床数据评估。
IF 0.9 4区 医学
Pediatric Allergy Immunology and Pulmonology Pub Date : 2022-03-14 DOI: 10.1089/ped.2021.0127
I. Duman, Gökçe Ünal, A. Yılmaz, A. Güney, Y. Durduran, S. Pekcan
{"title":"Inhaled Dry Powder Mannitol Treatment in Pediatric Patients with Cystic Fibrosis: Evaluation of Clinical Data in a Real-World Setting.","authors":"I. Duman, Gökçe Ünal, A. Yılmaz, A. Güney, Y. Durduran, S. Pekcan","doi":"10.1089/ped.2021.0127","DOIUrl":"https://doi.org/10.1089/ped.2021.0127","url":null,"abstract":"Background: Cystic fibrosis (CF) is a genetic disorder, in which defective clearance of airway secretions leads to progressive lung function loss. Inhaled mannitol is used to increase sputum and mucociliary clearance. There are little data from real-world studies on the effectiveness of mannitol in children. Our objective was to evaluate the spirometry and clinical results of mannitol in pediatric patients. Methods: We retrospectively reviewed the records of 30 children and adolescents with CF receiving inhaled mannitol who were already on recombinant human deoxyribonuclease (rhDNase) treatment. The change in forced expiratory volume in 1 second (FEV1) from baseline at 2-4 months was the primary outcome. Secondary measures were other spirometry results, body mass index (BMI), hospital admissions, sputum characteristics, and positive bacterial colonization. Results: Compared to baseline, we found significant improvement in percent predicted FEV1 at 2-4 months of treatment; 84.50 (58.00-99.00) vs. 96.00 (66.00-106.00) (P = 0.0007). The absolute change in FEV1 was +11.5% at 2-4 months, +6.5% at 5-7 months, and +4% at 8-12 months. Also, significant improvements in other spirometry results were observed. Adolescents had significantly lower FEV1 results, but the improvement in their lung function was sustained for a more extended period than children. Mannitol provided easier sputum removal, increased sputum volume, significant decline in hospitalizations, and significantly fewer patients with positive sputum cultures. A significant increase in BMI at 8-12 months was observed. Cough was the most frequent adverse effect. Conclusion: In a real-world setting, our results demonstrated that adding mannitol to rhDNase therapy is tolerable in pediatric patients with CF and may provide improved spirometry and clinical outcomes. In addition, our results showed that mannitol provided recovery in overall lung function at 2-4 months, which was sustained up to 12 months together with improved BMI, easier sputum removal, and a decline in bacterial colonization and hospital admissions. However, cough was the most frequent side effect.","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46849978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Psychological State of Parents of Children with Primary Immunodeficiencies During the COVID-19 Pandemic. 新冠肺炎大流行期间原发性免疫缺陷患儿家长的心理状态
IF 0.9 4区 医学
Pediatric Allergy Immunology and Pulmonology Pub Date : 2022-03-01 Epub Date: 2022-02-18 DOI: 10.1089/ped.2021.0081
Berhan Akdağ, Arif Önder, Özge Gizli Çoban, Dilara Fatma Kocacık Uygun, Aslı Sürer Adanır, Aybike Erdem, Enes Çelik, Zehra Ece Soğucak, Ayşen Bingöl
{"title":"Psychological State of Parents of Children with Primary Immunodeficiencies During the COVID-19 Pandemic.","authors":"Berhan Akdağ,&nbsp;Arif Önder,&nbsp;Özge Gizli Çoban,&nbsp;Dilara Fatma Kocacık Uygun,&nbsp;Aslı Sürer Adanır,&nbsp;Aybike Erdem,&nbsp;Enes Çelik,&nbsp;Zehra Ece Soğucak,&nbsp;Ayşen Bingöl","doi":"10.1089/ped.2021.0081","DOIUrl":"https://doi.org/10.1089/ped.2021.0081","url":null,"abstract":"<p><p><b><i>Background:</i></b> COVID-19 has affected humanity not only physically but also mentally. It was expected to have impact on high-risk groups such as the immunocompromised patients and parents/caregivers of them. Our study was aimed to investigate the COVID-19 related anxiety, post-traumatic stress levels, and sleep-related parameters of the parents of children with primary immunodeficiency. <b><i>Methods:</i></b> Parents of children with primary immunodeficiency and age and gender-matched control group completed questionnaires. <b><i>Results:</i></b> Anxiety and post-traumatic stress levels of the study group were found to be significantly higher than the control group. Furthermore, sleep time of the study group was significantly lower than the control group. The subjective sleep quality of the study group was also lower in the study group, but the difference did not reach a significant level. <b><i>Conclusions:</i></b> In the ongoing and other possible pandemic processes, professional support for the parents of these children is of great importance.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"35 1","pages":"12-18"},"PeriodicalIF":0.9,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39797178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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